ATE368641T1 - Verfahren zur herstellung von nateglinidin- kristallen - Google Patents

Verfahren zur herstellung von nateglinidin- kristallen

Info

Publication number: ATE368641T1
Authority: AT; Austria
Prior art keywords: crystals; producing; nateglinide; nateglinidine; reaction mixture
Prior art date: 2000-10-18

Application number

AT01974875T

Other languages

English (en)

Inventor

Daisuke Takahashi

Seiichi Nishi

Satoji Takahashi

Original Assignee

Ajinomoto Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-18

Filing date

2001-10-16

Publication date

2007-08-15

2001-10-16 Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE368641T1 publication Critical patent/ATE368641T1/de

Links

239000013078 crystal Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 abstract 4
229960000698 nateglinide Drugs 0.000 abstract 4
238000000034 method Methods 0.000 abstract 3
150000002576 ketones Chemical class 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
YXGDSBSUTMGHOL-UHFFFAOYSA-N 4-propan-2-ylcyclohexane-1-carbonyl chloride Chemical compound CC(C)C1CCC(C(Cl)=O)CC1 YXGDSBSUTMGHOL-UHFFFAOYSA-N 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
229930182832 D-phenylalanine Natural products 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000012046 mixed solvent Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01974875T 2000-10-18 2001-10-16 Verfahren zur herstellung von nateglinidin- kristallen ATE368641T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000317604		2000-10-18

Publications (1)

Publication Number	Publication Date
ATE368641T1 true ATE368641T1 (de)	2007-08-15

Family

ID=18796362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01974875T ATE368641T1 (de)	2000-10-18	2001-10-16	Verfahren zur herstellung von nateglinidin- kristallen

Country Status (18)

