BR0014945A - Modificação pós-traducional de proteìnas recombinantes produzidas em plantas - Google Patents
Modificação pós-traducional de proteìnas recombinantes produzidas em plantasInfo
- Publication number
- BR0014945A BR0014945A BR0014945-4A BR0014945A BR0014945A BR 0014945 A BR0014945 A BR 0014945A BR 0014945 A BR0014945 A BR 0014945A BR 0014945 A BR0014945 A BR 0014945A
- Authority
- BR
- Brazil
- Prior art keywords
- plants
- genetically engineered
- recombinant proteins
- proteins produced
- posttranslational modification
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 230000004481 post-translational protein modification Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16075899P | 1999-10-21 | 1999-10-21 | |
| US19528200P | 2000-04-07 | 2000-04-07 | |
| PCT/US2000/029027 WO2001029242A2 (fr) | 1999-10-21 | 2000-10-20 | Modification post-traductionnelle de proteines de recombinaison produites dans les plantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0014945A true BR0014945A (pt) | 2004-08-31 |
Family
ID=26857200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0014945-4A BR0014945A (pt) | 1999-10-21 | 2000-10-20 | Modificação pós-traducional de proteìnas recombinantes produzidas em plantas |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1224309A2 (fr) |
| AU (1) | AU1573601A (fr) |
| BR (1) | BR0014945A (fr) |
| CA (1) | CA2388432A1 (fr) |
| WO (1) | WO2001029242A2 (fr) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| DK1137789T3 (da) | 1998-12-09 | 2010-11-08 | Phyton Holdings Llc | Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type |
| DE60044858D1 (de) | 1999-10-26 | 2010-09-30 | Stichting Dienst Landbouwkundi | Säugetierartige Glykosylierung in Pflanzen |
| AT409381B (de) * | 2000-03-03 | 2002-07-25 | Gloessl Josef Dr | Xylosyltransferase-gen |
| EP2213743A1 (fr) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Protéines de fusion d'albumine |
| US7598055B2 (en) * | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
| US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
| DK1356068T3 (en) | 2001-01-19 | 2015-02-16 | Phyton Holdings Llc | PROCESS FOR THE PRODUCTION OF secretory glycoprotein with HUMAN TYPE SUGAR CHAIN FOR USING A PLANT CELL |
| US20030033637A1 (en) | 2001-06-05 | 2003-02-13 | Croptech Corporation | Gene expression and production of TGF-beta proteins including bioactive mullerian inhibiting substance from plants |
| CN1533438A (zh) * | 2001-06-08 | 2004-09-29 | �����Ŵ��Ƽ���˾ | 在植物生产蛋白质的方法 |
| WO2005003296A2 (fr) | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Proteines hybrides d'albumine |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| CN1665934B (zh) * | 2002-03-19 | 2010-05-26 | 国际植物研究所 | GNTIII(UDP-N乙酰葡萄糖胺:β-D-甘露糖苷β(1,4)-N-乙酰葡萄糖胺基-转移酶III)在植物中的表达 |
| CN101613705A (zh) * | 2002-03-19 | 2009-12-30 | 国际植物研究所 | 在植物中优化聚糖生成 |
| AU2008202355B2 (en) * | 2002-03-19 | 2011-04-07 | Stichting Dienst Landbouwkundig Onderzoek | Optimizing glycan processing in plants |
| CL2003002461A1 (es) | 2002-11-27 | 2005-01-07 | Dow Chemical Company Agroscien | Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas. |
| ATE335084T1 (de) * | 2002-12-20 | 2006-08-15 | Greenovation Biotech Gmbh | Verfahren zur herstellung von glykosylierten proteinen in bryophyten zellen |
