BR0308982A - Combinações de epinastina, beladona e pseudoefedrina como novas formulações farmacêuticas - Google Patents
Combinações de epinastina, beladona e pseudoefedrina como novas formulações farmacêuticasInfo
- Publication number
- BR0308982A BR0308982A BR0308982-7A BR0308982A BR0308982A BR 0308982 A BR0308982 A BR 0308982A BR 0308982 A BR0308982 A BR 0308982A BR 0308982 A BR0308982 A BR 0308982A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- epinastine
- amount
- combinations
- Prior art date
Links
- WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003449 epinastine Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 241001106067 Atropa Species 0.000 title 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 title 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 title 1
- 229960003908 pseudoephedrine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000000850 decongestant Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 208000036284 Rhinitis seasonal Diseases 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 230000001078 anti-cholinergic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008203 oral pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229950010450 pseudophedrine Drugs 0.000 abstract 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 abstract 1
- 230000001932 seasonal effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMBINAçõES DE EPINASTINA, BELADONA E PSEUDOEFEDRINA COMO NOVAS FORMULAçõES FARMACêUTICAS". A presente invenção refere-se a novas composições farmacêuticas orais compreendendo, como compostos farmaceuticamente ativos, uma combinação de uma quantidade antihistamínica eficaz de epinastina ou um sal farmaceuticamente aceitável da mesma, uma quantidade anticolinérgica de alcalóides de Beladona (Beladona) ou um sal farmaceuticamente aceitável dos mesmos e de uma quantidade descongestionante-eficaz ou um sal farmaceuticamente aceitável dos mesmos. Opcionalmente, a formulação pode compreender metilefedrina (metilefrina) em uma quantidade descongestionante - eficaz ou um sal farmaceuticamente aceitável da mesma. A formulação ainda compreende veículos ou excipientes farmaceuticamente aceitáveis. Outro aspecto da presente invenção se refere a métodos para a preparação dessas composições e métodos para uso dos mesmos no tratamento de doenças e/ou distúrbios alérgicos. Em particular, a composição da invenção é útil no tratamento de rinite alérgica sazonal e conjuntivite alérgica sazonal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02007568A EP1350512A1 (en) | 2002-04-03 | 2002-04-03 | Combinations of epinastine, belladonna and pseudoephedrine as new pharmaceutical formulations |
| PCT/EP2003/003263 WO2003082285A1 (en) | 2002-04-03 | 2003-03-28 | Combinations of epinastine, belladonna and pseudoephedrine as new pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0308982A true BR0308982A (pt) | 2005-01-04 |
Family
ID=27838061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0308982-7A BR0308982A (pt) | 2002-04-03 | 2003-03-28 | Combinações de epinastina, beladona e pseudoefedrina como novas formulações farmacêuticas |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030228359A1 (pt) |
| EP (2) | EP1350512A1 (pt) |
| JP (1) | JP2005522467A (pt) |
| AR (1) | AR039221A1 (pt) |
| AU (1) | AU2003221532A1 (pt) |
| BR (1) | BR0308982A (pt) |
| CA (1) | CA2477751A1 (pt) |
| MX (1) | MXPA04009582A (pt) |
| PE (1) | PE20040080A1 (pt) |
| PL (1) | PL371382A1 (pt) |
