ATE472530T1 - Pyrrolidonderivate als mao-b hemmer - Google Patents

Pyrrolidonderivate als mao-b hemmer

Info

Publication number: ATE472530T1
Authority: AT; Austria
Prior art keywords: hemmer; mao; pyrrolidone derivatives; pyrrolidone; derivatives
Prior art date: 2002-09-20

Application number

AT03750564T

Other languages

English (en)

Inventor

Hans Iding

Synese Jolidon

Daniela Krummenacher

Rosa Rodriguez-Sarmiento

Andrew Thomas

Beat Wirz

Wolfgang Wostl

Rene Wyler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-20

Filing date

2003-09-18

Publication date

2010-07-15

2003-09-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE472530T1 publication Critical patent/ATE472530T1/de

Links

102000010909 Monoamine Oxidase Human genes 0.000 title 1
108010062431 Monoamine oxidase Proteins 0.000 title 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical class O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Child & Adolescent Psychology (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT03750564T 2002-09-20 2003-09-18 Pyrrolidonderivate als mao-b hemmer ATE472530T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02021319		2002-09-20
PCT/EP2003/010356 WO2004026825A1 (en)	2002-09-20	2003-09-18	Pyrrolidone derivatives as maob inhibitors

Publications (1)

Publication Number	Publication Date
ATE472530T1 true ATE472530T1 (de)	2010-07-15

Family

ID=32010924

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03748052T ATE459601T1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer
AT03750564T ATE472530T1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT03748052T ATE459601T1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer

Country Status (31)

Country	Link
US (4)	US7151111B2 (de)
EP (3)	EP1542971A1 (de)
JP (3)	JP4335142B2 (de)
KR (3)	KR100676015B1 (de)
CN (3)	CN100503562C (de)
AR (3)	AR041298A1 (de)
AT (2)	ATE459601T1 (de)
AU (3)	AU2003273901B2 (de)
BR (4)	BRPI0314631B1 (de)
CA (3)	CA2498335A1 (de)
CY (1)	CY1110745T1 (de)
DE (2)	DE60331559D1 (de)
DK (1)	DK1542970T3 (de)
ES (2)	ES2338646T3 (de)
GT (3)	GT200300205A (de)
HR (3)	HRP20050262A2 (de)
JO (2)	JO2605B1 (de)
MX (3)	MXPA05002880A (de)
MY (3)	MY134480A (de)
NO (3)	NO330012B1 (de)
NZ (3)	NZ538046A (de)
PA (3)	PA8583001A1 (de)
PE (3)	PE20050077A1 (de)
PL (3)	PL376019A1 (de)
PT (1)	PT1542970E (de)
RU (3)	RU2336268C2 (de)
SI (1)	SI1542970T1 (de)
TW (3)	TWI286132B (de)
UY (3)	UY27990A1 (de)
WO (3)	WO2004026826A1 (de)
ZA (3)	ZA200501137B (de)

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PA8583001A1 (es) *	2002-09-20	2004-04-23	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
GB0314373D0 (en)	2003-06-19	2003-07-23	Glaxo Group Ltd	Chemical compounds
KR100845366B1 (ko) *	2004-08-02	2008-07-09	에프. 호프만-라 로슈 아게	모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
AU2005268894B2 (en) *	2004-08-02	2010-12-16	F. Hoffmann-La Roche Ag	Benzyloxy derivatives as MAOB inhibitors
CA2598762A1 (en)	2005-02-25	2006-08-31	F. Hoffmann-La Roche Ag	Tablets with improved drug substance dispersibility
US7501528B2 (en) *	2005-03-15	2009-03-10	Hoffmann-La Roche Inc.	Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
CN101142181B (zh) *	2005-03-15	2011-05-04	弗·哈夫曼-拉罗切有限公司	对映异构纯的4-吡咯烷子基苯基苄基醚衍生物的制备方法
TW200730494A (en)	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
TW200728258A (en)	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
EP1943216B1 (de) *	2005-10-10	2010-06-30	Glaxo Group Limited	Prolinamidderivate als natriumkanalmodulatoren
EP2171478A4 (de) *	2007-03-30	2013-01-30	Univ California	In-vivo-bildgebungsverfahren für sulfotransferasen
KR101220182B1 (ko)	2009-02-25	2013-01-11	에스케이바이오팜 주식회사	치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) *	2011-08-22	2013-09-04	Farmak, A. S.	Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) *	2013-02-28	2019-09-05	삼성디스플레이 주식회사	박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
NZ711598A (en)	2013-03-14	2016-09-30	Dart Neuroscience Cayman Ltd	Substituted naphthyridine and quinoline compounds as mao inhibitors
CZ305213B6 (cs)	2013-04-29	2015-06-10	Farmak, A. S.	Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
WO2015063001A1 (en)	2013-10-29	2015-05-07	F. Hoffmann-La Roche Ag	Crystalline forms of a pyrrolidone derivative useful in the treatment of alzheimer's disease and preparation thereof
WO2016102967A1 (en)	2014-12-23	2016-06-30	Convergence Pharmaceuticals Limited	Process for preparing alpha-carboxamide pyrrolidine derivatives
WO2016156124A1 (en)	2015-03-27	2016-10-06	F. Hoffmann-La Roche Ag	Pharmaceutical formulation comprising sembragiline
EP3689870B1 (de)	2017-09-27	2022-07-13	Kagoshima University	Analgetikum unter verwendung eines pac1-rezeptor-antagonisten-arzneimittels
EP3691634A4 (de)	2017-10-05	2021-03-31	Biogen Inc.	Verfahren zur herstellung von alpha-carboxamid-pyrolidin-derivaten
CN108299272B (zh) *	2018-01-31	2019-10-18	福州大学	一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
CA3092747A1 (en) *	2018-03-08	2019-09-12	Sunshine Lake Pharma Co., Ltd.	Pyrrolidineamide derivatives and uses thereof
WO2020175134A1 (ja)	2019-02-27	2020-09-03	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた鎮痒薬
WO2021225161A1 (ja)	2020-05-08	2021-11-11	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた抗うつ・抗不安薬
CN112851561A (zh) *	2021-01-29	2021-05-28	南京艾美斐生物医药科技有限公司	一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de)	2021-06-21	2022-12-29	Bayer Aktiengesellschaft	Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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FR2500831A1 (fr)	1981-02-27	1982-09-03	Delalande Sa	Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
DK0393607T3 (da)	1989-04-19	1996-03-18	Otsuka Pharma Co Ltd	Phenylcarboxylsyrederivater med en heteroring
NZ291508A (en) *	1994-08-30	1999-07-29	Sankyo Co	Isoxazoles; preparation and medicaments
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EP1165546A2 (de) *	1999-04-02	2002-01-02	Du Pont Pharmaceuticals Company	Lactamverbindungen als metalloprotease, tnf-alpha und aggrecanase inhibitoren
WO2001034172A2 (en)	1999-11-05	2001-05-17	Vela Pharmaceuticals Inc.	Methods and compositions for treating reward deficiency syndrome
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EP1255513B1 (de) *	2000-02-14	2005-05-25	Potencia Medical AG	Penisprothese
PA8583001A1 (es) *	2002-09-20	2004-04-23	Hoffmann La Roche	Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b
US20040267292A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with transverse attachment mechanism
US20040267291A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with non-mechanical attachment mechanism

