DK1546096T3 - Fremgangsmåde til fremstilling af aminopyrrolidinderivater - Google Patents
Fremgangsmåde til fremstilling af aminopyrrolidinderivaterInfo
- Publication number
- DK1546096T3 DK1546096T3 DK03766281T DK03766281T DK1546096T3 DK 1546096 T3 DK1546096 T3 DK 1546096T3 DK 03766281 T DK03766281 T DK 03766281T DK 03766281 T DK03766281 T DK 03766281T DK 1546096 T3 DK1546096 T3 DK 1546096T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- derivatives
- aminopyrrolidine derivatives
- sup
- protecting group
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- SBMSLRMNBSMKQC-UHFFFAOYSA-N pyrrolidin-1-amine Chemical class NN1CCCC1 SBMSLRMNBSMKQC-UHFFFAOYSA-N 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- NGXSWUFDCSEIOO-UHFFFAOYSA-N pyrrolidin-3-amine Chemical class NC1CCNC1 NGXSWUFDCSEIOO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02016944 | 2002-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1546096T3 true DK1546096T3 (da) | 2006-11-20 |
Family
ID=31197783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03766281T DK1546096T3 (da) | 2002-08-01 | 2003-07-24 | Fremgangsmåde til fremstilling af aminopyrrolidinderivater |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6872836B2 (da) |
| EP (1) | EP1546096B1 (da) |
| JP (1) | JP4368304B2 (da) |
| KR (1) | KR100919145B1 (da) |
| CN (1) | CN1297539C (da) |
| AT (1) | ATE338747T1 (da) |
| AU (1) | AU2003258536C1 (da) |
| BR (1) | BR0313355B1 (da) |
| CA (1) | CA2491133C (da) |
| CY (1) | CY1105781T1 (da) |
| DE (1) | DE60308204T2 (da) |
| DK (1) | DK1546096T3 (da) |
| ES (1) | ES2271652T3 (da) |
| MX (1) | MXPA05001150A (da) |
| PT (1) | PT1546096E (da) |
| TW (1) | TWI258466B (da) |
| WO (1) | WO2004013097A1 (da) |
| ZA (1) | ZA200500290B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006022045A (ja) * | 2004-07-08 | 2006-01-26 | Kaneka Corp | 光学活性１−ｔ−ブトキシカルボニル−３−アミノピロリジン塩の単離精製方法 |
| EP1818411A1 (en) * | 2006-02-13 | 2007-08-15 | Lonza AG | Process for the preparation of optically active chiral amines |
| EP1897956A1 (en) * | 2006-09-06 | 2008-03-12 | Lonza AG | Process for preparation of optically active amines by optical resolution of racemic amines employing a bacterial omega-transaminase |
| CN101955457A (zh) * | 2010-09-21 | 2011-01-26 | 海门慧聚药业有限公司 | 光学活性3-氨基吡咯烷、3-氨基哌啶烷及其衍生物的一种通用制备方法 |
| CN103373953A (zh) * | 2012-04-26 | 2013-10-30 | 上海阳帆医药科技有限公司 | 3-氨基哌啶及其光学异构体的制备方法 |
| CN103570601B (zh) * | 2012-07-20 | 2016-03-30 | 重庆博腾制药科技股份有限公司 | 一种光学活性药物中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4916141A (en) * | 1989-03-28 | 1990-04-10 | Warner-Lambert Company | (S)-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid |
| DE3910920A1 (de) * | 1989-04-05 | 1990-10-11 | Bayer Ag | Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren |
| JPH04346971A (ja) * | 1991-05-21 | 1992-12-02 | Fujisawa Pharmaceut Co Ltd | ピロリジン化合物またはその塩の製造法 |
| EP1138672A1 (en) * | 1998-01-12 | 2001-10-04 | Basilea Pharmaceutica AG | Process for the preparation of 3-amino-pyrrolidine derivatives |
-
2003
- 2003-07-24 AT AT03766281T patent/ATE338747T1/de active
- 2003-07-24 AU AU2003258536A patent/AU2003258536C1/en not_active Ceased
- 2003-07-24 DE DE60308204T patent/DE60308204T2/de not_active Expired - Lifetime
- 2003-07-24 ES ES03766281T patent/ES2271652T3/es not_active Expired - Lifetime
- 2003-07-24 CA CA002491133A patent/CA2491133C/en not_active Expired - Fee Related
- 2003-07-24 CN CNB038185032A patent/CN1297539C/zh not_active Expired - Fee Related
- 2003-07-24 WO PCT/EP2003/008132 patent/WO2004013097A1/en not_active Ceased
- 2003-07-24 DK DK03766281T patent/DK1546096T3/da active
- 2003-07-24 PT PT03766281T patent/PT1546096E/pt unknown
- 2003-07-24 MX MXPA05001150A patent/MXPA05001150A/es active IP Right Grant
