BG62912B1 - Фармацевтичен или ветеринарен състав, съдържащ мупироцин или негова сол - Google Patents

Фармацевтичен или ветеринарен състав, съдържащ мупироцин или негова сол Download PDF

Info

Publication number: BG62912B1
Authority: BG; Bulgaria
Prior art keywords: weight; composition according; composition; salt; mupirocin
Prior art date: 1993-10-22

Application number

BG100501A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG100501A (bg

Inventor

Harvey L. Zimmerman

Original Assignee

Smithkline Beecham Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1996-04-12

Publication date

2000-11-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26303736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG62912(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-10-22 Priority claimed from GB939321876A external-priority patent/GB9321876D0/en

1993-10-29 Priority claimed from GB939322288A external-priority patent/GB9322288D0/en

1996-04-12 Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation

1996-12-31 Publication of BG100501A publication Critical patent/BG100501A/bg

2000-11-30 Publication of BG62912B1 publication Critical patent/BG62912B1/bg

Links

239000000203 mixture Substances 0.000 title claims abstract description 45
150000003839 salts Chemical class 0.000 title claims abstract description 9
239000006071 cream Substances 0.000 claims abstract description 15
239000002480 mineral oil Substances 0.000 claims abstract description 15
235000010446 mineral oil Nutrition 0.000 claims abstract description 15
150000002148 esters Chemical class 0.000 claims abstract description 11
150000002191 fatty alcohols Chemical class 0.000 claims abstract description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
239000004094 surface-active agent Substances 0.000 claims abstract description 8
239000004034 viscosity adjusting agent Substances 0.000 claims abstract description 8
229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 6
229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 6
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 16
MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 claims description 14
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 14
229960003128 mupirocin Drugs 0.000 claims description 12
229930187697 mupirocin Natural products 0.000 claims description 12
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 10
-1 fatty alcohol esters Chemical class 0.000 claims description 10
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 8
229960000541 cetyl alcohol Drugs 0.000 claims description 7
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
159000000007 calcium salts Chemical class 0.000 claims description 5
229940075420 xanthine Drugs 0.000 claims description 5
239000011347 resin Substances 0.000 claims description 4
229920005989 resin Polymers 0.000 claims description 4
FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 claims description 3
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 3
238000000034 method Methods 0.000 claims description 3
230000001225 therapeutic effect Effects 0.000 claims description 3
235000019445 benzyl alcohol Nutrition 0.000 claims description 2
239000003755 preservative agent Substances 0.000 claims description 2
DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 claims 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
241001465754 Metazoa Species 0.000 claims 1
NHOGGUYTANYCGQ-UHFFFAOYSA-N ethenoxybenzene Chemical group C=COC1=CC=CC=C1 NHOGGUYTANYCGQ-UHFFFAOYSA-N 0.000 claims 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
230000002335 preservative effect Effects 0.000 claims 1
229920001285 xanthan gum Polymers 0.000 claims 1
229940082509 xanthan gum Drugs 0.000 claims 1
235000010493 xanthan gum Nutrition 0.000 claims 1
239000000230 xanthan gum Substances 0.000 claims 1
150000002194 fatty esters Chemical class 0.000 abstract 1
HAXVBVDETFUQGV-LNQHITRNSA-L mupirocin calcium (anhydrous) Chemical compound [Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 HAXVBVDETFUQGV-LNQHITRNSA-L 0.000 description 13
239000003814 drug Substances 0.000 description 5
229940057995 liquid paraffin Drugs 0.000 description 5
229940124597 therapeutic agent Drugs 0.000 description 5
IQXJCCZJOIKIAD-UHFFFAOYSA-N 1-(2-methoxyethoxy)hexadecane Chemical compound CCCCCCCCCCCCCCCCOCCOC IQXJCCZJOIKIAD-UHFFFAOYSA-N 0.000 description 4
239000002202 Polyethylene glycol Substances 0.000 description 4
229950009789 cetomacrogol 1000 Drugs 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
239000000047 product Substances 0.000 description 4
238000009472 formulation Methods 0.000 description 3
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
229920001214 Polysorbate 60 Polymers 0.000 description 2
229940028420 bactroban Drugs 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
150000004683 dihydrates Chemical group 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
239000002674 ointment Substances 0.000 description 2
239000012188 paraffin wax Substances 0.000 description 2
229960005323 phenoxyethanol Drugs 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
229920000053 polysorbate 80 Polymers 0.000 description 2
239000008213 purified water Substances 0.000 description 2
HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
239000004909 Moisturizer Substances 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
229940059904 light mineral oil Drugs 0.000 description 1
230000001333 moisturizer Effects 0.000 description 1
229940043348 myristyl alcohol Drugs 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
229940113124 polysorbate 60 Drugs 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG100501A 1993-10-22 1996-04-12 Фармацевтичен или ветеринарен състав, съдържащ мупироцин или негова сол BG62912B1 (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939321876A GB9321876D0 (en)	1993-10-22	1993-10-22	Novel composition
GB939322288A GB9322288D0 (en)	1993-10-29	1993-10-29	Novel composition
PCT/US1994/012026 WO1995010999A1 (en)	1993-10-22	1994-10-20	Novel composition

