TR200103806T2 - Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler. - Google Patents

Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.

Info

Publication number
TR200103806T2
TR200103806T2 TR2001/03806T TR200103806T TR200103806T2 TR 200103806 T2 TR200103806 T2 TR 200103806T2 TR 2001/03806 T TR2001/03806 T TR 2001/03806T TR 200103806 T TR200103806 T TR 200103806T TR 200103806 T2 TR200103806 T2 TR 200103806T2
Authority
TR
Turkey
Prior art keywords
replication
respiratory syncytial
syncytial virus
inhibit
substances
Prior art date
Application number
TR2001/03806T
Other languages
English (en)
Inventor
Eduard Janssens Frans
Petrus Marie-Jos Meerman Kathleen
Maria Sommen Francois
Jozef Lodewijk Marcel Andries Koenraad
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of TR200103806T2 publication Critical patent/TR200103806T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Bu bulus, solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler olarak formül (I) e sahip bilesikler, bunlarin ön ilaçlari, <I>N</I>-oksitler, katilma tuzlari, kuaterner aminleri, metal kompleksleri veya stereokimyasal izomerik sekilleri; bunlarin hazirlanmasi, bunlari ihtiva eden terkipler ve bunlarin ilaç olarak kullanimi ile ilgili olup; burada -a1=a2-a3=a4, formül -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH- veya -CH=CH-CH=N- ye sahip bir radikaldir; Q, (b-1), (b-2), (b-3), (b-4), (b-5), (b-6), (b-7) ve (b-8) formülüne sahip bir radikaldir; G, sübstitüentin bir oksijen atomu üzerinden baglandigi sübstitüe edilmis bir C1-10 alkandiildir; R1, istege bagli olarak sübstitüe edilmis bir monosiklik heterohalka veya arildir; ve diger degiskenler tarifnamede tarif edildigi gibidir.
TR2001/03806T 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler. TR200103806T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28

Publications (1)

Publication Number Publication Date
TR200103806T2 true TR200103806T2 (tr) 2002-06-21

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03806T TR200103806T2 (tr) 1999-06-28 2000-06-20 Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.

Country Status (33)

Country Link
US (3) US6747028B1 (tr)
EP (1) EP1196409B1 (tr)
JP (1) JP2003503402A (tr)
KR (1) KR100731271B1 (tr)
CN (1) CN1210275C (tr)
AR (1) AR035991A1 (tr)
AT (1) ATE258928T1 (tr)
AU (1) AU778218B2 (tr)
BG (1) BG65328B1 (tr)
BR (1) BR0012047A (tr)
CA (1) CA2376676C (tr)
DE (1) DE60008112T2 (tr)
DK (1) DK1196409T3 (tr)
EA (1) EA005027B1 (tr)
EE (1) EE04591B1 (tr)
ES (1) ES2215683T3 (tr)
HK (1) HK1045997A1 (tr)
HR (1) HRP20010935A2 (tr)
HU (1) HUP0201869A3 (tr)
IL (2) IL147327A0 (tr)
MX (1) MXPA02000120A (tr)
MY (1) MY127687A (tr)
NO (1) NO322458B1 (tr)
NZ (1) NZ515664A (tr)
PL (1) PL200674B1 (tr)
PT (1) PT1196409E (tr)
SI (1) SI1196409T1 (tr)
SK (1) SK19122001A3 (tr)
TR (1) TR200103806T2 (tr)
TW (1) TWI278454B (tr)
UA (1) UA74787C2 (tr)
WO (1) WO2001000612A2 (tr)
ZA (1) ZA200110479B (tr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495580B1 (en) 1998-01-29 2002-12-17 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
EP1418175A1 (en) * 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
ATE258928T1 (de) 1999-06-28 2004-02-15 Janssen Pharmaceutica Nv Respiratorisches syncytialvirus replikation inhibitoren
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
AU2003258176A1 (en) 2002-08-09 2004-02-25 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2004014317A2 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
AU2003301436A1 (en) * 2002-10-17 2004-05-04 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
US7323567B2 (en) 2003-10-30 2008-01-29 Boehringer Ingelheim (Canada) Ltd. RSV polymerase inhibitors
AR046972A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Derivados de los amino-bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
JP2007514718A (ja) 2003-12-18 2007-06-07 テイボテク・フアーマシユーチカルズ・リミテツド 呼吸器シンシチウムウイルス複製のインヒビターとしてのアミノ−ベンズイミダゾール誘導体
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
CN103450159A (zh) 2003-12-18 2013-12-18 泰博特克药品有限公司 作为呼吸道合胞病毒复制的抑制剂的哌啶-氨基-苯并咪唑类衍生物
TWI356055B (en) * 2003-12-18 2012-01-11 Tibotec Pharm Ltd Aminobenzimidazoles and benzimidazoles as inhibito
MY142783A (en) * 2003-12-18 2010-12-31 Tibotec Pharm Ltd 5-or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
DE102004010207A1 (de) * 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
MX2007011292A (es) 2005-03-17 2007-11-07 Tibotec Pharm Ltd 1,3-dihidro-bencimidazol-2-ilidenaminas como inhibidores de replicacion de virus respiratorios sinciciales.
US7884215B2 (en) * 2005-06-20 2011-02-08 Bonfanti Jean-Francois 2-substituted benzimidazoles
MX2007016537A (es) 2005-06-20 2008-03-06 Tibotec Pharm Ltd 1,3-dihidro-benzoimidazol-onas 1-(2-amino-3-(alquilo sustituido)-3h-bencimidazolilmetil)-3-sustituidas con actividad sobre virus respiratorios sinciciales.
WO2006136562A1 (en) 2005-06-20 2006-12-28 Tibotec Pharmaceuticals Ltd Heterocyclylaminoalkyl substituted benzimidazoles
WO2011097607A1 (en) * 2010-02-08 2011-08-11 Southern Research Institute Anti-viral treatment and assay to screen for anti-viral agent
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
DK3738434T3 (da) 2011-12-28 2023-12-04 Global Blood Therapeutics Inc Mellemprodukter til opnåelse af substituerede benzaldehydforbindelser og fremgangsmåder til anvendelse deraf ved øgning af vævsoxygenering
WO2013102145A1 (en) 2011-12-28 2013-07-04 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
PL2864323T3 (pl) 2012-06-15 2017-09-29 Janssen Sciences Ireland Uc Pochodne 1,3-dihydro-2h-benzoimidazol-2-onu podstawione heterocyklami jako środki przeciwwirusowe przeciwko wirusowi syncytium nabłonka oddechowego
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
AU2014237330A1 (en) 2013-03-15 2015-09-17 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
BR112015021982B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos e seus usos para a modulação de hemoglobina
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
KR102280614B1 (ko) 2013-03-15 2021-07-21 글로벌 블러드 테라퓨틱스, 인크. 헤모글로빈 조정을 위한 화합물 및 이의 용도
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
SI3102208T2 (sl) 2014-02-07 2024-10-30 Global Blood Therapeutics, Inc. Kristalinični polimorf proste baze 2-hidroksi-6-((2-(1-izopropil-1H-pirazol-5-IL)piridin-3-IL)metoksi)- benzaldehida
JP2016079168A (ja) 2014-10-17 2016-05-16 塩野義製薬株式会社 ９員縮合環誘導体
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
US11020382B2 (en) 2015-12-04 2021-06-01 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
WO2021250180A1 (en) 2020-06-11 2021-12-16 Janssen Sciences Ireland Unlimited Company Hemi (l)-tartrate forms of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one and pharmaceutical compositions comprising the same