Country	Link
US (3)	US7208622B2 (de)
EP (1)	EP1334963B1 (de)
JP (1)	JP4114200B2 (de)
KR (1)	KR100819358B1 (de)
CN (2)	CN1232502C (de)
AT (1)	ATE368641T1 (de)
AU (1)	AU2001294265A1 (de)
BR (1)	BR0114729A (de)
CA (1)	CA2425538C (de)
CY (1)	CY1106837T1 (de)
DE (1)	DE60129728T2 (de)
DK (1)	DK1334963T3 (de)
ES (1)	ES2291356T3 (de)
MX (1)	MXPA03003484A (de)
PT (1)	PT1334963E (de)
RU (2)	RU2273629C2 (de)
TW (1)	TWI251588B (de)
WO (1)	WO2002032854A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4116801A (en) *	2000-03-17	2001-09-24	Ajinomoto Kk	Drugs for complications of diabetes and neuropathy and utilization thereof
ES2290173T3 (es) *	2000-10-18	2008-02-16	Ajinomoto Co., Inc.	Procedimiento para la preparacion de acilfenilalaninas.
JP4114200B2 (ja)	2000-10-18	2008-07-09	味の素株式会社	ナテグリニド結晶の製造方法
AU2001296000A1 (en) *	2000-10-24	2002-05-27	Ajinomoto Co., Inc.	Nateglinide-containing hydrophilic drug preparations
DE60130014T2 (de) *	2000-10-24	2008-05-08	Ajinomoto Co., Inc.	Verfahren zur herstellung der b-form von nateglinid-kristallen
BR0114896A (pt) *	2000-10-24	2003-08-12	Ajinomoto Kk	Preparação contendo nateglinida, e, método para produzir a mesma
US7411089B2 (en)	2002-04-15	2008-08-12	Ajinomoto Co., Inc.	Nateglinide crystals
EP1496048A4 (de) *	2002-04-15	2006-08-02	Ajinomoto Kk	Neuer nateglinidkristall
US6861553B2 (en)	2002-07-03	2005-03-01	Teva Pharmaceuticals Industries Ltd.	Process for preparing nateglinide and intermediates thereof
CN100384813C (zh) *	2002-07-03	2008-04-30	特瓦制药工业有限公司	制备那格列奈及其中间体的方法
AU2003253971A1 (en) *	2002-07-18	2004-02-09	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7148376B2 (en)	2002-07-18	2006-12-12	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7534913B2 (en)	2002-07-18	2009-05-19	Teva Pharmaceutica Industries Ltd.	Crystalline form of nateglinide
US7420084B2 (en)	2002-07-18	2008-09-02	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7358390B2 (en)	2002-07-18	2008-04-15	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
CN1318392C (zh) *	2003-01-17	2007-05-30	中国人民解放军军事医学科学院毒物药物研究所	那格列奈改进的制备方法
US7449519B2 (en) *	2003-02-18	2008-11-11	Konishi Co., Ltd.	Curing resin, method for producing same and curing resin composition
HU227073B1 (hu) *	2003-07-10	2010-06-28	Richter Gedeon Nyrt	Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
ES2279921T3 (es) *	2003-11-26	2007-09-01	A.M.S.A. Anonima Materie Sintetiche E Affini S.P.A.	Procedimiento para la preparacion de nateglinida preferentemente en forma b.
US20060004102A1 (en) *	2004-05-07	2006-01-05	Shlomit Wizel	Polymorphic forms of nateglinide
GB0413084D0 (en)	2004-06-11	2004-07-14	Cipla Ltd	Process
US7425648B2 (en)	2005-01-03	2008-09-16	A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A.	Process for the preparation of nateglinide, preferably in B-form
CN101111266A (zh) *	2005-01-31	2008-01-23	味之素株式会社	含有降血糖药的用于改善或治疗糖耐量异常、临界性糖尿病、胰岛素抵抗性和高胰岛素血症的药物组合物
WO2007119580A1 (ja) *	2006-03-31	2007-10-25	Ajinomoto Co., Inc.	カルボン酸クロリド化合物の製造方法
WO2007113650A2 (en) *	2006-04-05	2007-10-11	Cadila Pharmaceuticals Limited	A novel and improved process fro the preparation of nateglinide and its polymorph form-h
KR100837843B1 (ko) *	2006-12-26	2008-06-13	씨제이제일제당 (주)	나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
KR101226024B1 (ko) *	2010-06-08	2013-01-24	삼성중공업 주식회사	선박
US9150499B2 (en)	2010-06-14	2015-10-06	Cipla Limited	Process for the preparation of nateglinide
KR20150146007A (ko)	2014-06-20	2015-12-31	주식회사 씨트리	나테글리니드의 신규한 제조방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6354321A (ja) *	1985-03-27	1988-03-08	Ajinomoto Co Inc	血糖降下剤
AU615966B2 (en) *	1987-12-04	1991-10-17	Takeda Chemical Industries Ltd.	Crystals of cephem hydrochloride
GB8820844D0 (en) *	1988-09-05	1988-10-05	Pfizer Ltd	Therapeutic agents
US5041232A (en) *	1990-03-16	1991-08-20	Lever Brothers Company, Division Of Conopco, Inc.	Sulfonimines as bleach catalysts
JPH0415221A (ja)	1990-05-08	1992-01-20	Daicel Chem Ind Ltd	ポリカーボネートの製造法
US5463116A (en) *	1991-07-30	1995-10-31	Ajinomoto Co., Inc.	Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
DE10199058I2 (de) *	1991-07-30	2006-04-27	Alcm Co	Kristalle von N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung
JPH0717899A (ja) *	1993-07-01	1995-01-20	Ajinomoto Co Inc	カルボン酸クロリドの製造法
PT1586314E (pt)	1996-11-15	2011-07-01	Ajinomoto Kk	Composição de comprimidos de nateglinida
PT1616561E (pt)	1999-12-28	2008-07-09	Ajinomoto Kk	Preparação antidiabética para administração oral
AU4116801A (en)	2000-03-17	2001-09-24	Ajinomoto Kk	Drugs for complications of diabetes and neuropathy and utilization thereof
JP4114200B2 (ja)	2000-10-18	2008-07-09	味の素株式会社	ナテグリニド結晶の製造方法
ES2290173T3 (es)	2000-10-18	2008-02-16	Ajinomoto Co., Inc.	Procedimiento para la preparacion de acilfenilalaninas.
DE60130014T2 (de)	2000-10-24	2008-05-08	Ajinomoto Co., Inc.	Verfahren zur herstellung der b-form von nateglinid-kristallen
BR0114896A (pt)	2000-10-24	2003-08-12	Ajinomoto Kk	Preparação contendo nateglinida, e, método para produzir a mesma
US6842673B2 (en)	2002-06-05	2005-01-11	Visteon Global Technologies, Inc.	Engine engagement control for a hybrid electric vehicle

