DK1305437T3 - Ekspression af biologisk aktive polypeptider i andemad - Google Patents
Ekspression af biologisk aktive polypeptider i andemadInfo
- Publication number
- DK1305437T3 DK1305437T3 DK01967946.3T DK01967946T DK1305437T3 DK 1305437 T3 DK1305437 T3 DK 1305437T3 DK 01967946 T DK01967946 T DK 01967946T DK 1305437 T3 DK1305437 T3 DK 1305437T3
- Authority
- DK
- Denmark
- Prior art keywords
- duckweed
- expression
- biologically active
- active polypeptides
- polypeptide
- Prior art date
Links
- 244000207740 Lemna minor Species 0.000 title abstract 7
- 229920001184 polypeptide Polymers 0.000 title abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 235000006439 Lemna minor Nutrition 0.000 title abstract 6
- 235000001855 Portulaca oleracea Nutrition 0.000 title abstract 6
- 230000028327 secretion Effects 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22170500P | 2000-07-31 | 2000-07-31 | |
| US29333001P | 2001-05-23 | 2001-05-23 | |
| PCT/US2001/023400 WO2002010414A2 (en) | 2000-07-31 | 2001-07-26 | Expression of biologically active polypeptides in duckweed |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1305437T3 true DK1305437T3 (da) | 2010-12-13 |
Family
ID=26916048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01967946.3T DK1305437T3 (da) | 2000-07-31 | 2001-07-26 | Ekspression af biologisk aktive polypeptider i andemad |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6815184B2 (da) |
| EP (1) | EP1305437B1 (da) |
| JP (1) | JP4795619B2 (da) |
| CN (2) | CN101676400A (da) |
| AT (1) | ATE479761T1 (da) |
| AU (2) | AU2001288226B2 (da) |
| CA (1) | CA2417415C (da) |
| CY (1) | CY1110959T1 (da) |
| DE (1) | DE60142971D1 (da) |
| DK (1) | DK1305437T3 (da) |
| NZ (1) | NZ523912A (da) |
| PT (1) | PT1305437E (da) |
| WO (1) | WO2002010414A2 (da) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
| US7161064B2 (en) * | 1997-08-12 | 2007-01-09 | North Carolina State University | Method for producing stably transformed duckweed using microprojectile bombardment |
| WO1999019497A1 (en) | 1997-10-10 | 1999-04-22 | Yeda Research And Development Co. Ltd. | Transgenic lemnaceae |
| US8022270B2 (en) * | 2000-07-31 | 2011-09-20 | Biolex Therapeutics, Inc. | Expression of biologically active polypeptides in duckweed |
| DK1305437T3 (da) * | 2000-07-31 | 2010-12-13 | Biolex Therapeutics Inc | Ekspression af biologisk aktive polypeptider i andemad |
| US7959910B2 (en) | 2000-07-31 | 2011-06-14 | Biolex Therapeutics, Inc. | C-terminally truncated interferon alpha variants |
| US7632983B2 (en) | 2000-07-31 | 2009-12-15 | Biolex Therapeutics, Inc. | Expression of monoclonal antibodies in duckweed |
| US20030100945A1 (en) | 2001-11-23 | 2003-05-29 | Mindguard Ltd. | Implantable intraluminal device and method of using same in treating aneurysms |
| DE60332358D1 (de) * | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| US20100196345A1 (en) * | 2003-04-27 | 2010-08-05 | Protalix | Production of high mannose proteins in plant culture |
| US7951557B2 (en) * | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| US7176024B2 (en) * | 2003-05-30 | 2007-02-13 | Biolex, Inc. | Bioreactor for growing biological materials supported on a liquid surface |
| ES2672640T3 (es) * | 2003-11-05 | 2018-06-15 | Roche Glycart Ag | Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas |
| RU2394103C2 (ru) * | 2004-02-11 | 2010-07-10 | Биолекс Терапьютикс, Инк. | Экспрессия плазминогена и микроплазминогена в ряске |
| ATE445009T1 (de) * | 2004-06-14 | 2009-10-15 | Novozymes As | Signalpeptid zur herstellung eines polypeptids |
