BG105252A - Isoquinolines as urokinase inhibitors - Google Patents

Isoquinolines as urokinase inhibitors

Info

Publication number: BG105252A
Authority: BG; Bulgaria
Prior art keywords: isoquinolines; urokinase inhibitors; urokinase; inhibitors; isoquinolinylguanidine
Prior art date: 1998-07-24

Application number

BG105252A

Other languages

Bulgarian (bg)

English (en)

Inventor

Christopher Barber

Roger DICKINSON

Paul FISH

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-24

Filing date

2001-02-14

Publication date

2001-12-29

1999-07-15 Priority claimed from PCT/IB1999/001289 external-priority patent/WO2000005214A2/en

2001-02-14 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2001-12-29 Publication of BG105252A publication Critical patent/BG105252A/xx

Links

239000002797 plasminogen activator inhibitor Substances 0.000 title abstract 2
150000002537 isoquinolines Chemical class 0.000 title 1
MBXFJGWNDTUZLK-UHFFFAOYSA-N 2-isoquinolin-1-ylguanidine Chemical class C1=CC=C2C(NC(=N)N)=NC=CC2=C1 MBXFJGWNDTUZLK-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BG105252A 1998-07-24 2001-02-14 Isoquinolines as urokinase inhibitors BG105252A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9816228.2A GB9816228D0 (en)	1998-07-24	1998-07-24	Isoquinolines
GBGB9908829.6A GB9908829D0 (en)	1998-07-24	1999-04-16	Isoquinolines
PCT/IB1999/001289 WO2000005214A2 (en)	1998-07-24	1999-07-15	Isoquinolines as urokinase inhibitors

Publications (1)

Publication Number	Publication Date
BG105252A true BG105252A (en)	2001-12-29

Family

ID=10836172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105252A BG105252A (en)	1998-07-24	2001-02-14	Isoquinolines as urokinase inhibitors

Country Status (39)

Country	Link
EP (1)	EP1077945B1 (de)
JP (1)	JP2002521367A (de)
KR (1)	KR20010083137A (de)
CN (1)	CN1318059A (de)
AR (1)	AR018960A1 (de)
AT (1)	ATE230730T1 (de)
AU (1)	AU745545B2 (de)
BG (1)	BG105252A (de)
BR (1)	BR9912374A (de)
CA (1)	CA2337247A1 (de)
CO (1)	CO5080787A1 (de)
DE (1)	DE69904814T2 (de)
DK (1)	DK1077945T3 (de)
DZ (1)	DZ2852A1 (de)
EA (1)	EA200100073A1 (de)
EE (1)	EE200100049A (de)
ES (1)	ES2189434T3 (de)
GB (2)	GB9816228D0 (de)
GT (1)	GT199900116A (de)
HK (1)	HK1040996A1 (de)
HN (1)	HN1999000116A (de)
HR (1)	HRP20010059A2 (de)
HU (1)	HUP0103665A3 (de)
ID (1)	ID26993A (de)
IS (1)	IS5789A (de)
MA (1)	MA26664A1 (de)
NO (1)	NO20010400L (de)
OA (1)	OA11578A (de)
PA (1)	PA8478901A1 (de)
PE (1)	PE20000937A1 (de)
PL (1)	PL346022A1 (de)
PT (1)	PT1077945E (de)
SI (1)	SI1077945T1 (de)
SK (1)	SK1062001A3 (de)
TN (1)	TNSN99149A1 (de)
TR (1)	TR200100222T2 (de)
TW (1)	TW530049B (de)
UY (1)	UY25663A1 (de)
ZA (1)	ZA200100230B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003219039A1 (en) *	2002-03-11	2003-09-22	Curacyte Ag	Urokinase inhibitors, production and use thereof
US7794987B2 (en)	2003-12-02	2010-09-14	Ucb Pharma Gmbh	Method for treating central neuropathic pain
EP1604655A1 (de)	2004-06-09	2005-12-14	Schwarz Pharma Ag	Neue Verwendung von Peptidverbindungen zur Behandlung von Trigeminusneuralgie
EP1604656A1 (de)	2004-06-09	2005-12-14	Schwarz Pharma Ag	Neue Verwendung von Peptidverbindungen zur Behandlung von amyotropher Lateralsklerose (ALS)
EA019757B1 (ru)	2006-06-15	2014-06-30	ЮСиБи ФАРМА ГМБХ	Фармацевтическая композиция с синергетическим противосудорожным эффектом

1998
- 1998-07-24 GB GBGB9816228.2A patent/GB9816228D0/en not_active Ceased
1999
- 1999-04-16 GB GBGB9908829.6A patent/GB9908829D0/en not_active Ceased
- 1999-07-15 OA OA1200100002A patent/OA11578A/en unknown
- 1999-07-15 BR BR9912374-6A patent/BR9912374A/pt not_active IP Right Cessation
- 1999-07-15 AT AT99928177T patent/ATE230730T1/de not_active IP Right Cessation
- 1999-07-15 SI SI9930178T patent/SI1077945T1/xx unknown
- 1999-07-15 DE DE69904814T patent/DE69904814T2/de not_active Expired - Fee Related
- 1999-07-15 KR KR1020017000956A patent/KR20010083137A/ko not_active Ceased
- 1999-07-15 DK DK99928177T patent/DK1077945T3/da active
- 1999-07-15 HK HK02102712.1A patent/HK1040996A1/zh unknown
- 1999-07-15 CA CA002337247A patent/CA2337247A1/en not_active Abandoned
- 1999-07-15 HR HR20010059A patent/HRP20010059A2/hr not_active Application Discontinuation
- 1999-07-15 HU HU0103665A patent/HUP0103665A3/hu unknown
- 1999-07-15 EP EP99928177A patent/EP1077945B1/de not_active Expired - Lifetime
- 1999-07-15 PL PL99346022A patent/PL346022A1/xx not_active Application Discontinuation
- 1999-07-15 JP JP2000561170A patent/JP2002521367A/ja active Pending
- 1999-07-15 TR TR2001/00222T patent/TR200100222T2/xx unknown
- 1999-07-15 SK SK106-2001A patent/SK1062001A3/sk unknown
- 1999-07-15 PT PT99928177T patent/PT1077945E/pt unknown
- 1999-07-15 EE EEP200100049A patent/EE200100049A/xx unknown
- 1999-07-15 AU AU45289/99A patent/AU745545B2/en not_active Ceased
- 1999-07-15 EA EA200100073A patent/EA200100073A1/ru unknown
- 1999-07-15 ID IDW20010169D patent/ID26993A/id unknown
- 1999-07-15 ES ES99928177T patent/ES2189434T3/es not_active Expired - Lifetime
- 1999-07-15 CN CN99809025A patent/CN1318059A/zh active Pending
- 1999-07-16 HN HN1999000116A patent/HN1999000116A/es unknown
- 1999-07-21 TN TNTNSN99149A patent/TNSN99149A1/fr unknown
- 1999-07-21 DZ DZ990152A patent/DZ2852A1/xx active
- 1999-07-21 PE PE1999000733A patent/PE20000937A1/es not_active Application Discontinuation
- 1999-07-21 MA MA25695A patent/MA26664A1/fr unknown
- 1999-07-22 AR ARP990103614A patent/AR018960A1/es not_active Application Discontinuation
- 1999-07-23 PA PA19998478901A patent/PA8478901A1/es unknown
- 1999-07-23 TW TW088112548A patent/TW530049B/zh active
- 1999-07-23 GT GT199900116A patent/GT199900116A/es unknown
- 1999-07-26 CO CO99047012A patent/CO5080787A1/es unknown
- 1999-08-16 UY UY25663A patent/UY25663A1/es unknown
2000
- 2000-12-22 IS IS5789A patent/IS5789A/is unknown
2001
- 2001-01-09 ZA ZA200100230A patent/ZA200100230B/en unknown
- 2001-01-23 NO NO20010400A patent/NO20010400L/no not_active Application Discontinuation
- 2001-02-14 BG BG105252A patent/BG105252A/xx unknown

