BR0314631A - Derivados de pirrolidona como inibidores de maob - Google Patents

Derivados de pirrolidona como inibidores de maob

Info

Publication number
BR0314631A
BR0314631A BR0314631-6A BR0314631A BR0314631A BR 0314631 A BR0314631 A BR 0314631A BR 0314631 A BR0314631 A BR 0314631A BR 0314631 A BR0314631 A BR 0314631A
Authority
BR
Brazil
Prior art keywords
derivatives
maob inhibitors
pyrrolidone derivatives
disease
maob
Prior art date
Application number
BR0314631-6A
Other languages
English (en)
Inventor
Hans Iding
Synese Jolidon
Daniela Krummenacher
Rosa Maria Rodriguez-Sarmiento
Andrew William Thomas
Beat Wirz
Wolfgang Wostl
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0314631A publication Critical patent/BR0314631A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"DERIVADOS DE PIRROLIDONA COMO INIBIDORES DE MAOB". A presente invenção refere-se a derivados de 4-pirrolidino racêmicos ou enantiomericamente puros, processos para sua preparação, composições farmacêuticas compreendendo os referidos derivados e seu uso na prevenção e tratamento de uma doença a qual é mediada por um inibidor de monoamina oxidase B, em particular mal de Alzheimer e demência senil.
BR0314631-6A 2002-09-20 2003-09-18 Derivados de pirrolidona como inibidores de maob BR0314631A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02021319 2002-09-20
PCT/EP2003/010356 WO2004026825A1 (en) 2002-09-20 2003-09-18 Pyrrolidone derivatives as maob inhibitors

Publications (1)

Publication Number Publication Date
BR0314631A true BR0314631A (pt) 2005-08-02

Family

ID=32010924

Family Applications (4)

Application Number Title Priority Date Filing Date
BRPI0314631-6A BRPI0314631B1 (pt) 2002-09-20 2003-09-18 Derivados de pirrolidona como inibidores de mao-b, seu uso, e composição farmacêutica
BR0314631-6A BR0314631A (pt) 2002-09-20 2003-09-18 Derivados de pirrolidona como inibidores de maob
BR0314299-0A BR0314299A (pt) 2002-09-20 2003-09-18 Derivados de pirrolidona como inibidores de mao-b
BR0314314-7A BR0314314A (pt) 2002-09-20 2003-09-18 Derivados do éter 4-pirrolidina-fenil-benzìlico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0314631-6A BRPI0314631B1 (pt) 2002-09-20 2003-09-18 Derivados de pirrolidona como inibidores de mao-b, seu uso, e composição farmacêutica

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR0314299-0A BR0314299A (pt) 2002-09-20 2003-09-18 Derivados de pirrolidona como inibidores de mao-b
BR0314314-7A BR0314314A (pt) 2002-09-20 2003-09-18 Derivados do éter 4-pirrolidina-fenil-benzìlico

Country Status (31)

Country Link
US (4) US7151111B2 (pt)
EP (3) EP1542971A1 (pt)
JP (3) JP4335142B2 (pt)
KR (3) KR100676015B1 (pt)
CN (3) CN100503562C (pt)
AR (3) AR041298A1 (pt)
AT (2) ATE459601T1 (pt)
AU (3) AU2003273901B2 (pt)
BR (4) BRPI0314631B1 (pt)
CA (3) CA2498335A1 (pt)
CY (1) CY1110745T1 (pt)
DE (2) DE60331559D1 (pt)
DK (1) DK1542970T3 (pt)
ES (2) ES2338646T3 (pt)
GT (3) GT200300205A (pt)
HR (3) HRP20050262A2 (pt)
JO (2) JO2605B1 (pt)
MX (3) MXPA05002880A (pt)
MY (3) MY134480A (pt)
NO (3) NO330012B1 (pt)
NZ (3) NZ538046A (pt)
PA (3) PA8583001A1 (pt)
PE (3) PE20050077A1 (pt)
PL (3) PL376019A1 (pt)
PT (1) PT1542970E (pt)
RU (3) RU2336268C2 (pt)
SI (1) SI1542970T1 (pt)
TW (3) TWI286132B (pt)
UY (3) UY27990A1 (pt)
WO (3) WO2004026826A1 (pt)
ZA (3) ZA200501137B (pt)