| US7527947B2 (en) | 2004-06-14 | 2009-05-05 | Novozymes A/S | Signal peptide for producing a polypeptide |
| US20060024272A1 (en) * | 2004-07-29 | 2006-02-02 | Large Scale Biology Corporation | C-terminally truncated interferon |
| BRPI0607315B1 (pt) | 2005-02-07 | 2022-05-17 | Roche Glycart Ag | Molécula de ligação ao antígeno anti-egfr humanizada e seus usos, composição farmacêutica, e método para detectar a presença de egfr em uma amostra |
| KR20070114324A (ko) * | 2005-03-25 | 2007-11-30 | 글리카트 바이오테크놀로지 아게 | Mcsp 에 향하며 증가된 fc 수용체 결합 친화도 및효과기 작용을 갖는 항원 결합 분자 |
| WO2007039818A2 (en) * | 2005-05-09 | 2007-04-12 | Glycart Biotechnology Ag | Antigen binding molecules having modified fc regions and altered binding to fc receptors |
| TWI478940B (zh) | 2005-08-26 | 2015-04-01 | Roche Glycart Ag | 具有經改變細胞傳訊活性之改質抗原結合分子 |
| US7622573B2 (en) * | 2006-01-17 | 2009-11-24 | Biolex, Inc. | Expression control elements from the lemnaceae family |
| WO2007084672A2 (en) * | 2006-01-17 | 2007-07-26 | Medarex, Inc. | Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues |
| AR062223A1 (es) * | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
| EA200970250A1 (ru) | 2006-09-05 | 2010-02-26 | Медарекс, Инк. | Антитела к костным морфогенетическим белкам и их рецепторам и способы их применения |
| PL2129396T3 (pl) | 2007-02-16 | 2014-02-28 | Merrimack Pharmaceuticals Inc | Przeciwciała przeciw ERBB3 i ich zastosowania |
| ES2660667T3 (es) | 2007-05-07 | 2018-03-23 | Protalix Ltd. | Biorreactor desechable a gran escala |
| BRPI0814363A2 (pt) * | 2007-07-25 | 2015-01-27 | Biolex Therapeutics Inc | Produtos fármacos de interferon de liberação controlada e tratamento de infecção por hcv usando os mesmos |
| EP2225275A4 (en) | 2007-11-28 | 2013-04-03 | Medimmune Llc | PROTEIN FORMULATION |
| CN102271704A (zh) | 2008-11-28 | 2011-12-07 | 梅里亚有限公司 | 重组禽流感疫苗及其用途 |
| WO2010096545A2 (en) * | 2009-02-18 | 2010-08-26 | Biolex Thepapeutids, Inc. | Aseptic bioreactor system for processing biological materials |
| EP2435562A1 (en) | 2009-05-26 | 2012-04-04 | Biolex Therapeutics, Inc. | Compositions and methods for production of aglycosylated plasminogen |
| WO2011005502A2 (en) | 2009-06-23 | 2011-01-13 | Biolex Therapeutics, Inc. | Methods and compositions for the cryopreservation of duckweed |
| RU2570554C2 (ru) | 2009-08-31 | 2015-12-10 | Роше Гликарт Аг | Гуманизированные моноклональные антитела к сеа с созревшей аффинностью |
| KR20120101572A (ko) | 2009-12-28 | 2012-09-13 | 메리얼 리미티드 | 재조합 ndv 항원 및 이의 용도 |
| EP2944322B1 (en) | 2010-03-12 | 2018-01-17 | Merial, Inc | Bluetongue virus recombinant vaccines and uses thereof |
| WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
| US20120213781A1 (en) | 2011-02-11 | 2012-08-23 | Zyngenia, Inc. | Monovalent and Multivalent Multispecific Complexes and Uses Thereof |
| BR112013021460B1 (pt) | 2011-03-02 | 2022-12-20 | Roche Glycart Ag | Anticorpos, composição e uso do anticorpo |
| EP2714738B1 (en) | 2011-05-24 | 2018-10-10 | Zyngenia, Inc. | Multivalent and monovalent multispecific complexes and their uses |
| US9603906B2 (en) | 2012-02-01 | 2017-03-28 | Protalix Ltd. | Inhalable liquid formulations of DNase I |
| BR112014021521B1 (pt) * | 2012-04-05 | 2022-05-10 | Basf Plant Science Company Gmbh | Método para aumentar a resistência à infecção por phakopsora em uma planta de soja transgênica, método para a produção de uma planta de soja transgênica, método para a produção de um produto e método para criar uma planta transgênica resistente a fungos |
| EP2964669B1 (en) | 2013-03-06 | 2018-09-12 | Protalix Ltd. | Use of plant cells expressing a tnfalpha polypeptide inhibitor in therapy |
