BG101787A - Aprotinine options having improved properties - Google Patents

Aprotinine options having improved properties

Info

Publication number: BG101787A
Authority: BG; Bulgaria
Prior art keywords: aprotinine; options; improved properties; improvedenzymoinhibiting; andto
Prior art date: 1996-07-25

Application number

BG101787A

Other languages

Bulgarian (bg)

English (en)

Inventor

Werner Schroeder

Soren Bjorn

Kjeld Norris

Viggo DINNES

Niels CHRISTENSEN

Leif Norkskov-Lauritsen

Original Assignee

Bayer Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-25

Filing date

1997-07-22

Publication date

1998-10-30

1997-07-22 Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft

1998-10-30 Publication of BG101787A publication Critical patent/BG101787A/xx

Links

ZPNFWUPYTFPOJU-MPSLMFKFSA-N aprotinin Chemical compound CC[C@H](C)[C@@H]1NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H]3NC(=O)CNC(=O)CNC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CSSC[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC3=O)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CSSC[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H]3CCCN3C(=O)[C@H](N)CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N3CCC[C@@H]3C(=O)N3CCC[C@H]3C(=O)N[C@H](Cc3ccc(O)cc3)C(=O)N[C@H]([C@H](C)O)C(=O)NCC(=O)N3CCC[C@H]3C(=O)N2)C(=O)NCC(=O)NCC(=O)N[C@H](C)C(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](NC1=O)[C@H](C)CC)[C@@H](C)O)C(C)C ZPNFWUPYTFPOJU-MPSLMFKFSA-N 0.000 title abstract 2
230000001900 immune effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Immunology (AREA)
Hematology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG101787A 1996-07-25 1997-07-22 Aprotinine options having improved properties BG101787A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19629982A DE19629982A1 (de)	1996-07-25	1996-07-25	Aprotinin-Varianten mit verbesserten Eigenschaften

Publications (1)

Publication Number	Publication Date
BG101787A true BG101787A (en)	1998-10-30

Family

ID=7800774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG101787A BG101787A (en)	1996-07-25	1997-07-22	Aprotinine options having improved properties

Country Status (37)

Country	Link
US (2)	US6482798B2 (fr)
EP (1)	EP0821007B1 (fr)
JP (1)	JPH10101700A (fr)
KR (1)	KR980009283A (fr)
CN (1)	CN1172116A (fr)
AR (1)	AR008783A1 (fr)
AT (1)	ATE260975T1 (fr)
AU (2)	AU2870197A (fr)
BG (1)	BG101787A (fr)
BR (1)	BR9704068A (fr)
CA (1)	CA2207071A1 (fr)
CO (1)	CO4890857A1 (fr)
CZ (1)	CZ236797A3 (fr)
DE (2)	DE19629982A1 (fr)
DZ (1)	DZ2276A1 (fr)
EE (1)	EE9700177A (fr)
ES (1)	ES2217350T3 (fr)
HN (1)	HN1997000094A (fr)
HR (1)	HRP970384A2 (fr)
HU (1)	HUP9701290A3 (fr)
ID (1)	ID17508A (fr)
IL (1)	IL121361A0 (fr)
MA (1)	MA24279A1 (fr)
NO (1)	NO973426L (fr)
NZ (1)	NZ328402A (fr)
PE (1)	PE92298A1 (fr)
PL (1)	PL321341A1 (fr)
RU (1)	RU2197983C2 (fr)
SG (1)	SG71714A1 (fr)
SK (1)	SK101997A3 (fr)
SV (1)	SV1997000068A (fr)
TN (1)	TNSN97130A1 (fr)
TR (1)	TR199700688A2 (fr)
TW (1)	TW480271B (fr)
UA (1)	UA55380C2 (fr)
YU (1)	YU31697A (fr)
ZA (1)	ZA976585B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19725014A1 (de) *	1997-06-13	1998-12-17	Bayer Ag	Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
US6974188B2 (en) *	2003-08-13	2005-12-13	Cosco Management, Inc.	Chair with pivotable chair back
US20060218667A1 (en) *	2004-10-12	2006-09-28	Vojdani Fakhrieh S	Plant-produced recombinant aprotinin and aprotinin variants
WO2006042327A2 (fr) *	2004-10-12	2006-04-20	Large Scale Biology Corporation	Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine
USD533000S1 (en) *	2005-02-18	2006-12-05	Atico International Usa, Inc.	Connector housing of an anti-pinching device of a folding chair
MX2007010113A (es) *	2005-02-18	2007-12-07	Angiochem Inc	Polipeptidos de aprotinina para transportar un compuesto a traves de la barrera hematoencefalica.
WO2008077478A1 (fr) *	2006-12-22	2008-07-03	Bayer Schering Pharma Aktiengesellschaft	Préparation et utilisation de variants du domaine 2 de kunitz du gène de la bikunine placentaire humaine
WO2008110301A1 (fr) *	2007-03-13	2008-09-18	Bayer Schering Pharma Aktiengesellschaft	Variants d'aprotinine à propriétés améliorées
DE102007056231A1 (de)	2007-09-08	2009-03-12	Bayer Healthcare Ag	Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
BRPI1103921A2 (pt)	2011-08-17	2013-08-06	Mahle Metal Leve Sa	camisa de cilindro e liga de ferro fundido
EP4460509A1 (fr) *	2022-01-05	2024-11-13	Helix Nanotechnologies Inc	Compositions comprenant une séquence prepro de facteur alpha et leurs utilisations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en)	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
US4595974A (en) *	1984-09-10	1986-06-17	Burroughs Corporation	Base drive circuit for a switching power transistor
GB2208511A (en)	1987-08-07	1989-04-05	Bayer Ag	Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5591603A (en)	1987-08-28	1997-01-07	Novo Nordisk A/S	Process for preparing aprotinin and aprotinin analogs in yeast cells
DK225488D0 (da) *	1988-04-26	1988-04-26	Novo Industri As	Polypeptid
DK463887D0 (da)	1987-09-07	1987-09-07	Novo Industri As	Gaerleader
DK105489D0 (da)	1989-03-03	1989-03-03	Novo Nordisk As	Polypeptid
US5231010A (en)	1989-09-13	1993-07-27	Bayer Aktiengesellschaft	Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
DE3930522A1 (de) *	1989-09-13	1991-03-21	Bayer Ag	Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
IL99585A0 (en) *	1990-10-01	1992-08-18	Novo Nordisk As	Aprotinin analogues,their production and pharmaceutical compositions containing them
US5747449A (en) *	1992-07-13	1998-05-05	Corvas International, Inc.	Bovine pancreatic trypsin inhibitor derived inhibitors of factor XA
KR100199565B1 (ko) *	1994-08-19	1999-06-15	차동천	승화형 감열전사 기록용 수용지의 중간층 제조방법

