BG98684A - 3-(n-isopropyl-n-h-propylamino)-5-(n-isopropyl) carbonoylchroman - Google Patents

3-(n-isopropyl-n-h-propylamino)-5-(n-isopropyl) carbonoylchroman

Info

Publication number: BG98684A
Authority: BG; Bulgaria
Prior art keywords: isopropyl; propylamino; depression; carbonoylchroman; carbamoylchroma
Prior art date: 1991-10-08

Application number

BG98684A

Other languages

Bulgarian (bg)

English (en)

Inventor

Eva Hammarberg

Lars Johansson

Svante Ross

Seth Thorberg

Original Assignee

Aktiebolaget Astra

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-08

Filing date

1994-03-29

Publication date

1995-05-31

1991-10-08 Priority claimed from SE9102905A external-priority patent/SE9102905D0/xx

1992-06-29 Priority claimed from SE9202000A external-priority patent/SE9202000D0/xx

1994-03-29 Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra

1995-05-31 Publication of BG98684A publication Critical patent/BG98684A/xx

Links

125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 title abstract 2
ASUOQDQYLLFLLH-UHFFFAOYSA-N 3,4-dihydrochromen-2-ylidenemethanone Chemical compound C1=CC=C2OC(=C=O)CCC2=C1 ASUOQDQYLLFLLH-UHFFFAOYSA-N 0.000 title 1
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
208000022531 anorexia Diseases 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
210000000748 cardiovascular system Anatomy 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010061428 decreased appetite Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001568 sexual effect Effects 0.000 abstract 1
230000001331 thermoregulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)

BG98684A 1991-10-08 1994-03-29 3-(n-isopropyl-n-h-propylamino)-5-(n-isopropyl) carbonoylchroman BG98684A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE9102905A SE9102905D0 (sv)	1991-10-08	1991-10-08	A new therapeutically active compound and a process for its preparation
SE9202000A SE9202000D0 (sv)	1992-06-29	1992-06-29	A new therapeutically active compound
PCT/SE1992/000708 WO1993007135A1 (en)	1991-10-08	1992-10-08	3-(n-isopropyl-n-n-propylamino)-5-(n-isopropyl)carbamoylchroman

Publications (1)

Publication Number	Publication Date
BG98684A true BG98684A (en)	1995-05-31

Family

ID=26661197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG98684A BG98684A (en)	1991-10-08	1994-03-29	3-(n-isopropyl-n-h-propylamino)-5-(n-isopropyl) carbonoylchroman

Country Status (32)

Country	Link
EP (3)	EP0607274B1 (cs)
JP (1)	JPH07500320A (cs)
CN (2)	CN1072411A (cs)
AP (1)	AP338A (cs)
AT (1)	ATE139774T1 (cs)
AU (1)	AU667687B2 (cs)
BG (1)	BG98684A (cs)
CA (1)	CA2118708A1 (cs)
CY (1)	CY1992A (cs)
CZ (1)	CZ51094A3 (cs)
DE (1)	DE69211857T2 (cs)
DK (1)	DK0607274T3 (cs)
EE (1)	EE02981B1 (cs)
ES (1)	ES2089571T3 (cs)
FI (1)	FI941616A7 (cs)
GR (1)	GR3020608T3 (cs)
HK (1)	HK55997A (cs)
HR (1)	HRP920935A2 (cs)
HU (1)	HUT68834A (cs)
IL (1)	IL103373A0 (cs)
IS (2)	IS1644B (cs)
MA (1)	MA22674A1 (cs)
MX (1)	MX9205744A (cs)
MY (1)	MY131174A (cs)
NO (1)	NO941256L (cs)
NZ (2)	NZ244618A (cs)
PL (1)	PL171013B1 (cs)
SI (1)	SI9200249A (cs)
SK (1)	SK36194A3 (cs)
TN (1)	TNSN92088A1 (cs)
WO (1)	WO1993007135A1 (cs)
YU (1)	YU90492A (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5420151A (en) *	1989-12-22	1995-05-30	Aktiebolaget Astra	Chroman derivatives
US5990114A (en) *	1996-02-28	1999-11-23	Recordati, S.A., Chemical And Pharmaceutical Company	Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
IL142082A (en) *	1998-09-23	2005-12-18	Res Dev	Tocoflowers, tocotrinols, derivatives as a novel and other side-chain and their uses
US6235938B1 (en) *	1999-06-10	2001-05-22	Yale University	Transition metal-catalyzed process for preparing N-aryl amine compounds
BR112019001407A2 (pt)	2016-07-29	2019-07-09	Sunovion Pharmaceuticals Inc.	compostos e composições e usos dos mesmos
MX2020000523A (es)	2017-08-02	2020-08-20	Sunovion Pharmaceuticals Inc	Compuestos de isocromano y usos de los mismos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH22522A (en) *	1985-09-03	1988-10-17	Ciba Geigy Ag	3-amino-dihydro-1-benzopyrans and benzothiopyrans, their pharmaceutical compositions and method of using said compounds
US4801605A (en) *	1986-08-29	1989-01-31	Ciba-Geigy Corporation	3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) *	1986-12-19	1986-12-19	Astra Laekemedel Ab	Novel chroman derivatives
JPH021429A (ja) *	1988-06-09	1990-01-05	Toray Ind Inc	光学活性１−メチル−３−フェニルプロピルアミンの製造方法
SE8904361D0 (sv) *	1989-12-22	1989-12-22	Astra Ab	New chroman and thiochroman derivatives

