BR0309401A - polinucleotìdeo isolado, vetor de expressão, célula cultivada, método para produzir polipeptìdeos, e um anticorpo para um polipeptìdeo, e, anticorpo - Google Patents
polinucleotìdeo isolado, vetor de expressão, célula cultivada, método para produzir polipeptìdeos, e um anticorpo para um polipeptìdeo, e, anticorpoInfo
- Publication number
- BR0309401A BR0309401A BRPI0309401-4A BR0309401A BR0309401A BR 0309401 A BR0309401 A BR 0309401A BR 0309401 A BR0309401 A BR 0309401A BR 0309401 A BR0309401 A BR 0309401A
- Authority
- BR
- Brazil
- Prior art keywords
- polypeptide
- antibody
- seq
- amino acids
- expression vector
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 10
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 10
- 210000004748 cultured cell Anatomy 0.000 title 1
- 239000013604 expression vector Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 7
- 208000036142 Viral infection Diseases 0.000 abstract 4
- 230000009385 viral infection Effects 0.000 abstract 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 3
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
"POLINUCLEOTìDEO ISOLADO, VETOR DE EXPRESSãO, CéLULA CULTIVADA, MéTODO PARA PRODUZIR POLIPEPTìDEOS, E UM ANTICORPO PARA UM POLIPEPTìDEO, E, ANTICORPO". Divulga-se métodos inéditos para formar um complexo de receptor heterodimérico com IL-28r e CRF2-4. Os métodos podem ser usados para detectar e tratar infecção viral, in vitro e in vivo. Também é possível utilizar polipeptídeos de receptor de ligação de ligando para bloquear atividade de ligando in vitro e in vivo. A presente invenção também inclui métodos de produzir a proteína, usos para a mesma e anticorpos para a mesma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37381302P | 2002-04-19 | 2002-04-19 | |
| PCT/US2003/012030 WO2003089603A2 (en) | 2002-04-19 | 2003-04-18 | Cytokine receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0309401A true BR0309401A (pt) | 2007-02-21 |
Family
ID=29251089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0309401-4A BR0309401A (pt) | 2002-04-19 | 2003-04-18 | polinucleotìdeo isolado, vetor de expressão, célula cultivada, método para produzir polipeptìdeos, e um anticorpo para um polipeptìdeo, e, anticorpo |
Country Status (13)
| Country | Link |
|---|---|
| US (7) | US20040029228A1 (pt) |
| EP (2) | EP2295455A1 (pt) |
| JP (2) | JP4409962B2 (pt) |
| CN (2) | CN1659274A (pt) |
| AT (1) | ATE493438T1 (pt) |
| AU (2) | AU2003225055B2 (pt) |
| BR (1) | BR0309401A (pt) |
| CA (1) | CA2482368A1 (pt) |
| DE (1) | DE60335536D1 (pt) |
| ES (1) | ES2356307T3 (pt) |
| IL (1) | IL164523A0 (pt) |
| RU (1) | RU2004133765A (pt) |
| WO (1) | WO2003089603A2 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2334888T3 (es) * | 2000-11-28 | 2010-03-17 | Zymogenetics, L.L.C. | Receptor de citocina zcytor19. |
| TW200300170A (en) * | 2001-11-09 | 2003-05-16 | Wyeth Corp | Type 2 cytokine receptor and nucleic acids encoding same |
| WO2003066002A2 (en) | 2002-02-08 | 2003-08-14 | University Of Medicine And Dentistry Of New Jersey | IFN-a/b-INDEPENDENT MECHANISM OF ANTIVIRAL PROTECTION |
| EP2295455A1 (en) * | 2002-04-19 | 2011-03-16 | ZymoGenetics, L.L.C. | Cytokine receptor |
| EP1575609A4 (en) * | 2002-10-23 | 2010-12-15 | Zymogenetics L L C | METHOD FOR THE TREATMENT OF VIRUS INFECTIONS USING IL-28 AND IL-29 |
| EP1927600A1 (en) * | 2003-08-07 | 2008-06-04 | Zymogenetics, Inc. | Homogeneous preparations of IL-28 and IL-29 |
| WO2005097165A2 (en) * | 2004-04-02 | 2005-10-20 | Zymogenetics, Inc. | Il-28 and il-29 cysteine mutants for treating viral infection |
| CA2574564C (en) | 2004-07-29 | 2013-04-16 | Zymogenetics, Inc. | Use of il-28 and il-29 to treat cancer and autoimmune disorders |
| CA2616004A1 (en) * | 2005-07-20 | 2007-02-01 | Zymogenetics, Inc. | Use of truncated cysteine il28 and il29 mutants to treat cancers and autoimmune disorders |