| WO2004057002A2 (fr) * | 2002-12-20 | 2004-07-08 | Greenovation Biotech Gmbh | Ameliorations apportees ou associees a la production de proteines |
| WO2004067029A1 (fr) * | 2002-12-27 | 2004-08-12 | Shenzhen Tsinghua Yuanxing Bio-Pharm Science & Technology Co., Ltd. | Procede de preparation d'un vaccin et vaccins antitumoraux |
| EP2248892B1 (fr) * | 2003-01-22 | 2015-04-22 | Roche Glycart AG | Constructions à fusion et utilisation associée pour produire des anticorps avec un récepteur FC liant l'affinité et fonction effectrice |
| CN100427599C (zh) * | 2003-12-26 | 2008-10-22 | 吉林大学第一医院 | Albsin/il－18mat杂交细胞因子 |
| DE602005023332D1 (de) * | 2004-09-29 | 2010-10-14 | Collplant Ltd | Kollagenproduzierende pflanzen sowie verfahren zu deren erzeugung und verwendung |
| JP2009526520A (ja) | 2006-01-17 | 2009-07-23 | バイオレックス セラピュティックス インク | 植物中でのｎ−グリカンのヒト化及び最適化のための組成物及び方法 |
| EP1816201A1 (fr) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée |
| RU2481399C2 (ru) * | 2006-11-08 | 2013-05-10 | Сентр Насьональ Де Ла Решерш Сьентифик-Снрс | Набор последовательностей для таргетинга экспрессии и контроля посттрансляционных модификаций рекомбинантного полипептида |
| WO2008125972A2 (fr) | 2007-04-17 | 2008-10-23 | Plant Research International B.V. | Glycosylation de type mammifère dans des plantes par l'expression de glycosyltransférases non mammifères |
| DK2155880T3 (en) * | 2007-06-15 | 2016-12-05 | Medicago Inc | Modification of glycoproteinproduktion i plants |
| WO2009056155A1 (fr) * | 2007-10-31 | 2009-05-07 | Bayer Bioscience N.V. | Procédé de production de plantes modifiées à schéma de n-glycosylation modifié |
| CA2700197C (fr) | 2007-11-08 | 2020-09-08 | Neogenix Oncology, Inc. | Anticorps monoclonaux recombinants et antigenes correspondants pour des cancers du colon et du pancreas |
| NZ590351A (en) | 2008-07-18 | 2012-11-30 | Medicago Inc | HA1 domain totally or partially free of N-linked glycosylation operatively linked to a regulatory region |
| EP2773964A4 (fr) * | 2011-11-03 | 2015-06-24 | Stc Biolog Inc | Procédé de détermination de propriétés pharmacologiques de protéines recombinantes |
| WO2014130922A1 (fr) | 2013-02-25 | 2014-08-28 | Trustees Of Boston University | Compositions et procédés pour le traitement d'infections fongiques |
| GB201308120D0 (en) * | 2013-05-06 | 2013-06-12 | Baden Wuerttemberg Stiftung Gmbh | Recombinant protein and method for its production |
| WO2015003114A1 (fr) | 2013-07-05 | 2015-01-08 | University Of Washington Through Its Center For Commercialization | Anticorps monoclonal neutralisant la protéine mic soluble pour le traitement du cancer |
| JPWO2015050005A1 (ja) * | 2013-10-02 | 2017-03-09 | 株式会社ＵｎｉＢｉｏ | Ｅｇｆ受容体を介して細胞増殖を促進するタンパク質組成物 |
| WO2016079739A2 (fr) | 2014-11-20 | 2016-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions et procédés de production de polypeptides présentant un schéma de glycosylation modifié dans des cellules végétales |
| KR20240005973A (ko) * | 2016-04-15 | 2024-01-12 | 리젠엑스바이오 인크. | 완전히-인간형의 번역후 변형된 항-VEGF Fab를 이용한 눈 질환의 치료 |
| SG11201808426XA (en) | 2016-04-15 | 2018-10-30 | Univ Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| US12558434B2 (en) | 2018-02-20 | 2026-02-24 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
| US20220135992A1 (en) * | 2019-03-06 | 2022-05-05 | Plantform Corporation | T-dna vectors with engineered 5' sequences upstream of post-translational modification enzymes and methods of use thereof |
| KR20230152783A (ko) | 2020-07-07 | 2023-11-03 | 칸큐어 엘엘씨 | Mic 항체 및 결합제 및 이의 사용 방법 |
| EP4288455A1 (fr) | 2021-02-03 | 2023-12-13 | Mozart Therapeutics, Inc. | Agents de liaison et leurs méthodes d'utilisation |
| US20240209080A1 (en) | 2021-04-10 | 2024-06-27 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| CA3216459A1 (fr) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anticorps anti-cd70, leurs conjugues et leurs procedes d'utilisation |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CA3225141A1 (fr) | 2021-07-13 | 2023-01-19 | Keystone Bio, Inc. | Diagnostic pour porphyromonas gingivalis |
| WO2023076876A1 (fr) | 2021-10-26 | 2023-05-04 | Mozart Therapeutics, Inc. | Modulation de réponses immunitaires à des vecteurs viraux |
| WO2023092099A1 (fr) | 2021-11-19 | 2023-05-25 | Ardeagen Corporation | Agents de liaison de gpc3, leurs conjugués et leurs procédés d'utilisation |
| WO2024030956A2 (fr) | 2022-08-03 | 2024-02-08 | Mozart Therapeutics, Inc. | Agents de liaison se liant spécifiquement à cd39 et leurs méthodes d'utilisation |
| LU103006B1 (de) * | 2022-09-15 | 2024-03-15 | Phaeosynt Gbr | Immunoassay zum nachweisen biologisch aktiver proteine |
| WO2024243423A1 (fr) | 2023-05-24 | 2024-11-28 | Mozart Therapeutics, Inc. | Protéines de liaison spécifiques de cd8 et leurs méthodes d'utilisation |
| AR133955A1 (es) | 2023-09-26 | 2025-11-19 | Profoundbio Us Co | Agentes de unión a ptk7, conjugados de éstos y métodos de uso de los mismos |
| WO2025149661A1 (fr) | 2024-01-10 | 2025-07-17 | Genmab A/S | Agents de liaison à slitrk6, conjugués de ceux-ci et leurs procédés d'utilisation |
| US20250381289A1 (en) | 2024-02-29 | 2025-12-18 | Genmab A/S | Egfr and c-met bispecific binding agents, conjugates thereof and methods of using the same |
| WO2025222129A2 (fr) | 2024-04-19 | 2025-10-23 | Mozart Therapeutics, Inc. | Cytokines modifiées et distribution ciblée de cytokines |
| US20260048137A1 (en) | 2024-08-16 | 2026-02-19 | Ardeagen Corporation | Anti-mesothelin antibody conjugates and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
| DE19754622A1 (de) * | 1997-12-09 | 1999-06-10 | Antje Von Dr Schaewen | Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität |
| DK1137789T3 (da) * | 1998-12-09 | 2010-11-08 | Phyton Holdings Llc | Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type |
| DE60044858D1 (de) * | 1999-10-26 | 2010-09-30 | Stichting Dienst Landbouwkundi | Säugetierartige Glykosylierung in Pflanzen |
| ES2349427T3 (es) * | 1999-10-26 | 2011-01-03 | Stichting Dienst Landbouwkundig Onderzoek | Glicosilación de tipo mamífero en plantas. |
-
2000
- 2000-10-20 BR BR0014945-4A patent/BR0014945A/pt not_active Application Discontinuation
- 2000-10-20 EP EP00978257A patent/EP1224309A2/fr not_active Withdrawn
- 2000-10-20 CA CA002388432A patent/CA2388432A1/fr not_active Abandoned
- 2000-10-20 WO PCT/US2000/029027 patent/WO2001029242A2/fr not_active Ceased
- 2000-10-20 AU AU15736/01A patent/AU1573601A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001029242A3 (fr) | 2002-02-21 |
| WO2001029242A2 (fr) | 2001-04-26 |
| EP1224309A2 (fr) | 2002-07-24 |
| CA2388432A1 (fr) | 2001-04-26 |
| AU1573601A (en) | 2001-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |