BR0114729A - Métodos para produzir cristais de nateglinida, e cristais do tipo h, cristais de nateglinida, e, cristais do tipo h de nateglinida - Google Patents

Métodos para produzir cristais de nateglinida, e cristais do tipo h, cristais de nateglinida, e, cristais do tipo h de nateglinida

Info

Publication number
BR0114729A
BR0114729A BR0114729-3A BR0114729A BR0114729A BR 0114729 A BR0114729 A BR 0114729A BR 0114729 A BR0114729 A BR 0114729A BR 0114729 A BR0114729 A BR 0114729A
Authority
BR
Brazil
Prior art keywords
crystals
nateglinide
type
methods
producing
Prior art date
Application number
BR0114729-3A
Other languages
English (en)
Inventor
Daisuke Takahashi
Seiichi Nishi
Satoji Takahashi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR0114729A publication Critical patent/BR0114729A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"MéTODOS PARA PRODUZIR CRISTAIS DE NATEGLINIDA, E CRISTAIS DO TIPO H, CRISTAIS DE NATEGLINIDA, E, CRISTAIS DO TIPO H DE NATEGLINIDA". São fornecidos métodos para produzir cristais de nateglinida, que compreendem as etapas de adicionar ácido(s) a uma mistura de reação contendo nateglinida para torná-la ácida, a mistura de reação sendo obtida pela reação de cloreto de trans-4-isopropilciclo-hexilcarbonila com D-feni-lalanina em um solvente misto de solvente de cetona e água na presença de um álcali; e depois ajustar a temperatura da mistura de 58<198>C para 72<198>C e a concentração de solvente de cetona para mais que 8% em peso e menos que 22% em peso para conduzir a precipitação de cristais de nateglinida. Este método de produção é o método industrialmente benéfico para a cristalização de nateglinida.
BR0114729-3A 2000-10-18 2001-10-16 Métodos para produzir cristais de nateglinida, e cristais do tipo h, cristais de nateglinida, e, cristais do tipo h de nateglinida BR0114729A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000317604 2000-10-18
PCT/JP2001/009069 WO2002032854A1 (en) 2000-10-18 2001-10-16 Process for producing nateglinide crystal

Publications (1)

Publication Number Publication Date
BR0114729A true BR0114729A (pt) 2003-10-14

Family

ID=18796362

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114729-3A BR0114729A (pt) 2000-10-18 2001-10-16 Métodos para produzir cristais de nateglinida, e cristais do tipo h, cristais de nateglinida, e, cristais do tipo h de nateglinida

Country Status (18)

