BG108757A - Подобрен метод за получаване на 3-{2-[4-(6-флуоро-1,2-бензизоксазол-3-ил)-1-пиперидинил]етил}-6,7,8,9-тетрахидро-2-метил-4н-пиридо[1,2-а]пиримидин-4-он - Google Patents

Подобрен метод за получаване на 3-{2-[4-(6-флуоро-1,2-бензизоксазол-3-ил)-1-пиперидинил]етил}-6,7,8,9-тетрахидро-2-метил-4н-пиридо[1,2-а]пиримидин-4-он Download PDF

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Publication number
BG108757A
BG108757A BG108757A BG10875704A BG108757A BG 108757 A BG108757 A BG 108757A BG 108757 A BG108757 A BG 108757A BG 10875704 A BG10875704 A BG 10875704A BG 108757 A BG108757 A BG 108757A
Authority
BG
Bulgaria
Prior art keywords
formula
methyl
oxime
benzisoxazol
tetrahydro
Prior art date
Application number
BG108757A
Other languages
Bulgarian (bg)
English (en)
Inventor
Laszlo Pongo
Jozsef Reiter
Gyula Simig
Gabor Berecz
Gyorgy Clementis
Peter Slegel
Janos Szulagyi
Laszlo Koncz
Donath Gyoergyi Vereczkeyne
Kalman Nagy
Gyulane Kortvelyessy
Original Assignee
Egis Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.
Publication of BG108757A publication Critical patent/BG108757A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BG108757A 2001-11-13 2004-06-11 Подобрен метод за получаване на 3-{2-[4-(6-флуоро-1,2-бензизоксазол-3-ил)-1-пиперидинил]етил}-6,7,8,9-тетрахидро-2-метил-4н-пиридо[1,2-а]пиримидин-4-он BG108757A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0104873A HU227118B1 (en) 2001-11-13 2001-11-13 Process for the preparation of 3-{2-[4-(6-fluoro-1,2-benzizoxazol-3-yl)-1-piperidinyl]-ethyl}-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one

Publications (1)

Publication Number Publication Date
BG108757A true BG108757A (bg) 2005-03-31

Family

ID=89979882

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108757A BG108757A (bg) 2001-11-13 2004-06-11 Подобрен метод за получаване на 3-{2-[4-(6-флуоро-1,2-бензизоксазол-3-ил)-1-пиперидинил]етил}-6,7,8,9-тетрахидро-2-метил-4н-пиридо[1,2-а]пиримидин-4-он

Country Status (14)

Country Link
US (1) US7307168B2 (cs)
EP (1) EP1461338B1 (cs)
JP (1) JP4297785B2 (cs)
AT (1) ATE361298T1 (cs)
BG (1) BG108757A (cs)
CZ (1) CZ2004698A3 (cs)
DE (1) DE60219957T8 (cs)
DK (1) DK1461338T3 (cs)
ES (1) ES2286332T3 (cs)
HU (1) HU227118B1 (cs)
PL (1) PL369233A1 (cs)
PT (1) PT1461338E (cs)
SK (1) SK2542004A3 (cs)
WO (1) WO2003042212A1 (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009591A1 (en) * 2002-07-22 2004-01-29 Aurobindo Pharma Ltd. A process for the preparation of antipsychotic risperidone
CN100390146C (zh) 2002-11-13 2008-05-28 斯索恩有限公司 制备利培酮的方法和用于该方法的中间体
HUP0401379A3 (en) * 2004-07-08 2006-04-28 Richter Gedeon Vegyeszet Process for the preparation of risperidon
HUP0402163A2 (en) * 2004-10-25 2006-05-29 Richter Gedeon Vegyeszet Process for the preparation of risperidone
HUP0600555A3 (en) * 2006-07-03 2008-10-28 Egis Gyogyszergyar Nyrt Use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]izoxazol-3-yl)piperidin-1-yl]ethylamino}2-methyl-3(2h)-piridazinon for the production of pharmaceutical compositions for influencing cognitive functions and causing neuroprotective effect
CN112624992B (zh) * 2021-01-19 2026-01-02 浙江华海药业股份有限公司 一种6-氟-3-（4-哌啶基）-1,2-苯并异噁唑盐酸盐的纯化方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
DE60009959T2 (de) * 2000-05-05 2005-03-31 Rpg Life Sciences Limited Verfahren zur herstellung von antipsychotischem 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-on

Also Published As

Publication number Publication date
JP2005513019A (ja) 2005-05-12
ATE361298T1 (de) 2007-05-15
DE60219957D1 (de) 2007-06-14
DE60219957T8 (de) 2008-04-24
HU0104873D0 (en) 2002-01-28
US20050004141A1 (en) 2005-01-06
US7307168B2 (en) 2007-12-11
WO2003042212A1 (en) 2003-05-22
HUP0104873A2 (hu) 2003-08-28
JP4297785B2 (ja) 2009-07-15
ES2286332T3 (es) 2007-12-01
CZ2004698A3 (cs) 2004-09-15
EP1461338A1 (en) 2004-09-29
EP1461338B1 (en) 2007-05-02
DK1461338T3 (da) 2007-09-03
DE60219957T2 (de) 2008-01-17
SK2542004A3 (en) 2004-12-01
HU227118B1 (en) 2010-07-28
PL369233A1 (en) 2005-04-18
HUP0104873A3 (en) 2003-11-28
PT1461338E (pt) 2007-07-23

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