BG103393A - Method for the preparation of substituted pyridines - Google Patents

Method for the preparation of substituted pyridines

Info

Publication number: BG103393A
Authority: BG; Bulgaria
Prior art keywords: preparation; formula; substituted pyridines; compounds; aminogroup
Prior art date: 1996-11-14

Application number

BG103393A

Other languages

Bulgarian (bg)

English (en)

Inventor

Keith DEVRIES

Robert DOW

Stephn WRIGHT

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-14

Filing date

1999-05-11

Publication date

2000-07-31

1999-05-11 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2000-07-31 Publication of BG103393A publication Critical patent/BG103393A/xx

Links

238000000034 method Methods 0.000 title abstract 3
150000003222 pyridines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
-1 nitro, amino Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

BG103393A 1996-11-14 1999-05-11 Method for the preparation of substituted pyridines BG103393A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3088096P	1996-11-14	1996-11-14
PCT/IB1997/001367 WO1998021184A1 (fr)	1996-11-14	1997-11-03	Procede de preparation de pyridines substituees

Publications (1)

Publication Number	Publication Date
BG103393A true BG103393A (en)	2000-07-31

Family

ID=21856496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103393A BG103393A (en)	1996-11-14	1999-05-11	Method for the preparation of substituted pyridines

Country Status (32)

Country	Link
US (1)	US6291489B1 (fr)
EP (1)	EP0938476B1 (fr)
JP (1)	JP3510635B2 (fr)
KR (1)	KR20000053314A (fr)
CN (1)	CN1237160A (fr)
AP (1)	AP805A (fr)
AR (1)	AR010584A1 (fr)
AT (1)	ATE319687T1 (fr)
AU (1)	AU4634697A (fr)
BG (1)	BG103393A (fr)
BR (1)	BR9712951A (fr)
CA (1)	CA2270386C (fr)
CO (1)	CO4930261A1 (fr)
DE (1)	DE69735433D1 (fr)
EA (1)	EA199900375A1 (fr)
GT (1)	GT199700118A (fr)
HR (1)	HRP970612A2 (fr)
ID (1)	ID18898A (fr)
IL (1)	IL129688A0 (fr)
IS (1)	IS5029A (fr)
MA (1)	MA24401A1 (fr)
MY (1)	MY132507A (fr)
NO (1)	NO992296D0 (fr)
OA (1)	OA11044A (fr)
PA (1)	PA8441401A1 (fr)
PE (1)	PE10299A1 (fr)
TN (1)	TNSN97172A1 (fr)
TR (1)	TR199901063T2 (fr)
UY (1)	UY24774A1 (fr)
WO (1)	WO1998021184A1 (fr)
YU (1)	YU22099A (fr)
ZA (1)	ZA9710186B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999052892A2 (fr) *	1998-04-08	1999-10-21	Novartis Ag	Nouveaux herbicides
US6090942A (en) *	1998-10-15	2000-07-18	Pfizer Inc.	Process and intermediates for a β3 -adrenergic receptor agonist
EP1153919A4 (fr)	1999-02-16	2002-10-02	Kaneka Corp	Derives d'acetylpyridine substituee et procede de preparation d'intermediaires pour agoniste du recepteur adrenergique beta3 optiquement actif, faisant appel a ces derives
US6455734B1 (en)	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
ES2228413T3 (es) *	1999-07-23	2005-04-16	Pfizer Products Inc.	Productos intermedios y un procedimiento para producir agonistas de receptores beta-adrenergicos.
JPWO2003033468A1 (ja) *	2001-10-17	2005-02-03	株式会社カネカ	（Ｓ）−α−ハロメチルピリジンメタノール誘導体の製造方法
MXPA04008298A (es)	2002-02-27	2004-11-26	Pfizer Prod Inc	Procesos e intermedios utiles en la preparacion de agonistas de receptor beta-3 adrenergico.
US6864268B2 (en)	2002-02-27	2005-03-08	Pfizer Inc.	β3 adrenergic receptor agonists
AU2003209527A1 (en)	2002-02-27	2003-09-09	Pfizer Products Inc.	Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
EP1424079A1 (fr) *	2002-11-27	2004-06-02	Boehringer Ingelheim International GmbH	Combinaison d'un agoniste du beta-3-récepteur et d'un inhibiteur de recaptage de sérotonine et/ou norépinéphrine
CA2523253C (fr)	2003-05-09	2010-06-22	F. Hoffmann-La Roche Ag	Methyle indoles et methyle pyrrolopyridines servant d'agonistes du recepteur adrenergique alpha-1
US8399666B2 (en)	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en)	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
CN102137858B (zh)	2008-05-23	2014-07-23	潘米拉制药有限责任公司	5-脂氧合酶-活化蛋白抑制剂
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4358455A (en)	1980-12-23	1982-11-09	Merck & Co., Inc.	Aralkylamindethanol heterocyclic compounds
US5019578A (en)	1987-11-27	1991-05-28	Merck & Co., Inc.	β-adrenergic agonists
US5767133A (en) *	1993-06-14	1998-06-16	Pfizer Inc.	Secondary amines as antidiabetic and antiobesity agents
IL113410A (en)	1994-04-26	1999-11-30	Merck & Co Inc	Substituted sulfonamides having an asymmetric center and pharmaceutical compositions containing them
CA2220538A1 (fr) *	1995-05-10	1996-11-14	Pfizer Inc.	Agonistes du recepteur .beta.-adrenergique
EP0824519A1 (fr)	1995-05-10	1998-02-25	Pfizer Inc.	Agonistes du recepteur beta-adrenergique

