BR0313355A - Processo para a preparação de derivados de aminopirrolidina - Google Patents

Processo para a preparação de derivados de aminopirrolidina

Info

Publication number
BR0313355A
BR0313355A BR0313355-9A BR0313355A BR0313355A BR 0313355 A BR0313355 A BR 0313355A BR 0313355 A BR0313355 A BR 0313355A BR 0313355 A BR0313355 A BR 0313355A
Authority
BR
Brazil
Prior art keywords
derivatives
amino
preparation
production
protecting group
Prior art date
Application number
BR0313355-9A
Other languages
English (en)
Other versions
BR0313355B1 (pt
Inventor
Marc Muller
Milan Soukup
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of BR0313355A publication Critical patent/BR0313355A/pt
Publication of BR0313355B1 publication Critical patent/BR0313355B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE AMINOPIRROLIDINA". A presente invenção refere-se a um processo para a produção de derivados de 3-amino-pirrolidina de fórmula (I), no qual R^ 1^ significa hidrogênio ou um grupo de proteção amino; Z significa hidrogênio ou um grupo de proteção amino; e * representa um centro de quiralidade. Derivados de 3-amino-pirrolidina, especialmente derivados de 3-amino-pirrolidina opticamente ativos, são intermediários para a produção de agroquímicos e de substâncias farmaceuticamente ativas tais como, por exemplo, de derivados de vinilpirrolidinona-cefalosporina.
BRPI0313355-9B1A 2002-08-01 2003-07-24 Processo para a preparação de derivados de aminopirrolidina BR0313355B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02016944.7 2002-08-01
EP02016944 2002-08-01
PCT/EP2003/008132 WO2004013097A1 (en) 2002-08-01 2003-07-24 Process for the preparation of amino-pyrrolidine derivatives

Publications (2)

Publication Number Publication Date
BR0313355A true BR0313355A (pt) 2005-07-12
BR0313355B1 BR0313355B1 (pt) 2014-04-22

Family

ID=31197783

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0313355-9B1A BR0313355B1 (pt) 2002-08-01 2003-07-24 Processo para a preparação de derivados de aminopirrolidina

Country Status (18)

Country Link
US (2) US6872836B2 (pt)
EP (1) EP1546096B1 (pt)
JP (1) JP4368304B2 (pt)
KR (1) KR100919145B1 (pt)
CN (1) CN1297539C (pt)
AT (1) ATE338747T1 (pt)
AU (1) AU2003258536C1 (pt)
BR (1) BR0313355B1 (pt)
CA (1) CA2491133C (pt)
CY (1) CY1105781T1 (pt)
DE (1) DE60308204T2 (pt)
DK (1) DK1546096T3 (pt)
ES (1) ES2271652T3 (pt)
MX (1) MXPA05001150A (pt)
PT (1) PT1546096E (pt)
TW (1) TWI258466B (pt)
WO (1) WO2004013097A1 (pt)
ZA (1) ZA200500290B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006022045A (ja) * 2004-07-08 2006-01-26 Kaneka Corp 光学活性１−ｔ−ブトキシカルボニル−３−アミノピロリジン塩の単離精製方法
EP1818411A1 (en) * 2006-02-13 2007-08-15 Lonza AG Process for the preparation of optically active chiral amines
EP1897956A1 (en) * 2006-09-06 2008-03-12 Lonza AG Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase
CN101955457A (zh) * 2010-09-21 2011-01-26 海门慧聚药业有限公司 光学活性3-氨基吡咯烷、3-氨基哌啶烷及其衍生物的一种通用制备方法
CN103373953A (zh) * 2012-04-26 2013-10-30 上海阳帆医药科技有限公司 3-氨基哌啶及其光学异构体的制备方法
CN103570601B (zh) * 2012-07-20 2016-03-30 重庆博腾制药科技股份有限公司 一种光学活性药物中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4916141A (en) * 1989-03-28 1990-04-10 Warner-Lambert Company (S)-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
DE3910920A1 (de) * 1989-04-05 1990-10-11 Bayer Ag Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren
JPH04346971A (ja) * 1991-05-21 1992-12-02 Fujisawa Pharmaceut Co Ltd ピロリジン化合物またはその塩の製造法
EP1138672A1 (en) * 1998-01-12 2001-10-04 Basilea Pharmaceutica AG Process for the preparation of 3-amino-pyrrolidine derivatives

