BR0307599A - Derivados de sulfonilamino como inibidores de histona deacetilase - Google Patents

Derivados de sulfonilamino como inibidores de histona deacetilase

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Publication number
BR0307599A
BR0307599A BR0307599-0A BR0307599A BR0307599A BR 0307599 A BR0307599 A BR 0307599A BR 0307599 A BR0307599 A BR 0307599A BR 0307599 A BR0307599 A BR 0307599A
Authority
BR
Brazil
Prior art keywords
derivatives
histone deacetylase
sulphonylamino
deacetylase inhibitors
histone
Prior art date
Application number
BR0307599-0A
Other languages
English (en)
Inventor
Kristof Van Emelen
Leo Jacobus Josef Backx
Sven Franciscus Anna Va Brandt
Marc Gustaaf Celine Verdonck
Hans Louis Jos De Winter
Patrick Rene Angibaud
Isabelle Noelle Consta Pilatte
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR0307599A publication Critical patent/BR0307599A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

"DERIVADOS DE SULFONILAMINO COMO INIBIDORES DE HISTONA DEACETILASE". A presente invenção refere-se aos novos compostos de fórmula (I), em que n, t, R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 5^, Q, X, Y, Z <sym> têm significados definidos, tendo atividade enzimática inibidora de histona deacetilase; sua preparação, composições contendo os mesmos e sua aplicação como um medicamento.
BR0307599-0A 2002-03-13 2003-03-11 Derivados de sulfonilamino como inibidores de histona deacetilase BR0307599A (pt)

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PCT/EP2003/002517 WO2003076401A1 (en) 2002-03-13 2003-03-11 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase

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