DK1272505T3 - 8beta-substituerede-11beta-pentyl- og 11beta-hexyl-estra-1,3,5(10)-trienderivater - Google Patents

8beta-substituerede-11beta-pentyl- og 11beta-hexyl-estra-1,3,5(10)-trienderivater

Info

Publication number: DK1272505T3
Authority: DK; Denmark
Prior art keywords: sup; 8beta; 11beta; substituted; compounds
Prior art date: 2000-04-12

Application number

DK01940331T

Other languages

English (en)

Inventor

Alexander Hillisch

Karl-Heinrich Fritzemeier

Olaf Peters

Nico Braeuer

Christa Hegele-Hartung

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-12

Filing date

2001-04-12

Publication date

2005-11-07

2000-04-12 Priority claimed from DE10019167A external-priority patent/DE10019167A1/de

2001-04-12 Application filed by Schering Ag filed Critical Schering Ag

2005-11-07 Application granted granted Critical

2005-11-07 Publication of DK1272505T3 publication Critical patent/DK1272505T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
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- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK01940331T 2000-04-12 2001-04-12 8beta-substituerede-11beta-pentyl- og 11beta-hexyl-estra-1,3,5(10)-trienderivater DK1272505T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10019167A DE10019167A1 (de)	2000-04-12	2000-04-12	Substituierte Estratriene als selektiv wirksame Estrogene
US20737000P	2000-05-26	2000-05-26

Publications (1)

Publication Number	Publication Date
DK1272505T3 true DK1272505T3 (da)	2005-11-07

Family

ID=26005365

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK01931609T DK1272504T3 (da)	2000-04-12	2001-04-12	8.Beta-hydrocarbylsubstituerede östradiener til anvendelse som selektive östrogener
DK01940331T DK1272505T3 (da)	2000-04-12	2001-04-12	8beta-substituerede-11beta-pentyl- og 11beta-hexyl-estra-1,3,5(10)-trienderivater

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK01931609T DK1272504T3 (da)	2000-04-12	2001-04-12	8.Beta-hydrocarbylsubstituerede östradiener til anvendelse som selektive östrogener

Country Status (25)

Country	Link
US (3)	US7378404B2 (da)
EP (2)	EP1272504B1 (da)
JP (2)	JP3828423B2 (da)
CN (1)	CN100453549C (da)
AT (2)	ATE363487T1 (da)
AU (3)	AU5834101A (da)
BG (1)	BG107173A (da)
BR (1)	BR0109983A (da)
CA (1)	CA2406177C (da)
CZ (1)	CZ20023382A3 (da)
DE (1)	DE50112561D1 (da)
DK (2)	DK1272504T3 (da)
EA (1)	EA006299B1 (da)
EE (1)	EE200200589A (da)
ES (2)	ES2287127T3 (da)
HR (1)	HRP20020892B1 (da)
HU (1)	HUP0300335A2 (da)
IL (2)	IL152248A0 (da)
MX (1)	MXPA02010066A (da)
NO (2)	NO325337B1 (da)
NZ (1)	NZ543724A (da)
PL (1)	PL207488B1 (da)
PT (1)	PT1272504E (da)
SK (1)	SK14632002A3 (da)
WO (2)	WO2001077138A1 (da)

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BR0109983A (pt) *	2000-04-12	2003-02-25	Schering Ag	Estratrienos substituìdos por 8.beta-hidrocarbila como estrogênios seletivamente eficientes
DE10027887A1 (de)	2000-05-31	2001-12-13	Jenapharm Gmbh	Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10039199A1 (de) *	2000-08-10	2002-02-21	Schering Ag	Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
GB0020498D0 (en)	2000-08-18	2000-10-11	Sterix Ltd	Compound
DE10151363A1 (de) *	2001-10-17	2003-05-08	Schering Ag	Somatotrope Therapie
DE10226326A1 (de) *	2002-06-11	2004-01-15	Schering Ag	9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene
DE60323938D1 (de) *	2003-03-27	2008-11-20	Pantarhei Bioscience Bv	Verwendung von Estrogenen zur Behandlung von Männerunfruchtbarkeit
DE10318896A1 (de)	2003-04-22	2004-11-25	Schering Ag	8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene
ES2307064T3 (es) *	2003-11-26	2008-11-16	Bayer Schering Pharma Aktiengesellschaft	Prevencion y tratamiento de enfermedades cardiacas hipertensivas por los estrogenos selectivos 8beta-vinil-estra-1,3,5(10)-trien-3,17beta-diol y 17beta-fluor-9alfa-vinil-estra-1,3,5(10)-trien-3,16alfa-diol.
US7534780B2 (en)	2004-05-21	2009-05-19	Bayer Schering Pharma Aktiengesellschaft	Estradiol prodrugs
DE102005057225A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102005057224A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP2014672A1 (en) *	2007-07-12	2009-01-14	Bayer Schering Pharma Aktiengesellschaft	8-beta-substituted estratrienes as selectively active estrogens
NZ586666A (en) *	2008-02-13	2012-04-27	Bayer Schering Pharma Ag	Estradiol-containing drug delivery system
EA018330B1 (ru) *	2008-02-13	2013-07-30	Байер Интеллекчуал Проперти Гмбх	Система доставки лекарственного средства со стабилизирующим эффектом
EP2143432A1 (en)	2008-07-11	2010-01-13	Bayer Schering Pharma AG	9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer
WO2010057594A1 (en) *	2008-11-21	2010-05-27	Bayer Schering Pharma Aktiengesellschaft	Drug delivery system
US9301920B2 (en)	2012-06-18	2016-04-05	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
BR112014012444B1 (pt)	2011-11-23	2021-12-14	Therapeuticsmd, Inc	Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
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RU2016143081A (ru)	2014-05-22	2018-06-26	Терапьютиксмд, Инк.	Натуральные комбинированные гормонозаместительные составы и терапии
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US10286077B2 (en)	2016-04-01	2019-05-14	Therapeuticsmd, Inc.	Steroid hormone compositions in medium chain oils
US9931349B2 (en)	2016-04-01	2018-04-03	Therapeuticsmd, Inc.	Steroid hormone pharmaceutical composition
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DE10019167A1 (de) *	2000-04-12	2001-10-18	Schering Ag	Substituierte Estratriene als selektiv wirksame Estrogene
BR0109983A (pt) *	2000-04-12	2003-02-25	Schering Ag	Estratrienos substituìdos por 8.beta-hidrocarbila como estrogênios seletivamente eficientes
DE10318896A1 (de) *	2003-04-22	2004-11-25	Schering Ag	8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene

2001
- 2001-04-12 BR BR0109983-3A patent/BR0109983A/pt not_active IP Right Cessation
- 2001-04-12 AT AT01931609T patent/ATE363487T1/de active
- 2001-04-12 US US10/257,288 patent/US7378404B2/en not_active Expired - Fee Related
- 2001-04-12 DE DE50112561T patent/DE50112561D1/de not_active Expired - Lifetime
- 2001-04-12 CA CA2406177A patent/CA2406177C/en not_active Expired - Fee Related
- 2001-04-12 AU AU5834101A patent/AU5834101A/xx active Pending
- 2001-04-12 HR HR20020892A patent/HRP20020892B1/xx not_active IP Right Cessation
- 2001-04-12 US US10/257,287 patent/US20040029847A1/en not_active Abandoned
- 2001-04-12 WO PCT/EP2001/004289 patent/WO2001077138A1/de not_active Ceased
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- 2001-04-12 CZ CZ20023382A patent/CZ20023382A3/cs unknown
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- 2001-04-12 DK DK01931609T patent/DK1272504T3/da active
- 2001-04-12 PT PT01931609T patent/PT1272504E/pt unknown
- 2001-04-12 WO PCT/EP2001/004290 patent/WO2001077139A1/de not_active Ceased
- 2001-04-12 MX MXPA02010066A patent/MXPA02010066A/es active IP Right Grant
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- 2001-04-12 AU AU2001273945A patent/AU2001273945A1/en not_active Abandoned
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- 2001-04-12 EA EA200201052A patent/EA006299B1/ru not_active IP Right Cessation
- 2001-04-12 ES ES01940331T patent/ES2245694T3/es not_active Expired - Lifetime
- 2001-04-12 DK DK01940331T patent/DK1272505T3/da active
2002
- 2002-10-08 BG BG107173A patent/BG107173A/bg unknown
- 2002-10-10 IL IL152248A patent/IL152248A/en not_active IP Right Cessation
- 2002-10-11 NO NO20024908A patent/NO325337B1/no unknown
- 2002-10-11 NO NO20024907A patent/NO20024907L/no not_active Application Discontinuation
2008
- 2008-03-11 US US12/045,979 patent/US20080182829A1/en not_active Abandoned
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Also Published As

Publication number	Publication date
JP2008280355A (ja)	2008-11-20
NO20024907L (no)	2002-12-05
HRP20020892B1 (en)	2011-08-31
DE50112561D1 (de)	2007-07-12
ES2287127T3 (es)	2007-12-16
EP1272504A1 (de)	2003-01-08
EA006299B1 (ru)	2005-10-27
PL358667A1 (en)	2004-08-09
JP3828423B2 (ja)	2006-10-04
SK14632002A3 (sk)	2003-03-04
ES2245694T3 (es)	2006-01-16
NO325337B1 (no)	2008-03-31
WO2001077139A1 (de)	2001-10-18
CZ20023382A3 (cs)	2003-02-12
NO20024908D0 (no)	2002-10-11
ATE302790T1 (de)	2005-09-15
PT1272504E (pt)	2007-08-29
US20040029847A1 (en)	2004-02-12
US7378404B2 (en)	2008-05-27
BR0109983A (pt)	2003-02-25
AU5834101A (en)	2001-10-23
EP1272504B1 (de)	2007-05-30
HK1057219A1 (zh)	2004-03-19
ATE363487T1 (de)	2007-06-15
DK1272504T3 (da)	2007-10-01
IL152248A0 (en)	2003-05-29
BG107173A (bg)	2003-05-30
MXPA02010066A (es)	2003-06-04
NO20024908L (no)	2002-11-13
JP2003530403A (ja)	2003-10-14
CN100453549C (zh)	2009-01-21
AU2001258341B2 (en)	2007-03-15
WO2001077138A1 (de)	2001-10-18
EP1272505A1 (de)	2003-01-08
HUP0300335A2 (hu)	2003-07-28
HRP20020892A2 (en)	2005-02-28
EA200201052A1 (ru)	2003-04-24
NO20024907D0 (no)	2002-10-11
EP1272505B1 (de)	2005-08-24
CA2406177A1 (en)	2001-10-18
EE200200589A (et)	2004-04-15
AU2001273945A1 (en)	2001-10-23
PL207488B1 (pl)	2010-12-31
NZ543724A (en)	2007-07-27
US20080182829A1 (en)	2008-07-31
CN1433424A (zh)	2003-07-30
US20030176405A1 (en)	2003-09-18
CA2406177C (en)	2010-06-22
IL152248A (en)	2008-06-05

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