BG103133A - New erythromycins and method for their preparation - Google Patents

New erythromycins and method for their preparation

Info

Publication number: BG103133A
Authority: BG; Bulgaria
Prior art keywords: preparation; erythromycins; new; new erythromycins; r1co2h
Prior art date: 1996-07-05

Application number

BG103133A

Other languages

Bulgarian (bg)

English (en)

Inventor

Peter LEADLAY

James Staunton

Jesus Cortes

Michael PACEY

Original Assignee

Pfizer Inc.

Biotica Technology Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-05

Filing date

1999-01-29

Publication date

2000-04-28

1996-07-05 Priority claimed from GBGB9614189.0A external-priority patent/GB9614189D0/en

1997-05-28 Priority claimed from GBGB9710962.3A external-priority patent/GB9710962D0/en

1999-01-29 Application filed by Pfizer Inc., Biotica Technology Limited filed Critical Pfizer Inc.

2000-04-28 Publication of BG103133A publication Critical patent/BG103133A/xx

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Natural products O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
244000005700 microbiome Species 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
241000187560 Saccharopolyspora Species 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Tropical Medicine & Parasitology (AREA)
Cardiology (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Plant Pathology (AREA)
Heart & Thoracic Surgery (AREA)
Physics & Mathematics (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

BG103133A 1996-07-05 1999-01-29 New erythromycins and method for their preparation BG103133A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GBGB9614189.0A GB9614189D0 (en)	1996-07-05	1996-07-05	Polyketides and their synthesis
US2418896P	1996-08-19	1996-08-19
GBGB9710962.3A GB9710962D0 (en)	1997-05-28	1997-05-28	Polyketides and their synthesis
PCT/GB1997/001810 WO1998001571A2 (en)	1996-07-05	1997-07-04	Erythromycins and process for their preparation

Publications (1)

Publication Number	Publication Date
BG103133A true BG103133A (en)	2000-04-28

Family

ID=27268361

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103133A BG103133A (en)	1996-07-05	1999-01-29	New erythromycins and method for their preparation

Country Status (28)

Country	Link
EP (3)	EP2182067A3 (is)
JP (2)	JP2000511063A (is)
KR (1)	KR20000023579A (is)
CN (1)	CN1179046C (is)
AP (1)	AP1029A (is)
AT (2)	ATE451455T1 (is)
AU (2)	AU731301B2 (is)
BG (1)	BG103133A (is)
BR (1)	BR9710209A (is)
CA (2)	CA2259463A1 (is)
DE (2)	DE69739688D1 (is)
DK (2)	DK0909327T3 (is)
EA (1)	EA001744B1 (is)
EE (1)	EE03976B1 (is)
ES (2)	ES2337424T3 (is)
GB (1)	GB2331518B (is)
GE (1)	GEP20012348B (is)
IL (1)	IL127916A0 (is)
IS (1)	IS4940A (is)
NO (1)	NO990012L (is)
NZ (1)	NZ333861A (is)
OA (1)	OA10952A (is)
PL (1)	PL331285A1 (is)
PT (1)	PT909327E (is)
SI (1)	SI0910633T1 (is)
SK (1)	SK182498A3 (is)
TR (1)	TR199900006T2 (is)
WO (2)	WO1998001546A2 (is)

