NO972881L - Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling - Google Patents

Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling

Info

Publication number
NO972881L
NO972881L NO972881A NO972881A NO972881L NO 972881 L NO972881 L NO 972881L NO 972881 A NO972881 A NO 972881A NO 972881 A NO972881 A NO 972881A NO 972881 L NO972881 L NO 972881L
Authority
NO
Norway
Prior art keywords
preparation
methods
piperazine derivatives
drugs containing
salts
Prior art date
Application number
NO972881A
Other languages
English (en)
Other versions
NO972881D0 (no
Inventor
Helmut Pieper
Volkhard Austel
Frank Himmelsbach
Guenter Linz
Brian Guth
Johannes Weisenberger
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944446301 external-priority patent/DE4446301A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO972881D0 publication Critical patent/NO972881D0/no
Publication of NO972881L publication Critical patent/NO972881L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Det beskrives piperazinderivater med den generelle formel. hvor. Ra, Yi til Yog E er som definert i krav 1, deres tautomerer, deres stereoisomerer, inklusivt deres blandinger og deres salter, særlig deres fysiologisk akseptable salter med uorganiske eller organiske syrer eller baser, og som oppviser verdifulle farmakologiske egenskaper, fortrinnsvis. , aggregasjonshemmende virkninger, legemidler som inneholder disse forbindelsene, deres anvendelse samt fremgangsmåter fortleres fremstilling.
NO972881A 1994-12-23 1997-06-20 Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling NO972881L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19944446301 DE4446301A1 (de) 1994-12-23 1994-12-23 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19526678A DE19526678A1 (de) 1994-12-23 1995-07-21 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995133639 DE19533639A1 (de) 1994-12-23 1995-09-12 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1995/005031 WO1996020173A1 (de) 1994-12-23 1995-12-19 Piperazinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
NO972881D0 NO972881D0 (no) 1997-06-20
NO972881L true NO972881L (no) 1997-06-20

Family

ID=27207101

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972881A NO972881L (no) 1994-12-23 1997-06-20 Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling

Country Status (20)

Country Link
US (1) US5922717A (no)
EP (1) EP0799202A1 (no)
JP (1) JPH10511374A (no)
CN (1) CN1183770A (no)
AR (1) AR002950A1 (no)
AU (1) AU4432496A (no)
BG (1) BG101582A (no)
BR (1) BR9510360A (no)
CA (1) CA2207618A1 (no)
CZ (1) CZ189197A3 (no)
EE (1) EE9700141A (no)
FI (1) FI972646L (no)
HR (1) HRP950609A2 (no)
IL (1) IL116517A0 (no)
MX (1) MX9704745A (no)
NO (1) NO972881L (no)
PL (1) PL321003A1 (no)
SK (1) SK79797A3 (no)
TR (1) TR199501634A2 (no)
WO (1) WO1996020173A1 (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10511359A (ja) * 1994-12-22 1998-11-04 スミスクライン・ビーチャム・コーポレイション フィブリノゲン受容体拮抗物質
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
JPH11513382A (ja) * 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
WO1999052894A1 (en) * 1998-04-09 1999-10-21 Meiji Seika Kaisha, Ltd. Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof
CZ20011872A3 (cs) * 1999-09-29 2002-03-13 Ortho-Mcneil Pharmaceutical, Inc. Isonipekotamidy pro léčbu onemocnění zprostředkovaných integriny
EP1533310A1 (en) * 1999-09-29 2005-05-25 Ortho-McNeil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
EP1389205B1 (en) * 2001-04-09 2005-12-21 Ortho-McNeil Pharmaceutical Research Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
US7763620B2 (en) 2001-08-24 2010-07-27 Yale University Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment
FR2829766A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
WO2003066589A1 (en) 2002-02-08 2003-08-14 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
CA2558585C (en) * 2004-02-27 2010-10-12 Amgen Inc. Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
US7851474B2 (en) * 2005-08-02 2010-12-14 Neurogen Corporation Dipiperazinyl ketones and related analogues
AU2006309050B2 (en) 2005-10-28 2012-08-16 Merck Sharp & Dohme Corp. Piperidine glycine transporter inhibitors
AU2007265467C1 (en) 2006-06-28 2013-11-07 Amgen Inc. Glycine transporter-1 inhibitors
WO2008013622A2 (en) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
EP2397477B1 (en) * 2007-01-16 2014-03-05 Purdue Pharma LP Heterocyclic-substituted piperidine compounds and the uses thereof
MY150602A (en) 2007-08-31 2014-01-30 Purdue Pharma Lp Subtituted-quinoxaline-type piperidine compounds and the uses thereof
WO2010081851A1 (en) 2009-01-14 2010-07-22 Genoscience Pharma Piperidin-4-ylpiperazine compounds for the treatment of hcv infection
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
JP2014527511A (ja) 2011-06-24 2014-10-16 アムジエン・インコーポレーテツド Ｔｒｐｍ８拮抗剤及び治療におけるそれらの使用
CN104334541A (zh) * 2012-02-16 2015-02-04 纽约大学 使用低聚氧代哌嗪非肽螺旋模拟物对低氧诱导基因表达的控制
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
WO2014113794A2 (en) 2013-01-19 2014-07-24 New York University Oligooxopiperazines for p53 reactivation
US10787424B2 (en) 2014-05-21 2020-09-29 New York University Oxopiperazine helix mimetics for control of Hypoxia-Inducible gene expression
CN118434717A (zh) * 2021-12-20 2024-08-02 西格马-奥尔德里奇有限责任公司 化学接头

