ATE258928T1 - Respiratorisches syncytialvirus replikation inhibitoren - Google Patents

Respiratorisches syncytialvirus replikation inhibitoren

Info

Publication number
ATE258928T1
ATE258928T1 AT00943840T AT00943840T ATE258928T1 AT E258928 T1 ATE258928 T1 AT E258928T1 AT 00943840 T AT00943840 T AT 00943840T AT 00943840 T AT00943840 T AT 00943840T AT E258928 T1 ATE258928 T1 AT E258928T1
Authority
AT
Austria
Prior art keywords
replication inhibitors
syncytialvirus
respiratory
respiratory syncytialvirus
replication
Prior art date
Application number
AT00943840T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Kathleen Petrus Marie Meersman
Francois Maria Sommen
Koenraad Jozef Lodewij Andries
Turnhoutseweg
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE258928T1 publication Critical patent/ATE258928T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00943840T 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren ATE258928T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28
PCT/EP2000/005675 WO2001000612A2 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (1)

Publication Number Publication Date
ATE258928T1 true ATE258928T1 (de) 2004-02-15

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00943840T ATE258928T1 (de) 1999-06-28 2000-06-20 Respiratorisches syncytialvirus replikation inhibitoren

Country Status (33)

Country Link
US (3) US6747028B1 (de)
EP (1) EP1196409B1 (de)
JP (1) JP2003503402A (de)
KR (1) KR100731271B1 (de)
CN (1) CN1210275C (de)
AR (1) AR035991A1 (de)
AT (1) ATE258928T1 (de)
AU (1) AU778218B2 (de)
BG (1) BG65328B1 (de)
BR (1) BR0012047A (de)
CA (1) CA2376676C (de)
DE (1) DE60008112T2 (de)
DK (1) DK1196409T3 (de)
EA (1) EA005027B1 (de)
EE (1) EE04591B1 (de)
ES (1) ES2215683T3 (de)
HK (1) HK1045997A1 (de)
HR (1) HRP20010935A2 (de)
HU (1) HUP0201869A3 (de)
IL (2) IL147327A0 (de)
MX (1) MXPA02000120A (de)
MY (1) MY127687A (de)
NO (1) NO322458B1 (de)
NZ (1) NZ515664A (de)
PL (1) PL200674B1 (de)
PT (1) PT1196409E (de)
SI (1) SI1196409T1 (de)
SK (1) SK19122001A3 (de)
TR (1) TR200103806T2 (de)
TW (1) TWI278454B (de)
UA (1) UA74787C2 (de)
WO (1) WO2001000612A2 (de)
ZA (1) ZA200110479B (de)

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EA005027B1 (ru) 1999-06-28 2004-10-28 Янссен Фармацевтика Н.В. Ингибиторы репликации респираторно-синцитиального вируса
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US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
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US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
CA2495266A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
US8119672B2 (en) 2002-08-09 2012-02-21 Microdose Therapeutx, Inc. Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
EP1551811A1 (de) * 2002-10-17 2005-07-13 Amgen Inc. Benzimidazolderivate und deren verwendung als vanilloidrezeptorliganden
WO2005042530A1 (en) 2003-10-30 2005-05-12 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
CN1894236B (zh) * 2003-12-18 2011-08-17 泰博特克药品有限公司 作为呼吸道合胞病毒复制抑制剂的氨基-苯并咪唑类衍生物
DE602004021135D1 (de) * 2003-12-18 2009-06-25 Tibotec Pharm Ltd Aminobenzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus
RU2369606C2 (ru) * 2003-12-18 2009-10-10 Тиботек Фармасьютикалз Лтд. Производные 5- или 6-замещенных бензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса
ATE501135T1 (de) * 2003-12-18 2011-03-15 Tibotec Pharm Ltd Piperidinamino-benzimidazol-derivate al respiratorisches syncytialvirus replikation inhibitoren
EP1697343B1 (de) 2003-12-18 2009-07-01 Tibotec Pharmaceuticals Ltd. Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
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BRPI0611744B8 (pt) 2005-06-20 2021-05-25 Janssen R & D Ireland benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica
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TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
ES2643403T3 (es) 2011-12-28 2017-11-22 Global Blood Therapeutics, Inc. Compuestos de benzaldehído sustituidos y métodos para su uso en el aumento de la oxigenación tisular
HK1203412A1 (en) 2011-12-28 2015-10-30 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
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MX379235B (es) 2013-03-15 2025-03-11 Global Blood Therapeutics Inc Compuestos y sus usos para modular la hemoglobina.
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
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JP2016079168A (ja) * 2014-10-17 2016-05-16 塩野義製薬株式会社 ９員縮合環誘導体
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TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin
JP2023528969A (ja) 2020-06-11 2023-07-06 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ３－（｛５－クロロ－１－［３－（メチルスルホニル）プロピル］－１Ｈ－インドール－２ イル｝メチル）－１－（２，２，２－トリフルオロエチル）－１，３－ジヒドロ－２Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－オンのヘミ（Ｌ）－酒石酸塩形態及びそれを含む医薬組成物

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Also Published As

Publication number Publication date
BR0012047A (pt) 2002-03-12
AU778218B2 (en) 2004-11-25
HRP20010935A2 (en) 2003-06-30
EA005027B1 (ru) 2004-10-28
IL147327A (en) 2007-06-03
UA74787C2 (en) 2006-02-15
KR20020003884A (ko) 2002-01-15
EP1196409B1 (de) 2004-02-04
BG106286A (en) 2002-10-31
HUP0201869A3 (en) 2003-12-29
EE200100688A (et) 2003-04-15
NO322458B1 (no) 2006-10-09
MXPA02000120A (es) 2002-07-02
BG65328B1 (bg) 2008-02-29
EP1196409A2 (de) 2002-04-17
MY127687A (en) 2006-12-29
EA200200088A1 (ru) 2002-06-27
CN1210275C (zh) 2005-07-13
SK19122001A3 (sk) 2003-01-09
US7528149B2 (en) 2009-05-05
IL147327A0 (en) 2002-08-14
WO2001000612A2 (en) 2001-01-04
DE60008112D1 (en) 2004-03-11
HUP0201869A2 (hu) 2002-11-28
PL200674B1 (pl) 2009-01-30
TR200103806T2 (tr) 2002-06-21
DK1196409T3 (da) 2004-06-07
PT1196409E (pt) 2004-06-30
HK1045997A1 (zh) 2002-12-20
US20070015747A1 (en) 2007-01-18
ES2215683T3 (es) 2004-10-16
DE60008112T2 (de) 2004-09-16
PL352378A1 (en) 2003-08-25
US6747028B1 (en) 2004-06-08
EE04591B1 (et) 2006-02-15
CN1358181A (zh) 2002-07-10
WO2001000612A3 (en) 2001-03-29
NO20016369L (no) 2002-02-20
TWI278454B (en) 2007-04-11
CA2376676C (en) 2009-01-20
US7179811B2 (en) 2007-02-20
ZA200110479B (en) 2003-03-20
NZ515664A (en) 2004-01-30
CA2376676A1 (en) 2001-01-04
JP2003503402A (ja) 2003-01-28
NO20016369D0 (no) 2001-12-27
KR100731271B1 (ko) 2007-06-21
US20070135404A1 (en) 2007-06-14
AU5816600A (en) 2001-01-31
SI1196409T1 (en) 2004-06-30
AR035991A1 (es) 2004-08-04

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