BG105807A - Състави с контролирано освобождаване на бетахистин - Google Patents

Състави с контролирано освобождаване на бетахистин Download PDF

Info

Publication number: BG105807A
Authority: BG; Bulgaria
Prior art keywords: release tablet; controlled; controlled release; hydrophilic polymer; tablet according
Prior art date: 1999-03-05

Application number

BG105807A

Other languages

Bulgarian (bg)

English (en)

Inventor

Flavio Fabiani

Enrico Frimonti

Mauro Valenti

Original Assignee

Farmaceutici Formenti S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-05

Filing date

2001-08-09

Publication date

2002-03-29

2001-08-09 Application filed by Farmaceutici Formenti S.P.A. filed Critical Farmaceutici Formenti S.P.A.

2002-03-29 Publication of BG105807A publication Critical patent/BG105807A/bg

Links

229960004536 betahistine Drugs 0.000 title claims abstract description 16
238000013270 controlled release Methods 0.000 title claims abstract description 16
UUQMNUMQCIQDMZ-UHFFFAOYSA-N betahistine Chemical group CNCCC1=CC=CC=N1 UUQMNUMQCIQDMZ-UHFFFAOYSA-N 0.000 title claims abstract description 13
239000000203 mixture Substances 0.000 title claims abstract description 10
238000000034 method Methods 0.000 claims abstract description 16
150000001875 compounds Chemical class 0.000 claims abstract description 15
239000004480 active ingredient Substances 0.000 claims abstract description 12
229920001477 hydrophilic polymer Polymers 0.000 claims abstract description 10
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 7
238000002156 mixing Methods 0.000 claims abstract description 5
239000008187 granular material Substances 0.000 claims abstract description 4
239000000126 substance Substances 0.000 claims description 15
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 10
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 10
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 10
238000007906 compression Methods 0.000 claims description 7
230000006835 compression Effects 0.000 claims description 7
238000002844 melting Methods 0.000 claims description 7
230000008018 melting Effects 0.000 claims description 7
238000005469 granulation Methods 0.000 claims description 6
230000003179 granulation Effects 0.000 claims description 6
150000003839 salts Chemical class 0.000 claims description 6
238000007908 dry granulation Methods 0.000 claims description 4
150000002148 esters Chemical class 0.000 claims description 4
150000002170 ethers Chemical class 0.000 claims description 3
-1 long-chain fatty acid triglycerides Chemical class 0.000 claims description 3
229920000642 polymer Polymers 0.000 claims description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
238000005550 wet granulation Methods 0.000 claims description 3
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
150000001298 alcohols Chemical class 0.000 claims description 2
229920000615 alginic acid Polymers 0.000 claims description 2
235000010443 alginic acid Nutrition 0.000 claims description 2
229920002678 cellulose Polymers 0.000 claims description 2
229920001577 copolymer Polymers 0.000 claims description 2
235000014113 dietary fatty acids Nutrition 0.000 claims description 2
239000000194 fatty acid Substances 0.000 claims description 2
229930195729 fatty acid Natural products 0.000 claims description 2
150000004665 fatty acids Chemical class 0.000 claims description 2
150000002334 glycols Chemical class 0.000 claims description 2
239000002480 mineral oil Substances 0.000 claims description 2
229920001223 polyethylene glycol Polymers 0.000 claims description 2
239000011347 resin Substances 0.000 claims description 2
229920005989 resin Polymers 0.000 claims description 2
239000008158 vegetable oil Substances 0.000 claims description 2
235000013311 vegetables Nutrition 0.000 claims description 2
229920003086 cellulose ether Polymers 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
238000007909 melt granulation Methods 0.000 abstract description 2
239000007787 solid Substances 0.000 abstract description 2
238000009472 formulation Methods 0.000 abstract 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
238000000338 in vitro Methods 0.000 description 15
239000000454 talc Substances 0.000 description 14
229910052623 talc Inorganic materials 0.000 description 14
229940049654 glyceryl behenate Drugs 0.000 description 13
238000002360 preparation method Methods 0.000 description 13
239000000377 silicon dioxide Substances 0.000 description 13
BXWNKGSJHAJOGX-UHFFFAOYSA-N n-hexadecyl alcohol Natural products CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 10
239000001267 polyvinylpyrrolidone Substances 0.000 description 10
229920000036 polyvinylpyrrolidone Polymers 0.000 description 10
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 10
229960000541 cetyl alcohol Drugs 0.000 description 7
230000000052 comparative effect Effects 0.000 description 6
OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 5
239000001856 Ethyl cellulose Substances 0.000 description 4
235000021355 Stearic acid Nutrition 0.000 description 4
229920001249 ethyl cellulose Polymers 0.000 description 4
235000019325 ethyl cellulose Nutrition 0.000 description 4
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 4
239000008117 stearic acid Substances 0.000 description 4
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
239000004359 castor oil Substances 0.000 description 3
235000019438 castor oil Nutrition 0.000 description 3
230000004927 fusion Effects 0.000 description 3
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 3
239000000314 lubricant Substances 0.000 description 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
229920003112 high viscosity grade hydroxypropyl cellulose Polymers 0.000 description 2
229920003113 low viscosity grade hydroxypropyl cellulose Polymers 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
208000012886 Vertigo Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000003405 delayed action preparation Substances 0.000 description 1
229940031954 dibutyl sebacate Drugs 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
150000002433 hydrophilic molecules Chemical class 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
229960001375 lactose Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229960001021 lactose monohydrate Drugs 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
231100000889 vertigo Toxicity 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

BG105807A 1999-03-05 2001-08-09 Състави с контролирано освобождаване на бетахистин BG105807A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI000454A IT1309591B1 (it)	1999-03-05	1999-03-05	Composizioni a rilascio controllato di betaistina.
PCT/EP2000/001642 WO2000053162A1 (en)	1999-03-05	2000-02-28	Controlled-release compositions of betahistine

Publications (1)

Publication Number	Publication Date
BG105807A true BG105807A (bg)	2002-03-29

Family

ID=11382165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105807A BG105807A (bg)	1999-03-05	2001-08-09	Състави с контролирано освобождаване на бетахистин

Country Status (37)

Country	Link
EP (1)	EP1158963B1 (id)
JP (1)	JP2002538197A (id)
KR (1)	KR20010102498A (id)
CN (1)	CN1165295C (id)
AR (1)	AR029154A1 (id)
AT (1)	ATE231392T1 (id)
AU (1)	AU762532B2 (id)
BG (1)	BG105807A (id)
BR (1)	BR0008739A (id)
CA (1)	CA2364226A1 (id)
CO (1)	CO5170438A1 (id)
CZ (1)	CZ299510B6 (id)
DE (1)	DE60001266T2 (id)
DK (1)	DK1158963T3 (id)
EE (1)	EE200100453A (id)
ES (1)	ES2189739T3 (id)
GE (1)	GEP20033078B (id)
HK (1)	HK1042246B (id)
HR (1)	HRP20010650A2 (id)
HU (1)	HUP0200243A2 (id)
ID (1)	ID30127A (id)
IL (1)	IL145263A0 (id)
IT (1)	IT1309591B1 (id)
MX (1)	MXPA01008893A (id)
NO (1)	NO319135B1 (id)
NZ (1)	NZ513949A (id)
PE (1)	PE20001547A1 (id)
PL (1)	PL196290B1 (id)
PT (1)	PT1158963E (id)
RU (1)	RU2248791C2 (id)
SI (1)	SI1158963T1 (id)
SK (1)	SK284584B6 (id)
TR (1)	TR200102566T2 (id)
UA (1)	UA65652C2 (id)
WO (1)	WO2000053162A1 (id)
YU (1)	YU64001A (id)
ZA (1)	ZA200107318B (id)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100500130C (zh) *	2003-01-23	2009-06-17	株式会社太平洋	缓释制剂及其制备方法
DK1493435T3 (da)	2003-07-04	2008-09-08	Formenti Farmaceutici Spa	Sammensætning af betahistin med styret frigivelse
CA2553309A1 (en)	2004-04-22	2005-11-03	Mor Research Applications Ltd.	Method of food intake management
US7728015B2 (en)	2004-04-22	2010-06-01	Mor Research Applications Ltd.	Compositions for weight management
WO2006009403A1 (en) *	2004-07-22	2006-01-26	Amorepacific Corporation	Sustained-release preparations containing topiramate and the producing method thereof
JP2006176461A (ja) *	2004-12-24	2006-07-06	Dai Ichi Seiyaku Co Ltd	粒状物
ES2419204T3 (es)	2008-05-27	2013-08-19	The University Of Melbourne	Métodos para tratar a mamíferos con disfunciones de la trompa de Eustaquio
EP2314296A1 (en) *	2009-10-22	2011-04-27	Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi	Orally Disintegrating Tablets of Betahistine
EP2491930A1 (en) *	2011-02-25	2012-08-29	Deva Holding Anonim Sirketi	Pharmaceutical combination of betahistine and trimetazidine
DE102012105528A1 (de)	2012-06-25	2014-01-02	Hennig Arzneimittel Gmbh & Co. Kg	Arzneiform zur Freisetzung von Wirkstoffen
WO2015053620A1 (en) *	2013-10-07	2015-04-16	Disphar International B.V.	Betahistine composition
PT3431078T (pt) *	2017-07-20	2021-04-21	Intas Pharmaceuticals Ltd	Composições orais sólidas de libertação prolongada não pulsáteis de betaistina

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2397840B1 (id) *	1977-07-22	1981-03-20	Cherqui Jean
FR2432313A1 (fr) *	1978-08-01	1980-02-29	Foulhoux Pierre	Nouvelle forme galenique de la betahistine et son procede d'obtention
GB2280604B (en) *	1993-07-02	1997-04-30	Resource Medical Limited	Processing of active agents
ATE277739T1 (de) *	1996-10-28	2004-10-15	Gen Mills Inc	Einbettung und einkapselung von teilchen zur kontrollierten abgabe

1999
- 1999-03-05 IT IT1999MI000454A patent/IT1309591B1/it active
2000
- 2000-02-28 AU AU32831/00A patent/AU762532B2/en not_active Ceased
- 2000-02-28 BR BR0008739-4A patent/BR0008739A/pt not_active Application Discontinuation
- 2000-02-28 NZ NZ513949A patent/NZ513949A/en unknown
- 2000-02-28 CZ CZ20013186A patent/CZ299510B6/cs not_active IP Right Cessation
- 2000-02-28 WO PCT/EP2000/001642 patent/WO2000053162A1/en not_active Ceased
- 2000-02-28 ES ES00910723T patent/ES2189739T3/es not_active Expired - Lifetime
- 2000-02-28 GE GEAP20006082A patent/GEP20033078B/en unknown
- 2000-02-28 AT AT00910723T patent/ATE231392T1/de not_active IP Right Cessation
- 2000-02-28 DK DK00910723T patent/DK1158963T3/da active
- 2000-02-28 UA UA2001085807A patent/UA65652C2/uk unknown
- 2000-02-28 HK HK02104045.5A patent/HK1042246B/zh not_active IP Right Cessation
- 2000-02-28 RU RU2001124607/15A patent/RU2248791C2/ru not_active IP Right Cessation
- 2000-02-28 IL IL14526300A patent/IL145263A0/xx unknown
- 2000-02-28 JP JP2000603651A patent/JP2002538197A/ja active Pending
- 2000-02-28 PL PL350232A patent/PL196290B1/pl unknown
- 2000-02-28 ID IDW00200101790A patent/ID30127A/id unknown
- 2000-02-28 EE EEP200100453A patent/EE200100453A/xx unknown
- 2000-02-28 DE DE60001266T patent/DE60001266T2/de not_active Expired - Fee Related
- 2000-02-28 MX MXPA01008893A patent/MXPA01008893A/es unknown
- 2000-02-28 HR HR20010650A patent/HRP20010650A2/hr not_active Application Discontinuation
- 2000-02-28 HU HU0200243A patent/HUP0200243A2/hu unknown
- 2000-02-28 YU YU64001A patent/YU64001A/sh unknown
- 2000-02-28 EP EP00910723A patent/EP1158963B1/en not_active Expired - Lifetime
- 2000-02-28 PT PT00910723T patent/PT1158963E/pt unknown
- 2000-02-28 CA CA002364226A patent/CA2364226A1/en not_active Abandoned
- 2000-02-28 SI SI200030050T patent/SI1158963T1/xx unknown
- 2000-02-28 TR TR2001/02566T patent/TR200102566T2/xx unknown
- 2000-02-28 CN CNB008046190A patent/CN1165295C/zh not_active Expired - Fee Related
- 2000-02-28 KR KR1020017011271A patent/KR20010102498A/ko not_active Ceased
- 2000-02-28 SK SK1249-2001A patent/SK284584B6/sk unknown
- 2000-03-02 CO CO00015153A patent/CO5170438A1/es not_active Application Discontinuation
- 2000-03-03 PE PE2000000181A patent/PE20001547A1/es not_active Application Discontinuation
- 2000-03-03 AR ARP000100974A patent/AR029154A1/es active IP Right Grant
2001
- 2001-08-09 BG BG105807A patent/BG105807A/bg unknown
- 2001-09-04 ZA ZA200107318A patent/ZA200107318B/en unknown
- 2001-09-04 NO NO20014301A patent/NO319135B1/no unknown

