BG20805A3 - Метод за получаване на субституирани азапуринони - Google Patents

Метод за получаване на субституирани азапуринони

Info

Publication number
BG20805A3
BG20805A3 BG019250A BG1925071A BG20805A3 BG 20805 A3 BG20805 A3 BG 20805A3 BG 019250 A BG019250 A BG 019250A BG 1925071 A BG1925071 A BG 1925071A BG 20805 A3 BG20805 A3 BG 20805A3
Authority
BG
Bulgaria
Prior art keywords
azapurinones
preparing substituted
substituted
preparing
substituted azapurinones
Prior art date
Application number
BG019250A
Other languages
Bulgarian (bg)
English (en)
Inventor
Barbara Broughton
Bryan Large
Stuart Marshall
David Pain
Kenneth Harry
Original Assignee
May & Baker Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd. filed Critical May & Baker Ltd.
Publication of BG20805A3 publication Critical patent/BG20805A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG019250A 1970-12-15 1971-12-15 Метод за получаване на субституирани азапуринони BG20805A3 (bg)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5955670 1970-12-15
GB5955270 1970-12-15
GB4975671A GB1338235A (en) 1970-12-15 1971-10-26 Azapurinones
GB5345771 1971-11-17

Publications (1)

Publication Number Publication Date
BG20805A3 true BG20805A3 (bg) 1975-12-20

Family

ID=27449009

Family Applications (3)

Application Number Title Priority Date Filing Date
BG020380A BG20807A3 (bg) 1970-12-15 1971-12-15 Метод за получаване на соли азапуринони
BG020379A BG20806A3 (bg) 1970-12-15 1971-12-15 Метод за получаване на субституирани азапуринони
BG019250A BG20805A3 (bg) 1970-12-15 1971-12-15 Метод за получаване на субституирани азапуринони

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BG020380A BG20807A3 (bg) 1970-12-15 1971-12-15 Метод за получаване на соли азапуринони
BG020379A BG20806A3 (bg) 1970-12-15 1971-12-15 Метод за получаване на субституирани азапуринони

Country Status (25)

Country Link
US (1) US3987160A (fr)
JP (1) JPS5310599B1 (fr)
AR (4) AR192602A1 (fr)
AT (4) AT319235B (fr)
AU (1) AU458277B2 (fr)
BE (1) BE776683A (fr)
BG (3) BG20807A3 (fr)
CH (5) CH556860A (fr)
DD (1) DD95007A5 (fr)
DE (1) DE2162096A1 (fr)
DK (1) DK141249B (fr)
FI (1) FI53457C (fr)
FR (1) FR2118078B1 (fr)
GB (1) GB1338235A (fr)
HK (1) HK42177A (fr)
HU (1) HU165079B (fr)
IE (1) IE35897B1 (fr)
IL (1) IL38364A (fr)
IS (1) IS1099B6 (fr)
LU (1) LU64457A1 (fr)
NL (1) NL174943C (fr)
NO (1) NO134257C (fr)
OA (1) OA03930A (fr)
SE (1) SE393381B (fr)
ZM (1) ZM18971A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1493685A (en) * 1970-12-15 1977-11-30 May & Baker Ltd 8-azapurinones
BE792648A (fr) * 1971-12-13 1973-06-12 May & Baker Ltd Derives de l'isoquinoleine
FR2406638A1 (fr) * 1977-10-21 1979-05-18 May & Baker Ltd Nouvelles aza-8 purinones-6, leur preparation et les compositions pharmaceutiques les contenant
EP0007727B1 (fr) * 1978-07-24 1983-11-30 Beecham Group Plc Benzopyranotriazoles, préparation de ces composés et composition pharmaceutique les contenant
JPS60226887A (ja) * 1984-04-25 1985-11-12 Dai Ichi Seiyaku Co Ltd トリアゾロピリミジン誘導体
CA1303037C (fr) * 1987-02-02 1992-06-09 Smith Kline & French Laboratories Limited Derives de purinone utilises comme bronchodilatateurs,vasodilatateurs et agents anti-allergiques
DE3873812D1 (de) * 1987-04-07 1992-09-24 Ciba Geigy Ag 3h-1,2,3-triazolo(4,5-d)pyrimidine.
US5204353A (en) * 1987-04-07 1993-04-20 Ciba-Geigy Corporation 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
FR2618073B1 (fr) * 1987-07-16 1990-09-07 Pf Medicament Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
DE4211239C2 (de) * 1992-04-03 1995-11-16 Max Planck Gesellschaft Arzneimittel gegen Herz-Kreislauf-Erkrankungen
GB9213623D0 (en) * 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents
US5734053A (en) * 1992-06-26 1998-03-31 Pfizer Inc Purinone antianginal agents
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US20080045573A1 (en) * 1993-09-20 2008-02-21 Bova David J Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US6362178B1 (en) 1997-11-12 2002-03-26 Bayer Aktiengesellschaft 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
DE19838705A1 (de) 1998-08-26 2000-03-02 Bayer Ag Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one
IT1318674B1 (it) * 2000-08-08 2003-08-27 Nicox Sa Faramaci per l'incontinenza.
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005009240A1 (de) 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
EP2527360B1 (fr) 2007-06-04 2015-10-28 Synergy Pharmaceuticals Inc. Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (fr) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
EP3241839B1 (fr) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905438A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
EP4620525A3 (fr) 2016-12-14 2025-12-03 Respira Therapeutics, Inc. Procédés et compositions pour le traitement de l'hypertension pulmonaire et d'autres troubles pulmonaires
TWI845600B (zh) 2019-01-24 2024-06-21 美商普羅米修斯生物科學股份有限公司 Gpr35調節劑
WO2020237096A1 (fr) 2019-05-21 2020-11-26 Ardelyx, Inc. Combinaison pour baisser le phosphate sérique chez un patient
WO2022020617A1 (fr) * 2020-07-23 2022-01-27 Prometheus Biosciences, Inc. Agents thérapeutiques ciblant gpr35
UY40234A (es) 2022-04-22 2023-11-15 Vertex Pharma Compuestos heteroarilo para el tratamiento del dolor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2407204A (en) * 1944-07-22 1946-09-03 American Cyanamid Co Triazolo (d) pyrimidines and methods of preparing the same
US2993039A (en) * 1959-11-06 1961-07-18 Upjohn Co Preparing nu-glycosides of aldose and ketose sugars

