BG48811A3 - Метод за получаване на 2-бром-алфа-ергокриптини - Google Patents

Метод за получаване на 2-бром-алфа-ергокриптини

Info

Publication number: BG48811A3
Authority: BG; Bulgaria
Prior art keywords: ergocryptins; bromo; alpha; obtaining; triarylbromosilane
Prior art date: 1986-06-27

Application number

BG080325A

Other languages

Bulgarian (bg)

English (en)

Inventor

Gabor Megyeri

Tibor Keve

Lajos Kovacs

Bela Stefko

Erik Bogsch

Anna Kassai Zieger

Ferenc Trischler

Gabor Szepesi

Maria Gazdag

Original Assignee

Richter Gedeon Vegyeszeti Gyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-27

Filing date

1987-06-26

Publication date

1991-05-15

1987-06-26 Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.

1991-05-15 Publication of BG48811A3 publication Critical patent/BG48811A3/xx

Links

238000000034 method Methods 0.000 title abstract 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
IYYIVELXUANFED-UHFFFAOYSA-N bromo(trimethyl)silane Chemical compound C[Si](C)(C)Br IYYIVELXUANFED-UHFFFAOYSA-N 0.000 abstract 1
VSCMNSZBNLOXNR-UHFFFAOYSA-N bromo(triphenyl)silane Chemical compound C=1C=CC=CC=1[Si](C=1C=CC=CC=1)(Br)C1=CC=CC=C1 VSCMNSZBNLOXNR-UHFFFAOYSA-N 0.000 abstract 1
VQPFDLRNOCQMSN-UHFFFAOYSA-N bromosilane Chemical compound Br[SiH3] VQPFDLRNOCQMSN-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000004587 chromatography analysis Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000007796 conventional method Methods 0.000 abstract 1
230000026030 halogenation Effects 0.000 abstract 1
238000005658 halogenation reaction Methods 0.000 abstract 1
229910000042 hydrogen bromide Inorganic materials 0.000 abstract 1
239000002831 pharmacologic agent Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BG080325A 1986-06-27 1987-06-26 Метод за получаване на 2-бром-алфа-ергокриптини BG48811A3 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU862690A HU196394B (en)	1986-06-27	1986-06-27	Process for preparing 2-halogenated ergoline derivatives

Publications (1)

Publication Number	Publication Date
BG48811A3 true BG48811A3 (bg)	1991-05-15

Family

ID=10960659

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG080325A BG48811A3 (bg)	1986-06-27	1987-06-26	Метод за получаване на 2-бром-алфа-ергокриптини

Country Status (19)

Country	Link
US (1)	US4816587A (da)
EP (1)	EP0251732B1 (da)
JP (1)	JPH085879B2 (da)
AR (1)	AR243194A1 (da)
AT (1)	ATE88705T1 (da)
AU (1)	AU597673B2 (da)
BG (1)	BG48811A3 (da)
CA (1)	CA1301163C (da)
CS (1)	CS264295B2 (da)
DD (1)	DD264430A5 (da)
DE (1)	DE3785613T2 (da)
DK (1)	DK328687A (da)
ES (1)	ES2054672T3 (da)
FI (1)	FI89048C (da)
HU (1)	HU196394B (da)
PL (1)	PL151562B1 (da)
SU (1)	SU1528320A3 (da)
UA (1)	UA5571A1 (da)
YU (1)	YU46557B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds
DE4033496A1 (de) *	1990-10-20	1992-04-23	Sandoz Ag	Neue ergolinderivate, ihre herstellung und verwendung
DK0678122T3 (da) *	1993-01-12	2000-03-06	Biogen Inc	Rekombinante anti-VLA4 antistofmolekyler
US6723550B1 (en)	1997-07-15	2004-04-20	Genencor International, Inc.	Proteases from gram-positive organisms
US20030157642A1 (en) *	1997-07-15	2003-08-21	Caldwell Robert M.	Increasing production of proteins in gram-positive microorganisms
US6521421B1 (en) *	1997-07-16	2003-02-18	Genencor International, Inc.	Expression vectors encoding Bacillus subtilis disulfide bond isomerase and methods of secreting proteins in gram-positive microorganisms using the same
US6521440B1 (en)	1997-09-15	2003-02-18	Genencor International, Inc.	Proteases from gram-positive organisms
US6316241B1 (en) *	1997-11-20	2001-11-13	Genencor International, Inc.	Alpha/beta hydrolase-fold enzymes
FR2786099B1 (fr) *	1998-11-24	2000-12-29	Aventis Laboratoire	Nouvelle application therapeutique de la 1,6-dimethyl-8beta- hydroxymethyl-10alpha-methoxyergoline
WO2002072787A2 (en) *	2001-03-13	2002-09-19	Sierra Sciences, Inc.	Telomerase expression repressor proteins and methods of using the same
ES2619313T3 (es)	2001-03-15	2017-06-26	Precision Biologics, Inc.	Terapia de anticuerpos monoclonales para el cáncer de páncreas
ATE465409T1 (de)	2001-07-02	2010-05-15	Sekisui Medical Co Ltd	Latex-trägerpartikel für ein testreagenz, und testreagenz
CA2478458A1 (en) *	2004-08-20	2006-02-20	Michael Panzara	Treatment of pediatric multiple sclerosis
RU2274640C1 (ru) *	2004-09-15	2006-04-20	Всероссийский научно-исследовательский институт лекарственных и ароматических растений ("ВИЛАР")	СПОСОБ БРОМИРОВАНИЯ α И β-ЭРГОКРИПТИНОВ
SMT202000306T1 (it)	2010-04-16	2020-07-08	Biogen Ma Inc	Anticorpi anti-vla-4
US8889768B2 (en)	2010-06-11	2014-11-18	Basf Se	Laser-transparent PBT with organic additives
EP2580047B1 (de)	2010-06-11	2018-06-06	Basf Se	Lasertransparentes pbt mit organischen additiven
CN105560244B (zh) *	2014-10-10	2019-01-11	上海交通大学	一种γ-分泌酶抑制剂及其应用
SI3221349T1 (sl)	2014-11-19	2021-02-26	Axon Neuroscience Se	Humanizirano tau protitelo pri alzheimerjevi bolezni
JP6849678B2 (ja)	2016-06-14	2021-03-24	デンカ株式会社	液体試料検査キット用膜担体、液体試料検査キット及び液体試料検査キットの製造方法
CN115453112B (zh)	2017-03-28	2025-09-09	电化株式会社	膜载体和使用其的液体试样检测试剂盒
JP6978489B2 (ja)	2017-03-28	2021-12-08	デンカ株式会社	膜担体、並びにそれを用いた液体試料検査キット及びその製造方法
US12037398B2 (en)	2018-06-04	2024-07-16	Biogen Ma Inc.	Anti-VLA-4 antibodies having reduced effector function
WO2023220381A1 (en) *	2022-05-12	2023-11-16	The Florida State University Research Foundation, Inc.	Lysergic acid derivatives and methods
US20240228479A1 (en) *	2022-12-31	2024-07-11	Ceruvia Lifesciences Llc	Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3901894A (en) *	1974-06-06	1975-08-26	Lilly Co Eli	8-thiomethylergolines
US3992422A (en) *	1975-08-14	1976-11-16	Schering Corporation	Process for the preparation of 21-halogeno-21-desoxy-17α-acyloxy-20-keto-pregnenes
US4098790A (en) *	1976-09-15	1978-07-04	Eli Lilly And Company	Ergoline chlorination process
YU216177A (en) *	1977-09-09	1984-02-29	Rudolf Rucman	Process for preparing 2-bromo ergosine
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
YU39849B (en) *	1978-09-26	1985-04-30	Lek Tovarna Farmacevtskih	Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds
HU193317B (en) *	1985-06-12	1987-09-28	Richter Gedeon Vegyeszet	Process for producing 2-bromo-alpha-ergochristin
HU193782B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
HU193780B (en) *	1985-06-21	1987-11-30	Richter Gedeon Vegyeszet	Process for producing 2-halogeno-6-methyl-ergol-9-ene derivatives and acid additional salts thereof
HU196598B (en) *	1986-04-25	1988-12-28	Richter Gedeon Vegyeszet	Process for producing 1- and/or 8-substituted 2-halogenated ergoline derivatives and pharmaceutics comprising such compounds

1986
- 1986-06-27 HU HU862690A patent/HU196394B/hu not_active IP Right Cessation
1987
- 1987-06-05 US US07/058,576 patent/US4816587A/en not_active Expired - Fee Related
- 1987-06-25 YU YU119987A patent/YU46557B/sh unknown
- 1987-06-26 DD DD87304197A patent/DD264430A5/de not_active IP Right Cessation
- 1987-06-26 JP JP62157949A patent/JPH085879B2/ja not_active Expired - Lifetime
- 1987-06-26 PL PL1987266477A patent/PL151562B1/pl unknown
- 1987-06-26 SU SU874202820A patent/SU1528320A3/ru active
- 1987-06-26 CA CA000540700A patent/CA1301163C/en not_active Expired - Lifetime
- 1987-06-26 AR AR87307983A patent/AR243194A1/es active
- 1987-06-26 FI FI872852A patent/FI89048C/fi not_active IP Right Cessation
- 1987-06-26 DE DE8787305716T patent/DE3785613T2/de not_active Expired - Fee Related
- 1987-06-26 CS CS874791A patent/CS264295B2/cs unknown
- 1987-06-26 AU AU74763/87A patent/AU597673B2/en not_active Ceased
- 1987-06-26 BG BG080325A patent/BG48811A3/xx unknown
- 1987-06-26 EP EP87305716A patent/EP0251732B1/en not_active Expired - Lifetime
- 1987-06-26 UA UA4202820A patent/UA5571A1/uk unknown
- 1987-06-26 AT AT87305716T patent/ATE88705T1/de not_active IP Right Cessation
- 1987-06-26 DK DK328687A patent/DK328687A/da not_active Application Discontinuation
- 1987-06-26 ES ES87305716T patent/ES2054672T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA1301163C (en)	1992-05-19
PL151562B1 (en)	1990-09-28
FI89048C (fi)	1993-08-10
HU196394B (en)	1988-11-28
EP0251732B1 (en)	1993-04-28
ES2054672T3 (es)	1994-08-16
FI872852L (fi)	1987-12-28
JPH085879B2 (ja)	1996-01-24
DD264430A5 (de)	1989-02-01
AR243194A1 (es)	1993-07-30
JPS6314783A (ja)	1988-01-21
EP0251732A2 (en)	1988-01-07
SU1528320A3 (ru)	1989-12-07
US4816587A (en)	1989-03-28
AU597673B2 (en)	1990-06-07
PL266477A1 (en)	1988-07-21
DE3785613D1 (de)	1993-06-03
ATE88705T1 (de)	1993-05-15
UA5571A1 (uk)	1994-12-28
AU7476387A (en)	1988-01-07
YU119987A (en)	1988-06-30
YU46557B (sh)	1993-11-16
DK328687D0 (da)	1987-06-26
HUT44541A (en)	1988-03-28
DE3785613T2 (de)	1993-08-12
FI89048B (fi)	1993-04-30
CS479187A2 (en)	1988-09-16
EP0251732A3 (en)	1989-05-10
CS264295B2 (en)	1989-06-13
DK328687A (da)	1987-12-28
FI872852A0 (fi)	1987-06-26

