EE200200589A - 8ß-hüdrokarbüülasendatud östratrieenid kasutamiseks selektiivsete östrogeenidena - Google Patents

8ß-hüdrokarbüülasendatud östratrieenid kasutamiseks selektiivsete östrogeenidena

Info

Publication number: EE200200589A
Authority: EE; Estonia
Prior art keywords: sup; compounds; action; 8beta; 5ht2a
Prior art date: 2000-04-12

Application number

EEP200200589A

Other languages

English (en)

Inventor

Peters Olaf

Hillisch Alexander

Thieme Ina

Elger Walter

Hegele-Hartung Christa

Kollenkirchen Uwe

Fritzemeier Karl-Heinrich

Patchev Vladimir

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-12

Filing date

2001-04-12

Publication date

2004-04-15

2000-04-12 Priority claimed from DE10019167A external-priority patent/DE10019167A1/de

2001-04-12 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

2004-04-15 Publication of EE200200589A publication Critical patent/EE200200589A/et

Links

150000002164 estratrienes Chemical class 0.000 title abstract 2
229940011871 estrogen Drugs 0.000 title 1
239000000262 estrogen Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
210000004291 uterus Anatomy 0.000 abstract 3
210000000988 bone and bone Anatomy 0.000 abstract 2
102000015694 estrogen receptors Human genes 0.000 abstract 2
108010038795 estrogen receptors Proteins 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
102000049773 5-HT2A Serotonin Receptor Human genes 0.000 abstract 1
101150104779 HTR2A gene Proteins 0.000 abstract 1
206010030247 Oestrogen deficiency Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000005466 alkylenyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000010494 dissociation reaction Methods 0.000 abstract 1
230000005593 dissociations Effects 0.000 abstract 1
BUIVJNVIIAIIFZ-MUSFGAPCSA-N estratriene group Chemical class C[C@@]12C=CC=C1C1=CCC3CCCC[C@@H]3[C@H]1CC2 BUIVJNVIIAIIFZ-MUSFGAPCSA-N 0.000 abstract 1
230000001076 estrogenic effect Effects 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
230000000638 stimulation Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0062—Estrane derivatives substituted in position 17 alfa not substituted in position 17 beta
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Toxicology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EEP200200589A 2000-04-12 2001-04-12 8ß-hüdrokarbüülasendatud östratrieenid kasutamiseks selektiivsete östrogeenidena EE200200589A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10019167A DE10019167A1 (de)	2000-04-12	2000-04-12	Substituierte Estratriene als selektiv wirksame Estrogene
US20737000P	2000-05-26	2000-05-26
PCT/EP2001/004290 WO2001077139A1 (de)	2000-04-12	2001-04-12	8.beta.-hydrocarbyl-substituierte estratriene als selektiv wirksame estrogene

Publications (1)

Publication Number	Publication Date
EE200200589A true EE200200589A (et)	2004-04-15

Family

ID=26005365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200589A EE200200589A (et)	2000-04-12	2001-04-12	8ß-hüdrokarbüülasendatud östratrieenid kasutamiseks selektiivsete östrogeenidena

Country Status (25)

Country	Link
US (3)	US7378404B2 (et)
EP (2)	EP1272504B1 (et)
JP (2)	JP3828423B2 (et)
CN (1)	CN100453549C (et)
AT (2)	ATE363487T1 (et)
AU (3)	AU5834101A (et)
BG (1)	BG107173A (et)
BR (1)	BR0109983A (et)
CA (1)	CA2406177C (et)
CZ (1)	CZ20023382A3 (et)
DE (1)	DE50112561D1 (et)
DK (2)	DK1272504T3 (et)
EA (1)	EA006299B1 (et)
EE (1)	EE200200589A (et)
ES (2)	ES2287127T3 (et)
HR (1)	HRP20020892B1 (et)
HU (1)	HUP0300335A2 (et)
IL (2)	IL152248A0 (et)
MX (1)	MXPA02010066A (et)
NO (2)	NO325337B1 (et)
NZ (1)	NZ543724A (et)
PL (1)	PL207488B1 (et)
PT (1)	PT1272504E (et)
SK (1)	SK14632002A3 (et)
WO (2)	WO2001077138A1 (et)