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US6500960B1 (en)	1995-07-06	2002-12-31	Stanford University (Board Of Trustees Of The Leland Stanford Junior University)	Method to produce novel polyketides
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US20030170725A1 (en)	1993-09-20	2003-09-11	Chaitan Khosla	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US6927057B2 (en)	1993-09-20	2005-08-09	Kosan Biosciences	Macrolide analogs
US6558942B1 (en)	1994-05-06	2003-05-06	The Leland Stanford Junior University	Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5712146A (en)	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
US6495348B1 (en)	1993-10-07	2002-12-17	Regents Of The University Of Minnesota	Mitomycin biosynthetic gene cluster
IL122859A0 (en)	1995-07-06	1998-08-16	Univ Leland Stanford Junior	Cell-free synthesis of polyketides
EP0870053A4 (en)	1995-12-19	2002-09-11	Univ Minnesota	METABOLIC METHOD FOR PRODUCING POLYHYDROXYALKANOATE MONOMER SYNTHASES
US6271255B1 (en)	1996-07-05	2001-08-07	Biotica Technology Limited	Erythromycins and process for their preparation
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GB9814006D0 (en) *	1998-06-29	1998-08-26	Biotica Tech Ltd	Polyketides and their synthesis
EP1100927A2 (en) *	1998-07-02	2001-05-23	The Board Of Trustees Of The Leland Stanford Junior University	Methods for making polyketides using altered pks
GB9814622D0 (en) *	1998-07-06	1998-09-02	Biotica Tech Ltd	Polyketides,their preparation,and materials for use therein
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KR20010083944A (ko)	1998-11-03	2001-09-03	실버스타인 아써 에이.	신규 마크롤라이드 항생물질
US6358712B1 (en)	1999-01-05	2002-03-19	Trustee Of Boston University	Ordered gene assembly
WO2000040715A2 (en)	1999-01-05	2000-07-13	Trustees Of Boston University	Improved nucleic acid cloning
CA2359708C (en)	1999-01-27	2005-10-25	Pfizer Products Inc.	Ketolide antibiotics
US7001748B2 (en)	1999-02-09	2006-02-21	The Board Of Trustees Of The Leland Stanford Junior University	Methods of making polyketides using hybrid polyketide synthases
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US6939861B2 (en)	1999-04-16	2005-09-06	Kosan Biosciences, Inc.	Amido macrolides
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ID30547A (id)	1999-04-16	2001-12-20	Kosan Biosciences Inc	Zat anti-infeksi makrolida
EA200100983A1 (ru)	1999-05-24	2002-10-31	Пфайзер Продактс Инк.	Производные 13-метилэритромицина
GB9912563D0 (en) *	1999-05-28	1999-07-28	Biotica Tech Ltd	Polyketides and their synthesis
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EP1101769A3 (en)	1999-11-18	2001-10-24	Pfizer Products Inc.	Nitrogen containing erythromycin derivatives
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MXPA04008071A (es) *	2002-02-19	2004-11-26	Dow Agrosciences Llc	Nuevas sintasas de poliquetida que producen espinosina.
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AU2011214135B2 (en)	2010-02-09	2014-07-31	Neurovive Pharmaceutical Ab	Sanglifehrin based compounds
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WO2013172782A1 (en) *	2012-05-16	2013-11-21	Nanyang Technological University	A polyketide synthase construct and its use in the preparation of polyketides
US10533016B2 (en)	2015-01-09	2020-01-14	Revolution Medicines, Inc.	Compounds that participate in cooperative binding and uses thereof
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JP2020501519A (ja)	2016-10-28	2020-01-23	ギンゴーバイオワークス，インコーポレイテッド	化合物の生産のための組成物および方法
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US6060234A (en) *	1991-01-17	2000-05-09	Abbott Laboratories	Polyketide derivatives and recombinant methods for making same
WO1993013663A1 (en) *	1992-01-17	1993-07-22	Abbott Laboratories	Method of directing biosynthesis of specific polyketides
US5712146A (en) *	1993-09-20	1998-01-27	The Leland Stanford Junior University	Recombinant combinatorial genetic library for the production of novel polyketides
ES2164713T3 (es) *	1993-09-20	2002-03-01	Univ Leland Stanford Junior	Produccion recombinante de nuevos poliquetidos.

1997
- 1997-07-04 AP APAP/P/1999/001444A patent/AP1029A/en active
- 1997-07-04 GE GEAP19974661A patent/GEP20012348B/en unknown
- 1997-07-04 ES ES97930631T patent/ES2337424T3/es not_active Expired - Lifetime
- 1997-07-04 JP JP10504933A patent/JP2000511063A/ja not_active Withdrawn
- 1997-07-04 DK DK97930626T patent/DK0909327T3/da active
- 1997-07-04 DE DE69739688T patent/DE69739688D1/de not_active Expired - Lifetime
- 1997-07-04 DE DE69733416T patent/DE69733416T2/de not_active Expired - Lifetime
- 1997-07-04 SK SK1824-98A patent/SK182498A3/sk unknown
- 1997-07-04 AU AU34509/97A patent/AU731301B2/en not_active Ceased
- 1997-07-04 TR TR1999/00006T patent/TR199900006T2/xx unknown
- 1997-07-04 AU AU34514/97A patent/AU731654B2/en not_active Ceased
- 1997-07-04 NZ NZ333861A patent/NZ333861A/xx unknown
- 1997-07-04 WO PCT/GB1997/001819 patent/WO1998001546A2/en not_active Ceased
- 1997-07-04 CN CNB97197649XA patent/CN1179046C/zh not_active Expired - Fee Related
- 1997-07-04 PT PT97930626T patent/PT909327E/pt unknown
- 1997-07-04 AT AT97930631T patent/ATE451455T1/de not_active IP Right Cessation
- 1997-07-04 CA CA002259463A patent/CA2259463A1/en not_active Abandoned
- 1997-07-04 GB GB9900156A patent/GB2331518B/en not_active Expired - Fee Related
- 1997-07-04 AT AT97930626T patent/ATE296893T1/de active
- 1997-07-04 EP EP09178121A patent/EP2182067A3/en not_active Withdrawn
- 1997-07-04 ES ES97930626T patent/ES2244001T3/es not_active Expired - Lifetime
- 1997-07-04 EP EP97930626A patent/EP0909327B1/en not_active Expired - Lifetime
- 1997-07-04 PL PL97331285A patent/PL331285A1/xx unknown
- 1997-07-04 EA EA199900087A patent/EA001744B1/ru not_active IP Right Cessation
- 1997-07-04 EP EP97930631A patent/EP0910633B1/en not_active Expired - Lifetime
- 1997-07-04 EE EEP199900014A patent/EE03976B1/xx not_active IP Right Cessation
- 1997-07-04 IL IL12791697A patent/IL127916A0/xx unknown
- 1997-07-04 DK DK97930631.3T patent/DK0910633T3/da active
- 1997-07-04 WO PCT/GB1997/001810 patent/WO1998001571A2/en not_active Ceased
- 1997-07-04 JP JP50492598A patent/JP4173551B2/ja not_active Expired - Fee Related
- 1997-07-04 BR BR9710209-1A patent/BR9710209A/pt not_active Application Discontinuation
- 1997-07-04 SI SI9730793T patent/SI0910633T1/sl unknown
- 1997-07-04 CA CA002259420A patent/CA2259420C/en not_active Expired - Fee Related
1999
- 1999-01-04 OA OA9900002A patent/OA10952A/en unknown
- 1999-01-04 IS IS4940A patent/IS4940A/is unknown
- 1999-01-04 NO NO990012A patent/NO990012L/no not_active Application Discontinuation
- 1999-01-05 KR KR1019997000024A patent/KR20000023579A/ko not_active Ceased
- 1999-01-29 BG BG103133A patent/BG103133A/xx unknown

Also Published As

Publication number	Publication date
ES2337424T3 (es)	2010-04-23
EA001744B1 (ru)	2001-08-27
JP4173551B2 (ja)	2008-10-29
DE69733416T2 (de)	2006-04-27
AU731301B2 (en)	2001-03-29
PL331285A1 (en)	1999-07-05
EE03976B1 (et)	2003-02-17
EA199900087A1 (ru)	1999-08-26
WO1998001571A3 (en)	1998-02-19
AP9901444A0 (en)	1999-03-31
CN1179046C (zh)	2004-12-08
EP2182067A2 (en)	2010-05-05
WO1998001546A3 (en)	1998-04-09
AU731654B2 (en)	2001-04-05
GB2331518A (en)	1999-05-26
GEP20012348B (en)	2001-01-25
PT909327E (pt)	2005-10-31
EE9900014A (et)	1999-08-16
DE69739688D1 (de)	2010-01-21
SI0910633T1 (sl)	2010-04-30
EP0910633B1 (en)	2009-12-09
ATE296893T1 (de)	2005-06-15
AP1029A (en)	2001-12-11
NO990012D0 (no)	1999-01-04
GB2331518B (en)	2001-03-14
DK0910633T3 (da)	2010-03-29
EP0909327A2 (en)	1999-04-21
IS4940A (is)	1999-01-04
SK182498A3 (en)	2000-05-16
TR199900006T2 (xx)	1999-04-21
CA2259420A1 (en)	1998-01-15
AU3450997A (en)	1998-02-02
DE69733416D1 (de)	2005-07-07
ES2244001T3 (es)	2005-12-01
IL127916A0 (en)	1999-11-30
NZ333861A (en)	2000-08-25
EP2182067A3 (en)	2010-07-14
CA2259420C (en)	2007-09-18
JP2000511063A (ja)	2000-08-29
AU3451497A (en)	1998-02-02
DK0909327T3 (da)	2005-09-26
EP0909327B1 (en)	2005-06-01
NO990012L (no)	1999-02-23
CN1229438A (zh)	1999-09-22
ATE451455T1 (de)	2009-12-15
WO1998001571A2 (en)	1998-01-15
JP2000516450A (ja)	2000-12-12
GB9900156D0 (en)	1999-02-24
BR9710209A (pt)	2000-01-11
EP0910633A2 (en)	1999-04-28
KR20000023579A (ko)	2000-04-25
WO1998001546A2 (en)	1998-01-15
OA10952A (en)	2002-02-25
CA2259463A1 (en)	1998-01-15

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