ES2058908T3 - Procedimiento para la separacion y purificacion de sialil-transferasas. - Google Patents

Procedimiento para la separacion y purificacion de sialil-transferasas.

Info

Publication number
ES2058908T3
ES2058908T3 ES90906090T ES90906090T ES2058908T3 ES 2058908 T3 ES2058908 T3 ES 2058908T3 ES 90906090 T ES90906090 T ES 90906090T ES 90906090 T ES90906090 T ES 90906090T ES 2058908 T3 ES2058908 T3 ES 2058908T3
Authority
ES
Spain
Prior art keywords
specific
lacnac
alpha
sialyl
transferasas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90906090T
Other languages
English (en)
Inventor
M Abdul Mazid
Mohammed A Kashem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alberta Innovates
Original Assignee
Alberta Innovates
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alberta Innovates filed Critical Alberta Innovates
Application granted granted Critical
Publication of ES2058908T3 publication Critical patent/ES2058908T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

TRANSFERASAS DE SIALILO ESPECIFICAS (ST) SON UNAS ENZIMAS IMPORTANTES EN LA FABRICACION DE PORCIONES DE CARBOHIDRATO UTILES PARA PROPOSITOS FARMACEUTICOS Y PARA PROCEDIMIENTOS CLINICOS Y DE DIAGNOSTICO. LA INVENCION OFRECE METODOS SIMPLIFICADOS PARA AISLAR FORMAS ALTAMENTE ESPECIFICAS DE ESTAS ENZIMAS ST AL TOMAR VENTAJA DE LA AFINIDAD DEL ST PARA SU SUSTRATO ACEPTADOR EN LA PRESENCIA DE LOS ANALOGOS DE SIALILO-CMP, TALES COMO CDP. SE ILUSTRAN ESPECIFICAMENTE, EL AISLAMIENTO DE ALFA 2,3-ST , ESPECIFICO PARA LE ELEVADO C O LACNAC, Y ALFA 2,6-ST, ESPECIFICO PARA LACNAC.
ES90906090T 1989-04-12 1990-04-12 Procedimiento para la separacion y purificacion de sialil-transferasas. Expired - Lifetime ES2058908T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/336,932 US5059535A (en) 1989-04-12 1989-04-12 Process for the separation and purification of sialyl transferases

Publications (1)

Publication Number Publication Date
ES2058908T3 true ES2058908T3 (es) 1994-11-01

Family

ID=23318345

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90906090T Expired - Lifetime ES2058908T3 (es) 1989-04-12 1990-04-12 Procedimiento para la separacion y purificacion de sialil-transferasas.

Country Status (10)

Country Link
US (1) US5059535A (es)
EP (1) EP0470969B1 (es)
JP (1) JPH05500154A (es)
AT (1) ATE92523T1 (es)
AU (1) AU633912B2 (es)
CA (1) CA2051374C (es)
DE (1) DE69002623T2 (es)
DK (1) DK0470969T3 (es)
ES (1) ES2058908T3 (es)
WO (1) WO1990012090A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079353A (en) * 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
DE4009630C2 (de) * 1990-03-26 1995-09-28 Reinhard Prof Dr Dr Brossmer CMP-aktivierte fluoreszierende Sialinsäuren sowie Verfahren zu ihrer Herstellung
US5374655A (en) * 1991-06-10 1994-12-20 Alberta Research Council Methods for the synthesis of monofucosylated oligosaccharides terminating in di-N-acetyllactosaminyl structures
EP0589951A1 (en) * 1991-06-10 1994-04-06 Glycomed Incorporated Modified sialyl lewis?x compounds
JPH06510745A (ja) * 1991-06-10 1994-12-01 グライカムド　インコーポレイテッド 修飾シアリルルイスａ化合物
US5352670A (en) * 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
ATE228565T1 (de) * 1992-03-09 2002-12-15 Univ California Nukleinsäure, expressionsvektor und zusammensetzungen zur identifizierung und herstellung von rekombinanten sialyltransferasen
WO1995018217A1 (en) 1993-12-24 1995-07-06 The Institute Of Physical And Chemical Research Novel sugar-chain synthetase and process for producing the same
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
CA2522345A1 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
EP1814573B1 (en) 2004-10-29 2016-03-09 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)
CA2593682C (en) 2005-01-10 2016-03-22 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
CN101516388B (zh) 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
EP2144923B1 (en) 2007-04-03 2013-02-13 BioGeneriX AG Methods of treatment using glycopegylated g-csf
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
DE102008005159B4 (de) 2008-01-18 2018-02-15 Robert Bosch Gmbh Verfahren und Steuergerät zur Ansteuerung von Personenschutzmittel für ein Fahrzeug
US20130189239A1 (en) 2008-02-27 2013-07-25 Novo Nordisk A/S Conjugated Factor VIII Molecules
EP3500244B1 (en) * 2016-08-22 2026-07-08 Lonza Sales AG Methods of suppressing delivery of exosomes to liver and spleen
AU2021314104A1 (en) * 2020-07-20 2023-01-19 Insmed, Inc. Methods for extracting neutrophil serine proteases and treating dipeptidyl peptidase 1-mediated conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250262A (en) * 1979-12-14 1981-02-10 Forsyth Dental Infirmary For Children Method of preparing a purified glucosyltransferase
JPS58209980A (ja) * 1982-04-27 1983-12-07 Kyowa Hakko Kogyo Co Ltd 酵素の精製法
ATE37984T1 (de) * 1983-03-01 1988-11-15 Crc Ricerca Chim Pharmazeutische zusammensetzung welche 5acetamido-3,5-dideoxy-d-glycero-dgalactononulosamins|ure cytidin monophosphat enthaelt.
US4925796A (en) * 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability

Also Published As

Publication number Publication date
AU633912B2 (en) 1993-02-11
CA2051374A1 (en) 1990-10-13
DE69002623T2 (de) 1993-11-25
DE69002623D1 (de) 1993-09-09
EP0470969A1 (en) 1992-02-19
ATE92523T1 (de) 1993-08-15
DK0470969T3 (da) 1994-01-03
EP0470969B1 (en) 1993-08-04
CA2051374C (en) 1996-02-27
WO1990012090A1 (en) 1990-10-18
US5059535A (en) 1991-10-22
JPH05500154A (ja) 1993-01-21
AU5528990A (en) 1990-11-05

Similar Documents

Publication Publication Date Title
ATE92523T1 (de) Verfahren zur abtrennung und reinigung von sialyl-transferasen.
ES2070253T3 (es) Ciclohexanoles sustituidos utiles como agentes para el sistema nervioso central.
BR9608558A (pt) Processos e usos de fator de crescimento de tecido conjuntivo como um agente de indução
IT1076361B (it) Pozzetto,specialmente per la costruzione di fognature,nonche' procedimento per la costruzione del medesimo
IT1004840B (it) Procedimento per la produzione di fibre di carbonio
DE3778948D1 (de) Teilchen, geeignet fuer die herstellung von tabletten als diagnostische reagenzien.
BR9910251A (pt) Estimulação hematopoiética
IT8667493A1 (it) Procedimento per la fabbricazione di perline vetrose.
IT7919003A0 (it) Procedimento per la fabbricazione di impiantati nonche' impiantati realizzati con detto procedimento.
ES2072251T3 (es) Composiciones y metodos para la sintesis y ensayo de enquefalinasa.
DE69020623D1 (de) Glasfrit, verwendbar zur Herstellung von Glashohlkugeln, und daraus hergestellte Glashohlkugeln.
NO913625D0 (no) Fremgangsmaate for fremstilling av nye carbocykliske adenosinanaloger.
IT7927440A0 (it) Enzima immobilizzato, procedimenti per la preparazione di detto enzima nonche' procedimento per effettuare una reazione enzimatica.
ES544664A0 (es) Procedimiento para el diagnostico in vitro del sexo
ES2056833T3 (es) Sondas de papilomavirus y procedimiento de diagnostico in vitro de infecciones por papilomavirus.
DE3855080D1 (de) Synoviale phospholipasen
IT8523289A0 (it) Composizione liquida e polimerizzabile per la produzionedi sostituiti di vetri ottici.
ES538403A0 (es) Procedimiento para la obtencion de antipodas opticos del (+7-1,7-difenil-3-metilaza-7-ciano-8-metil-nonano
NO872875L (no) Modifisert vevsplasminaktivator, samt fremgangsmŸte for fremstilling av en slik.
ES556437A0 (es) Procedimiento para preparar un agente que contiene tirosina o un derivado de tirosina como sustancia activa para mejorar la fecundidad de mamiferos.
IT1230866B (it) Procedimento per la produzione di coke.
IT8622286A0 (it) Procedimento per la raffinazione del carbone mediante agglomerazione selettiva.
SU535235A1 (ru) Оптическое стекло
DE3886367D1 (de) Verwendung von Antigestagenen zur Herstellung von Arzneimitteln.
FR2395984A1 (fr) Alpha-vinyl-amino-acides, leur obtention et leur utilisation pour le traitement de la maladie de parkinson et d'etat depressifs

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 470969

Country of ref document: ES