BG49717A3 - Метод за получаване на хирудин - Google Patents

Метод за получаване на хирудин

Info

Publication number: BG49717A3
Authority: BG; Bulgaria
Prior art keywords: hirudin; mature; obtaining; obtaining hirudin; yeast
Prior art date: 1985-05-02

Application number

BG077615A

Other languages

Bulgarian (bg)

English (en)

Inventor

Gerard Loison

Paul Tolstoshev

Yves Lemoine

Jean-Pierre Lecoco

Original Assignee

Transgene S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-02

Filing date

1986-12-19

Publication date

1992-01-15

1986-12-19 Application filed by Transgene S.A. filed Critical Transgene S.A.

1992-01-15 Publication of BG49717A3 publication Critical patent/BG49717A3/xx

Links

102000007625 Hirudins Human genes 0.000 title abstract 4
108010007267 Hirudins Proteins 0.000 title abstract 4
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title abstract 4
229940006607 hirudin Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940127219 anticoagulant drug Drugs 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Mycology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Instructional Devices (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

BG077615A 1985-05-02 1986-12-19 Метод за получаване на хирудин BG49717A3 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8506672A FR2593518B1 (fr)	1985-05-02	1985-05-02	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
PCT/FR1986/000153 WO1986006406A1 (fr)	1985-05-02	1986-05-02	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees

Publications (1)

Publication Number	Publication Date
BG49717A3 true BG49717A3 (bg)	1992-01-15

Family

ID=9318888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG077615A BG49717A3 (bg)	1985-05-02	1986-12-19	Метод за получаване на хирудин

Country Status (23)

Country	Link
EP (1)	EP0200655B1 (cs)
JP (2)	JP2580141B2 (cs)
KR (1)	KR870700234A (cs)
AT (1)	ATE121778T1 (cs)
AU (1)	AU600667B2 (cs)
BG (1)	BG49717A3 (cs)
CA (1)	CA1341501C (cs)
CZ (1)	CZ282928B6 (cs)
DE (1)	DE3650306T2 (cs)
DK (1)	DK174837B1 (cs)
ES (1)	ES8703930A1 (cs)
FI (1)	FI104635B (cs)
FR (2)	FR2593518B1 (cs)
HK (1)	HK1006183A1 (cs)
HU (1)	HU202919B (cs)
IE (1)	IE67136B1 (cs)
MC (1)	MC1785A1 (cs)
NO (1)	NO302375B1 (cs)
PL (1)	PL155074B1 (cs)
PT (1)	PT82490B (cs)
RU (1)	RU1774950C (cs)
WO (1)	WO1986006406A1 (cs)
ZA (1)	ZA863261B (cs)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3738541A1 (de) *	1987-11-13	1989-05-24	Hoechst Ag	Verfahren zur isolierung und reinigung von hirudin
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
GB8530631D0 (en)	1985-12-12	1986-01-22	Ciba Geigy Ag	Thrombin inhibitors
MY101203A (en) *	1985-12-12	1991-08-17	Ucp Gen Pharma Ag	Production of thrombin iinhibitors.
MC1834A1 (fr) *	1986-07-10	1988-06-03	Transgene Sa	Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
FR2607516B2 (fr) *	1986-12-01	1989-12-22	Transgene Sa	Vecteurs perfectionnes d'expression d'un variant de l'hirudine dans les levures, procede et produit obtenu
FR2607517B2 (fr) *	1986-12-01	1989-12-22	Transgene Sa	Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu
FR2611723B1 (fr) *	1987-02-27	1989-09-08	Transgene Sa	Vecteur d'expression d'adn recombinant codant pour l'hirudine, cultures de cellules de mammiferes infectees ou transformees, procede de preparation de l'hirudine et proteine obtenue
EP0371041A1 (en) *	1987-06-24	1990-06-06	Novo Nordisk A/S	A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation
US5256559A (en) *	1988-03-04	1993-10-26	Biogen, Inc.	Methods and compositions for inhibiting platelet aggregation
DE3819079A1 (de) *	1988-06-04	1989-12-07	Hoechst Ag	Hirudin-derivate mit verzoegerter wirkung
EP0387319B1 (en) *	1988-07-23	1996-03-06	Delta Biotechnology Limited	Secretory leader sequences
DE3835815A1 (de) *	1988-10-21	1990-04-26	Hoechst Ag	Neue isohirudine
US5053453A (en) *	1988-11-01	1991-10-01	Baxter International Inc.	Thromboresistant materials and methods for making same
CA2000887A1 (en) *	1988-11-01	1990-05-01	Cecilia S.L. Ku	Thromboresistant materials and methods for making same
FR2646437B1 (fr) *	1989-04-28	1991-08-30	Transgene Sa	Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
DE4009268A1 (de) *	1990-03-22	1991-09-26	Consortium Elektrochem Ind	Sekretion von hirudinderivaten
US6514730B1 (en)	1991-03-21	2003-02-04	Consortium für elektrochemische Industrie GmbH	Secretion of hirudin derivatives
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
DE4140381A1 (de) *	1991-12-07	1993-06-09	Hoechst Ag, 6230 Frankfurt, De	Neue synthetische isohirudine mit verbesserter stabilitaet
DE69329540T2 (de) *	1992-09-04	2001-06-07	Novartis Ag, Basel	Verfahren zur Herstellung von Proteaseinhibitoren
IL114160A (en) *	1994-06-17	2006-12-31	Novo Nordisk As	Dna constructs encoding heterologous proteins and processes for the heterologous protein production in yeast
US6500645B1 (en)	1994-06-17	2002-12-31	Novo Nordisk A/S	N-terminally extended proteins expressed in yeast
DE19529997C1 (de)	1995-08-16	1997-04-10	Hoechst Ag	Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen
DE19543737A1 (de)	1995-11-24	1997-05-28	Hoechst Ag	Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices
DE19544233A1 (de)	1995-11-28	1997-06-05	Hoechst Ag	Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten
ZA9610456B (en) *	1995-12-20	1997-06-20	Novo Nordisk As	N-terminally extended proteins expressed in yeast
DE69625623T2 (de)	1996-01-31	2003-11-06	Sumitomo Bakelite Co. Ltd., Tokio/Tokyo	Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung
US6265204B1 (en)	1997-01-17	2001-07-24	Genencor International, Inc.	DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
US7202059B2 (en)	2001-02-20	2007-04-10	Sanofi-Aventis Deutschland Gmbh	Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en)	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
DE10149678A1 (de)	2001-10-09	2009-03-12	Novel Science International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
DE10301255A1 (de)	2003-01-15	2004-07-29	Cpi Creative Pharma International Gmbh	Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung
US7795205B2 (en)	2004-04-12	2010-09-14	Canyon Pharmaceuticals, Inc.	Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0116201B1 (en) *	1983-01-12	1992-04-22	Chiron Corporation	Secretory expression in eukaryotes
AU572125B2 (en) *	1983-03-17	1988-05-05	Mabco Limited	Monoclonal antibodies with specificity for crosslinked fibrin and their diagnotic uses
JPS60501140A (ja) *	1983-04-22	1985-07-25	アムジエン	酵母による外因性ポリペプチドの分泌
JPS6041487A (ja) *	1983-04-25	1985-03-05	ジエネンテツク・インコ−ポレイテツド	酵母発現系でのアルフア因子配列の使用
NZ207926A (en) *	1983-04-25	1988-04-29	Genentech Inc	Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
JPS59227899A (ja) *	1983-05-25	1984-12-21	チロン・コ−ポレイシヨン	成長ホルモン放出因子の製造方法
CA1341417C (fr) *	1984-03-27	2003-01-21	Paul Tolstoshev	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE3583361D1 (de) *	1984-06-14	1991-08-08	Ucp Gen Pharma Ag	Verfahren zur herstellung von thrombin-inhibitoren.
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees

1985
- 1985-05-02 FR FR8506672A patent/FR2593518B1/fr not_active Expired
1986
- 1986-04-30 ZA ZA863261A patent/ZA863261B/xx unknown
- 1986-04-30 CA CA000508053A patent/CA1341501C/fr not_active Expired - Fee Related
- 1986-04-30 PT PT82490A patent/PT82490B/pt unknown
- 1986-05-02 EP EP86400961A patent/EP0200655B1/fr not_active Expired - Lifetime
- 1986-05-02 HU HU863185A patent/HU202919B/hu unknown
- 1986-05-02 PL PL1986259298A patent/PL155074B1/pl unknown
- 1986-05-02 MC MC86FR8600153D patent/MC1785A1/xx unknown
- 1986-05-02 AT AT86400961T patent/ATE121778T1/de not_active IP Right Cessation
- 1986-05-02 DE DE3650306T patent/DE3650306T2/de not_active Expired - Lifetime
- 1986-05-02 WO PCT/FR1986/000153 patent/WO1986006406A1/fr not_active Ceased
- 1986-05-02 KR KR860700971A patent/KR870700234A/ko not_active Ceased
- 1986-05-02 JP JP61502537A patent/JP2580141B2/ja not_active Expired - Lifetime
- 1986-05-02 ES ES555121A patent/ES8703930A1/es not_active Expired
- 1986-05-02 AU AU57787/86A patent/AU600667B2/en not_active Expired
- 1986-05-02 IE IE118386A patent/IE67136B1/en not_active IP Right Cessation
- 1986-05-04 CZ CS863217A patent/CZ282928B6/cs not_active IP Right Cessation
- 1986-07-10 FR FR868610090A patent/FR2601383B2/fr not_active Expired
- 1986-12-19 BG BG077615A patent/BG49717A3/xx unknown
- 1986-12-23 FI FI865303A patent/FI104635B/fi not_active IP Right Cessation
- 1986-12-30 NO NO865336A patent/NO302375B1/no not_active IP Right Cessation
- 1986-12-30 DK DK198606343A patent/DK174837B1/da not_active IP Right Cessation
- 1986-12-30 RU SU864028760A patent/RU1774950C/ru active
1996
- 1996-03-26 JP JP8070208A patent/JP2779930B2/ja not_active Expired - Lifetime
1998
- 1998-06-12 HK HK98105246A patent/HK1006183A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL155074B1 (en)	1991-10-31
FI104635B (fi)	2000-03-15
AU600667B2 (en)	1990-08-23
DE3650306D1 (de)	1995-06-01
AU5778786A (en)	1986-11-18
JPH09103295A (ja)	1997-04-22
HUT42131A (en)	1987-06-29
IE67136B1 (en)	1996-03-06
PT82490A (fr)	1986-05-01
FI865303A0 (fi)	1986-12-23
NO865336L (no)	1987-03-02
KR870700234A (ko)	1987-05-30
FR2593518B1 (fr)	1989-09-08
EP0200655B1 (fr)	1995-04-26
JP2779930B2 (ja)	1998-07-23
FR2601383B2 (fr)	1989-12-22
IE861183L (en)	1986-11-02
CZ321786A3 (en)	1997-07-16
FR2593518A1 (fr)	1987-07-31
ES8703930A1 (es)	1987-03-16
FR2601383A2 (fr)	1988-01-15
EP0200655A1 (fr)	1986-11-05
FI865303L (fi)	1986-12-23
PT82490B (pt)	1988-03-03
DK174837B1 (da)	2003-12-15
ES555121A0 (es)	1987-03-16
DK634386D0 (da)	1986-12-30
NO302375B1 (no)	1998-02-23
WO1986006406A1 (fr)	1986-11-06
HK1006183A1 (en)	1999-02-12
HU202919B (en)	1991-04-29
DE3650306T2 (de)	1995-10-12
CA1341501C (fr)	2006-03-14
JP2580141B2 (ja)	1997-02-12
JPS62502661A (ja)	1987-10-15
MC1785A1 (fr)	1987-09-02
DK634386A (da)	1986-12-30
CZ282928B6 (cs)	1997-11-12
RU1774950C (ru)	1992-11-07
ATE121778T1 (de)	1995-05-15
ZA863261B (en)	1986-12-30

