BR0108545A - Estimulação e concentração simultâneas das células - Google Patents

Estimulação e concentração simultâneas das células

Info

Publication number
BR0108545A
BR0108545A BR0108545-0A BR0108545A BR0108545A BR 0108545 A BR0108545 A BR 0108545A BR 0108545 A BR0108545 A BR 0108545A BR 0108545 A BR0108545 A BR 0108545A
Authority
BR
Brazil
Prior art keywords
cell
cells
processes
concentration
stimulation
Prior art date
Application number
BR0108545-0A
Other languages
English (en)
Inventor
Ron Berenson
Che Law
Mark Bonyhadi
Narinder Saund
Stewart Craig
Dale Kalamasz
Alan Hardwick
David Mcmillen
Original Assignee
Xcyte Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xcyte Therapies Inc filed Critical Xcyte Therapies Inc
Publication of BR0108545A publication Critical patent/BR0108545A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

"ESTIMULAçãO E CONCENTRAçãO SIMULTâNEAS DAS CéLULAS". A presente invenção se refere, de modo geral, aos processos para estimulação das células e, mais especificamente a um novo processo para concentrar e estimular células que maximiza a estimulação e/ou proliferação de tais células. Nas várias concretizações, as células são estimuladas e concentradas com uma superfície rendendo proliferação melhorada, transdução de sinal de célula e/ou agregação de porção de superfície de célula. Em determinados aspectos, os processos para estimulação da produção de células com tais células T, por concentração simultânea e ligação da porção de superfìcie da célula são providos por contato da população de células com uma superfície que possui anexado à mesma um ou mais agentes que ligam uma porção de superfície de célula e aplicam uma força que predominantemente impulsiona a concentração da célula e ligação da porção de superfície de célula, desta forma induzindo estimulação da célula, agregação da porção de superfície da célula e/ou melhoramento de sinalização do receptor. Também são providos processos para produção de células talhadas fenotipicamente, incluindo células T para uso em diagnósticos, descoberta de medicamentos e no tratamento de uma variedade de indicações incluindo câncer, infecções viróticas e distúrbios imunes correlatos. São adicionalmente providas composições das células possuindo propriedades fenotípicas produzidas por estes processos.
BR0108545-0A 2000-02-24 2001-02-26 Estimulação e concentração simultâneas das células BR0108545A (pt)

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