Also Published As

Publication number	Publication date
NZ513949A (en)	2003-10-31
HK1042246A1 (en)	2002-08-09
SK12492001A3 (sk)	2001-12-03
DK1158963T3 (da)	2003-04-28
AU3283100A (en)	2000-09-28
GEP20033078B (en)	2003-10-27
EP1158963B1 (en)	2003-01-22
JP2002538197A (ja)	2002-11-12
TR200102566T2 (tr)	2002-01-21
HUP0200243A2 (en)	2002-06-29
PL196290B1 (pl)	2007-12-31
NO319135B1 (no)	2005-06-20
ES2189739T3 (es)	2003-07-16
NO20014301D0 (no)	2001-09-04
AR029154A1 (es)	2003-06-18
PE20001547A1 (es)	2001-01-29
IT1309591B1 (it)	2002-01-24
EP1158963A1 (en)	2001-12-05
ITMI990454A1 (it)	2000-09-05
WO2000053162A1 (en)	2000-09-14
PL350232A1 (en)	2002-11-18
IL145263A0 (en)	2002-06-30
ID30127A (id)	2001-11-08
AU762532B2 (en)	2003-06-26
YU64001A (sh)	2004-05-12
CZ299510B6 (cs)	2008-08-20
DE60001266D1 (de)	2003-02-27
CA2364226A1 (en)	2000-09-14
DE60001266T2 (de)	2003-08-28
HRP20010650A2 (en)	2002-10-31
KR20010102498A (ko)	2001-11-15
MXPA01008893A (es)	2002-10-23
BR0008739A (pt)	2001-12-26
HK1042246B (zh)	2005-06-03
CZ20013186A3 (cs)	2002-02-13
PT1158963E (pt)	2003-06-30
SI1158963T1 (en)	2003-04-30
SK284584B6 (sk)	2005-07-01
ATE231392T1 (de)	2003-02-15
CN1165295C (zh)	2004-09-08
CO5170438A1 (es)	2002-06-27
NO20014301L (no)	2001-09-04
UA65652C2 (uk)	2004-04-15
ZA200107318B (en)	2002-09-04
EE200100453A (et)	2002-12-16
CN1342069A (zh)	2002-03-27
RU2248791C2 (ru)	2005-03-27

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