Publication	Publication Date	Title
BG49717A3 (bg)	1992-01-15	Метод за получаване на хирудин
BG47033A3 (en)	1990-04-16	Method for preparing of derivatives of imidazolamine
HUT39739A (en)	1986-10-29	Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof
IT8720059A0 (it)	1987-04-10	Process per la preparazione di (2,2)-paraciclofano e suoi derivati.
GR860571B (en)	1986-06-18	Labdan-derivatives process for their preparation and their use as medicaments
BG35465A3 (en)	1984-04-15	Method for preparing derivatives of 1-(cyclohexyl)-4-aryl-4- piperidine carbonic acid
IT8519885A0 (it)	1985-03-13	Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.
HUT46907A (en)	1988-12-28	Process for production of derivatives of 1,4-dihydropiridine and medical preparatives containing such substances
HUT47259A (en)	1989-02-28	Process for production of tetrasole-derivatives decreasing the patalogically high colestherin-level of blood
IT1138511B (it)	1986-09-17	Procedimento per la produzione di un concentrato spinto di fattore viii(ahf)
ATE95564T1 (de)	1993-10-15	Aeusseres membranprotein f von pseudomonas aeruginosa.
FR2607517B2 (fr)	1989-12-22	Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu
HU911811D0 (en)	1991-12-30	Process for the production of acylized alpha, omega-amino-alcoholic derivatives and for using them in pesticide substances
IL77668A (en)	1989-03-31	Production of cholecalciferol derivatives and novel intermediates used therefor
GB2199036B (en)	1990-07-18	New furanuronic acid derivatives, process for their production and their use
CS274677B2 (en)	1991-09-15	Method of 7-piperazino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxyl acid's derivatives production
ZA855594B (en)	1987-02-25	Naphthyl analogs of mevalonolactone and derivatives thereof,processes for their production and their use
ES8700652A1 (es)	1986-10-16	Un metodo de preparar n-4-(3-aminopropil)-aminobutil-2,2-di-hidroxietanoamida
DE3171100D1 (en)	1985-08-01	Process for separation of products containing propolis and products containing propolis
HUT45972A (en)	1988-09-28	Process for production of derivatives of subsituated amin-methil-5,6,7,8-tetrahydronaphtil-oxi-acetic acid, of medical compositions containing such substances and also of the intermediers
ZA857721B (en)	1986-09-24	Process for treatment of rheumatic diseases
IL77661A (en)	1989-06-30	Process for the preparation of 4,4-azetidinones,and novel intermediates thereof
GR3001052T3 (en)	1992-03-20	Novel 16,17-acetalsubstituted pregnane-21-oic acid derivatives, process for the preparation thereof and pharmaceutical preparation containing them
HUT40644A (en)	1987-01-28	Process for production of new derivatives of 1,4-dihydropiridin-3,5-dicarbonic acid esther and medical preparatives containing thereof
BG40653A3 (en)	1986-01-15	Method for preparing amidothiocarbamate derivatives of carbon acid