| RU (1) | RU2004132205A (pt) |
| WO (1) | WO2003082285A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19954516A1 (de) * | 1999-11-12 | 2001-05-17 | Boehringer Ingelheim Int | Epinastin-haltige Lösungen |
| US20030104017A1 (en) * | 2001-10-26 | 2003-06-05 | Boehringer Ingelheim International Gmbh | Epinastine formulation for oral administration |
| US20060036220A1 (en) * | 2003-01-22 | 2006-02-16 | Kohji Kawahara | Percutaneous absorption preparation for treating ophthalmic disease, use thereof and method for migration of ophthalmic remedy into topical tissue in eye |
| MXPA06003320A (es) * | 2003-09-24 | 2006-06-08 | Combinatorx Inc | Regimenes terapeuticos para administrar combinaciones de farmacos. |
| RU2006132043A (ru) * | 2004-02-06 | 2008-03-20 | МЕДА Фарма ГмбХ унд Ко.КГ (DE) | Комбинация и фармацевтический препарат для лечения ринита |
| JP4936420B2 (ja) * | 2005-08-02 | 2012-05-23 | 塩野義製薬株式会社 | 徐放性顆粒剤 |
| JP5162141B2 (ja) * | 2007-02-20 | 2013-03-13 | エスエス製薬株式会社 | フィルムコーティング用組成物 |
| RU2366446C1 (ru) * | 2008-06-27 | 2009-09-10 | Сергей Анатольевич Небера | Гомеопатическое средство для лечения конъюнктивитов |
| US8298591B2 (en) * | 2008-09-10 | 2012-10-30 | Micro-Dose Life Sciences Llc | Anti-fever botanical composition and uses thereof |
| JP5845172B2 (ja) * | 2009-05-01 | 2016-01-20 | アデア ファーマスーティカルズ，インコーポレイテッド | 高および低用量薬物の組み合わせを含む口腔内崩壊錠組成物 |
| JP5852816B2 (ja) * | 2010-09-10 | 2016-02-03 | ロート製薬株式会社 | 液状医薬組成物、及びこれを含有する軟カプセル剤 |
| RU2478377C1 (ru) * | 2011-08-08 | 2013-04-10 | Алексей Владимирович Брынцалов | Комбинированный препарат орвиум для устранения симптомов простудных заболеваний и гриппа |
| CN110237079B (zh) * | 2019-07-01 | 2021-05-14 | 山西大学 | 一种百部生物碱类似物的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10298107A (ja) * | 1997-04-25 | 1998-11-10 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| US6613357B2 (en) * | 2000-01-13 | 2003-09-02 | Osmotica Corp. | Osmotic device containing pseudoephedrine and an H1 antagonist |
-
2002
- 2002-04-03 EP EP02007568A patent/EP1350512A1/en not_active Withdrawn
-
2003
- 2003-03-25 US US10/396,234 patent/US20030228359A1/en not_active Abandoned
- 2003-03-28 BR BR0308982-7A patent/BR0308982A/pt not_active Application Discontinuation
- 2003-03-28 JP JP2003579822A patent/JP2005522467A/ja active Pending
- 2003-03-28 PL PL03371382A patent/PL371382A1/xx unknown
- 2003-03-28 MX MXPA04009582A patent/MXPA04009582A/es unknown
- 2003-03-28 WO PCT/EP2003/003263 patent/WO2003082285A1/en not_active Ceased
- 2003-03-28 AU AU2003221532A patent/AU2003221532A1/en not_active Abandoned
- 2003-03-28 CA CA002477751A patent/CA2477751A1/en not_active Abandoned
- 2003-03-28 EP EP03717248A patent/EP1492532A1/en not_active Withdrawn
- 2003-03-28 RU RU2004132205/15A patent/RU2004132205A/ru not_active Application Discontinuation
- 2003-04-01 PE PE2003000332A patent/PE20040080A1/es not_active Application Discontinuation
- 2003-04-02 AR ARP030101144A patent/AR039221A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL371382A1 (en) | 2005-06-13 |
| AR039221A1 (es) | 2005-02-09 |
| US20030228359A1 (en) | 2003-12-11 |
| MXPA04009582A (es) | 2005-01-11 |
| EP1350512A1 (en) | 2003-10-08 |
| JP2005522467A (ja) | 2005-07-28 |
| EP1492532A1 (en) | 2005-01-05 |
| PE20040080A1 (es) | 2004-04-22 |
| WO2003082285A1 (en) | 2003-10-09 |
| AU2003221532A1 (en) | 2003-10-13 |
| CA2477751A1 (en) | 2003-10-09 |
| RU2004132205A (ru) | 2005-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |