BR0213815A - Células endoteliais derivadas de células tronco embriÈnicas de primatas - Google Patents

Células endoteliais derivadas de células tronco embriÈnicas de primatas

Info

Publication number
BR0213815A
BR0213815A BR0213815-8A BR0213815A BR0213815A BR 0213815 A BR0213815 A BR 0213815A BR 0213815 A BR0213815 A BR 0213815A BR 0213815 A BR0213815 A BR 0213815A
Authority
BR
Brazil
Prior art keywords
endothelial cells
cells
derived
embryonic stem
stem cells
Prior art date
Application number
BR0213815-8A
Other languages
English (en)
Inventor
Dans S Kaufman
Rachel Lewis
Robert Auerbach
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of BR0213815A publication Critical patent/BR0213815A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"CéLULAS ENDOTELIAIS DERIVADAS DE CéLULAS TRONCO EMBRIÈNICAS DE PRIMATAS". Um método é descrito para induzir as células tronco embriênicas de primatas a diferenciar de uma população relativamente homogênea de células endoteliais. As células endoteliais derivadas de ES têm a morfologia geral e marcadores de superfície de células característicos de células endoteliais. As células endoteliais derivadas de ES também são capazes de induzir e participar na formação de vasos sanguíneos (ou vascularização) quando transplantadas no tecido in vivo.
BR0213815-8A 2001-11-02 2002-11-01 Células endoteliais derivadas de células tronco embriÈnicas de primatas BR0213815A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33533201P 2001-11-02 2001-11-02
PCT/US2002/035278 WO2003040319A2 (en) 2001-11-02 2002-11-01 Endothelial cells derived from primate embryonic stem cells

Publications (1)

Publication Number Publication Date
BR0213815A true BR0213815A (pt) 2004-10-19

Family

ID=23311328

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213815-8A BR0213815A (pt) 2001-11-02 2002-11-01 Células endoteliais derivadas de células tronco embriÈnicas de primatas

Country Status (15)

