BG103362A - Insulin c-peptides - Google Patents

Insulin c-peptides

Info

Publication number: BG103362A
Authority: BG; Bulgaria
Prior art keywords: fragment; peptide; atpase activity; sequence; relates
Prior art date: 1996-09-27

Application number

BG103362A

Other languages

Bulgarian (bg)

English (en)

Inventor

John Wahren

Bo - Lennart JOHANSSON

Hans Joernvall

Original Assignee

Creative Peptides Sweden Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-27

Filing date

1999-04-27

Publication date

2000-05-31

1999-04-27 Application filed by Creative Peptides Sweden Ab filed Critical Creative Peptides Sweden Ab

2000-05-31 Publication of BG103362A publication Critical patent/BG103362A/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
239000012634 fragment Substances 0.000 abstract 4
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
108091006112 ATPases Proteins 0.000 abstract 3
102000057290 Adenosine Triphosphatases Human genes 0.000 abstract 3
230000000694 effects Effects 0.000 abstract 3
208000002249 Diabetes Complications Diseases 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108010075254 C-Peptide Proteins 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
230000003592 biomimetic effect Effects 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
210000002950 fibroblast Anatomy 0.000 abstract 1
108010038088 glutamyl-glycyl-seryl-leucyl-glutamine Proteins 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
150000002894 organic compounds Chemical class 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

BG103362A 1996-09-27 1999-04-27 Insulin c-peptides BG103362A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9603533A SE520392C2 (sv)	1996-09-27	1996-09-27	Specifika peptider för behandling av diabetes mellitus
PCT/GB1997/002627 WO1998013384A1 (en)	1996-09-27	1997-09-26	Insulin c-peptides

Publications (1)

Publication Number	Publication Date
BG103362A true BG103362A (en)	2000-05-31

Family

ID=20404052

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103362A BG103362A (en)	1996-09-27	1999-04-27	Insulin c-peptides

Country Status (24)

