BG105191A - Заместители на лекарства от инхибитори с протоннапомпа - Google Patents

Заместители на лекарства от инхибитори с протоннапомпа

Info

Publication number
BG105191A
BG105191A BG105191A BG10519101A BG105191A BG 105191 A BG105191 A BG 105191A BG 105191 A BG105191 A BG 105191A BG 10519101 A BG10519101 A BG 10519101A BG 105191 A BG105191 A BG 105191A
Authority
BG
Bulgaria
Prior art keywords
proton pump
pump inhibitor
inhibitor drugs
benzimidazole
prodrugs
Prior art date
Application number
BG105191A
Other languages
English (en)
Other versions
BG64870B1 (bg
Inventor
Michael Garst
George Sachs
Jai Shin
Original Assignee
Regents Of University Of The California
Winston Pharmaceuticals, Llc
U.S. Government, Department Of Veteran's Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/131,481 external-priority patent/US6093734A/en
Application filed by Regents Of University Of The California, Winston Pharmaceuticals, Llc, U.S. Government, Department Of Veteran's Affairs filed Critical Regents Of University Of The California
Publication of BG105191A publication Critical patent/BG105191A/bg
Publication of BG64870B1 publication Critical patent/BG64870B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Reciprocating Pumps (AREA)
  • Fertilizing (AREA)

Abstract

Лекарствата заместители на инхибитори с пиридил метил сулфинил бензимидазолен тип протонна помпа имат една хидролизуема сулфинилна или арилосулфонилна група, прикрепена към бензимидазол азот, или включват една група, която образува основа на Mannichс бензимидазол азот. Лекарствата заместители осигуряват на инхибиторите с протонна помпа по-продължителен живот, измерен в часове. Те са в състояние да осигурят устойчиви плазмени концентрации на лекарства от инхибитори с протонна помпа за по-продължително време, в сравнение с известните лекарства.С прилагането им при физиологични условия се подобрява ефективността на лечение на заболявания, по-специално причинени от секреция на гастритна киселина.
BG105191A 1998-08-10 2001-01-26 Заместители на лекарства от инхибитори с протоннапомпа BG64870B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/131,481 US6093734A (en) 1998-08-10 1998-08-10 Prodrugs of proton pump inhibitors
US36438199A 1999-07-29 1999-07-29

Publications (2)

Publication Number Publication Date
BG105191A true BG105191A (bg) 2001-12-29
BG64870B1 BG64870B1 (bg) 2006-07-31

Family

ID=26829517

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105191A BG64870B1 (bg) 1998-08-10 2001-01-26 Заместители на лекарства от инхибитори с протоннапомпа

Country Status (27)

Country Link
US (1) US6559167B1 (bg)
EP (1) EP1105387B1 (bg)
JP (1) JP4346243B2 (bg)
KR (1) KR100472126B1 (bg)
CN (1) CN100396675C (bg)
AT (1) ATE231857T1 (bg)
AU (1) AU752292B2 (bg)
BG (1) BG64870B1 (bg)
BR (1) BR9912937A (bg)
CA (1) CA2338311C (bg)
DE (1) DE69905171T2 (bg)
DK (1) DK1105387T3 (bg)
ES (1) ES2192394T3 (bg)
FI (1) FI20010248A7 (bg)
HR (1) HRP20010106A2 (bg)
HU (1) HUP0103464A3 (bg)
ID (1) ID28273A (bg)
IL (2) IL141083A0 (bg)
IS (1) IS5826A (bg)
MX (1) MXPA01001464A (bg)
NO (1) NO322490B1 (bg)
NZ (1) NZ510180A (bg)
PL (1) PL346000A1 (bg)
TR (1) TR200100431T2 (bg)
UA (1) UA67788C2 (bg)
WO (1) WO2000009498A1 (bg)
YU (1) YU10101A (bg)

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AU2004264401A1 (en) * 2003-07-15 2005-02-24 Allergan, Inc. Process for preparing isomerically pure prodrugs of proton pump inhibitors
KR20060118421A (ko) * 2003-08-29 2006-11-23 다이노젠 파마세우티컬스, 인코포레이티드 위장 운동 장애의 치료에 유용한 조성물
TWI372066B (en) * 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
AU2005216863A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors
JP2007523163A (ja) * 2004-02-18 2007-08-16 アラーガン、インコーポレイテッド プロトンポンプインヒビターのプロドラッグの投与のための方法および組成物
EP1742630A4 (en) * 2004-04-16 2010-01-20 Santarus Inc COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND PROKINETIC AGENT
EP1740571B1 (en) * 2004-04-28 2009-07-29 Hetero Drugs Limited A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers
DE602004025386D1 (de) * 2004-05-28 2010-03-18 Hetero Drugs Ltd Neue stereoselektive synthese von benzimidazolsulfoxiden
KR20070027584A (ko) * 2004-06-17 2007-03-09 와이어쓰 고나도트로핀 방출 호르몬 수용체 길항제
AU2005264998A1 (en) * 2004-06-17 2006-01-26 Wyeth The present invention relates to methods of making Gonadotropin Releasing Hormone ('GnRH') (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists
CA2581454A1 (en) * 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyrimidine compounds, process for their preparation and compositions containing them
CA2587853A1 (en) * 2004-11-23 2006-06-01 Wyeth Gonadotropin releasing hormone receptor antagonists
US7538113B2 (en) * 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) * 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) * 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US20060189619A1 (en) * 2005-02-24 2006-08-24 Wyeth 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
US20070015782A1 (en) 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) * 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
CA2611917A1 (en) * 2005-06-13 2006-12-21 Takeda Pharmaceutical Company Limited Injection
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2008036201A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
WO2008036211A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
CA2667682A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
CN101497622B (zh) * 2008-01-30 2011-04-27 山东轩竹医药科技有限公司 吡啶甲基亚磺酰基咪唑并吡啶衍生物
JP2011512416A (ja) 2008-02-20 2011-04-21 ザ・キュレイターズ・オブ・ザ・ユニバーシティー・オブ・ミズーリ オメプラゾール及びランソプラゾールの組合せと緩衝剤を含んでなる組成物とそれを使用する方法
UA100192C2 (en) * 2008-11-11 2012-11-26 УАЙТ ЭлЭлСи 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands
CA2891523A1 (en) * 2012-11-19 2014-05-22 Jiangsu Hansoh Pharmaceutical Co., Ltd. Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof
WO2014133059A1 (ja) 2013-02-28 2014-09-04 武田薬品工業株式会社 スルホニルクロライド化合物の製造法
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
JP7799627B2 (ja) 2020-05-20 2026-01-15 エフ． ホフマン－ラ ロシュ アーゲー 質量分析のための試薬

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Also Published As

Publication number Publication date
CN100396675C (zh) 2008-06-25
FI20010248L (fi) 2001-02-09
IL141083A0 (en) 2002-02-10
ID28273A (id) 2001-05-10
FI20010248A7 (fi) 2001-04-09
ES2192394T3 (es) 2003-10-01
ATE231857T1 (de) 2003-02-15
MXPA01001464A (es) 2002-05-08
NO322490B1 (no) 2006-10-09
NZ510180A (en) 2002-11-26
UA67788C2 (uk) 2004-07-15
HUP0103464A3 (en) 2002-11-28
PL346000A1 (en) 2002-01-14
NO20010693L (no) 2001-03-05
WO2000009498A1 (en) 2000-02-24
KR100472126B1 (ko) 2005-03-08
IL141083A (en) 2006-07-05
KR20010103566A (ko) 2001-11-23
EP1105387A1 (en) 2001-06-13
US6559167B1 (en) 2003-05-06
NO20010693D0 (no) 2001-02-09
CA2338311C (en) 2007-01-23
TR200100431T2 (tr) 2001-06-21
BR9912937A (pt) 2001-05-08
JP4346243B2 (ja) 2009-10-21
IS5826A (is) 2001-01-29
HK1035368A1 (en) 2001-11-23
HUP0103464A2 (hu) 2002-02-28
YU10101A (sh) 2003-10-31
AU752292B2 (en) 2002-09-12
CN1312806A (zh) 2001-09-12
DE69905171D1 (de) 2003-03-06
AU5551899A (en) 2000-03-06
DE69905171T2 (de) 2003-11-20
EP1105387B1 (en) 2003-01-29
HRP20010106A2 (en) 2002-02-28
DK1105387T3 (da) 2003-06-23
CA2338311A1 (en) 2000-02-24
BG64870B1 (bg) 2006-07-31
JP2003534232A (ja) 2003-11-18

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