Publications (2)

Publication Number	Publication Date
BG100501A BG100501A (bg)	1996-12-31
BG62912B1 true BG62912B1 (bg)	2000-11-30

Family

ID=26303736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG100501A BG62912B1 (bg)	1993-10-22	1996-04-12	Фармацевтичен или ветеринарен състав, съдържащ мупироцин или негова сол

Country Status (27)

Country	Link
US (1)	US6025389A (de)
EP (1)	EP0727979B1 (de)
JP (1)	JPH09506865A (de)
KR (1)	KR100374462B1 (de)
CN (1)	CN1102410C (de)
AP (1)	AP608A (de)
AT (1)	ATE202467T1 (de)
AU (1)	AU692486B2 (de)
BG (1)	BG62912B1 (de)
BR (1)	BR9407840A (de)
CA (1)	CA2174658C (de)
CZ (1)	CZ292223B6 (de)
DE (1)	DE69427589T2 (de)
DK (1)	DK0727979T3 (de)
ES (1)	ES2157996T3 (de)
FI (1)	FI116931B (de)
GR (1)	GR3036591T3 (de)
HU (1)	HU221853B1 (de)
NO (1)	NO313446B1 (de)
NZ (1)	NZ275282A (de)
OA (1)	OA10361A (de)
PL (1)	PL177592B1 (de)
PT (1)	PT727979E (de)
RO (1)	RO112987B1 (de)
SK (1)	SK280222B6 (de)
UA (1)	UA39896C2 (de)
WO (1)	WO1995010999A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ112499A3 (cs) *	1996-10-01	1999-08-11	Smithkline Beecham Corporation	Použití mupirocinu k výrobě léčiva pro léčbu bakteriálních infekcí spojených s kolonizací nosohltanu patogenními organismy
CO4910145A1 (es) *	1996-10-01	2000-04-24	Smithkline Beecham Corp	Uso
CA2303443A1 (en) *	1997-09-11	1999-03-18	Anthony Guy Hatton	Compositions adapted for prolonged residence in the nasal pharynx
IL123143A (en) *	1998-02-02	2001-08-26	Agis Ind 1983 Ltd	Pharmaceutical compositions containing mupirocin
GB9808470D0 (en)	1998-04-22	1998-06-17	Smithkline Beecham Plc	Novel process and apparatus
IL137363A (en) *	2000-07-18	2005-12-18	Agis Ind 1983 Ltd	Pharmaceutical compositions containing mupirocin
IL150907A (en) *	2002-07-25	2007-07-04	Stephan Cherkez	Process for the preparation of stable amorphous calcium pseudomonate
US20040224981A1 (en) *	2003-05-01	2004-11-11	Nebojsa Janjic	Antibacterial methods and compositions
US20050123575A1 (en) *	2003-12-03	2005-06-09	Eilon Asculai	Spreadable compositions for topical use, an improved process of making same and methods of using same
WO2008007182A2 (en) *	2006-07-07	2008-01-17	Glenmark Pharmaceuticals Limited	Topical pharmaceutical compositions of mupirocin or pharmaceutically acceptable salts or esters thereof
ES2703253T3 (es)	2010-03-30	2019-03-07	Helperby Therapeutics Ltd	Nueva combinación y uso
WO2012017215A1 (en)	2010-08-05	2012-02-09	Helperby Therapeutics Limited	Combination of a pyrroloquinoline compound and a beta-lactam antimicrobial agent, mupirocin or chlorhexidine
GB201013207D0 (en)	2010-08-05	2010-09-22	Helperby Therapeutics Ltd	Novel combination
GB201015079D0 (en)	2010-09-10	2010-10-27	Helperby Therapeutics Ltd	Novel use
US20130245060A1 (en)	2010-10-08	2013-09-19	Helperby Therapeutics Limited	Novel composition
US20140065209A1 (en)	2011-05-03	2014-03-06	Dupont Nutrition Biosciences Aps	Probiotic bacteria for the topical treatment of skin disorders
GB201107755D0 (en)	2011-05-10	2011-06-22	Helperby Therapeutics Ltd	Novel compounds
CN102335122B (zh) *	2011-06-21	2013-04-17	北京协和药厂	一种莫匹罗星软膏及其制备方法
DE102012215511A1 (de)	2012-08-31	2014-06-12	Schülke & Mayr GmbH	Verfahren zur Herstellung einer Bispyridiniumalkan enthaltenden halbfesten Zubereitung
GB201305277D0 (en)	2013-03-22	2013-05-01	Helperby Therapeutics Ltd	Novel combination and use
GB201307989D0 (en)	2013-05-02	2013-06-12	Helperby Therapeutics Ltd	Novel combinations and use
EP3082424B1 (de)	2013-12-17	2023-10-04	Hatchtech Pty Ltd	Zusammensetzung gegen läuse
GB201401617D0 (en)	2014-01-30	2014-03-19	Helperby Therapeutics Ltd	Novel combination and use
CN107530397A (zh)	2014-12-18	2018-01-02	赫尔普百治疗有限公司	新型组合和用途
WO2016133471A1 (en)	2015-02-20	2016-08-25	Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A. Ş.	A topical composition comprising mupirocin and dexpanthenol
GB201518969D0 (en)	2015-10-27	2015-12-09	Helperby Therapeutics Ltd	Triple combination
GB201620095D0 (en)	2016-11-28	2017-01-11	Terali Innov Sas And Univ De Strasbourg And Inserm (Inst Nat De La Sante Et De La Rech Medicale) And	Novel use
US10293005B2 (en)	2016-04-19	2019-05-21	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Use of gram negative species to treat atopic dermatitis
CN109310626A (zh)	2016-04-19	2019-02-05	美利坚合众国,由健康及人类服务部部长代表	革兰氏阴性种治疗特应性皮炎的用途
GB201610869D0 (en)	2016-06-22	2016-08-03	Helperby Therapeutics Ltd	Combination
GB201709193D0 (en)	2017-06-09	2017-07-26	Helperby Therapeutics Ltd	Combination
WO2019141957A1 (en)	2018-01-19	2019-07-25	Cado Biotechnology Ivs	N-pyrimidinyl hydroxy pyrazole derivatives and uses thereof
KR20210013080A (ko)	2018-05-11	2021-02-03	포르테 서브시디어리, 인크.	피부 병태의 치료를 위한 조성물
US10709663B2 (en)	2018-10-17	2020-07-14	Glenmark Pharmaceuticals, Inc., Usa	Mupirocin cream in pump device
IL271778A (en)	2019-12-31	2021-06-30	Ichilov Tech Ltd	Methods for treating atopic dermatitis
US20210299019A1 (en) *	2020-03-31	2021-09-30	Chemistryrx	Methods for treating hyperpigmentation and compositions for same
BR112023020137A2 (pt)	2021-03-30	2023-11-28	Dupont Nutrition Biosci Aps	Composições, comprimido, estojo e método para tratar e/ou prevenir a inflamação gastrointestinal
WO2025080755A1 (en)	2023-10-13	2025-04-17	Nutrition & Biosciences USA 4, Inc.	Methods and compositions for aging and mitochondrial health