Also Published As

Publication number Publication date
KR100919145B1 (ko) 2009-09-28
AU2003258536B2 (en) 2009-06-25
JP2006506337A (ja) 2006-02-23
TWI258466B (en) 2006-07-21
EP1546096B1 (en) 2006-09-06
DE60308204T2 (de) 2007-08-23
ES2271652T3 (es) 2007-04-16
US20040127703A1 (en) 2004-07-01
KR20050023444A (ko) 2005-03-09
AU2003258536A1 (en) 2004-02-23
AU2003258536C1 (en) 2009-12-17
DE60308204D1 (de) 2006-10-19
ATE338747T1 (de) 2006-09-15
CA2491133C (en) 2009-09-01
PT1546096E (pt) 2006-12-29
MXPA05001150A (es) 2005-05-16
WO2004013097A1 (en) 2004-02-12
ZA200500290B (en) 2005-11-14
HK1080472A1 (en) 2006-04-28
CY1105781T1 (el) 2011-02-02
CN1671658A (zh) 2005-09-21
EP1546096A1 (en) 2005-06-29
TW200403222A (en) 2004-03-01
CA2491133A1 (en) 2004-02-12
BR0313355B1 (pt) 2014-04-22
US20040034236A1 (en) 2004-02-19
US7064199B2 (en) 2006-06-20
US6872836B2 (en) 2005-03-29
DK1546096T3 (da) 2006-11-20
CN1297539C (zh) 2007-01-31
JP4368304B2 (ja) 2009-11-18

Similar Documents

Publication Publication Date Title
BR0315047A (pt) Composto, composição fermacêutica que compreende o mesmo, processo para a preparação da composição farmacêutica, utilização dos compostos, método de tratamento e processo para a preparação do composto
BR9713465A (pt) Inibidores metalotprotease de amina cìclica sibstituìda
BR0206433A (pt) Composto, composição farmacêutica, processo para a prepapação de um composto, e, uso de um composto
BR0110492A (pt) Composto, composição farmacêutica que compreende esse composto, processo para a preparação de composição farmacêutica, utilização do composto e processo para a preparação do composto
ATE481987T1 (de) Verfahren zur radiofluoridierung von biologisch aktiven vektoren
BR0009411A (pt) Composto de anilina substituìda, e, processo para a preparação e uso de compostos
BR0307721A (pt) Processo para preparação de derivados de indolinona
BR0012631A (pt) Processo para a preparação de compostos de amina
BR0115036A (pt) Processo para a preparação de um composto
BRPI0411308A (pt) composto, composição farmacêutica, processo para a preparação de um composto, e, uso de um composto
BR0313795A (pt) Processo para a hidrogenação enantiosseletiva de aminoálcoois
NZ302072A (en) 1,3-diamino propyl stereomeric derivatives and organic acid and inorganic salts of their amine intermediates in the preparation of retroviral protease inhibitors
ATE194976T1 (de) Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen
BR9911250A (pt) Processo para preparação de compostos
BR0316702A (pt) xprocesso para preparação de (s)-pantoprazol
BR0016638B1 (pt) compostos anÁlogos de homopiperidilbenzimidazàis substituÍdos como relaxantes féndicos, processo para preparar os mesmos, composiÇço farmacÊutica e processo para preparÁ-la.
BR0113259A (pt) Processo para a preparação de um composto, composto e processo para a preparação de compostos
BR0314966A (pt) Processo para preparar um composto, e, composto
BR9807988A (pt) Processo para a preparação de um composto, e, composto.
BR0010225A (pt) Composto de amida, processo para prepará-lo, composição farmacêutica compreendendo dito composto, método de tratamento e uso
BR9912870A (pt) Processo para sìntese de derivados de (1h) - benzo (c)quinolizina-3-onas
BR9909870A (pt) Pirrolidinas como inibidores de neuraminidases
BRPI0017522B8 (pt) processo para preparação de secretagogos de hormônio de crescimento e polimorfo
BRPI0411652A (pt) processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos
TW200719889A (en) Amino acid derivatives

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/04/2014, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)