| US20160017021A1 (en) | 2013-03-06 | 2016-01-21 | Protalix Ltd. | TNF alpha INHIBITOR POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME, CELLS EXPRESSING SAME AND METHODS OF PRODUCING SAME |
| TWI463012B (zh) * | 2013-04-01 | 2014-12-01 | Lemnaceae Fermentation Inc | 浮萍水解物及其用途 |
| JP2016531088A (ja) | 2013-06-17 | 2016-10-06 | アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー | 5t4標的化免疫融合分子および方法 |
| MX366208B (es) * | 2013-08-21 | 2019-07-02 | Cold Spring Harbor Laboratory | Transformación de la lenteja de agua y sus usos. |
| CN103609304B (zh) * | 2013-11-22 | 2015-08-19 | 中国科学院成都生物研究所 | 一种快速提高浮萍淀粉含量的方法 |
| PH12017501834B1 (en) | 2015-04-06 | 2024-01-17 | Arcellx Inc | De novo binding domain containing polypeptides and uses thereof |
| US10946106B2 (en) | 2015-11-30 | 2021-03-16 | The Regents Of The University Of California | Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen |
| WO2017148880A1 (en) | 2016-03-01 | 2017-09-08 | F. Hoffmann-La Roche Ag | Obinutuzumab variants having altered cell death induction |
| IL245102A0 (en) | 2016-04-13 | 2016-07-31 | Yeda Res & Dev | Cultivation of wolffia plants |
| EP3538551A4 (en) | 2016-11-10 | 2020-11-11 | Fortis Therapeutics, Inc. | CD46 SPECIFIC EFFECTOR CELLS AND USES THEREOF |
| CN111511383A (zh) | 2017-11-14 | 2020-08-07 | 阿奇利克斯股份有限公司 | 多功能免疫细胞疗法 |
| MX2020004933A (es) | 2017-11-14 | 2021-01-08 | Arcellx Inc | Polipéptidos que contienen dominios d y sus usos. |
| US11484604B2 (en) | 2020-08-07 | 2022-11-01 | Fortis Therapeutics, Inc. | Immunoconjugates targeting CD46 and methods of use thereof |
| WO2022081775A1 (en) | 2020-10-13 | 2022-04-21 | Avitide LLC | Aav8 affinity agents |
| EP4229068A1 (en) | 2020-10-13 | 2023-08-23 | Avitide LLC | Affinity ligand libraries of three-helix bundle proteins and uses thereof |
| US20240236347A9 (en) | 2021-02-19 | 2024-07-11 | Avitide LLC | Aav2 affinity agents |
| IL306096A (en) | 2021-03-26 | 2023-11-01 | Arcellx Inc | Multifunctional immune cell therapies |
| CN118984834A (zh) | 2021-12-24 | 2024-11-19 | 阿维泰德有限责任公司 | Ch1结构域亲和配体和试剂 |
| EP4562022A1 (en) | 2022-07-29 | 2025-06-04 | Repligen Corporation | An affinity agent comprising a ligand that binds vce and comprises seq id no: 1 |
| AU2023339047A1 (en) | 2022-09-09 | 2025-03-20 | Repligen Corporation | Affinity agents |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8315980D0 (en) * | 1983-06-10 | 1983-07-13 | Biogen Nv | Producing hybrid dna sequences |
| US4956282A (en) | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
| US5256410A (en) * | 1988-12-01 | 1993-10-26 | Schering Corporation | Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon |
| US5850032A (en) | 1992-04-01 | 1998-12-15 | Union Camp Corporation | Method for production of plant biological products in precocious neomorphic embryoids |
| US6288302B1 (en) * | 1992-11-04 | 2001-09-11 | National Science Council Of R.O.C. | Application of α-amylase gene promoter and signal sequence in the production of recombinant proteins in transgenic plants and transgenic plant seeds |
| US5569828A (en) * | 1993-03-24 | 1996-10-29 | Pioneer Hi-Bred International, Inc. | Maize chlorotic dwarf virus and resistance thereto |
| US5780709A (en) * | 1993-08-25 | 1998-07-14 | Dekalb Genetics Corporation | Transgenic maize with increased mannitol content |
| US5693506A (en) | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
| AU6504796A (en) | 1995-07-20 | 1997-02-18 | Washington State University Research Foundation | Production of secreted foreign polypeptides in plant cell culture |
