BG63639B1 - Тромбопоетин-mpi-лигаден полипептид - Google Patents

Тромбопоетин-mpi-лигаден полипептид Download PDF

Info

Publication number: BG63639B1
Authority: BG; Bulgaria
Prior art keywords: ligand; mpl; dna; sequence; polypeptide
Prior art date: 1994-01-03

Application number

BG100693A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG100693A (en

Inventor

Dan Eaton

SAUVAGE Frederic DE

Original Assignee

Genentech, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-03

Filing date

1996-07-02

Publication date

2002-07-31

1994-02-15 Priority claimed from US08/196,689 external-priority patent/US8357513B1/en

1994-05-25 Priority claimed from US08/249,376 external-priority patent/US8192955B1/en

1994-12-02 Priority claimed from US08/348,657 external-priority patent/US6660256B1/en

1996-07-02 Application filed by Genentech, Inc. filed Critical Genentech, Inc.

1998-01-30 Publication of BG100693A publication Critical patent/BG100693A/xx

2002-07-31 Publication of BG63639B1 publication Critical patent/BG63639B1/bg

Links

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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Vehicle Body Suspensions (AREA)
Information Transfer Systems (AREA)

BG100693A 1994-01-03 1996-07-02 Тромбопоетин-mpi-лигаден полипептид BG63639B1 (bg)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
US17655394A	1994-01-03	1994-01-03
US18560794A	1994-01-21	1994-01-21
US08/196,689 US8357513B1 (en)	1994-01-03	1994-02-15	Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A	1994-04-04	1994-04-04
US08/249,376 US8192955B1 (en)	1994-01-03	1994-05-25	Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A	1994-12-02	1994-12-02
US08/348,657 US6660256B1 (en)	1994-01-03	1994-12-02	Porcine mpl ligand
PCT/US1994/014553 WO1995018858A1 (en)	1994-01-03	1994-12-28	Thrombopoietin

Publications (2)

Publication Number	Publication Date
BG100693A BG100693A (en)	1998-01-30
BG63639B1 true BG63639B1 (bg)	2002-07-31

Family

ID=27569151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG100693A BG63639B1 (bg)	1994-01-03	1996-07-02	Тромбопоетин-mpi-лигаден полипептид

Country Status (28)

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EP (1)	EP0738323A1 (da)
JP (2)	JPH09508262A (da)
CN (1)	CN1134539C (da)
AU (1)	AU704266B2 (da)
BG (1)	BG63639B1 (da)
CA (1)	CA2178482C (da)
CZ (1)	CZ296130B6 (da)
DK (1)	DK149194A (da)
ES (1)	ES2114786B1 (da)
FI (1)	FI121573B (da)
FR (1)	FR2714670B1 (da)
GB (1)	GB2285446B (da)
HR (1)	HRP941020A2 (da)
HU (1)	HUT75657A (da)
IE (1)	IE72517B1 (da)
IL (1)	IL112184A (da)
IT (1)	IT1283770B1 (da)
LU (1)	LU88573A1 (da)
LV (1)	LV11632B (da)
NL (1)	NL9500010A (da)
NO (1)	NO326903B1 (da)
NZ (1)	NZ278726A (da)
PT (1)	PT101627B (da)
RO (1)	RO117110B1 (da)
SG (1)	SG47030A1 (da)
SI (1)	SI9420079A (da)
SK (1)	SK282265B6 (da)
WO (1)	WO1995018858A1 (da)

Families Citing this family (59)

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Publication number	Priority date	Publication date	Assignee	Title
US6270989B1 (en) *	1991-11-05	2001-08-07	Transkaryotic Therapies, Inc.	Protein production and delivery
US5733761A (en)	1991-11-05	1998-03-31	Transkaryotic Therapies, Inc.	Protein production and protein delivery
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- 1994-12-21 GB GB9425831A patent/GB2285446B/en not_active Expired - Lifetime
- 1994-12-27 HR HR08/348,658A patent/HRP941020A2/hr not_active Application Discontinuation
- 1994-12-28 AU AU15146/95A patent/AU704266B2/en not_active Expired
- 1994-12-28 CN CNB941947513A patent/CN1134539C/zh not_active Expired - Lifetime
- 1994-12-28 NZ NZ278726A patent/NZ278726A/en not_active IP Right Cessation
- 1994-12-28 RO RO96-01347A patent/RO117110B1/ro unknown
- 1994-12-28 CZ CZ0192296A patent/CZ296130B6/cs not_active IP Right Cessation
- 1994-12-28 SK SK875-96A patent/SK282265B6/sk not_active IP Right Cessation
- 1994-12-28 JP JP7518499A patent/JPH09508262A/ja active Pending
- 1994-12-28 HU HU9601805A patent/HUT75657A/hu not_active Application Discontinuation
- 1994-12-28 SI SI9420079A patent/SI9420079A/sl unknown
- 1994-12-28 CA CA2178482A patent/CA2178482C/en not_active Expired - Lifetime
- 1994-12-28 DK DK149194A patent/DK149194A/da not_active Application Discontinuation
- 1994-12-28 WO PCT/US1994/014553 patent/WO1995018858A1/en not_active Ceased
- 1994-12-28 EP EP95906653A patent/EP0738323A1/en not_active Withdrawn
- 1994-12-29 IL IL11218494A patent/IL112184A/en not_active IP Right Cessation
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- 1994-12-30 PT PT101627A patent/PT101627B/pt not_active IP Right Cessation
1995
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- 1995-01-02 IT IT95TO000002A patent/IT1283770B1/it active IP Right Grant
- 1995-01-03 NL NL9500010A patent/NL9500010A/nl active Search and Examination
- 1995-01-03 LU LU88573A patent/LU88573A1/de unknown
- 1995-01-03 IE IE950002A patent/IE72517B1/en not_active IP Right Cessation
1996
- 1996-07-02 FI FI962723A patent/FI121573B/fi not_active IP Right Cessation
- 1996-07-02 BG BG100693A patent/BG63639B1/bg unknown
- 1996-07-02 NO NO19962783A patent/NO326903B1/no not_active IP Right Cessation
- 1996-07-24 LV LVP-96-315A patent/LV11632B/xx unknown
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Also Published As

