BG102678A - 1,4-dihydropyridine compounds as bradykinin antagonists - Google Patents

1,4-dihydropyridine compounds as bradykinin antagonists

Info

Publication number: BG102678A
Authority: BG; Bulgaria
Prior art keywords: bradykinin; compounds; octyl; alkyl; bradykinin antagonists
Prior art date: 1996-02-19

Application number

BG102678A

Other languages

Bulgarian (bg)

English (en)

Inventor

Takafumi Ikeda

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-19

Filing date

1998-08-10

Publication date

1999-04-30

1998-08-10 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

1999-04-30 Publication of BG102678A publication Critical patent/BG102678A/xx

Links

YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
239000003152 bradykinin antagonist Substances 0.000 title 1
101800004538 Bradykinin Proteins 0.000 abstract 2
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 2
102100035792 Kininogen-1 Human genes 0.000 abstract 2
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
-1 inflammations Chemical compound 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
206010019196 Head injury Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000004221 Multiple Trauma Diseases 0.000 abstract 1
208000023637 Multiple injury Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
230000036407 pain Effects 0.000 abstract 1
125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)

BG102678A 1996-02-19 1998-08-10 1,4-dihydropyridine compounds as bradykinin antagonists BG102678A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB9600132		1996-02-19
PCT/IB1997/000058 WO1997030048A1 (en)	1996-02-19	1997-01-27	1,4-dihydropyridine compounds as bradykinin antagonists

Publications (1)

Publication Number	Publication Date
BG102678A true BG102678A (en)	1999-04-30

Family

ID=11004406

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102678A BG102678A (en)	1996-02-19	1998-08-10	1,4-dihydropyridine compounds as bradykinin antagonists

Country Status (34)

Country	Link
US (1)	US6131226A (de)
EP (1)	EP0882044B1 (de)
JP (1)	JP3167335B2 (de)
KR (1)	KR19990082678A (de)
CN (1)	CN1211251A (de)
AR (1)	AR005841A1 (de)
AT (1)	ATE220676T1 (de)
AU (1)	AU1396497A (de)
BG (1)	BG102678A (de)
BR (1)	BR9707568A (de)
CA (1)	CA2245857C (de)
CO (1)	CO4650041A1 (de)
CZ (1)	CZ258698A3 (de)
DE (1)	DE69714019T2 (de)
DK (1)	DK0882044T3 (de)
ES (1)	ES2177921T3 (de)
HN (1)	HN1997000013A (de)
HR (1)	HRP970094A2 (de)
HU (1)	HUP9902810A3 (de)
ID (1)	ID16434A (de)
IL (1)	IL124867A0 (de)
IS (1)	IS4783A (de)
MA (1)	MA26419A1 (de)
NO (1)	NO983776L (de)
NZ (1)	NZ325455A (de)
OA (1)	OA10712A (de)
PE (1)	PE36298A1 (de)
PL (1)	PL328514A1 (de)
PT (1)	PT882044E (de)
SI (1)	SI0882044T1 (de)
TN (1)	TNSN97037A1 (de)
TR (1)	TR199801593T2 (de)
WO (1)	WO1997030048A1 (de)
ZA (1)	ZA971357B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11106375A (ja) *	1997-08-18	1999-04-20	Pfizer Pharmaceut Inc	ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物
EP1110962A1 (de) *	1999-12-10	2001-06-27	Pfizer Inc.	Verfahren zur herstellung von 1,4-dihydropyridine verbindungen
US6653313B2 (en) *	2000-08-10	2003-11-25	Warner-Lambert Company Llc	1,4-dihydropyridine compounds as bradykinin antagonists
GB0427281D0 (en) *	2004-12-14	2005-01-12	3M Innovative Properties Co	Methods of providing medicinal metal components having through holes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5120750A (en) *	1989-01-17	1992-06-09	Synphar Laboratories, Inc.	Generation of 1,4-dihydropyridine derivatives
WO1996006083A1 (en) *	1994-08-24	1996-02-29	Pfizer Pharmaceuticals Inc.	2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists
MX9701245A (es) *	1996-02-19	1998-04-30	Pfizer	Compuestos de 1,4 dihidropiridina.

