BG103393A - Method for the preparation of substituted pyridines - Google Patents

Method for the preparation of substituted pyridines

Info

Publication number: BG103393A
Authority: BG; Bulgaria
Prior art keywords: preparation; formula; substituted pyridines; compounds; aminogroup
Prior art date: 1996-11-14

Application number

BG103393A

Other languages

Bulgarian (bg)

English (en)

Inventor

Keith DEVRIES

Robert DOW

Stephn WRIGHT

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-14

Filing date

1999-05-11

Publication date

2000-07-31

1999-05-11 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2000-07-31 Publication of BG103393A publication Critical patent/BG103393A/xx

Links

238000000034 method Methods 0.000 title abstract 3
150000003222 pyridines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 2
-1 nitro, amino Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

BG103393A 1996-11-14 1999-05-11 Method for the preparation of substituted pyridines BG103393A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3088096P	1996-11-14	1996-11-14
PCT/IB1997/001367 WO1998021184A1 (en)	1996-11-14	1997-11-03	Process for substituted pyridines

Publications (1)

Publication Number	Publication Date
BG103393A true BG103393A (en)	2000-07-31

Family

ID=21856496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103393A BG103393A (en)	1996-11-14	1999-05-11	Method for the preparation of substituted pyridines

Country Status (32)

Country	Link
US (1)	US6291489B1 (is)
EP (1)	EP0938476B1 (is)
JP (1)	JP3510635B2 (is)
KR (1)	KR20000053314A (is)
CN (1)	CN1237160A (is)
AP (1)	AP805A (is)
AR (1)	AR010584A1 (is)
AT (1)	ATE319687T1 (is)
AU (1)	AU4634697A (is)
BG (1)	BG103393A (is)
BR (1)	BR9712951A (is)
CA (1)	CA2270386C (is)
CO (1)	CO4930261A1 (is)
DE (1)	DE69735433D1 (is)
EA (1)	EA199900375A1 (is)
GT (1)	GT199700118A (is)
HR (1)	HRP970612A2 (is)
ID (1)	ID18898A (is)
IL (1)	IL129688A0 (is)
IS (1)	IS5029A (is)
MA (1)	MA24401A1 (is)
MY (1)	MY132507A (is)
NO (1)	NO992296L (is)
OA (1)	OA11044A (is)
PA (1)	PA8441401A1 (is)
PE (1)	PE10299A1 (is)
TN (1)	TNSN97172A1 (is)
TR (1)	TR199901063T2 (is)
UY (1)	UY24774A1 (is)
WO (1)	WO1998021184A1 (is)
YU (1)	YU22099A (is)
ZA (1)	ZA9710186B (is)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1999052892A2 (en) *	1998-04-08	1999-10-21	Novartis Ag	Novel herbicides
US6090942A (en) *	1998-10-15	2000-07-18	Pfizer Inc.	Process and intermediates for a β3 -adrenergic receptor agonist
AU2571300A (en) *	1999-02-16	2000-09-04	Kaneka Corporation	Substituted acetylpyridine derivatives and process for the preparation of intermediates for optically active beta3 agonist by the use of the same
US6455734B1 (en) *	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
DE60015036T2 (de) *	1999-07-23	2006-03-02	Pfizer Products Inc., Groton	Zwischenprodukte und ein Verfahren zur Herstellung von beta3-Adrenergischer Rezeptor-Agoniste
US20040265991A1 (en) *	2001-10-17	2004-12-30	Naoaki Taoka	Process for preparation of (s)-alpha-halomethylpyridine-methanol derivatives
WO2003072547A1 (en)	2002-02-27	2003-09-04	Pfizer Products Inc.	PROCESSES AND INTERMEDIATES USEFUL IN PREPARING β3-ADRENERGIC RECEPTOR AGONISTS
US6864268B2 (en)	2002-02-27	2005-03-08	Pfizer Inc.	β3 adrenergic receptor agonists
WO2003072573A1 (en) *	2002-02-27	2003-09-04	Pfizer Products Inc.	Crystal forms of (r)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol
EP1424079A1 (en) *	2002-11-27	2004-06-02	Boehringer Ingelheim International GmbH	Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
RU2313524C2 (ru)	2003-05-09	2007-12-27	Ф.Хоффманн-Ля Рош Аг	МИТИЛИНДОЛЫ И МЕТИЛПИРРОЛОПИРИДИНЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ АКТИВНОСТЬЮ α-1-АДРЕНЕРГИЧЕСКИХ АГОНИСТОВ
GB2431927B (en)	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en)	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
MX2010012814A (es)	2008-05-23	2010-12-20	Amira Pharmaceuticals Inc	Inhibidor de proteina activadora de 5-lipoxigenasa.
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4358455A (en)	1980-12-23	1982-11-09	Merck & Co., Inc.	Aralkylamindethanol heterocyclic compounds
US5019578A (en)	1987-11-27	1991-05-28	Merck & Co., Inc.	β-adrenergic agonists
BR9406823A (pt) *	1993-06-14	1996-03-26	Pfizer	Aminas secundárias e agentes anti-diabéticos e antiobesidade
IL113410A (en) *	1994-04-26	1999-11-30	Merck & Co Inc	Substituted sulfonamides having an asymmetric center and pharmaceutical compositions containing them
WO1996035670A1 (en)	1995-05-10	1996-11-14	Pfizer Inc.	β-ADRENERGIC AGONISTS
US5977124A (en) *	1995-05-10	1999-11-02	Pfizer Inc.	β-adrenergic agonists

