BG60431B2 - Производни на бензоксазол- и бензотиазоламини - Google Patents

Производни на бензоксазол- и бензотиазоламини Download PDF

Info

Publication number
BG60431B2
BG60431B2 BG097875A BG9787593A BG60431B2 BG 60431 B2 BG60431 B2 BG 60431B2 BG 097875 A BG097875 A BG 097875A BG 9787593 A BG9787593 A BG 9787593A BG 60431 B2 BG60431 B2 BG 60431B2
Authority
BG
Bulgaria
Prior art keywords
formula
dream
parts
radical
alkyl
Prior art date
Application number
BG097875A
Other languages
Bulgarian (bg)
English (en)
Inventor
Raymond Stokbroekx
Marcel Gerebernus Luyckx
Frans Janssens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BG60431B2 publication Critical patent/BG60431B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Paints Or Removers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
BG097875A 1984-12-03 1993-06-16 Производни на бензоксазол- и бензотиазоламини BG60431B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67741284A 1984-12-03 1984-12-03

Publications (1)

Publication Number Publication Date
BG60431B2 true BG60431B2 (bg) 1995-03-31

Family

ID=24718604

Family Applications (1)

Application Number Title Priority Date Filing Date
BG097875A BG60431B2 (bg) 1984-12-03 1993-06-16 Производни на бензоксазол- и бензотиазоламини

Country Status (27)

Country Link
EP (1) EP0184257B1 (fr)
JP (1) JPH0759578B2 (fr)
KR (1) KR870001512B1 (fr)
CN (1) CN1014790B (fr)
AT (1) ATE54916T1 (fr)
AU (1) AU582601B2 (fr)
BG (1) BG60431B2 (fr)
CA (1) CA1260474A (fr)
CY (1) CY1690A (fr)
DE (1) DE3578885D1 (fr)
DK (1) DK165370C (fr)
DZ (1) DZ863A1 (fr)
ES (1) ES8606306A1 (fr)
FI (1) FI82046C (fr)
GR (1) GR852830B (fr)
HK (1) HK49593A (fr)
HU (1) HU196068B (fr)
IE (1) IE58807B1 (fr)
IL (1) IL77197A (fr)
MA (1) MA20582A1 (fr)
NO (1) NO160076C (fr)
NZ (1) NZ214320A (fr)
PH (1) PH26458A (fr)
PT (1) PT81586B (fr)
SU (1) SU1428203A3 (fr)
ZA (1) ZA859224B (fr)
ZW (1) ZW21685A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8333514D0 (en) * 1983-12-16 1984-01-25 Erba Farmitalia Tetrahydrothiazolo(5 4-c)pyridine derivatives
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB2225574B (en) * 1987-12-24 1991-04-24 Wyeth John & Brother Ltd Heterocyclic compounds
IE63474B1 (en) * 1987-12-24 1995-04-19 Wyeth John & Brother Ltd Heterocyclic compounds
JPH0393762A (ja) * 1989-09-04 1991-04-18 Wako Pure Chem Ind Ltd ４‐ハロゲノ‐２‐アルコキシイミノ‐３‐オキソ脂肪酸の製造方法
IE912760A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
ZW1992A1 (en) * 1991-02-25 1993-09-22 Janssen Pharmaceutica Nv 4-/(2-benzotiazolyl)methylamino/-b-/(3,4-difluorephenoxy)methyl/-1-piperidine ethanol
TW282469B (fr) * 1993-06-11 1996-08-01 Janssen Pharmaceutica Nv
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
FR2725989B1 (fr) * 1994-10-20 1997-01-10 Pf Medicament Nouvelles 2-(1-(omega-phenoxyalcoylpiperidin-4-yl) aminomethylene)-2h-benzofuran-3-ones substituees, leur preparation et leur application en therapeutique
MX9703839A (es) * 1994-11-24 1997-08-30 Janssen Pharmaceutica Nv Soluciones intravenosas de lubeluzol.
FR2737207B1 (fr) * 1995-07-26 1997-10-17 Pf Medicament Nouvelles n-heterocyclyl-1-aryloxyalcoyl-4-piperidinamines substituees, leur preparation et leur application en therapeutique
CN1200122A (zh) * 1995-10-25 1998-11-25 詹森药业有限公司 鲁贝洛唑n－氧化物
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
FR2753970B1 (fr) * 1996-10-01 1998-10-30 Synthelabo Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
EP1838706A1 (fr) * 2004-12-24 2007-10-03 Prosidion Limited Agonistes du récepteur couplé aux protéines g
MX2007010573A (es) * 2005-03-09 2007-10-04 Hoffmann La Roche Derivados de benzotiazol, tiazolopiridina, benzooxazol y oxazolopiridina como compuestos antidiabeticos.
CN101253171B (zh) * 2005-09-02 2011-06-15 霍夫曼-拉罗奇有限公司 苯并噁唑、噁唑并吡啶、苯并噻唑和噻唑并吡啶衍生物
DK2151439T3 (en) 2007-04-27 2014-03-10 Daiichi Sankyo Co Ltd Nitrogenated AROMATIC 6-membered RINGDERIVAT, AND THIS pharmaceutical composition comprising
FR3001151B1 (fr) 2013-01-21 2016-04-08 Pf Medicament Association d'un bloqueur de courant sodique lent et d'un inhibiteur du courant if sinusal et les compositions pharmarceutiques la contenant
CN107573301B (zh) * 2017-11-08 2020-08-11 江苏长青农化股份有限公司 一种三环唑中间体的制备方法
CN114349745B (zh) * 2022-01-14 2023-12-08 黑龙江中医药大学 一种用于治疗心肌缺血的药物及其制备方法
CN117229228B (zh) * 2023-09-15 2025-09-12 中国人民解放军军事科学院防化研究院 一种2-硫代苯并噻唑类化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE831249C (de) * 1948-02-09 1952-02-11 Ciba A G Verfahren zur Herstellung heterocyclisch substituierter Diaminochinazoline
GB1234058A (fr) * 1968-10-21 1971-06-03
DE2545645C2 (de) * 1975-10-11 1983-04-14 Bayer Ag, 5090 Leverkusen Thiazolinylamino-piperidin-Derivate
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (fr) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. N-(Hétérocycle bicyclyl)-4-pipéridinamines contenant des hétérocycles bicycliques
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines

Also Published As

Publication number Publication date
NO160076B (no) 1988-11-28
EP0184257A1 (fr) 1986-06-11
IL77197A (en) 1991-07-18
FI82046B (fi) 1990-09-28
SU1428203A3 (ru) 1988-09-30
CN85108556A (zh) 1986-07-30
CY1690A (en) 1994-01-14
JPH0759578B2 (ja) 1995-06-28
ES549542A0 (es) 1986-04-16
KR870001512B1 (ko) 1987-08-20
AU5057485A (en) 1986-07-17
CN1014790B (zh) 1991-11-20
DK558185D0 (da) 1985-12-02
CA1260474A (fr) 1989-09-26
ATE54916T1 (de) 1990-08-15
PT81586A (en) 1986-01-01
IE853023L (en) 1986-06-03
KR860004894A (ko) 1986-07-14
ZA859224B (en) 1987-07-29
HUT40668A (en) 1987-01-28
GR852830B (fr) 1986-03-27
ZW21685A1 (en) 1987-06-17
DK165370B (da) 1992-11-16
ES8606306A1 (es) 1986-04-16
NZ214320A (en) 1988-03-30
FI854768A7 (fi) 1986-06-04
DZ863A1 (fr) 2004-09-13
DK165370C (da) 1993-04-05
NO854837L (no) 1986-06-04
AU582601B2 (en) 1989-04-06
DE3578885D1 (de) 1990-08-30
FI82046C (fi) 1991-01-10
MA20582A1 (fr) 1986-07-01
FI854768A0 (fi) 1985-12-02
IE58807B1 (en) 1993-11-17
PT81586B (pt) 1988-01-22
JPS61137884A (ja) 1986-06-25
HK49593A (en) 1993-05-27
PH26458A (en) 1992-07-27
EP0184257B1 (fr) 1990-07-25
DK558185A (da) 1986-06-04
HU196068B (en) 1988-09-28
NO160076C (no) 1989-03-08

Similar Documents

Publication Publication Date Title
EP0184257B1 (fr) Dérivés de la benzoxazolamine et de la benzothiazolamine
CA2238818C (fr) Derives 1-(piperidinyl 1,2-disubstitue)-4-substitue-piperidine comme antagonistes des recepteurs de la tachykinine
CA2234096C (fr) Derives de piperazine a substitution en positions 1-(diperidinyle a disubstitution en positions 1,2)-4
CA2012432C (fr) Derives de carboxamide de n-(3-hydroxy-4-piperidinyl) (dihydrobenzofurane, dihydro-2h-benzopyrane ou dihydrobenzodioxine)
DK173674B1 (da) Anti-allergiske præparater indeholdende N-heterocyclyl-4-piperidinaminer, N-heterocyclyl-4-piperidinaminer til brug som antiallergikum og hidtil ukendte N-heterocyclyl-4-piperidinaminer samt fremgangsmåde til fremstilling deraf
FI78073C (fi) Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara n-piperidinyl-bensamidderivat.
FI81797C (fi) Foerfarande foer framstaellning av en fem-ledad heterocyklisk ring innehaollande terapeutiskt aktiva n-(bicyklisk heterocyklyl)-4-piperidinaminer.
WO2004041279A1 (fr) Modulateurs gamma-aminoamides de l&#39;activite de recepteur de chimiokine
JPH0768240B2 (ja) ４―〔（二環式複素環）―メチル及びヘテロ〕ピペリジン類及びその製法
US4835161A (en) Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
EP0199400B1 (fr) Oxazol- et thiazolamines condensées bicycliques N-[(4-piperidinyl)alkyl] substituées
DE3874013T2 (de) N-(4-piperidinyl)-bizyklisch kondensierte 2-imidazolamin-derivate.
US4861785A (en) Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents
US4689330A (en) Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
CZ580390A3 (en) 6-ARYL-5,6-DIHYDRO-IMIDAZO£2,1-b|THIAZOLE DERIVATIVES, PROCESS OF THEIR PREPARATION, INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
US5010198A (en) Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents
US4749702A (en) Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
US4826848A (en) Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines
KR870001511B1 (ko) 벤조옥사졸-및 벤조티아졸아민 유도체의 제조방법
KR880000247B1 (ko) 4-[(두고리 헤테로시클릴)-메틸 및-헤테로] 피페리딘 유도체의 제조방법
KR960001200B1 (ko) 4-(아로일아미노)피페리딘부탄아미드 유도체의 제조방법
KR860001584B1 (ko) N-(3-히드록시-4-피페리딘일)벤즈아미드 유도체의 제조방법