Country Link
US (1) US7176023B2 (pt)
EP (1) EP1446476A4 (pt)
JP (1) JP4085062B2 (pt)
KR (1) KR20050042215A (pt)
CN (1) CN100540657C (pt)
AU (1) AU2002356896B2 (pt)
BR (1) BR0213815A (pt)
CA (1) CA2465173C (pt)
IL (2) IL161461A0 (pt)
IS (1) IS7242A (pt)
LU (1) LU91074B1 (pt)
MX (1) MXPA04004067A (pt)
NZ (1) NZ532170A (pt)
SE (1) SE529427C8 (pt)
WO (1) WO2003040319A2 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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WO2003080801A2 (en) * 2002-03-19 2003-10-02 Advanced Research & Technology Transfer Adipose stromal stem cells for tissue and vascular modification
US20040009589A1 (en) * 2002-03-26 2004-01-15 Shulamit Levenberg Endothelial cells derived from human embryonic stem cells
EP1783207A4 (en) * 2004-06-22 2008-07-30 Mitsubishi Tanabe Pharma Corp PROCESS FOR THE PREPARATION OF VASCULAR ENDHELICELLS FROM EMBRYONAL STEM CELLS OF PRIMATES
KR102651433B1 (ko) 2006-04-14 2024-03-25 아스텔라스 인스티튜트 포 리제너러티브 메디슨 혈관 콜로니 형성 세포
US20080044847A1 (en) * 2006-06-23 2008-02-21 Shusta Eric V Blood-Brain Barrier Model
KR100986149B1 (ko) * 2007-09-14 2010-10-07 차의과학대학교 산학협력단 저 산소 배양액 조건을 이용한 배아 줄기 세포로부터유래된 배상체로부터 혈관 내피 전구 세포의 분화방법
WO2009104825A1 (en) 2008-02-18 2009-08-27 Kaist Method for inducing the defferentiation of embryonic stem cells into hemangioblast
RU2359030C1 (ru) * 2008-03-19 2009-06-20 Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты)
KR20210003301A (ko) 2008-05-06 2021-01-11 아스텔라스 인스티튜트 포 리제너러티브 메디슨 다능성 줄기세포로부터 유도된 탈핵 적혈구계 세포를 생산하는 방법
CA2802087A1 (en) 2010-06-15 2011-12-22 Cellular Dynamics International, Inc. A compendium of ready-built stem cell models for interrogation of biological response
WO2012006440A2 (en) * 2010-07-07 2012-01-12 Cellular Dynamics International, Inc. Endothelial cell production by programming
US20120295347A1 (en) * 2011-05-20 2012-11-22 Steven Kessler Methods and Compositions for Producing Endothelial Progenitor Cells from Pluripotent Stem Cells
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
RS57886B1 (sr) 2011-11-30 2019-01-31 Astellas Inst For Regenerative Medicine Mezenhimalne stromalne ćelije i primene vezane za njih
CN102719393B (zh) * 2012-06-05 2014-02-12 中山大学 一种诱导肿瘤干细胞向淋巴管内皮细胞分化的无血清培养基及方法
CA2876499C (en) 2012-07-12 2021-10-26 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
CN114558032B (zh) 2012-12-21 2025-07-29 安斯泰来再生医药协会 由多能干细胞制备血小板的方法及其组合物
CN103194423B (zh) * 2013-03-07 2015-02-25 中国人民解放军军事医学科学院野战输血研究所 培养基及其用途
JP6311707B2 (ja) * 2013-05-13 2018-04-18 コニカミノルタ株式会社 細胞染色方法及びその方法に使用する検体採取管
CA2914615C (en) 2013-06-05 2023-10-17 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
KR101756337B1 (ko) 2015-08-12 2017-07-10 고려대학교 산학협력단 Cxcr2 억제를 통한 인간 전분화능 줄기세포의 내배엽 및 중배엽 분화 방법
CN108779435B (zh) 2015-12-07 2022-05-03 再生疗法有限公司 用于重新衍生不同的多能干细胞衍生的褐色脂肪细胞的方法
EP4133058A4 (en) * 2020-04-06 2024-05-08 The Board of Trustees of the Leland Stanford Junior University GENERATING POPULATIONS OF HUMAN BLOOD AND BLOOD VESSEL PROGENITORS FROM PLURIPOTENT STEM CELLS
CN115316589A (zh) * 2021-03-30 2022-11-11 云南师范大学 一种三七茎叶中凝集素的去除方法

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US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
NZ314644A (en) 1993-05-24 2000-11-24 Immunex Corp Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue
JPH078273A (ja) * 1993-06-14 1995-01-13 Kurabo Ind Ltd 接着性動物細胞の無血清培養法
JPH09512184A (ja) * 1994-04-29 1997-12-09 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティド 内皮下細胞外基質上の内皮を利用する改善された血液接触表面
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
AU3392697A (en) 1996-06-14 1998-01-07 Regents Of The University Of California, The (in vitro) derivation and culture of primate pluripotent stem cells and therapeutic uses thereof

Also Published As

Publication number Publication date
WO2003040319A2 (en) 2003-05-15
WO2003040319A3 (en) 2003-10-23
MXPA04004067A (es) 2004-07-08
SE0401132D0 (sv) 2004-05-03
IL161461A (en) 2010-11-30
US20030166273A1 (en) 2003-09-04
EP1446476A4 (en) 2005-01-26
CA2465173C (en) 2010-04-20
LU91074B1 (en) 2004-04-30
US7176023B2 (en) 2007-02-13
IS7242A (is) 2004-04-30
JP2005508180A (ja) 2005-03-31
IL161461A0 (en) 2004-09-27
CN100540657C (zh) 2009-09-16
NZ532170A (en) 2008-05-30
KR20050042215A (ko) 2005-05-06
AU2002356896B2 (en) 2007-11-01
SE529427C2 (sv) 2007-08-07
JP4085062B2 (ja) 2008-04-30
CA2465173A1 (en) 2003-05-15
SE0401132L (sv) 2004-05-03
CN1582331A (zh) 2005-02-16
EP1446476A2 (en) 2004-08-18
SE529427C8 (sv) 2007-09-25

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: C12N 5/071 (2010.01), A61K 35/12 (2015.01)