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4556660A (en) 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
EP0144101B1 (en) 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4588722A (en) 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
CA1327579C (en) 1986-02-03 1994-03-08 Frans Eduard Janssens Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
NZ223654A (en) 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4897401A (en) 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
GB8716313D0 (en) * 1987-07-10 1987-08-19 Janssen Pharmaceutica Nv 2-(heterocyclylalkyl)imidazopyridines
US5360807A (en) * 1990-07-19 1994-11-01 Janssen Pharmaceutica N.V. Substituted thiazolyl and substituted pyridinyl derivatives
NZ238863A (en) * 1990-07-19 1993-03-26 Janssen Pharmaceutica Nv Substituted thiazolyl and pyridinyl derivatives
KR100190299B1 (ko) 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
US5693661A (en) 1995-06-07 1997-12-02 Eli Lilly And Company Anti-viral compounds
PE107598A1 (es) 1996-09-11 1999-01-29 Ucb Sa Cetirizina util para el tratamiento de enfermedades de tipo virico
AU6031898A (en) 1997-01-22 1998-08-07 Eli Lilly And Company Anti-viral compounds
AU7715198A (en) 1997-06-04 1998-12-21 Eli Lilly And Company Anti-viral compounds
ATE258928T1 (de) 1999-06-28 2004-02-15 Janssen Pharmaceutica Nv Respiratorisches syncytialvirus replikation inhibitoren

Also Published As

Publication number Publication date
CA2376676A1 (en) 2001-01-04
BG65328B1 (bg) 2008-02-29
EA200200088A1 (ru) 2002-06-27
MY127687A (en) 2006-12-29
DE60008112D1 (en) 2004-03-11
DE60008112T2 (de) 2004-09-16
UA74787C2 (en) 2006-02-15
PT1196409E (pt) 2004-06-30
US20070015747A1 (en) 2007-01-18
PL352378A1 (en) 2003-08-25
SI1196409T1 (en) 2004-06-30
CA2376676C (en) 2009-01-20
CN1358181A (zh) 2002-07-10
EP1196409A2 (en) 2002-04-17
US20070135404A1 (en) 2007-06-14
ES2215683T3 (es) 2004-10-16
EE200100688A (et) 2003-04-15
US7528149B2 (en) 2009-05-05
HK1045997A1 (zh) 2002-12-20
US6747028B1 (en) 2004-06-08
US7179811B2 (en) 2007-02-20
JP2003503402A (ja) 2003-01-28
BG106286A (en) 2002-10-31
NZ515664A (en) 2004-01-30
CN1210275C (zh) 2005-07-13
AU5816600A (en) 2001-01-31
TWI278454B (en) 2007-04-11
BR0012047A (pt) 2002-03-12
MXPA02000120A (es) 2002-07-02
NO20016369D0 (no) 2001-12-27
NO20016369L (no) 2002-02-20
WO2001000612A3 (en) 2001-03-29
KR100731271B1 (ko) 2007-06-21
EP1196409B1 (en) 2004-02-04
ZA200110479B (en) 2003-03-20
HUP0201869A3 (en) 2003-12-29
EA005027B1 (ru) 2004-10-28
AU778218B2 (en) 2004-11-25
WO2001000612A2 (en) 2001-01-04
IL147327A (en) 2007-06-03
HRP20010935A2 (en) 2003-06-30
AR035991A1 (es) 2004-08-04
ATE258928T1 (de) 2004-02-15
NO322458B1 (no) 2006-10-09
DK1196409T3 (da) 2004-06-07
HUP0201869A2 (hu) 2002-11-28
SK19122001A3 (sk) 2003-01-09
EE04591B1 (et) 2006-02-15
KR20020003884A (ko) 2002-01-15
PL200674B1 (pl) 2009-01-30
IL147327A0 (en) 2002-08-14

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