ATE231857T1 - Prodrugs für proton-pump-inhibitoren - Google Patents
Prodrugs für proton-pump-inhibitorenInfo
- Publication number
- ATE231857T1 ATE231857T1 AT99942057T AT99942057T ATE231857T1 AT E231857 T1 ATE231857 T1 AT E231857T1 AT 99942057 T AT99942057 T AT 99942057T AT 99942057 T AT99942057 T AT 99942057T AT E231857 T1 ATE231857 T1 AT E231857T1
- Authority
- AT
- Austria
- Prior art keywords
- proton pump
- pump inhibitor
- prodrugs
- drugs
- inhibitor drugs
- Prior art date
Links
- 229940126409 proton pump inhibitor Drugs 0.000 title abstract 5
- 239000000612 proton pump inhibitor Substances 0.000 title abstract 5
- 229940002612 prodrug Drugs 0.000 title abstract 4
- 239000000651 prodrug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 230000004962 physiological condition Effects 0.000 abstract 2
- HBDKFZNDMVLSHM-UHFFFAOYSA-N 2-(pyridin-2-ylmethylsulfinyl)-1h-benzimidazole Chemical compound N=1C2=CC=CC=C2NC=1S(=O)CC1=CC=CC=N1 HBDKFZNDMVLSHM-UHFFFAOYSA-N 0.000 abstract 1
- JJZPWCVHSLZLQC-UHFFFAOYSA-N [N].C1=CC=C2NC=NC2=C1 Chemical group [N].C1=CC=C2NC=NC2=C1 JJZPWCVHSLZLQC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Reciprocating Pumps (AREA)
- Fertilizing (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/131,481 US6093734A (en) | 1998-08-10 | 1998-08-10 | Prodrugs of proton pump inhibitors |
| US36438199A | 1999-07-29 | 1999-07-29 | |
| PCT/US1999/018048 WO2000009498A1 (en) | 1998-08-10 | 1999-08-09 | Prodrugs of proton pump inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231857T1 true ATE231857T1 (de) | 2003-02-15 |
Family
ID=26829517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99942057T ATE231857T1 (de) | 1998-08-10 | 1999-08-09 | Prodrugs für proton-pump-inhibitoren |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6559167B1 (de) |
| EP (1) | EP1105387B1 (de) |
| JP (1) | JP4346243B2 (de) |
| KR (1) | KR100472126B1 (de) |
| CN (1) | CN100396675C (de) |
| AT (1) | ATE231857T1 (de) |
| AU (1) | AU752292B2 (de) |
| BG (1) | BG64870B1 (de) |
| BR (1) | BR9912937A (de) |
| CA (1) | CA2338311C (de) |
| DE (1) | DE69905171T2 (de) |
| DK (1) | DK1105387T3 (de) |
| ES (1) | ES2192394T3 (de) |
| FI (1) | FI20010248A7 (de) |
| HR (1) | HRP20010106A2 (de) |
| HU (1) | HUP0103464A3 (de) |
| ID (1) | ID28273A (de) |
| IL (2) | IL141083A0 (de) |
| IS (1) | IS5826A (de) |
| MX (1) | MXPA01001464A (de) |
| NO (1) | NO322490B1 (de) |
| NZ (1) | NZ510180A (de) |
| PL (1) | PL346000A1 (de) |
| TR (1) | TR200100431T2 (de) |
| UA (1) | UA67788C2 (de) |
| WO (1) | WO2000009498A1 (de) |
| YU (1) | YU10101A (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1453493A2 (de) * | 2001-11-19 | 2004-09-08 | ALTANA Pharma AG | Reversibele protonpumpen-hemmer zur behandlung von atemwegserkrankungen |
| DE60304726T2 (de) | 2002-07-19 | 2007-08-09 | Winston Pharmaceuticals Llc, Newport Beach | Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer |
| JP2006188432A (ja) * | 2003-02-25 | 2006-07-20 | Zeria Pharmaceut Co Ltd | 四環系スルフェンアミド化合物 |
| BRPI0412590A (pt) * | 2003-07-15 | 2006-09-19 | Allergan Inc | processo para preparação de pró-drogas isomericamente puras de inibidores de bomba de próton |
| BRPI0414046A (pt) * | 2003-08-29 | 2006-10-24 | Dynogen Pharmaceuticals Inc | método de tratamento de um distúrbio de motilidade gastrintestinal, de tratamento de "gerd", de "gerd" noturno, composição farmacêutica, kit que compreende um composto e método para aumentar a motilidade esofágica em um paciente |
| TWI372066B (en) * | 2003-10-01 | 2012-09-11 | Wyeth Corp | Pantoprazole multiparticulate formulations |
| WO2005039640A1 (en) * | 2003-10-03 | 2005-05-06 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs |
| US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
| BRPI0507784A (pt) * | 2004-02-18 | 2007-07-17 | Allergan Inc | métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons |
| JP2007523164A (ja) * | 2004-02-18 | 2007-08-16 | アラーガン、インコーポレイテッド | プロトンポンプインヒビターに関連する化合物の静脈内投与のための方法および組成物 |
| CA2561700A1 (en) * | 2004-04-16 | 2005-12-15 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
| EP1740571B1 (de) * | 2004-04-28 | 2009-07-29 | Hetero Drugs Limited | Verfahren zur herstellung von pyridinylmethyl-1h-benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere |
| ATE456566T1 (de) * | 2004-05-28 | 2010-02-15 | Hetero Drugs Ltd | Neue stereoselektive synthese von benzimidazolsulfoxiden |
| RU2007101544A (ru) * | 2004-06-17 | 2008-08-10 | Уайт (Us) | Антагонисты рецепторов высвобождающего гонадотропин гормона |
| RU2007101509A (ru) * | 2004-06-17 | 2008-07-27 | Уайт (Us) | Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин |
| US7820654B2 (en) * | 2004-09-23 | 2010-10-26 | Dr. Reddy's Laboratories Ltd. | Pyrimidine compounds, process for their preparation and compositions containing them |
| CN101048383A (zh) * | 2004-11-23 | 2007-10-03 | 惠氏公司 | 促性腺激素释放激素受体拮抗剂 |