1997
- 1997-11-03 WO PCT/IB1997/001367 patent/WO1998021184A1/en not_active Ceased
- 1997-11-03 EA EA199900375A patent/EA199900375A1/ru unknown
- 1997-11-03 JP JP52233298A patent/JP3510635B2/ja not_active Expired - Fee Related
- 1997-11-03 EP EP97945047A patent/EP0938476B1/en not_active Expired - Lifetime
- 1997-11-03 TR TR1999/01063T patent/TR199901063T2/xx unknown
- 1997-11-03 CA CA002270386A patent/CA2270386C/en not_active Expired - Fee Related
- 1997-11-03 YU YU22099A patent/YU22099A/sh unknown
- 1997-11-03 AU AU46346/97A patent/AU4634697A/en not_active Abandoned
- 1997-11-03 AT AT97945047T patent/ATE319687T1/de not_active IP Right Cessation
- 1997-11-03 CN CN97199663A patent/CN1237160A/zh active Pending
- 1997-11-03 US US09/297,694 patent/US6291489B1/en not_active Expired - Fee Related
- 1997-11-03 BR BR9712951-8A patent/BR9712951A/pt not_active Application Discontinuation
- 1997-11-03 KR KR1019990704312A patent/KR20000053314A/ko not_active Abandoned
- 1997-11-03 DE DE69735433T patent/DE69735433D1/de not_active Expired - Lifetime
- 1997-11-03 IL IL12968897A patent/IL129688A0/xx unknown
- 1997-11-11 MA MA24864A patent/MA24401A1/fr unknown
- 1997-11-11 GT GT199700118A patent/GT199700118A/es unknown
- 1997-11-11 PE PE1997001004A patent/PE10299A1/es not_active Application Discontinuation
- 1997-11-12 UY UY24774A patent/UY24774A1/es unknown
- 1997-11-12 MY MYPI97005396A patent/MY132507A/en unknown
- 1997-11-12 ZA ZA9710186A patent/ZA9710186B/xx unknown
- 1997-11-12 AR ARP970105279A patent/AR010584A1/es not_active Application Discontinuation
- 1997-11-12 PA PA19978441401A patent/PA8441401A1/es unknown
- 1997-11-12 TN TNTNSN97172A patent/TNSN97172A1/fr unknown
- 1997-11-13 CO CO97066763A patent/CO4930261A1/es unknown
- 1997-11-13 AP APAP/P/1997/001147A patent/AP805A/en active
- 1997-11-13 ID IDP973662A patent/ID18898A/id unknown
- 1997-11-13 HR HR60/030,880A patent/HRP970612A2/hr not_active Application Discontinuation
1999
- 1999-04-16 IS IS5029A patent/IS5029A/is unknown
- 1999-05-07 OA OA9900096A patent/OA11044A/en unknown
- 1999-05-11 BG BG103393A patent/BG103393A/xx unknown
- 1999-05-12 NO NO992296A patent/NO992296L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU4634697A (en)	1998-06-03
MY132507A (en)	2007-10-31
US6291489B1 (en)	2001-09-18
CN1237160A (zh)	1999-12-01
JP2000504347A (ja)	2000-04-11
ID18898A (id)	1998-05-20
PA8441401A1 (es)	2000-05-24
NO992296D0 (no)	1999-05-12
IL129688A0 (en)	2000-02-29
AP805A (en)	2000-01-28
IS5029A (is)	1999-04-16
ATE319687T1 (de)	2006-03-15
CO4930261A1 (es)	2000-06-27
DE69735433D1 (de)	2006-05-04
EA199900375A1 (ru)	1999-12-29
CA2270386C (en)	2004-08-03
HRP970612A2 (en)	1998-08-31
BR9712951A (pt)	1999-12-07
OA11044A (en)	2002-02-20
AP9701147A0 (en)	1998-01-31
JP3510635B2 (ja)	2004-03-29
EP0938476A1 (en)	1999-09-01
YU22099A (sh)	2001-09-28
KR20000053314A (ko)	2000-08-25
ZA9710186B (en)	1999-05-12
MA24401A1 (fr)	1998-07-01
CA2270386A1 (en)	1998-05-22
AR010584A1 (es)	2000-06-28
TR199901063T2 (xx)	1999-08-23
TNSN97172A1 (fr)	2005-03-15
EP0938476B1 (en)	2006-03-08
GT199700118A (es)	1999-05-05
PE10299A1 (es)	1999-02-10
UY24774A1 (es)	1998-05-05
NO992296L (no)	1999-05-12
WO1998021184A1 (en)	1998-05-22

