BG46159A3 - Метод за получаване на протеин,хетероложен на дрожден микроорганизъм - Google Patents

Метод за получаване на протеин,хетероложен на дрожден микроорганизъм

Info

Publication number
BG46159A3
BG46159A3 BG060015A BG6001583A BG46159A3 BG 46159 A3 BG46159 A3 BG 46159A3 BG 060015 A BG060015 A BG 060015A BG 6001583 A BG6001583 A BG 6001583A BG 46159 A3 BG46159 A3 BG 46159A3
Authority
BG
Bulgaria
Prior art keywords
protein
heterologous
culture
medium
yeast
Prior art date
Application number
BG060015A
Other languages
English (en)
Inventor
Ronald Hitzeman
David Leung
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26998782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG46159(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of BG46159A3 publication Critical patent/BG46159A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/142—Interferon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)
  • Lubricants (AREA)

Abstract

Полученият по метода протеин намира приложение в медицината. Той се извлича в достатъчни за оползотворяване количества от средата, носеща дрождената култура, експресира се, преработва се и се секретира от дрождения организъм по начин, наподобяващ напълно неговото получаване в условията на природната клетка. Методът се състои в това, че дрожденият организъм сахаромицес церевизис 20 в-12 атсс 20626 или g мзс-2 атсс 20625 се трансформира с експресионно средство уерiрт, което носи функционално днк, кодираща препротеин, съдържащ зрял протеин и сигнален полипептид, хетероложен към дрождения организъм. Приготовлява се култура от организма, културата нараства и протеинът се извлича от нейната среда. Хетероложният сигнален полипептид е хибрид на сигнал, присъщ на протеина и на втори хетероложен сигнален полипептид. Клетъчната култура на дрождения организъм е способна да изнася в средата хетероложен протеин в самостоятелна форма. Експресионното средство, което носи функционално днк, кодира човешки левкоцитен да сигнален полипептид. 4 претенции
BG060015A 1982-03-08 1983-03-07 Метод за получаване на протеин,хетероложен на дрожден микроорганизъм BG46159A3 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35529782A 1982-03-08 1982-03-08
US06/438,236 US4775622A (en) 1982-03-08 1982-11-01 Expression, processing and secretion of heterologous protein by yeast

Publications (1)

Publication Number Publication Date
BG46159A3 true BG46159A3 (bg) 1989-10-16

Family

ID=26998782

Family Applications (1)

Application Number Title Priority Date Filing Date
BG060015A BG46159A3 (bg) 1982-03-08 1983-03-07 Метод за получаване на протеин,хетероложен на дрожден микроорганизъм

Country Status (28)

Country Link
US (1) US4775622A (bg)
EP (1) EP0088632B1 (bg)
JP (2) JPH0829111B2 (bg)
AU (1) AU574323B2 (bg)
BG (1) BG46159A3 (bg)
BR (1) BR8301150A (bg)
CZ (1) CZ282905B6 (bg)
DD (1) DD207220A5 (bg)
DE (2) DE3382694T2 (bg)
DK (1) DK163932C (bg)
DZ (1) DZ513A1 (bg)
ES (1) ES8500324A1 (bg)
FI (1) FI830774L (bg)
FR (1) FR2523152B1 (bg)
GB (1) GB2116567B (bg)
GR (1) GR78506B (bg)
IE (1) IE55743B1 (bg)
IL (1) IL68058A (bg)
MX (1) MX163813B (bg)
NO (1) NO830780L (bg)
NZ (1) NZ203494A (bg)
OA (1) OA07338A (bg)
PH (1) PH24804A (bg)
PL (1) PL153724B1 (bg)
PT (1) PT76360B (bg)
RO (1) RO88582A (bg)
YU (1) YU46723B (bg)
ZW (1) ZW6283A1 (bg)

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PH24804A (en) 1990-10-30
DK111283A (da) 1983-10-28
IE830498L (en) 1983-09-08
FR2523152B1 (fr) 1985-08-23
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ES520416A0 (es) 1984-11-01
JPH06181779A (ja) 1994-07-05
JPH0829111B2 (ja) 1996-03-27
YU46723B (sh) 1994-04-05
ES8500324A1 (es) 1984-11-01
FI830774A7 (fi) 1983-09-09
OA07338A (fr) 1984-08-31
MX163813B (es) 1992-06-22
US4775622A (en) 1988-10-04
EP0088632B1 (en) 1993-06-16
FI830774L (fi) 1983-09-09
DK111283D0 (da) 1983-03-07
PT76360B (en) 1986-02-12
DK163932B (da) 1992-04-21
FI830774A0 (fi) 1983-03-08
AU574323B2 (en) 1988-07-07
FR2523152A1 (fr) 1983-09-16
GB2116567B (en) 1986-01-02
BR8301150A (pt) 1983-11-22
EP0088632A2 (en) 1983-09-14
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RO88582A (ro) 1986-02-28
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