BG63116B1 - Метод за получаване на о-(3-амино-2-хидрокси-пропил)- хидроксимови ацилхалогениди - Google Patents

Метод за получаване на о-(3-амино-2-хидрокси-пропил)- хидроксимови ацилхалогениди Download PDF

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Publication number
BG63116B1
BG63116B1 BG103847A BG10384799A BG63116B1 BG 63116 B1 BG63116 B1 BG 63116B1 BG 103847 A BG103847 A BG 103847A BG 10384799 A BG10384799 A BG 10384799A BG 63116 B1 BG63116 B1 BG 63116B1
Authority
BG
Bulgaria
Prior art keywords
formula
hydroxy
reaction
carboxamide oxime
salt
Prior art date
Application number
BG103847A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103847A (en
Inventor
Laszlo Uroegdi
Mihaly Barabas
Ede Marvanyos
Magdolna Torok
Zita Csakai
Original Assignee
Biorex Kutato Es Fejlesztoe Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Kutato Es Fejlesztoe Rt. filed Critical Biorex Kutato Es Fejlesztoe Rt.
Publication of BG103847A publication Critical patent/BG103847A/xx
Publication of BG63116B1 publication Critical patent/BG63116B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/12—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reactions not involving the formation of oxyimino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG103847A 1997-04-03 1999-11-02 Метод за получаване на о-(3-амино-2-хидрокси-пропил)- хидроксимови ацилхалогениди BG63116B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9700699A HU220971B1 (hu) 1997-04-03 1997-04-03 Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
PCT/HU1997/000082 WO1998043948A1 (fr) 1997-04-03 1997-12-05 Procede de preparation d'halogenure d'acide o-(3-amino-2-hydroxy-propyl)-hydroxymique

Publications (2)

Publication Number Publication Date
BG103847A BG103847A (en) 2000-07-31
BG63116B1 true BG63116B1 (bg) 2001-04-30

Family

ID=89994956

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103847A BG63116B1 (bg) 1997-04-03 1999-11-02 Метод за получаване на о-(3-амино-2-хидрокси-пропил)- хидроксимови ацилхалогениди

Country Status (33)

Country Link
US (1) US6180787B1 (fr)
EP (1) EP0975585A1 (fr)
JP (1) JP2001521498A (fr)
KR (1) KR20010005943A (fr)
CN (1) CN1251574A (fr)
AP (1) AP9901646A0 (fr)
AR (1) AR012308A1 (fr)
AU (1) AU737994B2 (fr)
BG (1) BG63116B1 (fr)
BR (1) BR9714717A (fr)
CA (1) CA2285360A1 (fr)
CO (1) CO4940491A1 (fr)
EA (1) EA199900899A1 (fr)
EE (1) EE03868B1 (fr)
EG (1) EG22104A (fr)
HR (1) HRP980175A2 (fr)
HU (1) HU220971B1 (fr)
ID (1) ID20016A (fr)
IL (1) IL132048A0 (fr)
IS (1) IS5174A (fr)
MA (1) MA26143A1 (fr)
NO (1) NO312027B1 (fr)
NZ (1) NZ500020A (fr)
PE (1) PE83299A1 (fr)
PL (1) PL336072A1 (fr)
SK (1) SK134899A3 (fr)
TN (1) TNSN98046A1 (fr)
TR (1) TR199902207T2 (fr)
TW (1) TW455573B (fr)
UY (1) UY24945A1 (fr)
WO (1) WO1998043948A1 (fr)
YU (1) YU49499A (fr)
ZA (1) ZA982755B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900475D0 (en) 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
CA2471752A1 (fr) 2002-01-11 2003-07-17 Biorex Kutato Es Fejlesztoe Rt. Derives de carboxamidine et leur utilisation pour traiter des troubles vasculaires
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
US9551111B2 (en) * 2011-12-23 2017-01-24 Akzo Nobel Chemicals International B.V. Chemical compounds
BR112014028700B1 (pt) * 2012-06-14 2021-01-05 Alcon Inc. copolímero e monômero vinílico contendo azetidínio, lente de contato de silicone hidrogel e métodos de produção da mesma
CN103804309B (zh) * 2012-11-09 2019-08-02 广州喜鹊医药有限公司 一种氯肟类化合物及其制备方法和在制药中的应用
WO2022106614A1 (fr) 2020-11-19 2022-05-27 Orphazyme A/S Procédés de préparation de citrate d'arimoclomol et intermédiaires associés

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207305B (en) * 1988-03-23 1993-03-29 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoxime derivatives
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HUT54347A (en) * 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes

Also Published As

Publication number Publication date
IL132048A0 (en) 2001-03-19
AR012308A1 (es) 2000-10-18
EA199900899A1 (ru) 2000-04-24
IS5174A (is) 1999-09-10
TR199902207T2 (xx) 2000-02-21
WO1998043948A1 (fr) 1998-10-08
HUP9700699A2 (hu) 1999-01-28
HU9700699D0 (en) 1997-05-28
PE83299A1 (es) 1999-09-01
AU737994B2 (en) 2001-09-06
EG22104A (en) 2002-07-31
SK134899A3 (en) 2000-06-12
NO994628L (no) 1999-09-23
EE9900438A (et) 2000-04-17
CN1251574A (zh) 2000-04-26
CO4940491A1 (es) 2000-07-24
TNSN98046A1 (fr) 2005-03-15
BG103847A (en) 2000-07-31
AU5405598A (en) 1998-10-22
UY24945A1 (es) 1998-09-28
ZA982755B (en) 1998-10-01
EP0975585A1 (fr) 2000-02-02
MA26143A1 (fr) 2004-07-01
EE03868B1 (et) 2002-10-15
PL336072A1 (en) 2000-06-05
ID20016A (id) 1998-09-10
HU220971B1 (hu) 2002-07-29
NZ500020A (en) 2001-09-28
AP9901646A0 (en) 1999-09-30
HRP980175A2 (en) 1999-06-30
NO994628D0 (no) 1999-09-23
KR20010005943A (ko) 2001-01-15
TW455573B (en) 2001-09-21
BR9714717A (pt) 2000-06-20
US6180787B1 (en) 2001-01-30
HUP9700699A3 (en) 1999-04-28
NO312027B1 (no) 2002-03-04
JP2001521498A (ja) 2001-11-06
YU49499A (sh) 2001-09-28
CA2285360A1 (fr) 1998-10-08

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