Also Published As

Publication number	Publication date
CO5080787A1 (es)	2001-09-25
DK1077945T3 (da)	2003-04-22
NO20010400L (no)	2001-03-26
AU4528999A (en)	2000-02-14
AR018960A1 (es)	2001-12-12
GB9816228D0 (en)	1998-09-23
HUP0103665A2 (hu)	2002-02-28
DZ2852A1 (fr)	2003-12-01
TW530049B (en)	2003-05-01
EP1077945B1 (de)	2003-01-08
SI1077945T1 (en)	2003-04-30
HK1040996A1 (zh)	2002-06-28
PA8478901A1 (es)	2000-09-29
EA200100073A1 (ru)	2001-10-22
CN1318059A (zh)	2001-10-17
BR9912374A (pt)	2001-04-17
MA26664A1 (fr)	2004-12-20
CA2337247A1 (en)	2000-02-03
JP2002521367A (ja)	2002-07-16
DE69904814D1 (de)	2003-02-13
KR20010083137A (ko)	2001-08-31
HN1999000116A (es)	2000-11-11
ID26993A (id)	2001-02-22
ZA200100230B (en)	2002-03-01
DE69904814T2 (de)	2003-04-30
GB9908829D0 (en)	1999-06-16
HRP20010059A2 (en)	2002-02-28
ES2189434T3 (es)	2003-07-01
TNSN99149A1 (fr)	2005-11-10
NO20010400D0 (no)	2001-01-23
OA11578A (en)	2004-07-20
HUP0103665A3 (en)	2002-06-28
AU745545B2 (en)	2002-03-21
PL346022A1 (en)	2002-01-14
EE200100049A (et)	2002-06-17
PT1077945E (pt)	2003-03-31
TR200100222T2 (tr)	2001-12-21
GT199900116A (es)	2001-01-13
PE20000937A1 (es)	2000-09-18
ATE230730T1 (de)	2003-01-15
EP1077945A1 (de)	2001-02-28
IS5789A (is)	2000-12-22
SK1062001A3 (en)	2001-11-06
UY25663A1 (es)	2000-03-31

Publication	Publication Date	Title
NZ331993A (en)	2000-04-28	Pyrazinone thrombin inhibitors
BG105369A (en)	2001-12-29	Arylpiperazines and their use as metalloproteinase inhibiting agent (mmp
CA2260337A1 (en)	1999-07-27	Therapeutic agents
GEP20074185B (en)	2007-08-10	Incclusion complexs of aryl- heterocyclic salts
BG106586A (en)	2003-01-31	Pyrazolopyramidines as therapeutic agents
ATE218859T1 (de)	2002-06-15	Liganden des neuropeptids y
ZA200006577B (en)	2002-04-24	Phthalazine derivatives as phosphodiesterase 4 inhibitors.
MY138239A (en)	2009-05-29	Nitrogen containing heterobicycles as factor xa inhibitors
BG103310A (en)	2000-05-31	Benzonaphthyridins as bronchial therapeutical means
WO2000005214A3 (en)	2001-05-31	Isoquinolines as urokinase inhibitors
PT883405E (pt)	2004-06-30	Inibidores de amidino-protease
PL341239A1 (en)	2001-03-26	Dihydrobenzofuranes
AU9059798A (en)	2000-04-10	Urokinase inhibitors
IL135122A0 (en)	2001-05-20	Isoquinolines as urokinase inhibitors
GB2324091A (en)	1998-10-14	Metalloproteinase inhibitors
BG105539A (bg)	2001-12-29	Елетриптан хидробромид монохидрат
DK1204659T3 (da)	2004-04-05	Serotonerge benzofuraner
TR200100133T2 (tr)	2001-06-21	FKBP İnhibitörleri
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
MY133842A (en)	2007-11-30	Sodium-hydrogen exchanger type 1 inhibitor.
TR200100222T2 (tr)	2001-12-21	Ürokinaz önleyicileri olarak izokinolinler
MXPA04005226A (es)	2004-10-11	1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion.
UA85994C2 (en)	2009-03-25	N, n'-substituted-1,3-diamino-2-hydroxypropane derivatives
AP2001002047A0 (en)	2001-03-31	Isoquinoliness as urokinase inhibitors.
SI0937075T1 (en)	2004-06-30	New Imidazo- and Oxazolopyridines as Phosphodiesterase Inhibitors.