2001
- 2001-10-16 JP JP2002536038A patent/JP4114200B2/ja not_active Expired - Lifetime
- 2001-10-16 DE DE60129728T patent/DE60129728T2/de not_active Expired - Lifetime
- 2001-10-16 RU RU2003111021/04A patent/RU2273629C2/ru not_active IP Right Cessation
- 2001-10-16 ES ES01974875T patent/ES2291356T3/es not_active Expired - Lifetime
- 2001-10-16 EP EP01974875A patent/EP1334963B1/de not_active Expired - Lifetime
- 2001-10-16 KR KR1020037005388A patent/KR100819358B1/ko not_active Expired - Fee Related
- 2001-10-16 BR BR0114729-3A patent/BR0114729A/pt not_active IP Right Cessation
- 2001-10-16 AU AU2001294265A patent/AU2001294265A1/en not_active Abandoned
- 2001-10-16 CN CNB018206581A patent/CN1232502C/zh not_active Expired - Fee Related
- 2001-10-16 RU RU2005137243/04A patent/RU2318801C2/ru not_active IP Right Cessation
- 2001-10-16 CN CNB2005101188521A patent/CN100384814C/zh not_active Expired - Fee Related
- 2001-10-16 WO PCT/JP2001/009069 patent/WO2002032854A1/ja not_active Ceased
- 2001-10-16 MX MXPA03003484A patent/MXPA03003484A/es active IP Right Grant
- 2001-10-16 PT PT01974875T patent/PT1334963E/pt unknown
- 2001-10-16 AT AT01974875T patent/ATE368641T1/de active
- 2001-10-16 DK DK01974875T patent/DK1334963T3/da active
- 2001-10-16 CA CA2425538A patent/CA2425538C/en not_active Expired - Fee Related
- 2001-10-17 TW TW090125697A patent/TWI251588B/zh not_active IP Right Cessation
2003
- 2003-04-18 US US10/418,105 patent/US7208622B2/en not_active Expired - Fee Related
2007
- 2007-03-14 US US11/686,073 patent/US7459582B2/en not_active Expired - Fee Related
- 2007-08-28 CY CY20071101133T patent/CY1106837T1/el unknown
2008
- 2008-10-31 US US12/262,634 patent/US20090076301A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PT1334963E (pt)	2007-09-20
DK1334963T3 (da)	2007-09-24
CN100384814C (zh)	2008-04-30
KR20030059203A (ko)	2003-07-07
CA2425538C (en)	2010-10-12
CY1106837T1 (el)	2012-05-23
DE60129728T2 (de)	2008-04-24
US7459582B2 (en)	2008-12-02
EP1334963B1 (de)	2007-08-01
TWI251588B (en)	2006-03-21
WO2002032854A1 (en)	2002-04-25
CN1481356A (zh)	2004-03-10
US20090076301A1 (en)	2009-03-19
CA2425538A1 (en)	2003-04-10
EP1334963A1 (de)	2003-08-13
MXPA03003484A (es)	2003-07-14
CN1232502C (zh)	2005-12-21
RU2273629C2 (ru)	2006-04-10
RU2005137243A (ru)	2007-06-10
EP1334963A4 (de)	2005-08-17
AU2001294265A1 (en)	2002-04-29
US20070167523A1 (en)	2007-07-19
CN1769263A (zh)	2006-05-10
JPWO2002032854A1 (ja)	2004-02-26
RU2318801C2 (ru)	2008-03-10
US20040030182A1 (en)	2004-02-12
US7208622B2 (en)	2007-04-24
DE60129728D1 (de)	2007-09-13
BR0114729A (pt)	2003-10-14
ES2291356T3 (es)	2008-03-01
KR100819358B1 (ko)	2008-04-04
JP4114200B2 (ja)	2008-07-09