Also Published As

Publication number Publication date
CH555351A (fr) 1974-10-31
HU165079B (fr) 1974-06-28
AR199467A1 (es) 1974-09-09
FR2118078B1 (fr) 1975-08-01
AU458277B2 (en) 1975-02-20
AR192602A1 (es) 1973-02-28
ZM18971A1 (en) 1972-08-21
BE776683A (fr) 1972-06-14
LU64457A1 (fr) 1972-08-23
JPS5310599B1 (fr) 1978-04-14
AT319235B (de) 1974-12-10
CH552610A (fr) 1974-08-15
AT315839B (de) 1974-06-10
BG20807A3 (bg) 1975-12-20
BG20806A3 (bg) 1975-12-20
IL38364A0 (en) 1972-02-29
NO134257C (fr) 1976-09-08
AR199468A1 (es) 1974-09-09
CH546779A (fr) 1974-03-15
AR192689A1 (es) 1973-02-28
NO134257B (fr) 1976-05-31
GB1338235A (en) 1973-11-21
NL174943B (nl) 1984-04-02
FI53457B (fr) 1978-01-31
CH550814A (fr) 1974-06-28
DK141249C (fr) 1980-08-04
IE35897L (en) 1972-06-15
SE393381B (sv) 1977-05-09
NL7117142A (fr) 1972-06-19
AU3686771A (en) 1973-06-21
US3987160A (en) 1976-10-19
IS1099B6 (is) 1982-11-18
DK141249B (da) 1980-02-11
FI53457C (fi) 1978-05-10
NL174943C (nl) 1984-09-03
IS2047A7 (is) 1972-06-16
OA03930A (fr) 1975-08-14
DE2162096C2 (fr) 1988-02-11
IL38364A (en) 1975-08-31
IE35897B1 (en) 1976-06-23
AT315838B (de) 1974-06-10
HK42177A (en) 1977-08-19
AT317211B (de) 1974-08-26
DD95007A5 (fr) 1973-01-12
CH556860A (de) 1974-12-13
DE2162096A1 (de) 1972-07-06
FR2118078A1 (fr) 1972-07-28

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