1996
- 1996-07-25 DE DE19629982A patent/DE19629982A1/de not_active Withdrawn
1997
- 1997-06-20 HN HN1997000094A patent/HN1997000094A/es unknown
- 1997-07-14 EP EP97111980A patent/EP0821007B1/fr not_active Expired - Lifetime
- 1997-07-14 DE DE59711356T patent/DE59711356D1/de not_active Expired - Fee Related
- 1997-07-14 AT AT97111980T patent/ATE260975T1/de not_active IP Right Cessation
- 1997-07-14 ES ES97111980T patent/ES2217350T3/es not_active Expired - Lifetime
- 1997-07-15 HR HR19629982.9A patent/HRP970384A2/xx not_active Application Discontinuation
- 1997-07-17 US US08/896,322 patent/US6482798B2/en not_active Expired - Fee Related
- 1997-07-17 AU AU28701/97A patent/AU2870197A/en not_active Abandoned
- 1997-07-21 SV SV1997000068A patent/SV1997000068A/es unknown
- 1997-07-22 CA CA002207071A patent/CA2207071A1/fr not_active Abandoned
- 1997-07-22 IL IL12136197A patent/IL121361A0/xx unknown
- 1997-07-22 ID IDP972548A patent/ID17508A/id unknown
- 1997-07-22 JP JP9210197A patent/JPH10101700A/ja active Pending
- 1997-07-22 BG BG101787A patent/BG101787A/xx unknown
- 1997-07-23 YU YU31697A patent/YU31697A/sh unknown
- 1997-07-23 NZ NZ328402A patent/NZ328402A/xx unknown
- 1997-07-23 DZ DZ970126A patent/DZ2276A1/fr active
- 1997-07-23 AR ARP970103329A patent/AR008783A1/es not_active Application Discontinuation
- 1997-07-24 SK SK1019-97A patent/SK101997A3/sk unknown
- 1997-07-24 KR KR1019970034643A patent/KR980009283A/ko not_active Ceased
- 1997-07-24 CZ CZ972367A patent/CZ236797A3/cs unknown
- 1997-07-24 HU HU9701290A patent/HUP9701290A3/hu unknown
- 1997-07-24 RU RU97112745/14A patent/RU2197983C2/ru not_active IP Right Cessation
- 1997-07-24 PE PE1997000661A patent/PE92298A1/es not_active Application Discontinuation
- 1997-07-24 NO NO973426A patent/NO973426L/no not_active Application Discontinuation
- 1997-07-24 BR BR9704068A patent/BR9704068A/pt not_active IP Right Cessation
- 1997-07-24 EE EE9700177A patent/EE9700177A/xx unknown
- 1997-07-24 TN TNTNSN97130A patent/TNSN97130A1/fr unknown
- 1997-07-24 MA MA24733A patent/MA24279A1/fr unknown
- 1997-07-24 SG SG1997002627A patent/SG71714A1/en unknown
- 1997-07-24 UA UA97073949A patent/UA55380C2/uk unknown
- 1997-07-24 TW TW086110514A patent/TW480271B/zh not_active IP Right Cessation
- 1997-07-24 ZA ZA9706585A patent/ZA976585B/xx unknown
- 1997-07-25 TR TR97/00688A patent/TR199700688A2/xx unknown
- 1997-07-25 PL PL97321341A patent/PL321341A1/xx unknown
- 1997-07-25 CN CN97115348A patent/CN1172116A/zh active Pending
- 1997-07-25 CO CO97042648A patent/CO4890857A1/es unknown
2001
- 2001-06-06 AU AU51787/01A patent/AU762041B2/en not_active Ceased
2002
- 2002-09-23 US US10/252,967 patent/US20030096752A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EE9700177A (et)	1998-02-16
ATE260975T1 (de)	2004-03-15
NO973426D0 (no)	1997-07-24
DZ2276A1 (fr)	2002-12-18
ID17508A (id)	1998-01-08
US6482798B2 (en)	2002-11-19
HUP9701290A2 (hu)	1999-06-28
BR9704068A (pt)	1999-01-05
CN1172116A (zh)	1998-02-04
CO4890857A1 (es)	2000-02-28
DE19629982A1 (de)	1998-01-29
UA55380C2 (uk)	2003-04-15
AU762041B2 (en)	2003-06-19
NZ328402A (en)	1999-03-29
TW480271B (en)	2002-03-21
IL121361A0 (en)	1998-01-04
HU9701290D0 (en)	1997-09-29
SV1997000068A (es)	1998-07-09
HUP9701290A3 (en)	2000-08-28
DE59711356D1 (de)	2004-04-08
EP0821007B1 (fr)	2004-03-03
ZA976585B (en)	1998-02-03
US20030096752A1 (en)	2003-05-22
KR980009283A (ko)	1998-04-30
HRP970384A2 (en)	1998-04-30
AU5178701A (en)	2001-09-06
AR008783A1 (es)	2000-02-23
YU31697A (sh)	1999-07-28
EP0821007A3 (fr)	1998-11-18
MX9705605A (es)	1998-08-30
JPH10101700A (ja)	1998-04-21
NO973426L (no)	1998-01-26
SK101997A3 (en)	1998-03-04
TNSN97130A1 (fr)	2005-03-15
CZ236797A3 (cs)	1998-02-18
US20020103334A1 (en)	2002-08-01
EP0821007A2 (fr)	1998-01-28
AU2870197A (en)	1998-02-05
PE92298A1 (es)	1999-02-13
SG71714A1 (en)	2000-04-18
ES2217350T3 (es)	2004-11-01
MA24279A1 (fr)	1998-04-01
PL321341A1 (en)	1998-02-02
TR199700688A2 (xx)	1998-02-21
CA2207071A1 (fr)	1998-01-25
HN1997000094A (es)	1997-12-26
RU2197983C2 (ru)	2003-02-10