Country	Link
US (1)	US6610649B2 (cs)
EP (1)	EP0938503B1 (cs)
JP (1)	JP2001500893A (cs)
KR (1)	KR20000048643A (cs)
AT (1)	ATE347562T1 (cs)
AU (1)	AU741901B2 (cs)
BG (1)	BG103362A (cs)
BR (1)	BR9711573A (cs)
CA (1)	CA2266416C (cs)
CZ (1)	CZ108599A3 (cs)
DE (1)	DE69737065T2 (cs)
DK (1)	DK0938503T3 (cs)
ES (1)	ES2278394T3 (cs)
HU (1)	HUP0000432A3 (cs)
IL (1)	IL129143A0 (cs)
IS (1)	IS5008A (cs)
NO (1)	NO991483L (cs)
NZ (1)	NZ335231A (cs)
PL (1)	PL332494A1 (cs)
RU (1)	RU2206336C2 (cs)
SE (1)	SE520392C2 (cs)
SK (1)	SK39499A3 (cs)
TR (1)	TR199900694T2 (cs)
WO (1)	WO1998013384A1 (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0022342D0 (en) *	2000-09-12	2000-10-25	Creative Peptides Sweden Ab	Reduction of the electrocardiographic QT interval
DE10055857A1 (de) *	2000-11-10	2002-08-22	Creative Peptides Sweden Ab Dj	Neue pharmazeutische Depotformulierung
US20030198666A1 (en) *	2002-01-07	2003-10-23	Richat Abbas	Oral insulin therapy
CA2511530C (en) *	2003-01-06	2013-07-09	Emisphere Technologies, Inc.	Night-time oral insulin therapy
US20050026826A1 (en) *	2003-01-17	2005-02-03	Margarethe Hoenig	Feline proinsulin, insulin and constituent peptides
US20050203001A1 (en) *	2004-03-05	2005-09-15	Emisphere Technologies, Inc.	Oral insulin therapies and protocol
GB0323979D0 (en)	2003-10-13	2003-11-19	Creative Peptides Sweden Ab	Therapeutic applications for c-peptide
US7557081B2 (en) *	2004-05-27	2009-07-07	Essential Skincare, Llc	Alpha-1-acid glycoprotein for the treatment of diabetes
US7833513B2 (en)	2004-12-03	2010-11-16	Rhode Island Hospital	Treatment of Alzheimer's Disease
GB0601950D0 (en) *	2006-01-31	2006-03-15	Creative Peptides Sweden Ab	Compositions and methods of treating diabetes
JP5256199B2 (ja) *	2006-08-07	2013-08-07	テヴァバイオファーマシューティカルズユーエスエー，インコーポレーティッド	アルブミン−インスリン融合タンパク質
KR20100057640A (ko) *	2007-09-11	2010-05-31	몬도바이오테크 래보래토리즈 아게	치료제로서의 인슐린 ｃ-펩티드 단독 또는 ｇｌｐ-1과의 배합물의 용도
GB0723250D0 (en) *	2007-11-28	2008-01-09	Univ Leeds	Compositions and methods for reducing macrovascular complications in diabetic patients
EP2341942A1 (en)	2008-09-19	2011-07-13	Nektar Therapeutics	Polymer conjugates of therapeutic peptides
US20110165112A1 (en) *	2008-09-19	2011-07-07	Nektar Therapeutics	Polymer conjugates of c-peptides
US8410049B2 (en) *	2009-10-28	2013-04-02	Cebix	Methods and kits for preventing hypoglycemia
CA2798518A1 (en)	2010-05-17	2011-11-24	Cebix, Inc.	Pegylated c-peptide
ES2673672T3 (es)	2011-02-11	2018-06-25	The Regents Of The University Of Michigan	Composiciones tripeptídicas y su uso para el tratamiento de la diabetes
US8962553B2 (en)	2011-11-17	2015-02-24	Cebix Ab	Method of treating a diabetic subject having a microvascular impairment disorder by a pegylated C-peptide
RU2522897C1 (ru) *	2013-04-16	2014-07-20	Закрытое акционерное общество "ФАРМ-ХОЛДИНГ"	Твердая кишечнорастворимая лекарственная форма с-пептида проинсулина для перорального применения (варианты) и способ ее получения (варианты)
KR101676542B1 (ko) *	2014-12-30	2016-11-16	건국대학교 산학협력단	프로인슐린의 면역학적 용도
CN104888201B (zh) *	2015-06-29	2018-04-27	齐锦生	用于防治糖尿病及其慢性并发症的肽类药物
WO2018141970A1 (en)	2017-02-06	2018-08-09	Resiliun B.V.	Interaction between c-peptides and elastin receptor, a model for understanding vascular disease

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HU166913B (cs) *	1972-05-15	1975-06-28
JPS5210872B2 (cs)	1973-07-14	1977-03-26
JPS55105653A (en) *	1978-10-02	1980-08-13	Shionogi & Co Ltd	Tyrosyl c-peptides
CH650679A5 (de)	1981-08-27	1985-08-15	Lilly Co Eli	Gegen diabetes mellitus wirksames pharmazeutisches mittel.
US4652548A (en) *	1981-08-27	1987-03-24	Eli Lilly And Company	Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin
DE3326473A1 (de)	1983-07-22	1985-01-31	Hoechst Ag, 6230 Frankfurt	Pharmazeutisches mittel zur behandlung des diabetes mellitus
US4581165A (en) *	1984-06-14	1986-04-08	Eli Lilly And Company	Anti-diabetic compounds
US5104854A (en)	1989-02-01	1992-04-14	Washington University	Antiviral peptides
PT93057B (pt)	1989-02-09	1995-12-29	Lilly Co Eli	Processo para a preparacao de analogos da insulina
US5364757A (en)	1990-05-21	1994-11-15	Administrators Of The Tulane Educational Fund	Methods of supporting a diagnosis of systemic lupus erythematosus
IL99699A (en) *	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
JPH05268982A (ja)	1992-03-27	1993-10-19	Hoechst Japan Ltd	骨形成作用を有する新規な蛋白質およびその製造法
ES2142867T3 (es)	1992-04-13	2000-05-01	Oklahoma Med Res Found	Procedimientos y reactivos para el diagnostico de autoanticuerpos.
WO1994025071A1 (en)	1993-05-05	1994-11-10	Keith Rose	Polyoxime compounds and their preparation
AT400723B (de)	1993-08-27	1996-03-25	Biomay Prod & Handel	Rekombinante alternaria alternata allergene
DE69508605T2 (de)	1994-07-08	1999-07-22	Trustees Of Dartmouth College, Hanover, N.H.	Proinsulin-peptid-verbindungen für den nachweis und die behandlung von typ-i-diabetes
US6309853B1 (en) *	1994-08-17	2001-10-30	The Rockfeller University	Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
GB9422175D0 (en)	1994-11-03	1994-12-21	Univ Dundee	Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof
GB9509164D0 (en)	1995-05-05	1995-06-28	Smithkline Beecham Plc	Novel compounds
NZ331866A (en)	1996-03-15	2000-05-26	Corixa Corp	Compounds for immunotherapy and immunodiagnosis of prostate cancer
US6150500A (en)	1996-07-12	2000-11-21	Salerno; John C.	Activators of endothelial nitric oxide synthase

1996
- 1996-09-27 SE SE9603533A patent/SE520392C2/sv not_active IP Right Cessation
1997
- 1997-09-26 TR TR1999/00694T patent/TR199900694T2/xx unknown
- 1997-09-26 AU AU43915/97A patent/AU741901B2/en not_active Ceased
- 1997-09-26 ES ES97942119T patent/ES2278394T3/es not_active Expired - Lifetime
- 1997-09-26 EP EP97942119A patent/EP0938503B1/en not_active Expired - Lifetime
- 1997-09-26 WO PCT/GB1997/002627 patent/WO1998013384A1/en not_active Ceased
- 1997-09-26 SK SK394-99A patent/SK39499A3/sk unknown
- 1997-09-26 PL PL97332494A patent/PL332494A1/xx unknown
- 1997-09-26 CZ CZ991085A patent/CZ108599A3/cs unknown
- 1997-09-26 JP JP10515410A patent/JP2001500893A/ja not_active Ceased
- 1997-09-26 HU HU0000432A patent/HUP0000432A3/hu unknown
- 1997-09-26 AT AT97942119T patent/ATE347562T1/de not_active IP Right Cessation
- 1997-09-26 DE DE69737065T patent/DE69737065T2/de not_active Expired - Lifetime
- 1997-09-26 NZ NZ335231A patent/NZ335231A/xx unknown
- 1997-09-26 RU RU99108434/14A patent/RU2206336C2/ru not_active IP Right Cessation
- 1997-09-26 KR KR1019990702585A patent/KR20000048643A/ko not_active Withdrawn
- 1997-09-26 DK DK97942119T patent/DK0938503T3/da active
- 1997-09-26 CA CA002266416A patent/CA2266416C/en not_active Expired - Fee Related
- 1997-09-26 BR BR9711573-8A patent/BR9711573A/pt not_active Application Discontinuation
- 1997-09-26 US US09/269,439 patent/US6610649B2/en not_active Expired - Fee Related
- 1997-09-26 IL IL12914397A patent/IL129143A0/xx unknown
1999
- 1999-03-23 IS IS5008A patent/IS5008A/is unknown
- 1999-03-26 NO NO991483A patent/NO991483L/no not_active Application Discontinuation
- 1999-04-27 BG BG103362A patent/BG103362A/xx unknown