1992
- 1992-10-02 HR HR920935A patent/HRP920935A2/hr not_active Application Discontinuation
- 1992-10-05 MY MYPI92001795A patent/MY131174A/en unknown
- 1992-10-05 NZ NZ244618A patent/NZ244618A/en unknown
- 1992-10-05 NZ NZ270595A patent/NZ270595A/en unknown
- 1992-10-07 IS IS3929A patent/IS1644B/is unknown
- 1992-10-07 MA MA22959A patent/MA22674A1/fr unknown
- 1992-10-07 MX MX9205744A patent/MX9205744A/es unknown
- 1992-10-08 AU AU27684/92A patent/AU667687B2/en not_active Ceased
- 1992-10-08 EP EP92921525A patent/EP0607274B1/en not_active Expired - Lifetime
- 1992-10-08 ES ES92921525T patent/ES2089571T3/es not_active Expired - Lifetime
- 1992-10-08 IL IL103373A patent/IL103373A0/xx unknown
- 1992-10-08 EP EP95118114A patent/EP0703229A3/en not_active Withdrawn
- 1992-10-08 WO PCT/SE1992/000708 patent/WO1993007135A1/en not_active Ceased
- 1992-10-08 SI SI19929200249A patent/SI9200249A/sl unknown
- 1992-10-08 AP APAP/P/1992/000434A patent/AP338A/en active
- 1992-10-08 SK SK361-94A patent/SK36194A3/sk unknown
- 1992-10-08 CZ CZ94510A patent/CZ51094A3/cs unknown
- 1992-10-08 JP JP5506849A patent/JPH07500320A/ja active Pending
- 1992-10-08 TN TNTNSN92088A patent/TNSN92088A1/fr unknown
- 1992-10-08 DK DK92921525.9T patent/DK0607274T3/da active
- 1992-10-08 CN CN92112826A patent/CN1072411A/zh active Pending
- 1992-10-08 AT AT92921525T patent/ATE139774T1/de not_active IP Right Cessation
- 1992-10-08 PL PL92303101A patent/PL171013B1/pl unknown
- 1992-10-08 CA CA002118708A patent/CA2118708A1/en not_active Abandoned
- 1992-10-08 DE DE69211857T patent/DE69211857T2/de not_active Expired - Fee Related
- 1992-10-08 YU YU90492A patent/YU90492A/sh unknown
- 1992-10-08 HU HU9400993A patent/HUT68834A/hu unknown
- 1992-10-08 EP EP92850237A patent/EP0538222A1/en active Pending
- 1992-12-08 IS IS4310A patent/IS4310A/is unknown
1994
- 1994-03-29 BG BG98684A patent/BG98684A/xx unknown
- 1994-04-07 NO NO941256A patent/NO941256L/no unknown
- 1994-04-08 FI FI941616A patent/FI941616A7/fi not_active Application Discontinuation
- 1994-11-23 EE EE9400368A patent/EE02981B1/xx unknown
1996
- 1996-02-28 CN CN96103466A patent/CN1146992A/zh active Pending
- 1996-07-23 GR GR960401967T patent/GR3020608T3/el unknown
1997
- 1997-05-01 HK HK55997A patent/HK55997A/en not_active IP Right Cessation
- 1997-09-05 CY CY199297A patent/CY1992A/xx unknown