Country Link
US (3) US7208622B2 (pt)
EP (1) EP1334963B1 (pt)
JP (1) JP4114200B2 (pt)
KR (1) KR100819358B1 (pt)
CN (2) CN1232502C (pt)
AT (1) ATE368641T1 (pt)
AU (1) AU2001294265A1 (pt)
BR (1) BR0114729A (pt)
CA (1) CA2425538C (pt)
CY (1) CY1106837T1 (pt)
DE (1) DE60129728T2 (pt)
DK (1) DK1334963T3 (pt)
ES (1) ES2291356T3 (pt)
MX (1) MXPA03003484A (pt)
PT (1) PT1334963E (pt)
RU (2) RU2318801C2 (pt)
TW (1) TWI251588B (pt)
WO (1) WO2002032854A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070104953A (ko) * 2000-03-17 2007-10-29 아지노모토 가부시키가이샤 신경 장애용 약제
PT1334962E (pt) * 2000-10-18 2007-10-09 Ajinomoto Kk ''processo de preparação de acilfenilalaninas''
CA2425538C (en) 2000-10-18 2010-10-12 Ajinomoto Co., Inc. Methods for producing nateglinide crystals
ATE429217T1 (de) * 2000-10-24 2009-05-15 Ajinomoto Kk Nateglinid enthaltende hydrophile arzneimittelpräparate
CA2426745C (en) * 2000-10-24 2009-09-15 Ajinomoto Co., Inc. Methods for producing nateglinide b-type crystals
RU2271805C2 (ru) * 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
US7411089B2 (en) 2002-04-15 2008-08-12 Ajinomoto Co., Inc. Nateglinide crystals
EP2264004A1 (en) * 2002-04-15 2010-12-22 Ajinomoto Co., Inc. New nateglinide crystals
WO2004005240A1 (en) * 2002-07-03 2004-01-15 Teva Pharmaceutical Industries Ltd. Process for preparing nateglinide and intermediates thereof
US6861553B2 (en) 2002-07-03 2005-03-01 Teva Pharmaceuticals Industries Ltd. Process for preparing nateglinide and intermediates thereof
US7148376B2 (en) 2002-07-18 2006-12-12 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7534913B2 (en) 2002-07-18 2009-05-19 Teva Pharmaceutica Industries Ltd. Crystalline form of nateglinide
EP1467964A1 (en) * 2002-07-18 2004-10-20 Teva Pharmaceutical Industries Limited Polymorphic forms of nateglinide
US7420084B2 (en) 2002-07-18 2008-09-02 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
US7358390B2 (en) 2002-07-18 2008-04-15 Teva Pharmaceutical Industries Ltd. Polymorphic forms of nateglinide
CN1318392C (zh) * 2003-01-17 2007-05-30 中国人民解放军军事医学科学院毒物药物研究所 那格列奈改进的制备方法
EP1616886A4 (en) * 2003-02-18 2006-06-14 Konishi Co Ltd CURABLE RESIN, PROCESS FOR PRODUCING THE SAME, AND CURABLE RESIN COMPOSITION
HU227073B1 (hu) * 2003-07-10 2010-06-28 Richter Gedeon Nyrt Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
DE60310734T2 (de) * 2003-11-26 2007-10-11 A.M.S.A. Anonima Matèrie Sintètiche e Affini S.p.A. Verfahren zur Herstellung von Nateglinid in der B-Form
KR20070009726A (ko) * 2004-05-07 2007-01-18 테바 파마슈티컬 인더스트리즈 리미티드 나테글리나이드의 다형태
GB0413084D0 (en) 2004-06-11 2004-07-14 Cipla Ltd Process
US7425648B2 (en) 2005-01-03 2008-09-16 A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A. Process for the preparation of nateglinide, preferably in B-form
EP1891971A4 (en) * 2005-01-31 2010-02-03 Ajinomoto Kk MEDICAL COMPOSITION USING HYPERGLY CRAB MEDICAMENT TO TREAT OR TREAT GLUCOSE-INTOLERANCE, BORDERLINE DIABETES, INSULIN RESISTANCE AND HYPERINSULINEMIA
KR101399916B1 (ko) * 2006-03-31 2014-05-28 아지노모토 가부시키가이샤 카복실산 클로라이드 화합물의 제조방법
WO2007113650A2 (en) * 2006-04-05 2007-10-11 Cadila Pharmaceuticals Limited A novel and improved process fro the preparation of nateglinide and its polymorph form-h
KR100837843B1 (ko) * 2006-12-26 2008-06-13 씨제이제일제당 (주) 나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
KR101226024B1 (ko) * 2010-06-08 2013-01-24 삼성중공업 주식회사 선박
AU2011266820A1 (en) 2010-06-14 2013-01-24 Cipla Limited A process for the preparation of nateglinide
KR20150146007A (ko) 2014-06-20 2015-12-31 주식회사 씨트리 나테글리니드의 신규한 제조방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354321A (ja) * 1985-03-27 1988-03-08 Ajinomoto Co Inc 血糖降下剤
AU615966B2 (en) * 1987-12-04 1991-10-17 Takeda Chemical Industries Ltd. Crystals of cephem hydrochloride
GB8820844D0 (en) * 1988-09-05 1988-10-05 Pfizer Ltd Therapeutic agents
US5041232A (en) * 1990-03-16 1991-08-20 Lever Brothers Company, Division Of Conopco, Inc. Sulfonimines as bleach catalysts
JPH0415221A (ja) 1990-05-08 1992-01-20 Daicel Chem Ind Ltd ポリカーボネートの製造法
US5463116A (en) * 1991-07-30 1995-10-31 Ajinomoto Co., Inc. Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
DE10199058I2 (de) * 1991-07-30 2006-04-27 Alcm Co Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
JPH0717899A (ja) * 1993-07-01 1995-01-20 Ajinomoto Co Inc カルボン酸クロリドの製造法
AU718350B2 (en) 1996-11-15 2000-04-13 Ajinomoto Co., Inc. Tablet composition
CZ20022294A3 (cs) 1999-12-28 2002-11-13 Ajinomoto Co., Inc. Antidiabetický preparát k orálnímu uľití
KR20070104953A (ko) 2000-03-17 2007-10-29 아지노모토 가부시키가이샤 신경 장애용 약제
CA2425538C (en) 2000-10-18 2010-10-12 Ajinomoto Co., Inc. Methods for producing nateglinide crystals
PT1334962E (pt) 2000-10-18 2007-10-09 Ajinomoto Kk ''processo de preparação de acilfenilalaninas''
RU2271805C2 (ru) 2000-10-24 2006-03-20 Адзиномото Ко., Инк. Препарат, содержащий натеглинид
CA2426745C (en) 2000-10-24 2009-09-15 Ajinomoto Co., Inc. Methods for producing nateglinide b-type crystals
US6842673B2 (en) 2002-06-05 2005-01-11 Visteon Global Technologies, Inc. Engine engagement control for a hybrid electric vehicle

Also Published As

Publication number Publication date
CN100384814C (zh) 2008-04-30
DE60129728D1 (de) 2007-09-13
EP1334963A1 (en) 2003-08-13
US20070167523A1 (en) 2007-07-19
TWI251588B (en) 2006-03-21
JPWO2002032854A1 (ja) 2004-02-26
MXPA03003484A (es) 2003-07-14
DE60129728T2 (de) 2008-04-24
US7208622B2 (en) 2007-04-24
EP1334963A4 (en) 2005-08-17
ES2291356T3 (es) 2008-03-01
CN1769263A (zh) 2006-05-10
CY1106837T1 (el) 2012-05-23
RU2005137243A (ru) 2007-06-10
ATE368641T1 (de) 2007-08-15
CN1481356A (zh) 2004-03-10
KR20030059203A (ko) 2003-07-07
AU2001294265A1 (en) 2002-04-29
PT1334963E (pt) 2007-09-20
CA2425538A1 (en) 2003-04-10
CA2425538C (en) 2010-10-12
RU2273629C2 (ru) 2006-04-10
DK1334963T3 (da) 2007-09-24
US7459582B2 (en) 2008-12-02
KR100819358B1 (ko) 2008-04-04
EP1334963B1 (en) 2007-08-01
US20090076301A1 (en) 2009-03-19
JP4114200B2 (ja) 2008-07-09
WO2002032854A1 (en) 2002-04-25
CN1232502C (zh) 2005-12-21
RU2318801C2 (ru) 2008-03-10
US20040030182A1 (en) 2004-02-12

Similar Documents

Publication Publication Date Title
BR0114729A (pt) Métodos para produzir cristais de nateglinida, e cristais do tipo h, cristais de nateglinida, e, cristais do tipo h de nateglinida
RU2003111021A (ru) Способы получения кристаллов натеглинида
HRP20150757T1 (hr) Proizvodnja taložnog kalcijevog karbonata visoke äśistoä†e
EA201100571A1 (ru) Получение кремния для солнечных батарей из диоксида кремния
BR0310005A (pt) Método para a produção de ácido orgânico
DE50308134D1 (de) Kontinuierliches verfahren zur herstellung von pseudojononen und jononen
CN102295274A (zh) 一种过氧化氢稳定剂
BRPI0705682A (pt) método para produzir ácido metacrìlico
CN105148710A (zh) 一种氯化法生产三氯乙酰氯尾气吸收方法
BRPI0708623A2 (pt) método para preparar um complexo de amina orgánica/ácido lático
CN116813446B (zh) 一种砜基化合物还原脱砜的方法
KR880000389A (ko) L-시스테인 염산염의 1수화물의 분리방법
BR9912842A (pt) Processo para a preparação de sal de cálcio de zofenopril
CN102764572A (zh) 一种氯化法生产三氯乙酰氯尾气吸收新方法
CN117699827A (zh) 一种从提钾老卤中同步提取锂和溴的方法
KR20010097371A (ko) 폐 황산을 이용한 황산 마그네슘 제조
CN112047401B (zh) 一种利用硫酸钠增浓精制海水的方法
CN115650868A (zh) 一种左旋肉碱的制备方法
Porter Racemization in the Preparation of the Grignard Reagent
CN104211270B (zh) 硫辛酸生产过程中环合废水的处理方法
KR890012935A (ko) 1,4-디옥산의 함량이 낮은 황산화 알카놀 옥스에틸레이트 또는 알킬페놀 옥스에틸레이트의 제조방법
ES8707236A1 (es) Procedimiento para preparar 2-bromo-&lt;-ergocriptina y sus sales acidas complementarias
CN103333078B (zh) 一种阿那格雷关键中间体、类似物或其盐的合成方法
CN108752312A (zh) 一种新的制备2-甲基-3-噻吩-5-甲氧羰基磺酰氯的方法
SU1611869A1 (ru) Способ получени монотиоарсената натри

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 15A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.