ATE368641T1 - Verfahren zur herstellung von nateglinidin- kristallen - Google Patents

Verfahren zur herstellung von nateglinidin- kristallen

Info

Publication number: ATE368641T1
Authority: AT; Austria
Prior art keywords: crystals; producing; nateglinide; nateglinidine; reaction mixture
Prior art date: 2000-10-18

Application number

AT01974875T

Other languages

English (en)

Inventor

Daisuke Takahashi

Seiichi Nishi

Satoji Takahashi

Original Assignee

Ajinomoto Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-18

Filing date

2001-10-16

Publication date

2007-08-15

2001-10-16 Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk

2007-08-15 Application granted granted Critical

2007-08-15 Publication of ATE368641T1 publication Critical patent/ATE368641T1/de

Links

239000013078 crystal Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 abstract 4
229960000698 nateglinide Drugs 0.000 abstract 4
238000000034 method Methods 0.000 abstract 3
150000002576 ketones Chemical class 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
YXGDSBSUTMGHOL-UHFFFAOYSA-N 4-propan-2-ylcyclohexane-1-carbonyl chloride Chemical compound CC(C)C1CCC(C(Cl)=O)CC1 YXGDSBSUTMGHOL-UHFFFAOYSA-N 0.000 abstract 1
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
229930182832 D-phenylalanine Natural products 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
239000012046 mixed solvent Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01974875T 2000-10-18 2001-10-16 Verfahren zur herstellung von nateglinidin- kristallen ATE368641T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2000317604		2000-10-18

Publications (1)

Publication Number	Publication Date
ATE368641T1 true ATE368641T1 (de)	2007-08-15

Family

ID=18796362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01974875T ATE368641T1 (de)	2000-10-18	2001-10-16	Verfahren zur herstellung von nateglinidin- kristallen

Country Status (18)