Legal Events

Date

Code

Title

Description

2007-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1334963

Country of ref document: EP

Publication	Publication Date	Title
DE60129728D1 (de)	2007-09-13	Verfahren zur herstellung von nateglinidin-kristallen
RU2003111021A (ru)	2004-09-20	Способы получения кристаллов натеглинида
DE59609239D1 (de)	2002-06-27	Verfahren zur abtrennung von mittelsiedern aus einem gemisch aus leicht-, mittel- und hochsiedern
EP1460056A4 (de)	2006-03-29	Verfahren zur herstellung von kohlensäureester
ATE443069T1 (de)	2009-10-15	Verfahren zur herstellung von chlorotris (triphenylphosphan)rhodium (i)
DE60031917D1 (de)	2007-01-04	Ein Verfahren zur Herstellung lichtunempfindlicher Silberfettsäuresalzkörner und ein Apparat dafür
DE3772308D1 (de)	1991-09-26	Verfahren zur herstellung von retinoylchloriden.
ATE321039T1 (de)	2006-04-15	Verfahren zur herstellung von losartan und losartan-kaliumsalz
ATE129693T1 (de)	1995-11-15	Verfahren zur herstellung von s(+)-6-methoxy- alpha-methyl-2-naphthalin-essigsäure.
ATE145393T1 (de)	1996-12-15	Verfahren zur herstellung von 2-chloro- und 2,6- dichloranilinen
ATE266635T1 (de)	2004-05-15	Verfahren zur herstellung von zofenopril- calciumsalz
US4789686A (en)	1988-12-06	Process for the preparation of an aqueous solution of the sodium salt of methionine
EP1471047A4 (de)	2006-05-03	Verfahren zur herstellung von dicarbonsäure
ATE535507T1 (de)	2011-12-15	Ein verfahren zur herstellung des kaliumsalzes der 2-chlor-3-(phenylmethoxy)propionsäure
ATE212977T1 (de)	2002-02-15	Verfahren zur herstellung von kreatin oder kreatinmonohydrat
JPH0291049A (ja)	1990-03-30	ｒ―ブチロベタインの製造方法
ATE236078T1 (de)	2003-04-15	Verfahren zur rückgewinnung von schwefelsäure aus schwefelhaltigen nebenprodukten eines prozesses zur herstellung von 2-hydroxy-4- methylthiobuttersäure (mha)
ATE432251T1 (de)	2009-06-15	Verfahren zur herstellung von p-dichlorbenzol
SU1456407A1 (ru)	1989-02-07	Способ получени диацетонакриламида
SU1698239A1 (ru)	1991-12-15	Способ получени аммонийно-магниевого удобрени
ATE304002T1 (de)	2005-09-15	Verfahren zur herstellung von n-alkyl-2- benzthiazolylsulfenimiden und verfahren zu deren aufreinigung
JP3965787B2 (ja)	2007-08-29	２−クロロ−５−ヒドロキシピリジンの製造方法
JPH0794444B2 (ja)	1995-10-11	２，４‐イミダゾリジンオンの品質改良法
ATE474826T1 (de)	2010-08-15	Verfahren zur herstellung von dichlorhydrochinonethern
DE69911236D1 (de)	2003-10-16	Verfahren zur kristallisation von iopamidol