| US6066781A (en) | 1997-02-13 | 2000-05-23 | Applied Phytologics, Inc. | Production of mature proteins in plants |
| JP2001512318A (ja) * | 1997-02-13 | 2001-08-21 | アプライド フィトロジックス,インコーポレイテッド | 植物における成熟タンパク質の産生 |
| IL132580A0 (en) * | 1997-08-12 | 2001-03-19 | Univ North Carolina State | Genetically engineered duckweed |
| US7161064B2 (en) * | 1997-08-12 | 2007-01-09 | North Carolina State University | Method for producing stably transformed duckweed using microprojectile bombardment |
| US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
| WO1999019497A1 (en) * | 1997-10-10 | 1999-04-22 | Yeda Research And Development Co. Ltd. | Transgenic lemnaceae |
| US6095546A (en) * | 1997-12-03 | 2000-08-01 | Tekonsha Engineering Company | Trailer hitch cover and accessory components |
| US6096546A (en) | 1998-01-30 | 2000-08-01 | Board Of Trustees, Rutgers, The State University Of New Jersey | Methods for recovering polypeptides from plants and portions thereof |
| CA2323604A1 (en) * | 1998-03-19 | 1999-09-23 | Valentis, Inc. | Interferon alpha plasmids and delivery systems, and methods of making and using the same |
| DK1305437T3 (da) * | 2000-07-31 | 2010-12-13 | Biolex Therapeutics Inc | Ekspression af biologisk aktive polypeptider i andemad |
-
2001
- 2001-07-26 DK DK01967946.3T patent/DK1305437T3/da active
- 2001-07-26 WO PCT/US2001/023400 patent/WO2002010414A2/en not_active Ceased
- 2001-07-26 CA CA2417415A patent/CA2417415C/en not_active Expired - Fee Related
- 2001-07-26 CN CN200910174763A patent/CN101676400A/zh active Pending
- 2001-07-26 AU AU2001288226A patent/AU2001288226B2/en not_active Ceased
- 2001-07-26 EP EP01967946A patent/EP1305437B1/en not_active Expired - Lifetime
- 2001-07-26 PT PT01967946T patent/PT1305437E/pt unknown
- 2001-07-26 NZ NZ523912A patent/NZ523912A/en not_active IP Right Cessation
- 2001-07-26 CN CN01815064A patent/CN1451048A/zh active Pending
- 2001-07-26 JP JP2002516330A patent/JP4795619B2/ja not_active Expired - Fee Related
- 2001-07-26 AT AT01967946T patent/ATE479761T1/de active
- 2001-07-26 US US09/915,873 patent/US6815184B2/en not_active Expired - Fee Related
- 2001-07-26 DE DE60142971T patent/DE60142971D1/de not_active Expired - Lifetime
- 2001-07-26 AU AU8822601A patent/AU8822601A/xx active Pending
-
2004
- 2004-06-22 US US10/873,846 patent/US20050060776A1/en not_active Abandoned
-
2007
- 2007-07-16 US US11/778,480 patent/US20090282584A1/en not_active Abandoned
-
2010
- 2010-11-30 CY CY20101101098T patent/CY1110959T1/el unknown
-
2011
- 2011-09-14 US US13/232,602 patent/US20120258491A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6815184B2 (en) | 2004-11-09 |
| JP4795619B2 (ja) | 2011-10-19 |
| US20020088027A1 (en) | 2002-07-04 |
| JP2004504848A (ja) | 2004-02-19 |
| EP1305437A2 (en) | 2003-05-02 |
| CY1110959T1 (el) | 2015-06-11 |
| ATE479761T1 (de) | 2010-09-15 |
| AU8822601A (en) | 2002-02-13 |
| NZ523912A (en) | 2005-03-24 |
| PT1305437E (pt) | 2010-11-12 |
| CN1451048A (zh) | 2003-10-22 |
| CN101676400A (zh) | 2010-03-24 |
| US20050060776A1 (en) | 2005-03-17 |
| HK1055317A1 (en) | 2004-01-02 |
| CA2417415C (en) | 2012-10-09 |
| WO2002010414A3 (en) | 2002-12-27 |
| EP1305437B1 (en) | 2010-09-01 |
| AU2001288226B2 (en) | 2007-07-26 |
| DE60142971D1 (de) | 2010-10-14 |
| US20090282584A1 (en) | 2009-11-12 |
| US20120258491A1 (en) | 2012-10-11 |
| WO2002010414A2 (en) | 2002-02-07 |
| WO2002010414A9 (en) | 2003-10-30 |
| CA2417415A1 (en) | 2002-02-07 |
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| JP2002325574A5 (da) | ||
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