BR0012084A - Compostos, composição farmacêutica e usos dos compostos - Google Patents

Compostos, composição farmacêutica e usos dos compostos

Info

Publication number
BR0012084A
BR0012084A BR0012084-7A BR0012084A BR0012084A BR 0012084 A BR0012084 A BR 0012084A BR 0012084 A BR0012084 A BR 0012084A BR 0012084 A BR0012084 A BR 0012084A
Authority
BR
Brazil
Prior art keywords
compounds
disorders
new compounds
pharmaceutical composition
relates
Prior art date
Application number
BR0012084-7A
Other languages
English (en)
Inventor
Albert J Robichaud
Taekyu Lee
Wei Deng
Ian S Mitchell
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of BR0012084A publication Critical patent/BR0012084A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

"COMPOSTOS, COMPOSIçãO FARMACêUTICA E USOS DOS COMPOSTOS". A presente invenção se refere a determinados compostos novos representados pela Fórmula estrutural (I); ou as suas formas de sais farmaceuticamente aceitáveis, na qual R^ 1^, R^ 5^ R^ 6a^, R^ 6b^, R^ 7^, R^ 8^, R^ 9^, X, b, k, m, e n, e as linhas descontínuas são aqui descritos. A invenção também se refere a formulações farmacêuticas que compreendem esses novos compostos como ingredientes ativos e ao uso dos novos compostos e de suas formulações no tratamento de determinados distúrbios. Os compostos da presente invenção são agonistas e antagonistas de serotonina e são úteis no controle ou na prevenção de distúrbios do sistema nervoso central incluindo a obesidade, a ansiedade, a depressão, a psicose, a esquizofrenia, os distúrbios do sono, distúrbios sexuais, enxaqueca, condições associadas com a dor cefálica, fobias sociais, e distúrbios gastrintestinais tais como a disfunção da motilidade do trato gastrintestinal.
BR0012084-7A 1999-06-15 2000-06-15 Compostos, composição farmacêutica e usos dos compostos BR0012084A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13932199P 1999-06-15 1999-06-15
PCT/US2000/016375 WO2000077001A1 (en) 1999-06-15 2000-06-15 Substituted heterocycle fused gamma-carbolines

Publications (1)

Publication Number Publication Date
BR0012084A true BR0012084A (pt) 2002-04-02

Family

ID=22486095

Family Applications (3)

Application Number Title Priority Date Filing Date
BR0012084-7A BR0012084A (pt) 1999-06-15 2000-06-15 Compostos, composição farmacêutica e usos dos compostos
BR0012411-7A BR0012411A (pt) 1999-06-15 2000-06-15 Compostos agonistas e antagonistas de serotonina, composição farmacêutica e usos dos compostos
BR0012086-3A BR0012086A (pt) 1999-06-15 2000-06-15 Compostos derivados de gama-carbolinas fundidas com heterociclos substituìdos, composição farmacêutica e usos dos compostos

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR0012411-7A BR0012411A (pt) 1999-06-15 2000-06-15 Compostos agonistas e antagonistas de serotonina, composição farmacêutica e usos dos compostos
BR0012086-3A BR0012086A (pt) 1999-06-15 2000-06-15 Compostos derivados de gama-carbolinas fundidas com heterociclos substituìdos, composição farmacêutica e usos dos compostos

Country Status (19)

Country Link
US (7) US6548493B1 (pt)
EP (3) EP1189905B1 (pt)
JP (3) JP4916633B2 (pt)
CN (3) CN1370176A (pt)
AR (3) AR024378A1 (pt)
AT (3) ATE277048T1 (pt)
AU (3) AU5738000A (pt)
BR (3) BR0012084A (pt)
CA (3) CA2373920A1 (pt)
DE (3) DE60014079T2 (pt)
ES (3) ES2223537T3 (pt)
HK (3) HK1042481A1 (pt)
IL (3) IL145998A0 (pt)
MX (3) MXPA01012969A (pt)
NO (3) NO20016128L (pt)
NZ (1) NZ516031A (pt)
TR (1) TR200103658T2 (pt)
WO (3) WO2000077001A1 (pt)
ZA (1) ZA200109735B (pt)

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