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2926472A1 (de) * 1979-06-30 1981-01-15 Thomae Gmbh Dr K Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel
ZA825719B (en) * 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
US4895846A (en) * 1984-04-11 1990-01-23 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties
US4778796A (en) * 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4332168A1 (de) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
AU692438B2 (en) * 1993-03-29 1998-06-11 Astrazeneca Ab Heterocyclic derivatives as platelet aggregation inhibitors
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4326344A1 (de) * 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5814636A (en) * 1994-07-15 1998-09-29 Meiji Seika Kabushiki Kaisha Compounds with platelet aggregation inhibitor activity
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives

Also Published As

Publication number Publication date
FI972646A7 (fi) 1997-08-19
NO972881D0 (no) 1997-06-20
HRP950609A2 (en) 1997-10-31
TR199501634A2 (tr) 1996-07-21
SK79797A3 (en) 1997-11-05
AU4432496A (en) 1996-07-19
FI972646A0 (fi) 1997-06-19
PL321003A1 (en) 1997-11-24
FI972646L (fi) 1997-08-19
EE9700141A (et) 1997-12-15
CN1183770A (zh) 1998-06-03
JPH10511374A (ja) 1998-11-04
IL116517A0 (en) 1996-03-31
WO1996020173A1 (de) 1996-07-04
MX9704745A (es) 1997-10-31
BR9510360A (pt) 1997-12-23
AR002950A1 (es) 1998-05-27
US5922717A (en) 1999-07-13
CA2207618A1 (en) 1996-07-04
CZ189197A3 (cs) 1998-01-14
EP0799202A1 (de) 1997-10-08
BG101582A (bg) 1998-01-30

Similar Documents

Publication Publication Date Title
NO972881L (no) Piperazinderivater, legemidler som inneholder disse, anvendelse derav og fremgangsmåte for deres fremstilling
NO920957L (no) Cykliske urinstoffderivater og legemidler inneholdende disse forbindelser
NO934501L (no) Karboksylsyrederivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling
NO923466L (no) Heterocykliske forbindelser med 5 ledd, fremgangsmaate forfremstilling, samt legemidler som inneholder disse forbindelser
NO933248L (no) Cykliske urinstoffderivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling
NO922940L (no) Fem-leddete heterocykliske forbindelser, fremgangsmaate for deres fremstilling og legemidler inneholdende dem
NO940261L (no) 5-leddete heterocykler, fremgangsmåte ved fremstilling derav og legemidler som inneholder disse forbindelser
NO932120L (no) Bifenylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
NO984084L (no) 4-Amino-pyrimidin-derivater, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte ved fremstilling derav
NO984081L (no) Pyrimido[5,4-d]pyrimidiner, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmÕte for fremtilling derav
DK0483667T3 (da) Cykliske iminoderivater, lægemidler indholdende disse forbindelser og fremgangsmåde til fremstilling deraf
MX9803954A (es) Derivados de aminoacidos, composiciones farmaceuticas que contienen estos compuestos y procesos para prepararlos.
NO941677D0 (no) Tetrazolderivater av gallesyrer, fremgangsmåter for fremstilling og deres anvendelse som legemiddel
DK0496378T3 (da) Biphenylderivater, lægemidler indeholdende disse forbindelser og fremgangsmåder til deres fremstilling
BR0113039A (pt) Composto ou um seu sal ou solvato fisiologicamente aceitável, uso do mesmo, composição farmacêutica, formulação farmacêutica em aerossol, método para o tratamento de um indivìduo humano ou animal com uma condição antiinflamatória e/ou alérgica, e, processo para preparar um composto
NO931526L (no) Cykliske iminoderivater, fremgangsmaate for deres fremstilling, og legemiddelpreparater inneholdende dem
NO20064166L (no) Utvalgte CGRP-antagonister, deres fremstilling og deres anvendelse som medikanmenter
NO20023161L (no) Substituerte piperidiner, legemidler inneholdende disse forbindelser og fremgangsmåter for fremstilling av dem
NO991761L (no) Nye piperidin-kotokarbonsyre-derivater, deres fremstilling og anvendelse
NO20076680L (no) Utvalgte CGRP-antagonister, metoder for fremstilling av disse og deres anvendelse som medikamenter
MX9700020A (es) Derivados ciclicos de una urea, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
NO931527L (no) Cykliske iminoderivater, medisinpreparater inneholdende disse, og fremgangsmaate for deres fremstilling
NO940524L (no)
DK163581C (da) Kondenserede pyrazol-3-oxo-propannitrilderivater og fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende forbindelserne
NO20023001L (no) Substituerte piperazinderivater som MTP inhibitorer