Country	Link
US (3)	US7208622B2 (de)
EP (1)	EP1334963B1 (de)
JP (1)	JP4114200B2 (de)
KR (1)	KR100819358B1 (de)
CN (2)	CN1232502C (de)
AT (1)	ATE368641T1 (de)
AU (1)	AU2001294265A1 (de)
BR (1)	BR0114729A (de)
CA (1)	CA2425538C (de)
CY (1)	CY1106837T1 (de)
DE (1)	DE60129728T2 (de)
DK (1)	DK1334963T3 (de)
ES (1)	ES2291356T3 (de)
MX (1)	MXPA03003484A (de)
PT (1)	PT1334963E (de)
RU (2)	RU2273629C2 (de)
TW (1)	TWI251588B (de)
WO (1)	WO2002032854A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20070104953A (ko) *	2000-03-17	2007-10-29	아지노모토 가부시키가이샤	신경 장애용 약제
ATE368641T1 (de) *	2000-10-18	2007-08-15	Ajinomoto Kk	Verfahren zur herstellung von nateglinidin- kristallen
CN1273442C (zh) *	2000-10-18	2006-09-06	味之素株式会社	酰基苯丙氨酸的制备方法
MXPA03003685A (es) *	2000-10-24	2004-01-26	Ajinomoto Kk	Preparaciones que contienen nateglinida.
AU2001296000A1 (en) *	2000-10-24	2002-05-27	Ajinomoto Co., Inc.	Nateglinide-containing hydrophilic drug preparations
RU2275354C2 (ru) *	2000-10-24	2006-04-27	Адзиномото Ко., Инк.	Способы получения кристаллов в-типа натеглинида
US7411089B2 (en)	2002-04-15	2008-08-12	Ajinomoto Co., Inc.	Nateglinide crystals
JP4538842B2 (ja) *	2002-04-15	2010-09-08	味の素株式会社	新規ナテグリニド結晶
AU2003256454A1 (en) *	2002-07-03	2004-01-23	Teva Pharmaceutical Industries Ltd.	Process for preparing nateglinide and intermediates thereof
US6861553B2 (en)	2002-07-03	2005-03-01	Teva Pharmaceuticals Industries Ltd.	Process for preparing nateglinide and intermediates thereof
US7148376B2 (en)	2002-07-18	2006-12-12	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
IL166308A0 (en) *	2002-07-18	2006-01-15		Polymorphic forms of nateglinide
US7358390B2 (en)	2002-07-18	2008-04-15	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7420084B2 (en)	2002-07-18	2008-09-02	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of nateglinide
US7534913B2 (en)	2002-07-18	2009-05-19	Teva Pharmaceutica Industries Ltd.	Crystalline form of nateglinide
CN1318392C (zh) *	2003-01-17	2007-05-30	中国人民解放军军事医学科学院毒物药物研究所	那格列奈改进的制备方法
US7449519B2 (en) *	2003-02-18	2008-11-11	Konishi Co., Ltd.	Curing resin, method for producing same and curing resin composition
HU227073B1 (hu) *	2003-07-10	2010-06-28	Richter Gedeon Nyrt	Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata
EP1535900B1 (de) *	2003-11-26	2006-12-27	A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.	Verfahren zur Herstellung von Nateglinidin der B-Form
US20060004102A1 (en) *	2004-05-07	2006-01-05	Shlomit Wizel	Polymorphic forms of nateglinide
GB0413084D0 (en)	2004-06-11	2004-07-14	Cipla Ltd	Process
US7425648B2 (en)	2005-01-03	2008-09-16	A.M.S.A. Anonima Materie Sintetiche E. Affini S.P.A.	Process for the preparation of nateglinide, preferably in B-form
WO2006080524A1 (ja) *	2005-01-31	2006-08-03	Ajinomoto Co., Inc.	血糖降下剤を含有する、耐糖能異常、境界型糖尿病、インスリン抵抗性及び高インスリン血症の改善ないし治療用医薬組成物
CN101415668B (zh) *	2006-03-31	2013-06-19	味之素株式会社	羧酸酰氯化合物的制造方法
WO2007113650A2 (en) *	2006-04-05	2007-10-11	Cadila Pharmaceuticals Limited	A novel and improved process fro the preparation of nateglinide and its polymorph form-h
KR100837843B1 (ko) *	2006-12-26	2008-06-13	씨제이제일제당 (주)	나테글리나이드 결정형, 그 제조방법, 및 그를 포함하는약제학적 조성물
KR101226024B1 (ko) *	2010-06-08	2013-01-24	삼성중공업 주식회사	선박
AU2011266820A1 (en)	2010-06-14	2013-01-24	Cipla Limited	A process for the preparation of nateglinide
KR20150146007A (ko)	2014-06-20	2015-12-31	주식회사 씨트리	나테글리니드의 신규한 제조방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6354321A (ja) *	1985-03-27	1988-03-08	Ajinomoto Co Inc	血糖降下剤
AU615966B2 (en) *	1987-12-04	1991-10-17	Takeda Chemical Industries Ltd.	Crystals of cephem hydrochloride
GB8820844D0 (en) *	1988-09-05	1988-10-05	Pfizer Ltd	Therapeutic agents
US5041232A (en) *	1990-03-16	1991-08-20	Lever Brothers Company, Division Of Conopco, Inc.	Sulfonimines as bleach catalysts
JPH0415221A (ja)	1990-05-08	1992-01-20	Daicel Chem Ind Ltd	ポリカーボネートの製造法
ES2100291T3 (es) *	1991-07-30	1997-06-16	Ajinomoto Kk	Cristales de n-(trans-4-isopropilciclohexilcarbonil)-d-fenilalanina y metodos para prepararlos.
US5463116A (en) *	1991-07-30	1995-10-31	Ajinomoto Co., Inc.	Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
JPH0717899A (ja) *	1993-07-01	1995-01-20	Ajinomoto Co Inc	カルボン酸クロリドの製造法
ATE503472T1 (de)	1996-11-15	2011-04-15	Ajinomoto Kk	Nateglinide-tablettenzubereitungen
CA2395993A1 (en)	1999-12-28	2001-07-05	Ajinomoto Co., Inc.	Antidiabetic preparation for oral administration
KR20070104953A (ko)	2000-03-17	2007-10-29	아지노모토 가부시키가이샤	신경 장애용 약제
CN1273442C (zh)	2000-10-18	2006-09-06	味之素株式会社	酰基苯丙氨酸的制备方法
ATE368641T1 (de) *	2000-10-18	2007-08-15	Ajinomoto Kk	Verfahren zur herstellung von nateglinidin- kristallen
MXPA03003685A (es)	2000-10-24	2004-01-26	Ajinomoto Kk	Preparaciones que contienen nateglinida.
RU2275354C2 (ru)	2000-10-24	2006-04-27	Адзиномото Ко., Инк.	Способы получения кристаллов в-типа натеглинида
US6842673B2 (en)	2002-06-05	2005-01-11	Visteon Global Technologies, Inc.	Engine engagement control for a hybrid electric vehicle

2001
- 2001-10-16 AT AT01974875T patent/ATE368641T1/de active
- 2001-10-16 KR KR1020037005388A patent/KR100819358B1/ko not_active Expired - Fee Related
- 2001-10-16 CN CNB018206581A patent/CN1232502C/zh not_active Expired - Fee Related
- 2001-10-16 AU AU2001294265A patent/AU2001294265A1/en not_active Abandoned
- 2001-10-16 BR BR0114729-3A patent/BR0114729A/pt not_active IP Right Cessation
- 2001-10-16 DE DE60129728T patent/DE60129728T2/de not_active Expired - Lifetime
- 2001-10-16 RU RU2003111021/04A patent/RU2273629C2/ru not_active IP Right Cessation
- 2001-10-16 DK DK01974875T patent/DK1334963T3/da active
- 2001-10-16 JP JP2002536038A patent/JP4114200B2/ja not_active Expired - Lifetime
- 2001-10-16 EP EP01974875A patent/EP1334963B1/de not_active Expired - Lifetime
- 2001-10-16 CA CA2425538A patent/CA2425538C/en not_active Expired - Fee Related
- 2001-10-16 ES ES01974875T patent/ES2291356T3/es not_active Expired - Lifetime
- 2001-10-16 RU RU2005137243/04A patent/RU2318801C2/ru not_active IP Right Cessation
- 2001-10-16 MX MXPA03003484A patent/MXPA03003484A/es active IP Right Grant
- 2001-10-16 WO PCT/JP2001/009069 patent/WO2002032854A1/ja not_active Ceased
- 2001-10-16 CN CNB2005101188521A patent/CN100384814C/zh not_active Expired - Fee Related
- 2001-10-16 PT PT01974875T patent/PT1334963E/pt unknown
- 2001-10-17 TW TW090125697A patent/TWI251588B/zh not_active IP Right Cessation
2003
- 2003-04-18 US US10/418,105 patent/US7208622B2/en not_active Expired - Fee Related
2007
- 2007-03-14 US US11/686,073 patent/US7459582B2/en not_active Expired - Fee Related
- 2007-08-28 CY CY20071101133T patent/CY1106837T1/el unknown
2008
- 2008-10-31 US US12/262,634 patent/US20090076301A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090076301A1 (en)	2009-03-19
DK1334963T3 (da)	2007-09-24
CN1481356A (zh)	2004-03-10
EP1334963A1 (de)	2003-08-13
CN1232502C (zh)	2005-12-21
WO2002032854A1 (en)	2002-04-25
US20070167523A1 (en)	2007-07-19
CY1106837T1 (el)	2012-05-23
KR100819358B1 (ko)	2008-04-04
TWI251588B (en)	2006-03-21
ES2291356T3 (es)	2008-03-01
JPWO2002032854A1 (ja)	2004-02-26
MXPA03003484A (es)	2003-07-14
CN100384814C (zh)	2008-04-30
JP4114200B2 (ja)	2008-07-09
RU2318801C2 (ru)	2008-03-10
CN1769263A (zh)	2006-05-10
RU2273629C2 (ru)	2006-04-10
RU2005137243A (ru)	2007-06-10
PT1334963E (pt)	2007-09-20
DE60129728T2 (de)	2008-04-24
AU2001294265A1 (en)	2002-04-29
US7459582B2 (en)	2008-12-02
US7208622B2 (en)	2007-04-24
US20040030182A1 (en)	2004-02-12
KR20030059203A (ko)	2003-07-07
DE60129728D1 (de)	2007-09-13
CA2425538C (en)	2010-10-12
CA2425538A1 (en)	2003-04-10
BR0114729A (pt)	2003-10-14
EP1334963B1 (de)	2007-08-01
EP1334963A4 (de)	2005-08-17

Legal Events

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2007-11-15

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Publication of translation of european patent specification

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Publication	Publication Date	Title
ATE368641T1 (de)	2007-08-15	Verfahren zur herstellung von nateglinidin- kristallen
RU2003111021A (ru)	2004-09-20	Способы получения кристаллов натеглинида
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SU1456407A1 (ru)	1989-02-07	Способ получени диацетонакриламида
AU6615994A (en)	1995-01-27	Recovery of organic acid salts from impure process streams by addition of bases
ATE304002T1 (de)	2005-09-15	Verfahren zur herstellung von n-alkyl-2- benzthiazolylsulfenimiden und verfahren zu deren aufreinigung
JP3965787B2 (ja)	2007-08-29	２−クロロ−５−ヒドロキシピリジンの製造方法
JPH0413657A (ja)	1992-01-17	２，４―ジアミノベンゼンスルホン酸の製造方法
JPH0794444B2 (ja)	1995-10-11	２，４‐イミダゾリジンオンの品質改良法
DE69911236D1 (de)	2003-10-16	Verfahren zur kristallisation von iopamidol
ATE161825T1 (de)	1998-01-15	Verfahren zur herstellung von alpha-alkoxy- iminophenylacetonitril
ATE214394T1 (de)	2002-03-15	Verfahren zur herstellung von 1- hydroxythienoimidazolcarbonsäure und thienoimidazolcarbonsäure
EP0143881A3 (de)	1986-10-29	Verfahren zur Herstellung eines alpha-L-Aspartyl-L-Phenylalanin-alkylesters