Similar Documents

Publication	Publication Date	Title
BG48811A3 (bg)	1991-05-15	Метод за получаване на 2-бром-алфа-ергокриптини
FI872379A0 (fi)	1987-05-28	Menetelmä farmakologisesti vaikuttavien 1,5-diaryyli-3-(w-substituoitu-alempi-alkyyli)-pyratsolien valmistamiseksi
DE3479119D1 (en)	1989-08-31	Novel carbostyril derivative and process for preparing same
FI875681L (fi)	1988-06-25	Menetelmä farmaseuttisesti aktiivisten 4-(2,6,6-trimetyyli-sykloheks-1-enyl)-but-3-en-1-ynyylisubstituoitujen yhdisteiden valmistamiseksi
NO175531C (no)	1994-10-26	Analogifremgangsmåte til fremstilling av terapeutisk aktive imidazo(4,5-b)-kinolinyloksyalkansyreamider
ATE192153T1 (de)	2000-05-15	Amino-imidazo (4,5-c) chinoline
RO85270A (ro)	1984-09-29	Procedeu pentru prepararea unor derivati de ergolinil
NO884835D0 (no)	1988-10-28	Fremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-furo- og -tieno (2,3.-c) pyridiner.
FI873350A7 (fi)	1988-02-05	Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi
FI871087A7 (fi)	1987-09-15	Menetelmä terapeuttisesti aktiivisten 1,2,3,4-tetrahydro-3-karbamoyyli-2-tiokso/okso-5-pyrimidiinikarboksyylihappojohdannaisten valmistamiseksi
FI880467A0 (fi)	1988-02-02	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
GR870824B (en)	1987-09-30	Process for the preparation of new 1,4 - dihydropyridines useful as antithrombotic drugs
NO176098C (no)	1995-02-01	Analogifremgangsmåte for fremstilling av 2-substituerte N,N'-ditrimetoksybenzoyl-piperaziner
FI900145L (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
FI871535A7 (fi)	1987-10-10	Menetelmä terapeuttisesti aktiivisten tiasykloalkeno/3,2-b/pyridiinien valmistamiseksi
FI893121L (fi)	1989-06-27	Menetelmä farmakologisesti aktiivisten 6,21-dimetyyli-19-norprogesteronijohdannaisten valmistamiseksi
FI905930A7 (fi)	1992-05-31	Menetelmä uusien, farmakologisesti käyttökelpoisten bispilokarpiinihapon esterijohdannaisten valmistamiseksi
FI910159A7 (fi)	1991-01-11	Menetelmä uusien, terapeuttisesti käyttökelpoisten 9a-hydroksi-3-okso- 4,24(25)-stigmastadieeni-26-happojohdannaisten valmistamiseksi
KR930004265A (ko)	1993-03-22	신규 치환 n-플루오로피리디늄술포네이트, 그의 중간체 및 그의 제조방법
EP0008950A3 (en)	1980-06-11	Pyrimido(1,6-a)indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing the derivatives and their use
IT1226045B (it)	1990-12-10	Derivati tetraidrochinolici
FR2592877B1 (fr)	1991-03-15	Derives d'ester d'acide imidazol-1-yl-carboxylique, procede pour les preparer et composition fongicide comprenant le derive comme produit actif
IT1190908B (it)	1988-02-24	Procedimento per la preparazione di 6-(3,6-diidro-1(2h)-piridil) pirimidin-3-ossidi
ES8300747A1 (es)	1982-11-01	Procedimiento para la preparacion de derivados de acido in- dolacetico
FI931893L (fi)	1993-04-27	Menetelmä uusien terapeuttisesti käyttökelpoisten 7,8-dihydroksi-1,2,5-oksa-, tia- ja seleenidiatsolo/3,4-f/kinoksaliinijohdannaisten valmistamiseksi