1996
- 1996-02-18 TN TNTNSN97037A patent/TNSN97037A1/fr unknown
1997
- 1997-01-27 CN CN97192240A patent/CN1211251A/zh active Pending
- 1997-01-27 SI SI9730361T patent/SI0882044T1/xx unknown
- 1997-01-27 HU HU9902810A patent/HUP9902810A3/hu unknown
- 1997-01-27 EP EP97900401A patent/EP0882044B1/de not_active Expired - Lifetime
- 1997-01-27 TR TR1998/01593T patent/TR199801593T2/xx unknown
- 1997-01-27 CA CA002245857A patent/CA2245857C/en not_active Expired - Fee Related
- 1997-01-27 WO PCT/IB1997/000058 patent/WO1997030048A1/en not_active Ceased
- 1997-01-27 KR KR1019980706424A patent/KR19990082678A/ko not_active Ceased
- 1997-01-27 NZ NZ325455A patent/NZ325455A/xx unknown
- 1997-01-27 IL IL12486797A patent/IL124867A0/xx unknown
- 1997-01-27 BR BR9707568A patent/BR9707568A/pt active Search and Examination
- 1997-01-27 JP JP52913897A patent/JP3167335B2/ja not_active Expired - Fee Related
- 1997-01-27 DE DE69714019T patent/DE69714019T2/de not_active Expired - Fee Related
- 1997-01-27 PL PL97328514A patent/PL328514A1/xx unknown
- 1997-01-27 ES ES97900401T patent/ES2177921T3/es not_active Expired - Lifetime
- 1997-01-27 PT PT97900401T patent/PT882044E/pt unknown
- 1997-01-27 US US09/125,137 patent/US6131226A/en not_active Expired - Fee Related
- 1997-01-27 HN HN1997000013A patent/HN1997000013A/es unknown
- 1997-01-27 AT AT97900401T patent/ATE220676T1/de not_active IP Right Cessation
- 1997-01-27 AU AU13964/97A patent/AU1396497A/en not_active Abandoned
- 1997-01-27 DK DK97900401T patent/DK0882044T3/da active
- 1997-01-27 CZ CZ982586A patent/CZ258698A3/cs unknown
- 1997-02-10 PE PE1997000085A patent/PE36298A1/es not_active Application Discontinuation
- 1997-02-13 CO CO97007547A patent/CO4650041A1/es unknown
- 1997-02-17 AR ARP970100614A patent/AR005841A1/es unknown
- 1997-02-18 HR HRPCT/IB96/00132A patent/HRP970094A2/xx not_active Application Discontinuation
- 1997-02-18 ZA ZA971357A patent/ZA971357B/xx unknown
- 1997-02-18 ID IDP970467A patent/ID16434A/id unknown
- 1997-02-18 MA MA24498A patent/MA26419A1/fr unknown
1998
- 1998-06-25 IS IS4783A patent/IS4783A/is unknown
- 1998-07-10 OA OA9800111A patent/OA10712A/en unknown
- 1998-08-10 BG BG102678A patent/BG102678A/xx unknown
- 1998-08-18 NO NO983776A patent/NO983776L/no unknown

Also Published As

Publication number	Publication date
ZA971357B (en)	1998-08-18
KR19990082678A (ko)	1999-11-25
EP0882044B1 (de)	2002-07-17
CZ258698A3 (cs)	1999-06-16
IS4783A (is)	1998-06-25
WO1997030048A1 (en)	1997-08-21
OA10712A (en)	2001-06-04
HN1997000013A (es)	1997-06-26
TNSN97037A1 (fr)	2005-03-15
BR9707568A (pt)	1999-07-27
DK0882044T3 (da)	2002-09-02
JP3167335B2 (ja)	2001-05-21
EP0882044A1 (de)	1998-12-09
PL328514A1 (en)	1999-02-01
PE36298A1 (es)	1998-07-18
SI0882044T1 (en)	2002-10-31
ATE220676T1 (de)	2002-08-15
PT882044E (pt)	2002-11-29
CO4650041A1 (es)	1998-09-03
JPH11507949A (ja)	1999-07-13
HUP9902810A2 (hu)	2000-05-28
IL124867A0 (en)	1999-01-26
ES2177921T3 (es)	2002-12-16
HRP970094A2 (en)	1998-06-30
ID16434A (id)	1997-09-25
NO983776D0 (no)	1998-08-18
CA2245857A1 (en)	1997-08-21
CN1211251A (zh)	1999-03-17
AR005841A1 (es)	1999-07-14
HUP9902810A3 (en)	2000-09-28
MA26419A1 (fr)	2004-12-20
DE69714019D1 (de)	2002-08-22
NO983776L (no)	1998-08-18
DE69714019T2 (de)	2002-11-14
TR199801593T2 (xx)	1999-12-21
NZ325455A (en)	1999-07-29
US6131226A (en)	2000-10-17
AU1396497A (en)	1997-09-02
CA2245857C (en)	2002-10-01

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FI970489A7 (fi)	1997-02-05	Paikallisesti käytettäviä silmälääkekoostumuksia, jotka sisältävät dok sepiinijohdoksia ja soveltuvat allergisten silmäsairauksien hoitoon
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BR0110487A (pt)	2003-04-01	Composição farmacêutica e método de tratamento de doenças de disfunção cognitiva em um mamìfero
GR3036655T3 (en)	2001-12-31	Use of IL-4 receptors for the therapy, prophylaxis and diagnosis of allergic, viral, paracitic and bacterial diseases, as well as of fungal infections.
BR9714677A (pt)	2000-10-03	"enantiÈmeros 3-piridila e seu uso como analgésicos"
ATE201992T1 (de)	2001-06-15	Carbostyrilderivat zur behandlung von ophthalmologischen erkrankungen
DE4394931T1 (de)	1995-07-20	Verwendung von Norastemizol zur Behandlung von allergischen Erkrankungen
DK0837935T3 (da)	2003-12-15	Den 3'-ikke-translaterede region af det humane prohibitin-gen
HUP9900927A3 (en)	2002-02-28	Substituted 4-(1h-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
ATE83376T1 (de)	1993-01-15	Chinolinylaether tetrazole als mittel zur behandlung von hyperempfindlichen krankheiten.
ATE82127T1 (de)	1992-11-15	N-acetylglucosamin-zubereitungen zur buccalen anwendung.
EA200000242A1 (ru)	2000-08-28	Применение фанхинона для лечения болезни альцгеймера
AU3401093A (en)	1993-09-09	Therapeutic agent for threatened abortion
TR199901385T2 (xx)	1999-11-22	Piperidin t�revleri.
IT9020968A0 (it)	1990-07-18	Metodi e composizioni farmaceutiche per il trattamento di malattie oftalmiche
NO995838L (no)	2000-01-31	Nye heteroetynylenforbindelser og farmasoeytiske og kosmetiske preparater inneholdende de samme
FI952953L (fi)	1995-12-18	Aineita metabolisten luustosairauksien hoitamiseen
ATE147978T1 (de)	1997-02-15	Verwendung von (e) - 2 - (p -fluorophenethyl)- 3 - fluoroallylamine zur behandlung der alzheimerschen krankheit
DE69429447D1 (de)	2002-01-24	Verwendung von 2-aminopurinderivaten zur behandlung und prophylaxe der menschlichen herpesvirus 7 infektionen
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HUP0301971A3 (en)	2007-09-28	Uses of thaliporphine or its derivatives for producing pharmaceutical compositions suitable for treating cardiac diseases and the compounds
SE9901273D0 (sv)	1999-04-09	Novel compounds