- 2003-07-24 JP JP2004525302A patent/JP4368304B2/ja not_active Expired - Fee Related
- 2003-07-24 EP EP03766281A patent/EP1546096B1/en not_active Expired - Lifetime
- 2003-07-24 BR BRPI0313355-9B1A patent/BR0313355B1/pt not_active IP Right Cessation
- 2003-07-29 TW TW092120682A patent/TWI258466B/zh not_active IP Right Cessation
- 2003-07-29 US US10/629,483 patent/US6872836B2/en not_active Expired - Fee Related
- 2003-12-22 US US10/743,365 patent/US7064199B2/en not_active Expired - Fee Related
-
2005
- 2005-01-12 ZA ZA200500290A patent/ZA200500290B/en unknown
- 2005-01-19 KR KR1020057001035A patent/KR100919145B1/ko not_active Expired - Fee Related
-
2006
- 2006-11-14 CY CY20061101653T patent/CY1105781T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2271652T3 (es) | 2007-04-16 |
| ATE338747T1 (de) | 2006-09-15 |
| JP2006506337A (ja) | 2006-02-23 |
| TW200403222A (en) | 2004-03-01 |
| DE60308204T2 (de) | 2007-08-23 |
| CN1671658A (zh) | 2005-09-21 |
| CY1105781T1 (el) | 2011-02-02 |
| US6872836B2 (en) | 2005-03-29 |
| EP1546096A1 (en) | 2005-06-29 |
| WO2004013097A1 (en) | 2004-02-12 |
| CA2491133C (en) | 2009-09-01 |
| EP1546096B1 (en) | 2006-09-06 |
| US20040127703A1 (en) | 2004-07-01 |
| KR100919145B1 (ko) | 2009-09-28 |
| AU2003258536A1 (en) | 2004-02-23 |
| US7064199B2 (en) | 2006-06-20 |
| PT1546096E (pt) | 2006-12-29 |
| AU2003258536B2 (en) | 2009-06-25 |
| BR0313355A (pt) | 2005-07-12 |
| CA2491133A1 (en) | 2004-02-12 |
| TWI258466B (en) | 2006-07-21 |
| AU2003258536C1 (en) | 2009-12-17 |
| ZA200500290B (en) | 2005-11-14 |
| JP4368304B2 (ja) | 2009-11-18 |
| HK1080472A1 (en) | 2006-04-28 |
| MXPA05001150A (es) | 2005-05-16 |
| DE60308204D1 (de) | 2006-10-19 |
| CN1297539C (zh) | 2007-01-31 |
| BR0313355B1 (pt) | 2014-04-22 |
| KR20050023444A (ko) | 2005-03-09 |
| US20040034236A1 (en) | 2004-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2189968T3 (es) | Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS. | |
| YU41801A (sh) | Derivati fenilglicina | |
| PL341044A1 (en) | Derivatives of orthoantranilic amide as anticoagulants | |
| NO20031490L (no) | Alifatisk nitrogenholdig 5-kantet ring-forbindelse | |
| AU6645998A (en) | Oxygen or sulfur containing heteroaromatics as factor xa inhibitors | |
| DK1265606T3 (da) | Celleadhæsionsinhibitorer | |
| ZA99940B (en) | Chemical compounds. | |
| CY1106534T1 (el) | Αρωματικες εξαμελεις κυκλικες ενωσεις που περιεχουν αζωτο | |
| PT1070056E (pt) | Inibidores de pde iii/iv a base de ftalazinona | |
| AU2002351124A1 (en) | Pyrazoles-pyrimidine fungicides | |
| HUP0300743A2 (hu) | Heteroarilszármazékok és alkalmazásuk gyógyszerként | |
| YU57603A (sh) | Inhibitori fosfodiesteraze 4 | |
| BRPI0414593A (pt) | derivados de ácido sulfonamida substituìda-indol-2-carboxìlico como inibidores de pai-1 | |
| DE60135919D1 (de) | Farnesyl transferase-hemmende 6-heterocyclylmethyl-chinolin und chinazol-derivate | |
| CO5580821A2 (es) | 4-cetolactamas y -lactonas 3-fenil-3-substituidas, espirociclicas | |
| ATE383340T1 (de) | Unsymmetrische zyklische diaminverbindung | |
| MY140749A (en) | Novel piperidine compound | |
| ES2180932T3 (es) | Derivados de camptotecina y su uso como agentes antitumorales. | |
| DE60308204D1 (de) | Verfahren zur herstellung von aminopyrrolidinderivaten | |
| DE60202669D1 (de) | 6-phenylbenzonaphthyidine | |
| DE69901627D1 (de) | Verfahren zur Herstellug von 3-Amino-pyrrolidinderivaten | |
| MXPA02007973A (es) | Compuestos de aminoacidos y su uso como inhibidores de nep, ace y ece. | |
| GB0215392D0 (en) | Chemical compounds | |
| ATE255226T1 (de) | Chloridsensitive elektrodenmembran | |
| BRPI0417423A (pt) | processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis |