BG107173A - 8 бета-хидрокарбил-заместени естратриени като селективно действащи естрогени - Google Patents

8 бета-хидрокарбил-заместени естратриени като селективно действащи естрогени Download PDF

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Publication number: BG107173A
Authority: BG; Bulgaria
Prior art keywords: group; hydrogen atom; estra; atom; vinyl
Prior art date: 2000-04-12

Application number

BG107173A

Other languages

Bulgarian (bg)

English (en)

Inventor

Olaf Peters

Alexander Hillisch

Ina Thieme

Walter Elger

Christa Hegele-Hartung

Uwe Kollenkirchen

Karl-Heinrich Fritzemeier

Vladimir Patchev

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-12

Filing date

2002-10-08

Publication date

2003-05-30

2000-04-12 Priority claimed from DE10019167A external-priority patent/DE10019167A1/de

2002-10-08 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2003-05-30 Publication of BG107173A publication Critical patent/BG107173A/bg

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
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- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG107173A 2000-04-12 2002-10-08 8 бета-хидрокарбил-заместени естратриени като селективно действащи естрогени BG107173A (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10019167A DE10019167A1 (de)	2000-04-12	2000-04-12	Substituierte Estratriene als selektiv wirksame Estrogene
US20737000P	2000-05-26	2000-05-26
PCT/EP2001/004290 WO2001077139A1 (de)	2000-04-12	2001-04-12	8.beta.-hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene

Publications (1)

Publication Number	Publication Date
BG107173A true BG107173A (bg)	2003-05-30

Family

ID=26005365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107173A BG107173A (bg)	2000-04-12	2002-10-08	8 бета-хидрокарбил-заместени естратриени като селективно действащи естрогени

Country Status (25)

Country	Link
US (3)	US7378404B2 (da)
EP (2)	EP1272504B1 (da)
JP (2)	JP3828423B2 (da)
CN (1)	CN100453549C (da)
AT (2)	ATE363487T1 (da)
AU (3)	AU5834101A (da)
BG (1)	BG107173A (da)
BR (1)	BR0109983A (da)
CA (1)	CA2406177C (da)
CZ (1)	CZ20023382A3 (da)
DE (1)	DE50112561D1 (da)
DK (2)	DK1272504T3 (da)
EA (1)	EA006299B1 (da)
EE (1)	EE200200589A (da)
ES (2)	ES2287127T3 (da)
HR (1)	HRP20020892B1 (da)
HU (1)	HUP0300335A2 (da)
IL (2)	IL152248A0 (da)
MX (1)	MXPA02010066A (da)
NO (2)	NO325337B1 (da)
NZ (1)	NZ543724A (da)
PL (1)	PL207488B1 (da)
PT (1)	PT1272504E (da)
SK (1)	SK14632002A3 (da)
WO (2)	WO2001077138A1 (da)

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DE10027887A1 (de)	2000-05-31	2001-12-13	Jenapharm Gmbh	Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10039199A1 (de) *	2000-08-10	2002-02-21	Schering Ag	Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
GB0020498D0 (en)	2000-08-18	2000-10-11	Sterix Ltd	Compound
DE10151363A1 (de) *	2001-10-17	2003-05-08	Schering Ag	Somatotrope Therapie
DE10226326A1 (de) *	2002-06-11	2004-01-15	Schering Ag	9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene
DE60323938D1 (de) *	2003-03-27	2008-11-20	Pantarhei Bioscience Bv	Verwendung von Estrogenen zur Behandlung von Männerunfruchtbarkeit
DE10318896A1 (de)	2003-04-22	2004-11-25	Schering Ag	8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene
ES2307064T3 (es) *	2003-11-26	2008-11-16	Bayer Schering Pharma Aktiengesellschaft	Prevencion y tratamiento de enfermedades cardiacas hipertensivas por los estrogenos selectivos 8beta-vinil-estra-1,3,5(10)-trien-3,17beta-diol y 17beta-fluor-9alfa-vinil-estra-1,3,5(10)-trien-3,16alfa-diol.
US7534780B2 (en)	2004-05-21	2009-05-19	Bayer Schering Pharma Aktiengesellschaft	Estradiol prodrugs
DE102005057225A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102005057224A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP2014672A1 (en) *	2007-07-12	2009-01-14	Bayer Schering Pharma Aktiengesellschaft	8-beta-substituted estratrienes as selectively active estrogens
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EP2143432A1 (en)	2008-07-11	2010-01-13	Bayer Schering Pharma AG	9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer
WO2010057594A1 (en) *	2008-11-21	2010-05-27	Bayer Schering Pharma Aktiengesellschaft	Drug delivery system
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BR112014012444B1 (pt)	2011-11-23	2021-12-14	Therapeuticsmd, Inc	Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
RU2016143081A (ru)	2014-05-22	2018-06-26	Терапьютиксмд, Инк.	Натуральные комбинированные гормонозаместительные составы и терапии
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US9931349B2 (en)	2016-04-01	2018-04-03	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
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DE4018828C2 (de) *	1989-06-08	1999-05-12	Schering Ag	Verfahren zur Herstellung C7-alpha-substituierter 8alpha- und 8ß-Estra-1,3,5(10)-triene und C8-alpha-substituierter Estra-1,3,5(10)-triene sowie neue Zwischenprodukte für dieses Verfahren
WO1997041145A1 (en) *	1996-05-01	1997-11-06	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	21-substituted progesterone derivatives as new antiprogestational agents
DE69902684T2 (de) *	1998-11-20	2003-04-24	Akzo Nobel N.V., Arnheim/Arnhem	Estrogenische estra-1,3,5(10)-trien verbindungen mit verschiedenen wirkungen auf estrogenrezeptor alpha und beta mit einer unverzweigten kohlenwasserstoffkette von 5-9 kohlenstoffatomen in position 11
DE10019167A1 (de) *	2000-04-12	2001-10-18	Schering Ag	Substituierte Estratriene als selektiv wirksame Estrogene
BR0109983A (pt) *	2000-04-12	2003-02-25	Schering Ag	Estratrienos substituìdos por 8.beta-hidrocarbila como estrogênios seletivamente eficientes
DE10318896A1 (de) *	2003-04-22	2004-11-25	Schering Ag	8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene

2001
- 2001-04-12 BR BR0109983-3A patent/BR0109983A/pt not_active IP Right Cessation
- 2001-04-12 AT AT01931609T patent/ATE363487T1/de active
- 2001-04-12 US US10/257,288 patent/US7378404B2/en not_active Expired - Fee Related
- 2001-04-12 DE DE50112561T patent/DE50112561D1/de not_active Expired - Lifetime
- 2001-04-12 CA CA2406177A patent/CA2406177C/en not_active Expired - Fee Related
- 2001-04-12 AU AU5834101A patent/AU5834101A/xx active Pending
- 2001-04-12 HR HR20020892A patent/HRP20020892B1/xx not_active IP Right Cessation
- 2001-04-12 US US10/257,287 patent/US20040029847A1/en not_active Abandoned
- 2001-04-12 WO PCT/EP2001/004289 patent/WO2001077138A1/de not_active Ceased
- 2001-04-12 JP JP2001575608A patent/JP3828423B2/ja not_active Expired - Lifetime
- 2001-04-12 CZ CZ20023382A patent/CZ20023382A3/cs unknown
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- 2001-04-12 DK DK01931609T patent/DK1272504T3/da active
- 2001-04-12 PT PT01931609T patent/PT1272504E/pt unknown
- 2001-04-12 WO PCT/EP2001/004290 patent/WO2001077139A1/de not_active Ceased
- 2001-04-12 MX MXPA02010066A patent/MXPA02010066A/es active IP Right Grant
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- 2001-04-12 AU AU2001273945A patent/AU2001273945A1/en not_active Abandoned
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- 2001-04-12 ES ES01940331T patent/ES2245694T3/es not_active Expired - Lifetime
- 2001-04-12 DK DK01940331T patent/DK1272505T3/da active
2002
- 2002-10-08 BG BG107173A patent/BG107173A/bg unknown
- 2002-10-10 IL IL152248A patent/IL152248A/en not_active IP Right Cessation
- 2002-10-11 NO NO20024908A patent/NO325337B1/no unknown
- 2002-10-11 NO NO20024907A patent/NO20024907L/no not_active Application Discontinuation
2008
- 2008-03-11 US US12/045,979 patent/US20080182829A1/en not_active Abandoned
- 2008-06-25 JP JP2008166585A patent/JP2008280355A/ja active Pending

Also Published As

Publication number	Publication date
JP2008280355A (ja)	2008-11-20
NO20024907L (no)	2002-12-05
HRP20020892B1 (en)	2011-08-31
DE50112561D1 (de)	2007-07-12
ES2287127T3 (es)	2007-12-16
EP1272504A1 (de)	2003-01-08
EA006299B1 (ru)	2005-10-27
PL358667A1 (en)	2004-08-09
JP3828423B2 (ja)	2006-10-04
SK14632002A3 (sk)	2003-03-04
ES2245694T3 (es)	2006-01-16
NO325337B1 (no)	2008-03-31
WO2001077139A1 (de)	2001-10-18
CZ20023382A3 (cs)	2003-02-12
NO20024908D0 (no)	2002-10-11
ATE302790T1 (de)	2005-09-15
PT1272504E (pt)	2007-08-29
US20040029847A1 (en)	2004-02-12
US7378404B2 (en)	2008-05-27
BR0109983A (pt)	2003-02-25
AU5834101A (en)	2001-10-23
EP1272504B1 (de)	2007-05-30
HK1057219A1 (zh)	2004-03-19
DK1272505T3 (da)	2005-11-07
ATE363487T1 (de)	2007-06-15
DK1272504T3 (da)	2007-10-01
IL152248A0 (en)	2003-05-29
MXPA02010066A (es)	2003-06-04
NO20024908L (no)	2002-11-13
JP2003530403A (ja)	2003-10-14
CN100453549C (zh)	2009-01-21
AU2001258341B2 (en)	2007-03-15
WO2001077138A1 (de)	2001-10-18
EP1272505A1 (de)	2003-01-08
HUP0300335A2 (hu)	2003-07-28
HRP20020892A2 (en)	2005-02-28
EA200201052A1 (ru)	2003-04-24
NO20024907D0 (no)	2002-10-11
EP1272505B1 (de)	2005-08-24
CA2406177A1 (en)	2001-10-18
EE200200589A (et)	2004-04-15
AU2001273945A1 (en)	2001-10-23
PL207488B1 (pl)	2010-12-31
NZ543724A (en)	2007-07-27
US20080182829A1 (en)	2008-07-31
CN1433424A (zh)	2003-07-30
US20030176405A1 (en)	2003-09-18
CA2406177C (en)	2010-06-22
IL152248A (en)	2008-06-05

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US6958327B1 (en)	2005-10-25	18 Norsteroids as selectively active estrogens
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CA2486495C (en)	2011-04-19	9-alpha-substituted estratrienes as selectively active estrogens
JP2003513102A (ja)	2003-04-08	選択的な作用を有するエストロゲンとしての１８−ノル−ステロイド
KR100825534B1 (ko)	2008-04-25	선택적 에스트로겐으로 유용한 8베타-히드로카르빌 치환된에스트라트리엔
US20060270845A1 (en)	2006-11-30	16-Hydroxyestratrienes as selectively active estrogens
AU2008274198A1 (en)	2009-01-15	8-beta-substituted estratrienes as selectively active estrogens
US20050282791A1 (en)	2005-12-22	18-nor steroids as selectively active estrogens
AU2004201405A1 (en)	2004-04-29	Ent-Steroids as selectively active estrogens
NZ536882A (en)	2007-07-27	9-Alpha-substituted estratrienes as selectively active estrogens
HK1057219B (en)	2009-08-21	8.beta-.hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene