BR0012047A - Inibidores da replicação do vìrus sincicial respiratório - Google Patents
Inibidores da replicação do vìrus sincicial respiratórioInfo
- Publication number
- BR0012047A BR0012047A BR0012047-2A BR0012047A BR0012047A BR 0012047 A BR0012047 A BR 0012047A BR 0012047 A BR0012047 A BR 0012047A BR 0012047 A BR0012047 A BR 0012047A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- hydrogen
- formula
- optionally substituted
- aryl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 2
- 230000029812 viral genome replication Effects 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- -1 Hetcarbonyl Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005189 alkyl hydroxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Patente de Invenção: "INIBIDORES DA REPLICAçãO DO VìRUS SINCICIAL RESPIRATóRIO". A invenção diz respeito aos compostos de fórmula (1), pró-drogas, N-óxidos, sais de adição, aminas quaternárias, complexos metálicos ou formas estereoquimicamente isoméricas dos mesmos em que -a^ 1^=a^ 2^-a^ 3^ =a^ 4^- é um radical de fórmula -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=NCH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N- em que cada átomo de hidrogênio pode ser substituído opcionalmente; Q é um radical de fórmula (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7), (b-8), em que Alq é C~ 1-6~ alcanodiil; Y^ 1^ é um radical bivalente de fórmula -NR^ 2^- ou -CH(NR^ 2^R^ 4^)-; X^ 1^ é NR^ 4^, S, S(=O), C(=O)~ 2~, O, CH~ 2~, C(=O), CH(=CH~ 2~), CH(OH), CH(CH~ 3~), CH(OCH~ 3~), CH(SCH~ 3~), CH(NR^ 5a^R^ 5b^), CH~ 2~-NR^ 4^ ou NR^ 4^-CH~ 2~; X^ 1^ é uma ligação direta, CH2, C(=O), NR^ 4^, C~ 1-4~ alquil-NR^ 4^, NR^ 4^-C~ 1-4~ alquil; t é 2 a 5; u é 1 a 5; v é 2 ou 3; e em que cada hidrogênio em Alq e em (b-3), (b-4), (b-5), (b-6), (b-7) e (b-8) pode ser substituído opcionalmente por R3; com a condição de que quando R^ 3^ é hidróxi ou C~ 1-6~ alquilóxi, então R^ 3^ não pode substituir um átomo de hidrogênio na posição <244> em relação a um átomo de nitrogênio; G é C~ 1-10 alcanodiil substituído em que o substituinte é ligado através de um átomo de oxigênio; R^ 1^ é um aril ou heterociclo monocíclico opcionalmente substituído; R^ 2^ é hidrogênio, formil, C~ 1-6~ alquilcarbonil, Hetcarbonil, pirrolidinil, piperidinil, homopiperidinil, C3-7 cicioalquil ou C~ 1-10~ alquil substituído com N(R^ 6^)~ 2~ e opcionalmente com outro substituinte; R^ 3^ é hidrogênio, hidróxi, C~ 1-6~ alquil, C~ 1-6~ alquilóxi, aril C~ 1-6~ alquil ou aril C~ 1-6~ alquilóxi; R^ 4^ é hidrogênio, C~ 1-6~ alquil ou aril C~ 1-6~ alquil; R^ 5a^, R^ 5b^, R^ 5c^ e R^ 5d^ são hidrogênio ou C~ 1-6~ alquil; ou R^ 5a^ e R^ 5b^, ou R^ 5c^ e R^ 5d^ tomados juntos formam um radical bivalente de fórmula -(CH~ 2~)~ S~-em que s é 4 ou 5; R^ 6^ é hidrogênio, C~ 1-6~ alquil, formil, hidróxi C~ 1-6~ alquil, C~ 1-6 alquilcarbonil OU C~ 1-6~ alquiloxicarbonil; aril é fenil opcionalmente substituído; Het é piridil, pirimidinil, pirazinil, piridazinil; como inibidores da replicação do vírus sincicial respiratório; sua preparação, composições contendo os mesmos e sua aplicação como um medicamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99202088 | 1999-06-28 | ||
| PCT/EP2000/005675 WO2001000612A2 (en) | 1999-06-28 | 2000-06-20 | Respiratory syncytial virus replication inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0012047A true BR0012047A (pt) | 2002-03-12 |
Family
ID=8240373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0012047-2A BR0012047A (pt) | 1999-06-28 | 2000-06-20 | Inibidores da replicação do vìrus sincicial respiratório |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US6747028B1 (pt) |
| EP (1) | EP1196409B1 (pt) |
| JP (1) | JP2003503402A (pt) |
| KR (1) | KR100731271B1 (pt) |
| CN (1) | CN1210275C (pt) |
| AR (1) | AR035991A1 (pt) |
| AT (1) | ATE258928T1 (pt) |
| AU (1) | AU778218B2 (pt) |
| BG (1) | BG65328B1 (pt) |
| BR (1) | BR0012047A (pt) |
| CA (1) | CA2376676C (pt) |
| DE (1) | DE60008112T2 (pt) |
| DK (1) | DK1196409T3 (pt) |
| EA (1) | EA005027B1 (pt) |
| EE (1) | EE04591B1 (pt) |
| ES (1) | ES2215683T3 (pt) |
| HK (1) | HK1045997A1 (pt) |
| HR (1) | HRP20010935A2 (pt) |
| HU (1) | HUP0201869A3 (pt) |
| IL (2) | IL147327A0 (pt) |
| MX (1) | MXPA02000120A (pt) |
| MY (1) | MY127687A (pt) |
| NO (1) | NO322458B1 (pt) |
| NZ (1) | NZ515664A (pt) |
| PL (1) | PL200674B1 (pt) |
| PT (1) | PT1196409E (pt) |
| SI (1) | SI1196409T1 (pt) |
| SK (1) | SK19122001A3 (pt) |
| TR (1) | TR200103806T2 (pt) |
| TW (1) | TWI278454B (pt) |
| UA (1) | UA74787C2 (pt) |
| WO (1) | WO2001000612A2 (pt) |
| ZA (1) | ZA200110479B (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495580B1 (en) | 1998-01-29 | 2002-12-17 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| MXPA02000120A (es) | 1999-06-28 | 2002-07-02 | Janssen Pharmaceutica Nv | Inhibidores de la replicacion del virus sincitial respiratorio. |
| EP1418175A1 (en) * | 1999-06-28 | 2004-05-12 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| US8202896B2 (en) | 2002-08-09 | 2012-06-19 | Microdose Therapeutx, Inc. | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| EP1539691A2 (en) | 2002-08-09 | 2005-06-15 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| JP2006505570A (ja) * | 2002-10-17 | 2006-02-16 | アムジエン・インコーポレーテツド | ベンズイミダゾール誘導体およびそれのバニロイド受容体リガンドとしての使用 |
| WO2005042530A1 (en) | 2003-10-30 | 2005-05-12 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| ATE435222T1 (de) * | 2003-12-18 | 2009-07-15 | Tibotec Pharm Ltd | Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus |
| AR046770A1 (es) * | 2003-12-18 | 2005-12-21 | Tibotec Pharm Ltd | Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio |
| AR046972A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| TWI349007B (en) | 2003-12-18 | 2011-09-21 | Tibotec Pharm Ltd | Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication |
| MXPA06007110A (es) | 2003-12-18 | 2006-08-23 | Tibotec Pharm Ltd | Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio. |
| DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
| RU2410382C2 (ru) | 2005-03-17 | 2011-01-27 | Тиботек Фармасьютикалз Лтд | 1, 3-дигидробензимидазол-2-илиденовые амины в качестве ингибиторов репликации респираторного синцитиального вируса |
| AU2006260969B2 (en) | 2005-06-20 | 2011-11-17 | Janssen Sciences Ireland Uc | 1- ( 2-amino-3- (substituted alkyl)-3H-benzimidazolylmethyl) -3-substituted-1,3-dihydro-benzoimidazol-2-ones with activity on respiratory syncytial virus |
| MX2007016311A (es) * | 2005-06-20 | 2008-03-07 | Tibotec Pharm Ltd | Bencimidazoles sustituidos con heterociclilaminoalquilo. |
| PL1896450T3 (pl) * | 2005-06-20 | 2013-01-31 | Janssen Sciences Ireland Uc | 2-podstawione benzimidazole |
| WO2011097607A1 (en) * | 2010-02-08 | 2011-08-11 | Southern Research Institute | Anti-viral treatment and assay to screen for anti-viral agent |
| TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
| TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
| TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
| TWI541241B (zh) | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| PL2797416T3 (pl) | 2011-12-28 | 2017-12-29 | Global Blood Therapeutics, Inc. | Podstawione związki benzaldehydowe i sposoby ich zastosowania do zwiększania natlenienia tkanek |
| US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| CA2873920C (en) | 2012-06-15 | 2021-07-20 | Janssen R&D Ireland | 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EP2968299B1 (en) | 2013-03-15 | 2021-01-20 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| BR112015021982B1 (pt) | 2013-03-15 | 2022-12-13 | Global Blood Therapeutics, Inc | Compostos e seus usos para a modulação de hemoglobina |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
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| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| JP6426694B2 (ja) | 2013-03-15 | 2018-11-21 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| AP2016009261A0 (en) | 2014-02-07 | 2016-06-30 | Global Blood Therapeutics Inc | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| JP2016079168A (ja) * | 2014-10-17 | 2016-05-16 | 塩野義製薬株式会社 | ９員縮合環誘導体 |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| PL3383392T3 (pl) | 2015-12-04 | 2025-11-17 | Global Blood Therapeutics, Inc. | Schematy dawkowania dla 2-hydroksy-6-((2-(1-izopropylo-1H-pirazol-5-ilo)pirydyn3-ylo)metoksy)benzaldehydu |
| TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
| JP2023528969A (ja) | 2020-06-11 | 2023-07-06 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２ イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンのヘミ（Ｌ）－酒石酸塩形態及びそれを含む医薬組成物 |
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2000
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- 2000-06-20 NZ NZ515664A patent/NZ515664A/xx unknown
- 2000-06-20 HU HU0201869A patent/HUP0201869A3/hu unknown
- 2000-06-20 EA EA200200088A patent/EA005027B1/ru not_active IP Right Cessation
- 2000-06-20 IL IL14732700A patent/IL147327A0/xx active IP Right Grant
- 2000-06-20 PT PT00943840T patent/PT1196409E/pt unknown
- 2000-06-20 BR BR0012047-2A patent/BR0012047A/pt not_active Application Discontinuation
- 2000-06-20 CN CNB008095442A patent/CN1210275C/zh not_active Expired - Fee Related
- 2000-06-20 WO PCT/EP2000/005675 patent/WO2001000612A2/en not_active Ceased
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- 2000-06-20 CA CA002376676A patent/CA2376676C/en not_active Expired - Fee Related
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- 2000-06-20 JP JP2001507021A patent/JP2003503402A/ja not_active Withdrawn
- 2000-06-20 HR HR20010935A patent/HRP20010935A2/hr not_active Application Discontinuation
- 2000-06-20 KR KR1020017015295A patent/KR100731271B1/ko not_active Expired - Fee Related
- 2000-06-20 SI SI200030315T patent/SI1196409T1/xx unknown
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- 2000-06-20 UA UA2002010360A patent/UA74787C2/uk unknown
- 2000-06-20 EP EP00943840A patent/EP1196409B1/en not_active Expired - Lifetime
- 2000-06-20 US US10/019,380 patent/US6747028B1/en not_active Expired - Fee Related
- 2000-06-20 DE DE60008112T patent/DE60008112T2/de not_active Expired - Fee Related
- 2000-06-20 EE EEP200100688A patent/EE04591B1/xx not_active IP Right Cessation
- 2000-06-20 SK SK1912-2001A patent/SK19122001A3/sk unknown
- 2000-06-20 DK DK00943840T patent/DK1196409T3/da active
- 2000-06-26 TW TW089112478A patent/TWI278454B/zh not_active IP Right Cessation
- 2000-06-27 AR ARP000103221A patent/AR035991A1/es not_active Application Discontinuation
- 2000-06-27 MY MYPI20002907A patent/MY127687A/en unknown
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2001
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2002
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