| US7538113B2 (en) * | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7534796B2 (en) * | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
| US7582634B2 (en) * | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
| US20060189619A1 (en) * | 2005-02-24 | 2006-08-24 | Wyeth | 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds |
| US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
| US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
| US7531542B2 (en) | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
| US7582636B2 (en) * | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
| US20090036406A1 (en) * | 2005-06-13 | 2009-02-05 | Takeda Pharmaceutical Company Limited | Injection |
| WO2007073301A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Benzoimidazole derivatives as prodrugs of proton pump inhibitors |
| WO2008036211A1 (en) * | 2006-09-19 | 2008-03-27 | Alevium Pharmaceuticals, Inc. | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety |
| US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| EP2086543A2 (de) | 2006-10-27 | 2009-08-12 | The Curators of the University of Missouri | Zusammensetzungen mit mindestens einem säurelabilen protonenpumpen-hemmenden mittel, wahlweise anderen pharmazeutisch wirksamen mitteln und anwendungsverfahren dafür |
| CN101497622B (zh) * | 2008-01-30 | 2011-04-27 | 山东轩竹医药科技有限公司 | 吡啶甲基亚磺酰基咪唑并吡啶衍生物 |
| JP2011512416A (ja) | 2008-02-20 | 2011-04-21 | ザ・キュレイターズ・オブ・ザ・ユニバーシティー・オブ・ミズーリ | オメプラゾール及びランソプラゾールの組合せと緩衝剤を含んでなる組成物とそれを使用する方法 |
| UA100192C2 (en) * | 2008-11-11 | 2012-11-26 | УАЙТ ЭлЭлСи | 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands |
| US9388133B2 (en) * | 2012-11-19 | 2016-07-12 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof |
| CA2902624C (en) | 2013-02-28 | 2021-05-18 | Takeda Pharmaceutical Company Limited | Method for producing sulfonyl chloride compound |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| WO2021234002A1 (en) | 2020-05-20 | 2021-11-25 | F. Hoffmann-La Roche Ag | Reagent for mass spectrometry |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
| SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| JPS6150978A (ja) * | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| FI90544C (fi) | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
| US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| DE69131627T2 (de) * | 1990-06-20 | 2000-04-27 | Astra Ab Soedertaelje | Dialkoxypyridinylbenzimidazolderivate, verfahren zur herstellung und ihre pharmazeutische verwendung |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| WO1995029897A1 (en) * | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
| US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| SE9602442D0 (sv) | 1996-06-20 | 1996-06-20 | Astra Ab | Administration of pharmaceuticals |
-
1999
- 1999-08-09 NZ NZ510180A patent/NZ510180A/xx not_active IP Right Cessation
- 1999-08-09 ES ES99942057T patent/ES2192394T3/es not_active Expired - Lifetime
- 1999-08-09 WO PCT/US1999/018048 patent/WO2000009498A1/en not_active Ceased
- 1999-08-09 DE DE69905171T patent/DE69905171T2/de not_active Expired - Lifetime
- 1999-08-09 AU AU55518/99A patent/AU752292B2/en not_active Expired
- 1999-08-09 HR HR20010106A patent/HRP20010106A2/hr not_active Application Discontinuation
- 1999-08-09 MX MXPA01001464A patent/MXPA01001464A/es not_active IP Right Cessation
- 1999-08-09 IL IL14108399A patent/IL141083A0/xx active IP Right Grant
- 1999-08-09 EP EP99942057A patent/EP1105387B1/de not_active Expired - Lifetime
- 1999-08-09 CN CNB998095125A patent/CN100396675C/zh not_active Expired - Fee Related
- 1999-08-09 DK DK99942057T patent/DK1105387T3/da active
- 1999-08-09 TR TR2001/00431T patent/TR200100431T2/xx unknown
- 1999-08-09 KR KR10-2001-7001705A patent/KR100472126B1/ko not_active Expired - Fee Related
- 1999-08-09 AT AT99942057T patent/ATE231857T1/de not_active IP Right Cessation
- 1999-08-09 HU HU0103464A patent/HUP0103464A3/hu unknown
- 1999-08-09 ID IDW20010545A patent/ID28273A/id unknown
- 1999-08-09 YU YU10101A patent/YU10101A/sh unknown
- 1999-08-09 JP JP2000564950A patent/JP4346243B2/ja not_active Expired - Fee Related
- 1999-08-09 BR BR9912937-0A patent/BR9912937A/pt not_active Application Discontinuation
- 1999-08-09 CA CA002338311A patent/CA2338311C/en not_active Expired - Lifetime
- 1999-08-09 PL PL99346000A patent/PL346000A1/xx not_active IP Right Cessation
- 1999-09-08 UA UA2001020908A patent/UA67788C2/uk unknown
-
2001
- 2001-01-24 IL IL141083A patent/IL141083A/en not_active IP Right Cessation
- 2001-01-26 IS IS5826A patent/IS5826A/is unknown
- 2001-01-26 BG BG105191A patent/BG64870B1/bg unknown
- 2001-02-09 NO NO20010693A patent/NO322490B1/no not_active IP Right Cessation
- 2001-02-09 FI FI20010248A patent/FI20010248A7/fi unknown
- 2001-02-14 US US09/783,807 patent/US6559167B1/en not_active Expired - Lifetime
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