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3758686A (en) *	1971-12-07	1973-09-11	American Cyanamid Co	Method of using steroid acetonides
US3934013A (en) *	1975-02-21	1976-01-20	Syntex (U.S.A.) Inc.	Pharmaceutical composition
NZ200918A (en) *	1981-07-02	1985-07-31	Gist Brocades Nv	Stable fatty oil-in-water emulsion cream for topical application
GB8530796D0 (en) *	1985-12-13	1986-01-22	Beecham Group Plc	Pharmaceutical composition
IE59628B1 (en) *	1986-06-26	1994-03-09	Beecham Group Plc	Treatment of fungal infections
US4847068A (en) *	1987-08-06	1989-07-11	Johnson & Johnson Consumer Products, Inc.	Skin care compositions

1994
- 1994-10-20 DK DK94931943T patent/DK0727979T3/da active
- 1994-10-20 AP APAP/P/1996/000798A patent/AP608A/en active
- 1994-10-20 NZ NZ275282A patent/NZ275282A/en not_active IP Right Cessation
- 1994-10-20 PL PL94314038A patent/PL177592B1/pl unknown
- 1994-10-20 WO PCT/US1994/012026 patent/WO1995010999A1/en not_active Ceased
- 1994-10-20 BR BR9407840A patent/BR9407840A/pt not_active Application Discontinuation
- 1994-10-20 CA CA002174658A patent/CA2174658C/en not_active Expired - Lifetime
- 1994-10-20 JP JP7512208A patent/JPH09506865A/ja active Pending
- 1994-10-20 DE DE69427589T patent/DE69427589T2/de not_active Expired - Lifetime
- 1994-10-20 EP EP94931943A patent/EP0727979B1/de not_active Expired - Lifetime
- 1994-10-20 RO RO96-00817A patent/RO112987B1/ro unknown
- 1994-10-20 PT PT94931943T patent/PT727979E/pt unknown
- 1994-10-20 SK SK495-96A patent/SK280222B6/sk not_active IP Right Cessation
- 1994-10-20 AT AT94931943T patent/ATE202467T1/de active
- 1994-10-20 CZ CZ19961120A patent/CZ292223B6/cs not_active IP Right Cessation
- 1994-10-20 HU HU9601030A patent/HU221853B1/hu active IP Right Grant
- 1994-10-20 CN CN94194238A patent/CN1102410C/zh not_active Expired - Lifetime
- 1994-10-20 ES ES94931943T patent/ES2157996T3/es not_active Expired - Lifetime
- 1994-10-20 UA UA96041570A patent/UA39896C2/uk unknown
- 1994-10-20 KR KR1019960702041A patent/KR100374462B1/ko not_active Expired - Lifetime
- 1994-10-20 AU AU80847/94A patent/AU692486B2/en not_active Expired
1996
- 1996-04-12 BG BG100501A patent/BG62912B1/bg unknown
- 1996-04-19 NO NO19961588A patent/NO313446B1/no not_active IP Right Cessation
- 1996-04-19 FI FI961720A patent/FI116931B/fi not_active IP Right Cessation
- 1996-04-22 OA OA60817A patent/OA10361A/en unknown
1997
- 1997-07-25 US US08/903,255 patent/US6025389A/en not_active Expired - Lifetime
2001
- 2001-09-11 GR GR20010401448T patent/GR3036591T3/el unknown

Also Published As

Publication number	Publication date
SK49596A3 (en)	1997-02-05
DE69427589T2 (de)	2002-04-25
WO1995010999A1 (en)	1995-04-27
KR100374462B1 (ko)	2003-06-09
CN1102410C (zh)	2003-03-05
HU221853B1 (hu)	2003-02-28
NO961588L (no)	1996-04-19
DK0727979T3 (da)	2001-10-01
EP0727979A4 (de)	1996-11-27
DE69427589D1 (de)	2001-08-02
EP0727979B1 (de)	2001-06-27
SK280222B6 (sk)	1999-10-08
AP9600798A0 (en)	1996-04-30
BR9407840A (pt)	1997-05-13
US6025389A (en)	2000-02-15
RO112987B1 (ro)	1998-03-30
CZ292223B6 (cs)	2003-08-13
NO961588D0 (no)	1996-04-19
BG100501A (bg)	1996-12-31
FI961720A0 (fi)	1996-04-19
HK1012284A1 (en)	1999-07-30
CA2174658A1 (en)	1995-04-27
FI961720L (fi)	1996-04-19
EP0727979A1 (de)	1996-08-28
CN1135715A (zh)	1996-11-13
CA2174658C (en)	2000-12-19
AU692486B2 (en)	1998-06-11
ES2157996T3 (es)	2001-09-01
FI116931B (fi)	2006-04-13
GR3036591T3 (en)	2001-12-31
NO313446B1 (no)	2002-10-07
PL177592B1 (pl)	1999-12-31
PT727979E (pt)	2001-11-30
AU8084794A (en)	1995-05-08
ATE202467T1 (de)	2001-07-15
UA39896C2 (uk)	2001-07-16
PL314038A1 (en)	1996-08-05
AP608A (en)	1997-08-28
HUT74510A (en)	1997-01-28
JPH09506865A (ja)	1997-07-08
NZ275282A (en)	1996-10-28
HU9601030D0 (en)	1996-06-28
OA10361A (en)	2001-11-21
CZ112096A3 (en)	1996-07-17

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BG62912B1 (bg)	2000-11-30	Фармацевтичен или ветеринарен състав, съдържащ мупироцин или негова сол
SK11993A3 (en)	1993-07-07	External preparation containing cyclosporin
CZ285679B6 (cs)	1999-10-13	Farmaceutický a kosmetický prostředek k místnímu nanášení na pokožku a způsob jeho přípravy
JPS6321648B2 (de)	1988-05-09
US5538989A (en)	1996-07-23	Fenbendazole formulations
AU2001276567B2 (en)	2006-02-16	Antifungal ketoconazole composition for topical use
EP0445540B1 (de)	1995-04-19	Antimykotische Imidazol enthaltende Zubereitung zur äusserlichen Anwendung
AU2001276567A1 (en)	2002-05-30	Antifungal ketoconazole composition for topical use
HK1007104B (en)	1999-04-01	Antimycotic external imidazole preparations
RU2148998C1 (ru)	2000-05-20	Фармацевтическая или ветеринарная композиция (варианты) и способ получения композиции
HK1012284B (en)	2002-02-22	Novel composition
EP0056681A2 (de)	1982-07-28	Formulierungen des Levonantradols und N-Methyllevonantradols
CZ269293A3 (en)	1994-07-13	Medicinal ointment without skin irritating effect and process for preparing thereof
KR101829049B1 (ko)	2018-02-26	비타민 d 유사체와 코르티코스테로이드를 포함하는 개선된 안정성을 갖는 약학 조성물