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ID23374A (id)	2000-04-20	Halogenopirimidin
GB9425109D0 (en)	1995-02-08	Novel fusarium isolate and lipases, cutinases and enzyme compositions derived therefrom
ZA979202B (en)	1998-05-11	Conditioning shampoo compositions having improved silicone deposition.
GR970300016T1 (en)	1997-05-31	Lactobacillus strains of human origin, their compositions and uses thereof
ZA974585B (en)	1997-11-24	Sizing compositions.
AU5186799A (en)	2000-02-07	Peptides of il-2 and derivatives thereof and their use as therapeutic agents
HUP0004085A3 (en)	2003-05-28	Novel 3,6-hemiketals from the class of 9a-azalides
IL128500A0 (en)	2000-01-31	Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta (b) benzofurans
MX9806041A (es)	1998-11-30	Proteina purificada sr-p70.
YU31697A (sh)	1999-07-28	Varijante aprotinina sa poboljšanim svojstvima
IL139604A0 (en)	2002-02-10	Novel peptides
DE69737457D1 (de)	2007-04-19	O-fukosyltransferase
BG104373A (en)	2000-12-29	Polymorphous forms of dofetilide
BG104707A (en)	2001-04-30	Caspase-8 interacting proteins
ZA977491B (en)	1998-02-19	Use of polyhydroxycarboxylamides as EP additives.
ZA987660B (en)	2000-02-25	Novel tissue-specific calpains, their preparation and use.
GB2325466A (en)	1998-11-25	Nucleotide sequence from goat liver
BG102937A (en)	1999-09-30	Zona pelucida proteins as contraceptives
ZA9610510B (en)	1998-06-15	Novel peptides, the preparation and use thereof.