Also Published As

Publication number	Publication date
NZ244618A (en)	1996-10-28
EE02981B1 (et)	1997-04-15
EP0607274B1 (en)	1996-06-26
MA22674A1 (fr)	1993-07-01
IL103373A0 (en)	1993-03-15
EP0703229A2 (en)	1996-03-27
HU9400993D0 (en)	1994-08-29
ES2089571T3 (es)	1996-10-01
AP338A (en)	1994-04-26
YU90492A (sh)	1995-12-04
JPH07500320A (ja)	1995-01-12
EP0703229A3 (en)	1996-06-26
EP0607274A1 (en)	1994-07-27
NO941256D0 (no)	1994-04-07
SK36194A3 (en)	1994-12-07
MX9205744A (es)	1993-04-01
HUT68834A (en)	1995-08-28
ATE139774T1 (de)	1996-07-15
AU2768492A (en)	1993-05-03
DE69211857D1 (de)	1996-08-01
TNSN92088A1 (fr)	1993-06-08
MY131174A (en)	2007-07-31
FI941616A0 (fi)	1994-04-08
HK55997A (en)	1997-05-09
AP9200434A0 (en)	1992-10-31
SI9200249A (en)	1993-06-30
IS1644B (is)	1997-03-25
PL171013B1 (pl)	1997-02-28
IS4310A (is)	1993-04-09
AU667687B2 (en)	1996-04-04
CZ51094A3 (en)	1994-11-16
CN1146992A (zh)	1997-04-09
NZ270595A (en)	1996-10-28
CN1072411A (zh)	1993-05-26
EP0538222A1 (en)	1993-04-21
DK0607274T3 (da)	1996-11-04
FI941616A7 (fi)	1994-04-08
IS3929A (is)	1993-04-09
NO941256L (no)	1994-04-07
DE69211857T2 (de)	1996-10-24
HRP920935A2 (en)	1995-08-31
WO1993007135A1 (en)	1993-04-15
GR3020608T3 (en)	1996-10-31
CY1992A (en)	1997-09-05
CA2118708A1 (en)	1993-04-15

Publication	Publication Date	Title
TW229205B (cs)	1994-09-01
EP1458708A4 (en)	2005-11-16	HETEROARYLSUBSTITUTED TRIAZOLE MODULATORS OF THE METABOTROPIC GLUTAMATAR RECEPTOR 5
RU2008123376A (ru)	2009-12-27	Производные 4-(4-алкокси-3-гидроксифенил)-2-пирролидона в качестве ингибиторов pde-4 для лечения неврологических синдромов
NO20013546D0 (no)	2001-07-17	Godt renset etylEPA og andre EPA-derivater for psykiatriske og nevrologiske sykdommer
MX9203346A (es)	1992-08-31	(+)-1-(3-dimetilaminopropil)-1-(4'-fluorfenil)-1,3-dihidro-sobenofuran -5-carbonitrilo y sus sales de adicion de acido no toxicas farmaceuticamente utiles.
GR3031492T3 (en)	2000-01-31	1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders
ATE182591T1 (de)	1999-08-15	5-ht4 rezeptor antagonisten
SE9601110D0 (sv)	1996-03-22	Substituted 1,2,3,4-tetrahydronaphthalene derivatives
SE9501567D0 (sv)	1995-04-27	A new combination
FI930968A0 (fi)	1993-03-04	Indolderivat
KR970001306A (ko)	1997-01-24	향멜라토닌성 n-아실-2-아릴 시클로알킬메틸아민 유도체 및 이를 함유한 약제조성물
NO941256L (no)	1994-04-07	3-(N-isopropyl-N-n-propylamino)-5-(N-isopropyl)karbamoylkroman
FI92320B (fi)	1994-07-15	Menetelmä uusien terapeuttisesti käyttökelpoisten bisfenyylialkyylipiperatsiinijohdannaisten valmistamiseksi
KR920701122A (ko)	1992-08-11	신규 이환식 아미노-치환 화합물
ATE152708T1 (de)	1997-05-15	(1,2n) und (3,2n)-karbozyklische-2-amino- tetralinderivate
HUT61993A (en)	1993-03-29	Process for producing new imidazolylmethylpyridyl derivatives and pharmaceutical compositions comprising same as active ingredient
ATE123277T1 (de)	1995-06-15	2,3,3a,4,5,9b-hexahydro-1h-benzo(e>indol- derivate.
GB0120821D0 (en)	2001-10-17	Novel piperidin-2-6-dione salts and their use for the treatment of stress-related afective disorders
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