Publication number	Publication date
CZ192296A3 (en)	1997-05-14
ITTO950002A0 (it)	1995-01-02
IL112184A0 (en)	1995-03-15
CN1134539C (zh)	2004-01-14
CN1141061A (zh)	1997-01-22
WO1995018858A1 (en)	1995-07-13
ITTO950002A1 (it)	1996-07-02
FI962723A0 (fi)	1996-07-02
IE72517B1 (en)	1997-04-23
IT1283770B1 (it)	1998-04-30
RO117110B1 (ro)	2001-10-30
JPH10113186A (ja)	1998-05-06
SK282265B6 (sk)	2001-12-03
GB2285446B (en)	1999-07-28
DK149194A (da)	1995-07-04
IE950002A1 (en)	1995-07-12
NO962783D0 (no)	1996-07-02
ES2114786A1 (es)	1998-06-01
SK87596A3 (en)	1997-11-05
CZ296130B6 (cs)	2006-01-11
LU88573A1 (de)	1995-06-01
JPH09508262A (ja)	1997-08-26
SG47030A1 (en)	1998-03-20
EP0738323A1 (en)	1996-10-23
ES2114786B1 (es)	1999-01-01
FR2714670B1 (fr)	1997-01-10
NO326903B1 (no)	2009-03-16
AU1514695A (en)	1995-08-01
FI121573B (fi)	2011-01-14
NO962783L (no)	1996-09-03
BG100693A (en)	1998-01-30
GB2285446A (en)	1995-07-12
HRP941020A2 (en)	1997-04-30
GB9425831D0 (en)	1995-02-22
SI9420079A (en)	1997-02-28
HUT75657A (en)	1997-05-28
IL112184A (en)	2004-07-25
LV11632A (lv)	1996-12-20
HU9601805D0 (en)	1996-08-28
AU704266B2 (en)	1999-04-15
FR2714670A1 (fr)	1995-07-07
CA2178482A1 (en)	1995-07-13
PT101627B (pt)	1996-11-29
NL9500010A (nl)	1995-08-01
CA2178482C (en)	2012-01-03
NZ278726A (en)	1998-06-26
PT101627A (pt)	1995-11-30
FI962723L (fi)	1996-09-03
LV11632B (en)	1997-04-20

Publication	Publication Date	Title
AU704266B2 (en)	1999-04-15	Thrombopoietin
RU2245365C2 (ru)	2005-01-27	Тромбопоэтин
AU749175B2 (en)	2002-06-20	Thrombopoietin
AU782245B2 (en)	2005-07-14	Thrombopoietin
LT4120B (en)	1997-03-25	Thrombopoetin
US8192955B1 (en)	2012-06-05	Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
DE19500030A1 (de)	1995-07-06	Thrombopoietin
KR100607613B1 (ko)	2007-03-02	트롬보포이에틴
US8278099B1 (en)	2012-10-02	Monoclonal antibody to human thrombopoietin
US8147844B1 (en)	2012-04-03	Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
KR20040065249A (ko)	2004-07-21	트롬보포이에틴
US8241900B1 (en)	2012-08-14	mpl ligand
US8399250B1 (en)	2013-03-19	Anti-mpl ligand (thromobpoietin) antibodies
SA95150635B1 (ar)	2006-05-27	ثرومبوبواييتين thrombopoietin (عامل مولد للصفائح الدموية )
IL161813A (en)	2008-07-08	CHIMERIC POLYPEPTIDES COMPRISING A HETEROLOGOUS POLYPEPTIDE AND A FRAGMENT OF A mpl LIGAND