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PA8583001A1 (es) * 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
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KR101220182B1 (ko) 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) * 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) * 2013-02-28 2019-09-05 삼성디스플레이 주식회사 박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
NZ711598A (en) 2013-03-14 2016-09-30 Dart Neuroscience Cayman Ltd Substituted naphthyridine and quinoline compounds as mao inhibitors
CZ305213B6 (cs) 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
WO2015063001A1 (en) 2013-10-29 2015-05-07 F. Hoffmann-La Roche Ag Crystalline forms of a pyrrolidone derivative useful in the treatment of alzheimer's disease and preparation thereof
WO2016102967A1 (en) 2014-12-23 2016-06-30 Convergence Pharmaceuticals Limited Process for preparing alpha-carboxamide pyrrolidine derivatives
WO2016156124A1 (en) 2015-03-27 2016-10-06 F. Hoffmann-La Roche Ag Pharmaceutical formulation comprising sembragiline
EP3689870B1 (en) 2017-09-27 2022-07-13 Kagoshima University Analgesic drug using pac1 receptor antagonistic drug
EP3691634A4 (en) 2017-10-05 2021-03-31 Biogen Inc. PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES
CN108299272B (zh) * 2018-01-31 2019-10-18 福州大学 一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
CA3092747A1 (en) * 2018-03-08 2019-09-12 Sunshine Lake Pharma Co., Ltd. Pyrrolidineamide derivatives and uses thereof
WO2020175134A1 (ja) 2019-02-27 2020-09-03 国立大学法人鹿児島大学 Ｐａｃ１受容体拮抗薬を用いた鎮痒薬
WO2021225161A1 (ja) 2020-05-08 2021-11-11 国立大学法人鹿児島大学 Ｐａｃ１受容体拮抗薬を用いた抗うつ・抗不安薬
CN112851561A (zh) * 2021-01-29 2021-05-28 南京艾美斐生物医药科技有限公司 一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de) 2021-06-21 2022-12-29 Bayer Aktiengesellschaft Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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KR100681586B1 (ko) 2007-02-09
DK1542970T3 (da) 2010-08-02
PL376019A1 (en) 2005-12-12
AR041297A1 (es) 2005-05-11
EP1542969A1 (en) 2005-06-22
CN1681779A (zh) 2005-10-12
GT200300204A (es) 2004-04-29
HK1083498A1 (zh) 2006-07-07
PE20050077A1 (es) 2005-03-01
NZ538046A (en) 2007-08-31
TWI286132B (en) 2007-09-01
KR20050057456A (ko) 2005-06-16
JO2604B1 (en) 2011-11-01
CA2498785C (en) 2011-07-26
RU2005111968A (ru) 2006-11-10
MY133332A (en) 2007-11-30
JO2605B1 (en) 2011-11-01
EP1542969B1 (en) 2010-03-03
EP1542970A1 (en) 2005-06-22
CN100383118C (zh) 2008-04-23
CA2496756A1 (en) 2004-04-01
BR0314299A (pt) 2005-12-13
HRP20050263A2 (en) 2006-12-31
GT200300206A (es) 2004-04-29
CA2496756C (en) 2012-01-10
AU2003267381A1 (en) 2004-04-08
UY27993A1 (es) 2004-03-31
US7151111B2 (en) 2006-12-19
JP2006503834A (ja) 2006-02-02
MY135696A (en) 2008-06-30
AU2003270213A1 (en) 2004-04-08
US20040106650A1 (en) 2004-06-03
PA8583501A1 (es) 2004-04-23
HK1084383A1 (en) 2006-07-28
ES2338646T3 (es) 2010-05-11
ATE459601T1 (de) 2010-03-15
AU2003273901A1 (en) 2004-04-08
EP1542971A1 (en) 2005-06-22
HK1083499A1 (zh) 2006-07-07
US20040116707A1 (en) 2004-06-17
BR0314314A (pt) 2005-07-26
HRP20050263B1 (hr) 2013-09-30
SI1542970T1 (sl) 2010-08-31
PE20050079A1 (es) 2005-03-01
NO330012B1 (no) 2011-02-07
EP1542970B1 (en) 2010-06-30
TW200413350A (en) 2004-08-01
CN100400509C (zh) 2008-07-09
JP2006503833A (ja) 2006-02-02
CY1110745T1 (el) 2015-06-10
NO329754B1 (no) 2010-12-13
ZA200501557B (en) 2005-09-08
HRP20050262A2 (en) 2006-06-30
AU2003273901B2 (en) 2008-07-10
PA8583601A1 (es) 2004-09-16
US20040097578A1 (en) 2004-05-20
DE60333202D1 (de) 2010-08-12
AR041298A1 (es) 2005-05-11
US7122562B2 (en) 2006-10-17
BRPI0314631B1 (pt) 2018-04-17
US7235581B2 (en) 2007-06-26
KR20050057466A (ko) 2005-06-16
JP4335142B2 (ja) 2009-09-30
RU2005111969A (ru) 2006-01-20
KR100676014B1 (ko) 2007-01-30
DE60331559D1 (de) 2010-04-15
MY134480A (en) 2007-12-31
PE20050078A1 (es) 2005-02-28
US20060122235A1 (en) 2006-06-08
WO2004026826A1 (en) 2004-04-01
ZA200501137B (en) 2006-12-27
GT200300205A (es) 2004-04-29
NZ538048A (en) 2007-05-31
TW200408624A (en) 2004-06-01
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MXPA05002881A (es) 2005-05-27
PL216030B1 (pl) 2014-02-28
JP4335140B2 (ja) 2009-09-30
PL376021A1 (en) 2005-12-12
RU2336267C2 (ru) 2008-10-20
ZA200501311B (en) 2006-10-25
HRP20050261A2 (en) 2006-05-31
PL376018A1 (en) 2005-12-12
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