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BR0109983A (pt) *	2000-04-12	2003-02-25	Schering Ag	Estratrienos substituìdos por 8.beta-hidrocarbila como estrogênios seletivamente eficientes
DE10027887A1 (de)	2000-05-31	2001-12-13	Jenapharm Gmbh	Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10039199A1 (de) *	2000-08-10	2002-02-21	Schering Ag	Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen
GB0020498D0 (en)	2000-08-18	2000-10-11	Sterix Ltd	Compound
DE10151363A1 (de) *	2001-10-17	2003-05-08	Schering Ag	Somatotrope Therapie
DE10226326A1 (de) *	2002-06-11	2004-01-15	Schering Ag	9-alpha-substiuierte Estratriene als selektiv wirksame Estrogene
DE60323938D1 (de) *	2003-03-27	2008-11-20	Pantarhei Bioscience Bv	Verwendung von Estrogenen zur Behandlung von Männerunfruchtbarkeit
DE10318896A1 (de)	2003-04-22	2004-11-25	Schering Ag	8beta-Vinyl-11beta-(omega-substituierte)alkyl-estra-1,3,5(10)-triene
ES2307064T3 (es) *	2003-11-26	2008-11-16	Bayer Schering Pharma Aktiengesellschaft	Prevencion y tratamiento de enfermedades cardiacas hipertensivas por los estrogenos selectivos 8beta-vinil-estra-1,3,5(10)-trien-3,17beta-diol y 17beta-fluor-9alfa-vinil-estra-1,3,5(10)-trien-3,16alfa-diol.
US7534780B2 (en)	2004-05-21	2009-05-19	Bayer Schering Pharma Aktiengesellschaft	Estradiol prodrugs
DE102005057225A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE102005057224A1 (de) *	2005-11-29	2007-05-31	Bayer Schering Pharma Ag	Prodrugs ERß-selektiver Substanzen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP2014672A1 (en) *	2007-07-12	2009-01-14	Bayer Schering Pharma Aktiengesellschaft	8-beta-substituted estratrienes as selectively active estrogens
NZ586666A (en) *	2008-02-13	2012-04-27	Bayer Schering Pharma Ag	Estradiol-containing drug delivery system
EA018330B1 (ru) *	2008-02-13	2013-07-30	Байер Интеллекчуал Проперти Гмбх	Система доставки лекарственного средства со стабилизирующим эффектом
EP2143432A1 (en)	2008-07-11	2010-01-13	Bayer Schering Pharma AG	9-alpha estratriene derivatives as ER-beta selective ligands for the prevention and treatment of intestinal cancer
WO2010057594A1 (en) *	2008-11-21	2010-05-27	Bayer Schering Pharma Aktiengesellschaft	Drug delivery system
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BR112014012444B1 (pt)	2011-11-23	2021-12-14	Therapeuticsmd, Inc	Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US10806697B2 (en)	2012-12-21	2020-10-20	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en)	2012-06-18	2020-10-20	Therapeuticsmd, Inc.	Natural combination hormone replacement formulations and therapies
US20150196640A1 (en)	2012-06-18	2015-07-16	Therapeuticsmd, Inc.	Progesterone formulations having a desirable pk profile
US20130338122A1 (en)	2012-06-18	2013-12-19	Therapeuticsmd, Inc.	Transdermal hormone replacement therapies
US10568891B2 (en)	2012-12-21	2020-02-25	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en)	2012-12-21	2022-02-15	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en)	2012-12-21	2020-01-21	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en)	2012-12-21	2019-11-12	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en)	2012-12-21	2022-03-08	Therapeuticsmd, Inc.	Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en)	2012-12-21	2015-11-10	Therapeuticsmd, Inc.	Soluble estradiol capsule for vaginal insertion
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2001
- 2001-04-12 BR BR0109983-3A patent/BR0109983A/pt not_active IP Right Cessation
- 2001-04-12 AT AT01931609T patent/ATE363487T1/de active
- 2001-04-12 US US10/257,288 patent/US7378404B2/en not_active Expired - Fee Related
- 2001-04-12 DE DE50112561T patent/DE50112561D1/de not_active Expired - Lifetime
- 2001-04-12 CA CA2406177A patent/CA2406177C/en not_active Expired - Fee Related
- 2001-04-12 AU AU5834101A patent/AU5834101A/xx active Pending
- 2001-04-12 HR HR20020892A patent/HRP20020892B1/xx not_active IP Right Cessation
- 2001-04-12 US US10/257,287 patent/US20040029847A1/en not_active Abandoned
- 2001-04-12 WO PCT/EP2001/004289 patent/WO2001077138A1/de not_active Ceased
- 2001-04-12 JP JP2001575608A patent/JP3828423B2/ja not_active Expired - Lifetime
- 2001-04-12 CZ CZ20023382A patent/CZ20023382A3/cs unknown
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- 2001-04-12 CN CNB018107745A patent/CN100453549C/zh not_active Expired - Fee Related
- 2001-04-12 HU HU0300335A patent/HUP0300335A2/hu unknown
- 2001-04-12 AU AU2001258341A patent/AU2001258341B2/en not_active Ceased
- 2001-04-12 DK DK01931609T patent/DK1272504T3/da active
- 2001-04-12 PT PT01931609T patent/PT1272504E/pt unknown
- 2001-04-12 WO PCT/EP2001/004290 patent/WO2001077139A1/de not_active Ceased
- 2001-04-12 MX MXPA02010066A patent/MXPA02010066A/es active IP Right Grant
- 2001-04-12 SK SK1463-2002A patent/SK14632002A3/sk unknown
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- 2001-04-12 EP EP01931609A patent/EP1272504B1/de not_active Expired - Lifetime
- 2001-04-12 PL PL358667A patent/PL207488B1/pl not_active IP Right Cessation
- 2001-04-12 EP EP01940331A patent/EP1272505B1/de not_active Expired - Lifetime
- 2001-04-12 AT AT01940331T patent/ATE302790T1/de not_active IP Right Cessation
- 2001-04-12 EE EEP200200589A patent/EE200200589A/et unknown
- 2001-04-12 AU AU2001273945A patent/AU2001273945A1/en not_active Abandoned
- 2001-04-12 ES ES01931609T patent/ES2287127T3/es not_active Expired - Lifetime
- 2001-04-12 EA EA200201052A patent/EA006299B1/ru not_active IP Right Cessation
- 2001-04-12 ES ES01940331T patent/ES2245694T3/es not_active Expired - Lifetime
- 2001-04-12 DK DK01940331T patent/DK1272505T3/da active
2002
- 2002-10-08 BG BG107173A patent/BG107173A/bg unknown
- 2002-10-10 IL IL152248A patent/IL152248A/en not_active IP Right Cessation
- 2002-10-11 NO NO20024908A patent/NO325337B1/no unknown
- 2002-10-11 NO NO20024907A patent/NO20024907L/no not_active Application Discontinuation
2008
- 2008-03-11 US US12/045,979 patent/US20080182829A1/en not_active Abandoned
- 2008-06-25 JP JP2008166585A patent/JP2008280355A/ja active Pending

Also Published As

Publication number	Publication date
JP2008280355A (ja)	2008-11-20
NO20024907L (no)	2002-12-05
HRP20020892B1 (en)	2011-08-31
DE50112561D1 (de)	2007-07-12
ES2287127T3 (es)	2007-12-16
EP1272504A1 (de)	2003-01-08
EA006299B1 (ru)	2005-10-27
PL358667A1 (en)	2004-08-09
JP3828423B2 (ja)	2006-10-04
SK14632002A3 (sk)	2003-03-04
ES2245694T3 (es)	2006-01-16
NO325337B1 (no)	2008-03-31
WO2001077139A1 (de)	2001-10-18
CZ20023382A3 (cs)	2003-02-12
NO20024908D0 (no)	2002-10-11
ATE302790T1 (de)	2005-09-15
PT1272504E (pt)	2007-08-29
US20040029847A1 (en)	2004-02-12
US7378404B2 (en)	2008-05-27
BR0109983A (pt)	2003-02-25
AU5834101A (en)	2001-10-23
EP1272504B1 (de)	2007-05-30
HK1057219A1 (zh)	2004-03-19
DK1272505T3 (da)	2005-11-07
ATE363487T1 (de)	2007-06-15
DK1272504T3 (da)	2007-10-01
IL152248A0 (en)	2003-05-29
BG107173A (bg)	2003-05-30
MXPA02010066A (es)	2003-06-04
NO20024908L (no)	2002-11-13
JP2003530403A (ja)	2003-10-14
CN100453549C (zh)	2009-01-21
AU2001258341B2 (en)	2007-03-15
WO2001077138A1 (de)	2001-10-18
EP1272505A1 (de)	2003-01-08
HUP0300335A2 (hu)	2003-07-28
HRP20020892A2 (en)	2005-02-28
EA200201052A1 (ru)	2003-04-24
NO20024907D0 (no)	2002-10-11
EP1272505B1 (de)	2005-08-24
CA2406177A1 (en)	2001-10-18
AU2001273945A1 (en)	2001-10-23
PL207488B1 (pl)	2010-12-31
NZ543724A (en)	2007-07-27
US20080182829A1 (en)	2008-07-31
CN1433424A (zh)	2003-07-30
US20030176405A1 (en)	2003-09-18
CA2406177C (en)	2010-06-22
IL152248A (en)	2008-06-05

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