Also Published As

Publication number	Publication date
DK0938503T3 (da)	2007-04-10
DE69737065T2 (de)	2007-06-28
TR199900694T2 (xx)	1999-06-21
EP0938503B1 (en)	2006-12-06
CA2266416C (en)	2008-04-29
DE69737065D1 (en)	2007-01-18
EP0938503A1 (en)	1999-09-01
RU2206336C2 (ru)	2003-06-20
HUP0000432A2 (hu)	2000-08-28
NO991483L (no)	1999-05-18
ES2278394T3 (es)	2007-08-01
KR20000048643A (ko)	2000-07-25
IS5008A (is)	1999-03-23
SE9603533D0 (sv)	1996-09-27
CA2266416A1 (en)	1998-04-02
PL332494A1 (en)	1999-09-13
NO991483D0 (no)	1999-03-26
HUP0000432A3 (en)	2000-10-30
IL129143A0 (en)	2000-02-17
SE9603533L (sv)	1998-03-28
SK39499A3 (en)	1999-10-08
AU4391597A (en)	1998-04-17
SE520392C2 (sv)	2003-07-01
NZ335231A (en)	2000-11-24
WO1998013384A1 (en)	1998-04-02
US20020107175A1 (en)	2002-08-08
AU741901B2 (en)	2001-12-13
ATE347562T1 (de)	2006-12-15
US6610649B2 (en)	2003-08-26
JP2001500893A (ja)	2001-01-23
BR9711573A (pt)	2000-01-18
CZ108599A3 (cs)	1999-08-11

Publication	Publication Date	Title
BG103362A (en)	2000-05-31	Insulin c-peptides
ATE251642T1 (de)	2003-10-15	Biologisch aktive fragmente des glucagon ähnlichen, insulinotropen peptides
NZ512083A (en)	2003-02-28	Methods of increasing lean tissue mass using OB protein compositions
DE69833667D1 (de)	2006-04-27	Polynukleotid kodierend für ein polypeptid mit heparanase-aktivität und dessen expression in transduzierten zellen
WO2003053339A3 (en)	2005-04-14	Insulin molecule having protracted time action
ATE273996T1 (de)	2004-09-15	Zusammensetzung zur therapie von diabetes mellitus und fettsucht
HUP0100928A3 (en)	2001-11-28	Methods for treatment of diabetes using peptide analogues of insulin
EP0919242A3 (en)	2003-01-02	Method for administering acylated insulin
PT93910A (pt)	1991-01-08	Prodesso para a preparacao de uma proteina heterologa mediante secrecao a partir de uma celula
NZ294743A (en)	1999-06-29	A formulation for administering transdermally a protein or polypeptide such as insulin
PT1100529E (pt)	2005-10-31	A timosina beta 4 promove a preparacao de feridas
NZ504752A (en)	2002-10-25	Hydrophobically-modified protein compositions (particularly hedgehog proteins)
ATE447410T1 (de)	2009-11-15	Verwendung von humanem parathyroid-hormon
GB9422175D0 (en)	1994-12-21	Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof
AU3346289A (en)	1989-10-05	Heparin-binding proteins, DNA coding for them, processes for producing them as well as therapeutic preparations containing them
WO1999064598A3 (de)	2000-03-16	Neue insulinanaloga mit erhöhter zinkbindung
ATE432287T1 (de)	2009-06-15	Peptidfragmente mit den zelltod verhindernder aktivität
AU5508396A (en)	1996-11-29	Pcna binding substance
WO1999053064A3 (en)	2000-03-16	Methods of delivering glp-1
WO1999031229A3 (en)	1999-08-26	Peptides and nucleic acids derived from eisenia foetida and the use thereof
WO1999030670A3 (en)	1999-08-19	Methods of treatment using novel ligands of the neuropeptide receptor hfgan72 and agonists or antagonists thereof
WO2001032693A3 (de)	2002-06-20	Mit trp-proteinen verwandtes protein mtr1 und dieses codierende dna-sequenz
WO2003044159A9 (en)	2013-10-31	Zinc finger proteins, polynucleotides encoding same and antibodies thereto
WO2001047957A3 (en)	2002-02-14	Human fgf-10- (kgf-2)-like protein zfgf-10
WO1994015962A3 (en)	1994-09-29	Derivatized calcitonins