BG107061A - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
BG107061A
BG107061A BG107061A BG10706102A BG107061A BG 107061 A BG107061 A BG 107061A BG 107061 A BG107061 A BG 107061A BG 10706102 A BG10706102 A BG 10706102A BG 107061 A BG107061 A BG 107061A
Authority
BG
Bulgaria
Prior art keywords
group
compound
formula
citalopram
alkynyl
Prior art date
Application number
BG107061A
Other languages
Bulgarian (bg)
English (en)
Inventor
Hans Petersen
Michael Rock
Haleh Ahmadian
Original Assignee
H.Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H.Lundbeck A/S filed Critical H.Lundbeck A/S
Publication of BG107061A publication Critical patent/BG107061A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG107061A 2000-02-24 2002-09-04 Method for the preparation of citalopram BG107061A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200000296 2000-02-24
DKPA200000401 2000-03-13
PCT/DK2001/000123 WO2001043525A2 (en) 2000-02-24 2001-02-22 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
BG107061A true BG107061A (en) 2003-05-30

Family

ID=26068779

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107061A BG107061A (en) 2000-02-24 2002-09-04 Method for the preparation of citalopram

Country Status (26)

Country Link
US (1) US6420574B2 (is)
EP (1) EP1259501A2 (is)
JP (1) JP2003523955A (is)
KR (1) KR20020081355A (is)
CN (1) CN1608057A (is)
AR (1) AR029658A1 (is)
AU (1) AU2001235358A1 (is)
BE (1) BE1011177A6 (is)
BG (1) BG107061A (is)
BR (1) BR0108937A (is)
CA (1) CA2401236A1 (is)
EA (1) EA005315B1 (is)
FR (1) FR2805812A1 (is)
GR (1) GR1004073B (is)
HR (1) HRP20020660A2 (is)
HU (1) HUP0300212A2 (is)
IE (1) IES20010163A2 (is)
IL (1) IL151059A0 (is)
IS (1) IS6487A (is)
IT (1) ITMI20010386A1 (is)
MX (1) MXPA02008228A (is)
NL (1) NL1017415C1 (is)
NO (1) NO20023928L (is)
PL (1) PL363119A1 (is)
SK (1) SK13672002A3 (is)
WO (1) WO2001043525A2 (is)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) * 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
TR200401456T1 (tr) 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
EA004742B1 (ru) 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
BR9917604A (pt) 1999-12-30 2002-12-31 Lundbeck & Co As H Método para preparação de citalopram
HUP0300343A2 (hu) * 2000-01-14 2003-06-28 H. Lundbeck A/S Eljárás 5-cianoftalid előállítására
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
IES20010157A2 (en) * 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
TR200202155T2 (tr) 2000-03-14 2002-12-23 H. Lundbeck A/S Sitalopramin preparasyon metodu
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
NL1017525C1 (nl) 2000-12-22 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van zuiver Citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
CA2465186A1 (en) * 2001-11-08 2003-05-15 Sepracor, Inc. Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1706394B1 (en) * 2003-11-12 2014-12-17 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
TWI339651B (en) 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
NZ580738A (en) * 2007-05-18 2012-02-24 Cipla Ltd Process for the preparation of escitalopram
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (is) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US5296007A (en) 1986-11-17 1994-03-22 Ensci Inc. Process for removing sulfur from coal
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
WO1998019513A2 (en) 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EP1042310B1 (en) 1997-11-11 2002-07-31 H. Lundbeck A/S Method for the preparation of citalopram
CA2291134C (en) 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
CH692298A5 (de) 1999-10-25 2002-04-30 Lundbeck & Co As H Verfahren zur Herstellung von Zwischenstufen für die Citalopramsynthese sowie zur Herstellung von Escitalopram.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
HUP0300212A2 (hu) 2003-06-28
EA200200898A1 (ru) 2003-02-27
BE1011177A6 (fr) 2001-07-03
GR20010100098A (el) 2001-10-31
WO2001043525A2 (en) 2001-06-21
NL1017415C1 (nl) 2001-05-18
SK13672002A3 (sk) 2003-03-04
IES20010163A2 (en) 2002-03-06
WO2001043525A3 (en) 2002-01-31
JP2003523955A (ja) 2003-08-12
MXPA02008228A (es) 2004-04-05
NO20023928D0 (no) 2002-08-19
FR2805812A1 (fr) 2001-09-07
NO20023928L (no) 2002-08-19
AR029658A1 (es) 2003-07-10
CN1608057A (zh) 2005-04-20
ITMI20010386A1 (it) 2002-08-26
US20010027256A1 (en) 2001-10-04
HRP20020660A2 (en) 2004-12-31
CA2401236A1 (en) 2001-06-21
PL363119A1 (en) 2004-11-15
EP1259501A2 (en) 2002-11-27
IS6487A (is) 2002-07-29
KR20020081355A (ko) 2002-10-26
GR1004073B (el) 2002-11-26
BR0108937A (pt) 2003-06-17
EA005315B1 (ru) 2004-12-30
IL151059A0 (en) 2003-04-10
US6420574B2 (en) 2002-07-16
AU2001235358A1 (en) 2001-06-25

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