| JP2009502803A (ja) * | 2005-07-20 | 2009-01-29 | ザイモジェネティクス, インコーポレイテッド | Il−28およびil−29のシステイン欠失変異体、ならびにそれを用いる抗ウイルス法 |
| WO2013103981A1 (en) * | 2012-01-06 | 2013-07-11 | Ember Therapeutics, Inc. | Compositions and methods of use of fndc5 polypeptides |
| EP2617732A1 (en) * | 2012-01-19 | 2013-07-24 | Vib Vzw | Tools and methods for expression of membrane proteins |
| GB201514875D0 (en) * | 2015-08-20 | 2015-10-07 | Autolus Ltd | Receptor |
| AU2016369490C1 (en) | 2015-12-18 | 2021-12-23 | Sangamo Therapeutics, Inc. | Targeted disruption of the T cell receptor |
| JP7743500B2 (ja) * | 2020-08-05 | 2025-09-24 | シンセカイン インコーポレイテッド | Il10受容体結合性分子および使用方法 |
| WO2022032045A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | IL10Rα/IL2Rγ SYNTHETIC CYTOKINES |
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| EP2295455A1 (en) * | 2002-04-19 | 2011-03-16 | ZymoGenetics, L.L.C. | Cytokine receptor |
| EP1575609A4 (en) * | 2002-10-23 | 2010-12-15 | Zymogenetics L L C | METHOD FOR THE TREATMENT OF VIRUS INFECTIONS USING IL-28 AND IL-29 |
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-
2003
- 2003-04-18 EP EP10180287A patent/EP2295455A1/en not_active Withdrawn
- 2003-04-18 CA CA002482368A patent/CA2482368A1/en not_active Abandoned
- 2003-04-18 DE DE60335536T patent/DE60335536D1/de not_active Expired - Lifetime
- 2003-04-18 JP JP2003586316A patent/JP4409962B2/ja not_active Expired - Fee Related
- 2003-04-18 CN CN03812713.XA patent/CN1659274A/zh active Pending
- 2003-04-18 CN CN200910175119A patent/CN101676728A/zh active Pending
- 2003-04-18 EP EP03721762A patent/EP1497415B1/en not_active Expired - Lifetime
- 2003-04-18 WO PCT/US2003/012030 patent/WO2003089603A2/en not_active Ceased
- 2003-04-18 AU AU2003225055A patent/AU2003225055B2/en not_active Ceased
- 2003-04-18 RU RU2004133765/13A patent/RU2004133765A/ru not_active Application Discontinuation
- 2003-04-18 AT AT03721762T patent/ATE493438T1/de not_active IP Right Cessation
- 2003-04-18 US US10/420,034 patent/US20040029228A1/en not_active Abandoned
- 2003-04-18 ES ES03721762T patent/ES2356307T3/es not_active Expired - Lifetime
- 2003-04-18 BR BRPI0309401-4A patent/BR0309401A/pt unknown
-
2004
- 2004-10-12 IL IL16452304A patent/IL164523A0/xx unknown
-
2006
- 2006-10-09 US US11/539,841 patent/US20070048847A1/en not_active Abandoned
- 2006-10-09 US US11/539,780 patent/US7723298B2/en not_active Expired - Lifetime
- 2006-10-09 US US11/539,816 patent/US20070134727A1/en not_active Abandoned
- 2006-10-09 US US11/539,789 patent/US20070264685A1/en not_active Abandoned
-
2009
- 2009-07-23 AU AU2009203007A patent/AU2009203007A1/en not_active Abandoned
- 2009-07-24 JP JP2009172922A patent/JP2009268469A/ja not_active Ceased
-
2010
- 2010-03-12 US US12/723,364 patent/US20110171627A1/en not_active Abandoned
-
2011
- 2011-10-04 US US13/252,723 patent/US20120053321A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003225055A1 (en) | 2003-11-03 |
| ES2356307T3 (es) | 2011-04-06 |
| CN101676728A (zh) | 2010-03-24 |
| JP2006504401A (ja) | 2006-02-09 |
| US7723298B2 (en) | 2010-05-25 |
| WO2003089603A2 (en) | 2003-10-30 |
| RU2004133765A (ru) | 2005-06-27 |
| IL164523A0 (en) | 2005-12-18 |
| AU2003225055B2 (en) | 2009-04-23 |
| US20120053321A1 (en) | 2012-03-01 |
| CN1659274A (zh) | 2005-08-24 |
| EP1497415B1 (en) | 2010-12-29 |
| AU2009203007A1 (en) | 2009-08-13 |
| ATE493438T1 (de) | 2011-01-15 |
| US20040029228A1 (en) | 2004-02-12 |
| WO2003089603A3 (en) | 2004-09-16 |
| US20070134727A1 (en) | 2007-06-14 |
| EP2295455A1 (en) | 2011-03-16 |
| DE60335536D1 (de) | 2011-02-10 |
| EP1497415A4 (en) | 2006-03-22 |
| US20070122879A1 (en) | 2007-05-31 |
| US20070048847A1 (en) | 2007-03-01 |
| JP4409962B2 (ja) | 2010-02-03 |
| CA2482368A1 (en) | 2003-10-30 |
| JP2009268469A (ja) | 2009-11-19 |
| EP1497415A2 (en) | 2005-01-19 |
| US20110171627A1 (en) | 2011-07-14 |
| US20070264685A1 (en) | 2007-11-15 |
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