BR0011121A - Compostos antibacterianos - Google Patents

Compostos antibacterianos

Info

Publication number
BR0011121A
BR0011121A BR0011121-0A BR0011121A BR0011121A BR 0011121 A BR0011121 A BR 0011121A BR 0011121 A BR0011121 A BR 0011121A BR 0011121 A BR0011121 A BR 0011121A
Authority
BR
Brazil
Prior art keywords
alkyl
antibacterial compounds
compounds
antibacterial
alkylsulfoxyl
Prior art date
Application number
BR0011121-0A
Other languages
English (en)
Inventor
William H Miller
Kenneth A Newlander
Mark Seefeld
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0011121A publication Critical patent/BR0011121A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS ANTIBACTERIANOS". Compostos de fórmula (I) são descritos, os quais são inibidores de Fab I e são úteis no tratamento de infecções bacterianas, em que: R^ 1^ é Ar ou Het; R^ 2^ é H, alquila C~ 1-6~ ou Ar-alquila C~ 0-6~; X é H, alquila C~ 1-4~, OR', SR', alquilsulfonila C~ 1-4~, alquilsulfoxila C~ 1-4~, CN, N(R')~ 2~, CH~ 2~N(R')~ 2~, NO~ 2~, CF~ 3~, CO~ 2~R', CON(R')~ 2~, COR', NR'C(O)R', F, Cl, Br, I, ou CF~ 3~S (0)~ r~-; R' é H, alquila C~ 1-6~ ou Ar-alquila C~ 0-5~; e r é 0, 1 ou 2; ou um sal farmaceuticamente aceitável destes.
BR0011121-0A 1999-06-01 2000-06-01 Compostos antibacterianos BR0011121A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13700499P 1999-06-01 1999-06-01
PCT/US2000/015154 WO2000072846A1 (en) 1999-06-01 2000-06-01 Antibacterial compounds

Publications (1)

Publication Number Publication Date
BR0011121A true BR0011121A (pt) 2002-02-26

Family

ID=22475391

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011121-0A BR0011121A (pt) 1999-06-01 2000-06-01 Compostos antibacterianos

Country Status (23)

Country Link
US (2) US6573272B1 (pt)
EP (1) EP1180030B1 (pt)
JP (1) JP4733836B2 (pt)
KR (1) KR20020005767A (pt)
CN (1) CN1365280A (pt)
AR (1) AR024158A1 (pt)
AT (1) ATE283049T1 (pt)
AU (1) AU773550B2 (pt)
BR (1) BR0011121A (pt)
CA (1) CA2375630A1 (pt)
CO (1) CO5370679A1 (pt)
CZ (1) CZ20014290A3 (pt)
DE (1) DE60016198T2 (pt)
HK (1) HK1045644A1 (pt)
HU (1) HUP0201206A3 (pt)
IL (1) IL146514A0 (pt)
MX (1) MXPA01012326A (pt)
NO (1) NO20015722L (pt)
NZ (1) NZ515611A (pt)
PL (1) PL351959A1 (pt)
TR (1) TR200103485T2 (pt)
WO (1) WO2000072846A1 (pt)
ZA (1) ZA200109733B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
AR025976A1 (es) 1999-10-08 2002-12-26 Affinium Pharm Inc Inhibidores de fab i.
US6762201B1 (en) 1999-10-08 2004-07-13 Affinium Pharmaceuticals, Inc. Fab I inhibitors
EP1225894B1 (en) * 1999-10-08 2006-07-05 Affinium Pharmaceuticals, Inc. Fab i inhibitors
US6730684B1 (en) * 1999-10-08 2004-05-04 Affinium Pharmaceuticals, Inc. Fab I inhibitors
DE60111774T2 (de) * 2000-12-08 2006-05-04 Smithkline Beecham Corp. Antibakterielle verbindungen
AU2002237731B2 (en) * 2000-12-21 2007-03-22 Michael J. Kirisits Fab I and inhibition of apicomplexan parasites
AU2002246728A1 (en) * 2001-02-12 2002-08-28 Lilly Icos Llc Carboline derivatives
CA2444597A1 (en) * 2001-04-06 2002-10-06 Affinium Pharmaceuticals, Inc. Fab i inhibitors
CA2508792C (en) * 2002-12-06 2013-02-05 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
WO2004096802A2 (en) * 2003-04-29 2004-11-11 Oscient Pharmaceuticals ANTIBIOTIC TETRAHYDRO-β-CARBOLINE DERIVATIVES
CA2568914C (en) * 2004-06-04 2013-09-24 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
EP1973902A2 (en) * 2005-12-05 2008-10-01 Affinium Pharmaceuticals, Inc. 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
EP2687533B1 (en) * 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
US7854963B2 (en) * 2006-10-13 2010-12-21 Solopower, Inc. Method and apparatus for controlling composition profile of copper indium gallium chalcogenide layers
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
WO2009073534A2 (en) 2007-11-30 2009-06-11 Maxthera Inc. Bicyclic ppat inhibitors as antibacterial agents
KR101135179B1 (ko) * 2009-02-20 2012-04-16 한국생명공학연구원 ＦａｂＩ 저해 물질 비나산손을 포함하는 항균용 조성물
WO2012127885A1 (ja) 2011-03-18 2012-09-27 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
SMT201900411T1 (it) 2012-06-19 2019-09-09 Debiopharm Int Sa Derivati di profaramci di (e)-n-metil-n-((3-metilbenzofuran-2-il)metil -3-(7-osso-5,6,7,8-tetraidro-1,8-naftiridin-3-il)acrilammide
BR122023021456A2 (pt) 2016-02-26 2024-02-20 Debiopharm International S.A. Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
US12371429B2 (en) 2018-08-16 2025-07-29 Recreo Pharmaceuticals Llc Antibiotic resistance-modifying tricyclic heteroaryl compounds and uses thereof
FI3923914T3 (fi) 2019-02-14 2023-04-27 Debiopharm Int Sa Afabisiiniformulaatio, menetelmä sen valmistamiseksi
MA56184A (fr) 2019-06-14 2022-04-20 Debiopharm Int Sa Afabicine pour utilisation dans le traitement d'infections bactériennes impliquant un biofilm

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Publication number Priority date Publication date Assignee Title
US3828068A (en) 1971-05-10 1974-08-06 Tenneco Chem ((substituted indazolyl)-n1-methyl)carbamates
US4154943A (en) * 1977-12-29 1979-05-15 University Of Vermont Preparation of vincadifformine
US4267330A (en) * 1978-08-24 1981-05-12 Omnium Chimique Societe Anonyme Process for the synthesis of vincadifformine and related derivatives
FR2619111B1 (fr) * 1987-08-07 1991-01-11 Synthelabo Derives de (piperidinyl-4)methyl-2 tetrahydro-1,2,3,4 9h-pyrido (3,4-b) indole, leur preparation et leur application en therapeutique
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5416193A (en) * 1993-04-30 1995-05-16 Pfizer Inc. Coupling reagent and method
MA23420A1 (fr) 1994-01-07 1995-10-01 Smithkline Beecham Corp Antagonistes bicycliques de fibrinogene.
US5614551A (en) 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
AU702661B2 (en) 1994-06-29 1999-02-25 Smithkline Beecham Corporation Vitronectin receptor antagonists
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
JPH10310582A (ja) * 1997-03-13 1998-11-24 Sankyo Co Ltd ピペリジン環縮合カルバペネム化合物
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PT1042287E (pt) * 1997-12-24 2005-08-31 Aventis Pharma Gmbh Derivados de indole como inibidores do factor xa
IL141396A0 (en) * 1998-08-20 2002-03-10 Agouron Pharma Non-peptide gnrh agents, methods and intermediates for their preparation
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CO5180550A1 (es) 1999-04-19 2002-07-30 Smithkline Beecham Corp Inhibidores de fab i
AR024077A1 (es) 1999-05-25 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
CO5370679A1 (es) 1999-06-01 2004-02-27 Smithkline Beecham Corp Inhibidores fab 1
CO5180605A1 (es) 1999-06-23 2002-07-30 Smithkline Beecham Corp Compuestos de indol
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
EP1225894B1 (en) 1999-10-08 2006-07-05 Affinium Pharmaceuticals, Inc. Fab i inhibitors
WO2001026654A1 (en) 1999-10-08 2001-04-19 Smithkline Beecham Corporation Fab i inhibitors
AR025976A1 (es) 1999-10-08 2002-12-26 Affinium Pharm Inc Inhibidores de fab i.
US6503908B1 (en) 1999-10-11 2003-01-07 Pfizer Inc Pharmaceutically active compounds
US6656703B1 (en) 1999-12-29 2003-12-02 Millennium Pharamaceuticals, Inc. High throughput screen for inhibitors of fatty acid biosynthesis in bacteria
US6372752B1 (en) 2000-02-07 2002-04-16 Genzyme Corporation Inha inhibitors and methods of use thereof
CA2428191A1 (en) 2000-11-07 2002-05-30 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
AU2002232558A1 (en) 2000-12-12 2002-06-24 Corvas International, Inc. Compounds, compositions and methods for treatment of parasitic infections

Also Published As

Publication number Publication date
CO5370679A1 (es) 2004-02-27
AU773550B2 (en) 2004-05-27
US6964970B2 (en) 2005-11-15
AU5177400A (en) 2000-12-18
PL351959A1 (en) 2003-07-14
TR200103485T2 (tr) 2002-04-22
JP2003500448A (ja) 2003-01-07
CZ20014290A3 (cs) 2002-05-15
NO20015722D0 (no) 2001-11-23
WO2000072846A1 (en) 2000-12-07
HK1045644A1 (zh) 2002-12-06
HUP0201206A2 (en) 2002-08-28
ATE283049T1 (de) 2004-12-15
DE60016198T2 (de) 2005-12-01
US6573272B1 (en) 2003-06-03
CA2375630A1 (en) 2000-12-07
US20030232850A1 (en) 2003-12-18
HUP0201206A3 (en) 2003-07-28
NO20015722L (no) 2001-11-23
NZ515611A (en) 2004-05-28
AR024158A1 (es) 2002-09-04
MXPA01012326A (es) 2002-07-30
IL146514A0 (en) 2002-07-25
JP4733836B2 (ja) 2011-07-27
ZA200109733B (en) 2002-09-11
EP1180030B1 (en) 2004-11-24
KR20020005767A (ko) 2002-01-17
DE60016198D1 (de) 2004-12-30
EP1180030A1 (en) 2002-02-20
EP1180030A4 (en) 2002-09-25
CN1365280A (zh) 2002-08-21

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: AFFINIUM PHARMACEUTICALS, INC. (CA)

Free format text: TRANSFERIDO DE: SMITHKLINE BEECHAM CORPORATION

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.

B15K Others concerning applications: alteration of classification

Ipc: C07D 471/04 (2006.01), A61P 31/04 (2006.01)