1997
- 1997-11-03 EA EA199900375A patent/EA199900375A1/ru unknown
- 1997-11-03 BR BR9712951-8A patent/BR9712951A/pt not_active Application Discontinuation
- 1997-11-03 DE DE69735433T patent/DE69735433D1/de not_active Expired - Lifetime
- 1997-11-03 IL IL12968897A patent/IL129688A0/xx unknown
- 1997-11-03 CN CN97199663A patent/CN1237160A/zh active Pending
- 1997-11-03 YU YU22099A patent/YU22099A/sh unknown
- 1997-11-03 US US09/297,694 patent/US6291489B1/en not_active Expired - Fee Related
- 1997-11-03 WO PCT/IB1997/001367 patent/WO1998021184A1/fr not_active Ceased
- 1997-11-03 TR TR1999/01063T patent/TR199901063T2/xx unknown
- 1997-11-03 EP EP97945047A patent/EP0938476B1/fr not_active Expired - Lifetime
- 1997-11-03 CA CA002270386A patent/CA2270386C/fr not_active Expired - Fee Related
- 1997-11-03 JP JP52233298A patent/JP3510635B2/ja not_active Expired - Fee Related
- 1997-11-03 AT AT97945047T patent/ATE319687T1/de not_active IP Right Cessation
- 1997-11-03 KR KR1019990704312A patent/KR20000053314A/ko not_active Abandoned
- 1997-11-03 AU AU46346/97A patent/AU4634697A/en not_active Abandoned
- 1997-11-11 PE PE1997001004A patent/PE10299A1/es not_active Application Discontinuation
- 1997-11-11 GT GT199700118A patent/GT199700118A/es unknown
- 1997-11-11 MA MA24864A patent/MA24401A1/fr unknown
- 1997-11-12 PA PA19978441401A patent/PA8441401A1/es unknown
- 1997-11-12 AR ARP970105279A patent/AR010584A1/es not_active Application Discontinuation
- 1997-11-12 MY MYPI97005396A patent/MY132507A/en unknown
- 1997-11-12 UY UY24774A patent/UY24774A1/es unknown
- 1997-11-12 ZA ZA9710186A patent/ZA9710186B/xx unknown
- 1997-11-12 TN TNTNSN97172A patent/TNSN97172A1/fr unknown
- 1997-11-13 ID IDP973662A patent/ID18898A/id unknown
- 1997-11-13 AP APAP/P/1997/001147A patent/AP805A/en active
- 1997-11-13 CO CO97066763A patent/CO4930261A1/es unknown
- 1997-11-13 HR HR60/030,880A patent/HRP970612A2/hr not_active Application Discontinuation
1999
- 1999-04-16 IS IS5029A patent/IS5029A/is unknown
- 1999-05-07 OA OA9900096A patent/OA11044A/en unknown
- 1999-05-11 BG BG103393A patent/BG103393A/xx unknown
- 1999-05-12 NO NO992296A patent/NO992296D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0938476A1 (fr)	1999-09-01
PE10299A1 (es)	1999-02-10
CA2270386C (fr)	2004-08-03
AP805A (en)	2000-01-28
CN1237160A (zh)	1999-12-01
ID18898A (id)	1998-05-20
IS5029A (is)	1999-04-16
GT199700118A (es)	1999-05-05
US6291489B1 (en)	2001-09-18
IL129688A0 (en)	2000-02-29
PA8441401A1 (es)	2000-05-24
BR9712951A (pt)	1999-12-07
WO1998021184A1 (fr)	1998-05-22
MA24401A1 (fr)	1998-07-01
ATE319687T1 (de)	2006-03-15
TR199901063T2 (xx)	1999-08-23
HRP970612A2 (en)	1998-08-31
TNSN97172A1 (fr)	2005-03-15
KR20000053314A (ko)	2000-08-25
JP2000504347A (ja)	2000-04-11
UY24774A1 (es)	1998-05-05
AP9701147A0 (en)	1998-01-31
NO992296L (no)	1999-05-12
EP0938476B1 (fr)	2006-03-08
AR010584A1 (es)	2000-06-28
JP3510635B2 (ja)	2004-03-29
MY132507A (en)	2007-10-31
CA2270386A1 (fr)	1998-05-22
YU22099A (sh)	2001-09-28
CO4930261A1 (es)	2000-06-27
OA11044A (en)	2002-02-20
ZA9710186B (en)	1999-05-12
EA199900375A1 (ru)	1999-12-29
NO992296D0 (no)	1999-05-12
AU4634697A (en)	1998-06-03
DE69735433D1 (de)	2006-05-04

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DK0839126T3 (da)	2001-08-06	Fremgangsmåde til fremstilling af organiske nitrogenforbindelser, specielle organiske nitrogenforbindelser og blandinger af sådanne forbindelser samt deres anvendelse som brændstof- og smøremiddeladditiver
YU5399A (sh)	2002-03-18	Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenove
DK0641328T3 (da)	2002-05-21	Broforbundne, azabicykliske derivater som substans P-antagonister
MX9603050A (es)	1997-03-29	Derivados de la 1-h-3-aril-pirrolidin-2,4-diona como agentes pesticidas.
PL336990A1 (en)	2000-07-31	3(5)-heteroaryl group substituted pyrazoles as inhibitors of kinase p 38
PT885210E (pt)	2002-09-30	Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao
SG64399A1 (en)	1999-04-27	Process for preparing compositions useful as intermediates for preparing lubricanting oil and fuel additives
YU22099A (sh)	2001-09-28	Dobijanje supstituisanih piridina
PL329681A1 (en)	1999-04-12	Halogen-substituted inhibitor of proteinous kinase c
ES2182349T3 (es)	2003-03-01	Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2.
DK0815065T3 (da)	1999-08-23	Isoleringsmørtel
EP0908452A3 (fr)	2001-08-16	Procédé pour la préparation des indazoles-3-substitués
WO2003024400A3 (fr)	2003-06-26	Procede de preparation de 1,5-diarylpyrazoles
PT1282617E (pt)	2009-12-09	Derivados de hidantoína com afinidade para os receptores da somatostatina
PT97479A (pt)	1992-01-31	Processo de preparacao de {i}benzotieno{2,3(1h,4h)-dionas e de composicoes farmaceuticas que as contem
NZ330464A (en)	2000-04-28	Methods for the preparation of biphenyl isoxazole sulfonamides
MX9603199A (es)	1997-07-31	Antagonistas de receptores a endotelina.
BG102287A (en)	1998-09-30	New anticonvulsion 1-ar(alk)-imidazolin-2-ons with diasubstituted amine residue in forth place and method for their preparation
GB9323162D0 (en)	1994-01-05	4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf
BR9503845A (pt)	1996-04-16	Processo para a preparação de um composto e composto obtido
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ES552024A0 (es)	1987-03-01	Un metodo para preparar derivados de 1-amino-2-benzoilpirrol
BG101236A (en)	1997-09-30	Herbicidal composition