EE04591B1 - Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt - Google Patents

Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt

Info

Publication number
EE04591B1
EE04591B1 EEP200100688A EEP200100688A EE04591B1 EE 04591 B1 EE04591 B1 EE 04591B1 EE P200100688 A EEP200100688 A EE P200100688A EE P200100688 A EEP200100688 A EE P200100688A EE 04591 B1 EE04591 B1 EE 04591B1
Authority
EE
Estonia
Prior art keywords
preparation
intermediates
product
pharmaceutical composition
respiratory syncytial
Prior art date
Application number
EEP200100688A
Other languages
English (en)
Inventor
Eduard Janssens Frans
Maria Sommen Fran�ois
Petrus Marie-Jos Meersman Kathleen
Jozef Lodewijk Marcel Andries Koenraad
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100688A publication Critical patent/EE200100688A/et
Publication of EE04591B1 publication Critical patent/EE04591B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EEP200100688A 1999-06-28 2000-06-20 Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt EE04591B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28
PCT/EP2000/005675 WO2001000612A2 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (2)

Publication Number Publication Date
EE200100688A EE200100688A (et) 2003-04-15
EE04591B1 true EE04591B1 (et) 2006-02-15

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100688A EE04591B1 (et) 1999-06-28 2000-06-20 Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt

Country Status (33)

Country Link
US (3) US6747028B1 (et)
EP (1) EP1196409B1 (et)
JP (1) JP2003503402A (et)
KR (1) KR100731271B1 (et)
CN (1) CN1210275C (et)
AR (1) AR035991A1 (et)
AT (1) ATE258928T1 (et)
AU (1) AU778218B2 (et)
BG (1) BG65328B1 (et)
BR (1) BR0012047A (et)
CA (1) CA2376676C (et)
DE (1) DE60008112T2 (et)
DK (1) DK1196409T3 (et)
EA (1) EA005027B1 (et)
EE (1) EE04591B1 (et)
ES (1) ES2215683T3 (et)
HK (1) HK1045997A1 (et)
HR (1) HRP20010935A2 (et)
HU (1) HUP0201869A3 (et)
IL (2) IL147327A0 (et)
MX (1) MXPA02000120A (et)
MY (1) MY127687A (et)
NO (1) NO322458B1 (et)
NZ (1) NZ515664A (et)
PL (1) PL200674B1 (et)
PT (1) PT1196409E (et)
SI (1) SI1196409T1 (et)
SK (1) SK19122001A3 (et)
TR (1) TR200103806T2 (et)
TW (1) TWI278454B (et)
UA (1) UA74787C2 (et)
WO (1) WO2001000612A2 (et)
ZA (1) ZA200110479B (et)

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WO2004014316A2 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
PL377215A1 (pl) * 2002-10-17 2006-01-23 Amgen Inc. Pochodne benzimidazolu oraz ich zastosowanie w charakterze ligandów receptora waniloidowego
US7323567B2 (en) 2003-10-30 2008-01-29 Boehringer Ingelheim (Canada) Ltd. RSV polymerase inhibitors
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DE602004021135D1 (de) 2003-12-18 2009-06-25 Tibotec Pharm Ltd Aminobenzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
AR046770A1 (es) * 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio
RU2381224C2 (ru) 2003-12-18 2010-02-10 Тиботек Фармасьютикалз Лтд. Пиперидинаминобензимидазольные производные как ингибиторы репликации респираторного синцитиального вируса
MY140893A (en) * 2003-12-18 2010-01-29 Tibotec Pharm Ltd Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
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TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
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US20150111868A1 (en) 2012-06-15 2015-04-23 Jansen R&D Ireland Novel 1,3-dihydro-2h-benzimidazol-2-one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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Also Published As

Publication number Publication date
NZ515664A (en) 2004-01-30
AR035991A1 (es) 2004-08-04
MY127687A (en) 2006-12-29
WO2001000612A3 (en) 2001-03-29
AU5816600A (en) 2001-01-31
TR200103806T2 (tr) 2002-06-21
NO322458B1 (no) 2006-10-09
US20070135404A1 (en) 2007-06-14
HRP20010935A2 (en) 2003-06-30
SK19122001A3 (sk) 2003-01-09
CN1210275C (zh) 2005-07-13
BG106286A (en) 2002-10-31
BG65328B1 (bg) 2008-02-29
UA74787C2 (en) 2006-02-15
EA200200088A1 (ru) 2002-06-27
MXPA02000120A (es) 2002-07-02
NO20016369D0 (no) 2001-12-27
IL147327A (en) 2007-06-03
DE60008112T2 (de) 2004-09-16
KR20020003884A (ko) 2002-01-15
JP2003503402A (ja) 2003-01-28
ATE258928T1 (de) 2004-02-15
HK1045997A1 (zh) 2002-12-20
AU778218B2 (en) 2004-11-25
EP1196409B1 (en) 2004-02-04
CN1358181A (zh) 2002-07-10
BR0012047A (pt) 2002-03-12
TWI278454B (en) 2007-04-11
CA2376676A1 (en) 2001-01-04
IL147327A0 (en) 2002-08-14
PL352378A1 (en) 2003-08-25
ES2215683T3 (es) 2004-10-16
US20070015747A1 (en) 2007-01-18
CA2376676C (en) 2009-01-20
EP1196409A2 (en) 2002-04-17
ZA200110479B (en) 2003-03-20
KR100731271B1 (ko) 2007-06-21
SI1196409T1 (en) 2004-06-30
US7528149B2 (en) 2009-05-05
PT1196409E (pt) 2004-06-30
WO2001000612A2 (en) 2001-01-04
HUP0201869A2 (hu) 2002-11-28
US6747028B1 (en) 2004-06-08
PL200674B1 (pl) 2009-01-30
HUP0201869A3 (en) 2003-12-29
DE60008112D1 (en) 2004-03-11
EA005027B1 (ru) 2004-10-28
DK1196409T3 (da) 2004-06-07
US7179811B2 (en) 2007-02-20
NO20016369L (no) 2002-02-20
EE200100688A (et) 2003-04-15

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