TR200401456T1 - Sitalopram hazırlanması için yöntem. - Google Patents

Sitalopram hazırlanması için yöntem.

Info

Publication number
TR200401456T1
TR200401456T1 TR2004/01456T TR200401456T TR200401456T1 TR 200401456 T1 TR200401456 T1 TR 200401456T1 TR 2004/01456 T TR2004/01456 T TR 2004/01456T TR 200401456 T TR200401456 T TR 200401456T TR 200401456 T1 TR200401456 T1 TR 200401456T1
Authority
TR
Turkey
Prior art keywords
citalopram
preparation
formula
arylsulfonyl
alkylsulfonyl
Prior art date
Application number
TR2004/01456T
Other languages
English (en)
Inventor
Michael Rock Harold
Petersen Hans
Ellegaard Peter
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Priority claimed from PCT/DK1999/000581 external-priority patent/WO2000012044A2/en
Publication of TR200401456T1 publication Critical patent/TR200401456T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Citalopram'in hazirlanmasi için, R'nin C1-6 alkil, asit, C1-6 alkilsülfonil ya da arilsülfonil oldugu Formül (IV)'ün bir bilesiginin, 3-(N,N-dimetilamino)-propil magnezyum halid ile reaksiyona girmesini içeren bir yöntem. (Formül (IV)).
TR2004/01456T 1999-10-25 1999-10-25 Sitalopram hazırlanması için yöntem. TR200401456T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
TR200401456T1 true TR200401456T1 (tr) 2005-04-21

Family

ID=8157164

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/01456T TR200401456T1 (tr) 1999-10-25 1999-10-25 Sitalopram hazırlanması için yöntem.

Country Status (25)

Country Link
US (1) US6566540B2 (tr)
EP (1) EP1298124B1 (tr)
KR (1) KR100505820B1 (tr)
AR (1) AR024518A1 (tr)
AT (2) ATE355268T1 (tr)
CA (1) CA2291133C (tr)
CY (1) CY1107635T1 (tr)
CZ (1) CZ292894B6 (tr)
DE (3) DE69935355T2 (tr)
DK (2) DK1298124T3 (tr)
EA (1) EA002801B1 (tr)
ES (1) ES2282365T3 (tr)
HK (1) HK1043129B (tr)
HR (1) HRP20020344B1 (tr)
HU (1) HUP0200169A3 (tr)
IL (3) IL143875A0 (tr)
IS (1) IS2260B (tr)
NO (1) NO20071311L (tr)
NZ (1) NZ512406A (tr)
PL (1) PL201056B1 (tr)
PT (2) PT1228056E (tr)
SI (2) SI1228056T1 (tr)
SK (1) SK287140B6 (tr)
TR (1) TR200401456T1 (tr)
UA (1) UA72238C2 (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
CN100349885C (zh) * 2002-12-23 2007-11-21 H·隆德贝克有限公司 依他普仑氢溴酸盐及其制备方法
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ZA200804086B (en) * 2005-10-14 2009-07-29 Lundbeck & Co As H Stable pharmaceutical formulations containing escitalo-pram and bupropion
EP1954257A4 (en) * 2005-10-14 2009-05-20 Lundbeck & Co As H METHOD FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM WITH A LOW-DOSED COMBINATION OF ESCITALOPRAM AND BUPROPION
HUE036004T2 (hu) * 2007-08-03 2018-06-28 Richter Gedeon Nyrt Dopamin receptor ligandumokat tartalmazó gyógyszerkészítmények és kezelési eljárások dopamin receptor ligandumok alkalmazásával

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (tr) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
TR200000066T2 (tr) 1997-07-08 2000-11-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) * 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
CN1149208C (zh) 1998-12-23 2004-05-12 H.隆德贝克有限公司 制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
NZ514671A (en) 1999-04-14 2003-10-31 H Method for the preparation of citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
CA2359810C (en) 2000-12-28 2002-11-05 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
CA2291133C (en) 2003-06-17
NO20071311L (no) 2001-08-24
DK1228056T3 (da) 2005-01-24
DE69920526D1 (de) 2004-10-28
IL143875A (en) 2008-03-20
HK1043129A1 (en) 2002-09-06
IS5970A (is) 2001-06-15
HRP20020344B1 (hr) 2010-10-31
CA2291133A1 (en) 2001-04-25
PL349440A1 (en) 2002-07-29
SI1298124T1 (sl) 2007-08-31
EP1298124A1 (en) 2003-04-02
ATE277032T1 (de) 2004-10-15
HUP0200169A2 (en) 2002-06-29
DE19983836C1 (de) 2003-10-23
IL143875A0 (en) 2002-04-21
ES2282365T3 (es) 2007-10-16
DE69935355T2 (de) 2007-11-08
AR024518A1 (es) 2002-10-16
KR100505820B1 (ko) 2005-08-03
EP1298124B1 (en) 2007-02-28
US20020177722A1 (en) 2002-11-28
EA200100593A1 (ru) 2001-10-22
SK287140B6 (sk) 2010-01-07
CZ292894B6 (cs) 2003-12-17
ATE355268T1 (de) 2006-03-15
HRP20020344A2 (en) 2004-02-29
IL176943A0 (en) 2006-12-10
DE69920526T2 (de) 2006-02-23
DK1298124T3 (da) 2007-07-09
HUP0200169A3 (en) 2002-11-28
US6566540B2 (en) 2003-05-20
HK1043129B (zh) 2004-10-21
UA72238C2 (en) 2005-02-15
PT1228056E (pt) 2005-02-28
NZ512406A (en) 2004-01-30
IS2260B (is) 2007-06-15
CY1107635T1 (el) 2013-04-18
PL201056B1 (pl) 2009-03-31
PT1298124E (pt) 2007-05-31
DE69935355D1 (de) 2007-04-12
EA002801B1 (ru) 2002-10-31
SI1228056T1 (en) 2005-02-28
KR20010092799A (ko) 2001-10-27

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