Publication	Publication Date	Title
BG103393A (en)	2000-07-31	Method for the preparation of substituted pyridines
DK0657428T3 (da)	2001-05-07	Fremstilling af 3,4,4-trisubstituerede-piperidinyl-N-alkylcarboxylater og mellemprodukter, der er egnede som opioidantagonister
DK0839126T3 (da)	2001-08-06	Fremgangsmåde til fremstilling af organiske nitrogenforbindelser, specielle organiske nitrogenforbindelser og blandinger af sådanne forbindelser samt deres anvendelse som brændstof- og smøremiddeladditiver
YU5399A (sh)	2002-03-18	Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenove
DK0641328T3 (da)	2002-05-21	Broforbundne, azabicykliske derivater som substans P-antagonister
PT885210E (pt)	2002-09-30	Compostos triciclicos que possuem afinidade de ligacao para receptores de melatonina sua producao e utilizacao
SG64399A1 (en)	1999-04-27	Process for preparing compositions useful as intermediates for preparing lubricanting oil and fuel additives
MX9801987A (es)	1998-08-30	Nuevos derivados de aminoacido, su obtencion y su uso.
ES2182349T3 (es)	2003-03-01	Procedimiento de orto-metalizacion para la sintesis de 1-(tetrazol-5-il)bencenos sustituidos en la posicion 2.
DK0815065T3 (da)	1999-08-23	Isoleringsmørtel
EP0908452A3 (en)	2001-08-16	Process for preparing 3-substituted indazoles
NO961404L (no)	1996-10-11	4-indolylpiperazinyl-derivater
WO2003024400A3 (en)	2003-06-26	Process for the preparation of 1,5-diarylpyrazoles
PT1282617E (pt)	2009-12-09	Derivados de hidantoína com afinidade para os receptores da somatostatina
PT97479A (pt)	1992-01-31	Processo de preparacao de {i}benzotieno{2,3(1h,4h)-dionas e de composicoes farmaceuticas que as contem
NZ330464A (en)	2000-04-28	Methods for the preparation of biphenyl isoxazole sulfonamides
MX9603199A (es)	1997-07-31	Antagonistas de receptores a endotelina.
BG102287A (en)	1998-09-30	New anticonvulsion 1-ar(alk)-imidazolin-2-ons with diasubstituted amine residue in forth place and method for their preparation
GB9323162D0 (en)	1994-01-05	4-(1h-2-methylimidazo(4,5-c)pyridinylmethyl)phenylsulphonamid e derivatives as antagonists of paf
BR9503845A (pt)	1996-04-16	Processo para a preparação de um composto e composto obtido
DE50001717D1 (en)	2003-05-15	Herbizide substituierte thienocycloalk(en)ylamino-1,3,5-triazine
ES532507A0 (es)	1985-08-01	Un metodo de preparar espiro (indolo (1, 7-ab) (1, 5)-benzodiazepin-2, 4'-piperidinas)
ES552022A0 (es)	1987-02-16	Un metodo para preparar derivados de 1-amino-2-benzoilpirrol
BG101236A (en)	1997-09-30	Herbicidal composition
SE9804274D0 (sv)	1998-12-10	Novel receptor