2003
- 2003-09-17 PA PA20038583001A patent/PA8583001A1/es unknown
- 2003-09-17 PE PE2003000952A patent/PE20050077A1/es not_active Application Discontinuation
- 2003-09-17 TW TW092125618A patent/TWI286132B/zh not_active IP Right Cessation
- 2003-09-17 MY MYPI20033545A patent/MY134480A/en unknown
- 2003-09-18 JP JP2004537121A patent/JP4335142B2/ja not_active Expired - Fee Related
- 2003-09-18 CA CA002498335A patent/CA2498335A1/en not_active Abandoned
- 2003-09-18 US US10/667,087 patent/US7151111B2/en not_active Expired - Lifetime
- 2003-09-18 TW TW092125735A patent/TWI337604B/zh not_active IP Right Cessation
- 2003-09-18 CN CNB038212560A patent/CN100503562C/zh not_active Expired - Fee Related
- 2003-09-18 AU AU2003273901A patent/AU2003273901B2/en not_active Ceased
- 2003-09-18 CA CA2496756A patent/CA2496756C/en not_active Expired - Fee Related
- 2003-09-18 JP JP2004537120A patent/JP4335141B2/ja not_active Expired - Fee Related
- 2003-09-18 AU AU2003270213A patent/AU2003270213B8/en not_active Ceased
- 2003-09-18 EP EP03757866A patent/EP1542971A1/de not_active Withdrawn
- 2003-09-18 KR KR1020057004683A patent/KR100676015B1/ko not_active Expired - Fee Related
- 2003-09-18 UY UY27990A patent/UY27990A1/es not_active Application Discontinuation
- 2003-09-18 SI SI200331830T patent/SI1542970T1/sl unknown
- 2003-09-18 MX MXPA05002880A patent/MXPA05002880A/es active IP Right Grant
- 2003-09-18 HR HR20050262A patent/HRP20050262A2/xx not_active Application Discontinuation
- 2003-09-18 AR ARP030103384A patent/AR041298A1/es unknown
- 2003-09-18 CN CNB038217678A patent/CN100400509C/zh not_active Expired - Fee Related
- 2003-09-18 PA PA20038583501A patent/PA8583501A1/es unknown
- 2003-09-18 DE DE60331559T patent/DE60331559D1/de not_active Expired - Lifetime
- 2003-09-18 NZ NZ538046A patent/NZ538046A/en not_active IP Right Cessation
- 2003-09-18 ES ES03748052T patent/ES2338646T3/es not_active Expired - Lifetime
- 2003-09-18 WO PCT/EP2003/010383 patent/WO2004026826A1/en not_active Ceased
- 2003-09-18 AR ARP030103383A patent/AR041297A1/es unknown
- 2003-09-18 PT PT03750564T patent/PT1542970E/pt unknown
- 2003-09-18 PL PL03376019A patent/PL376019A1/xx not_active Application Discontinuation
- 2003-09-18 MX MXPA05002881A patent/MXPA05002881A/es active IP Right Grant
- 2003-09-18 RU RU2005111968/04A patent/RU2336268C2/ru not_active IP Right Cessation
- 2003-09-18 GT GT200300205A patent/GT200300205A/es unknown
- 2003-09-18 KR KR1020057004718A patent/KR100676014B1/ko not_active Expired - Fee Related
- 2003-09-18 RU RU2005111974/04A patent/RU2336267C2/ru not_active IP Right Cessation
- 2003-09-18 US US10/667,088 patent/US7037935B2/en not_active Expired - Fee Related
- 2003-09-18 GT GT200300206A patent/GT200300206A/es unknown
- 2003-09-18 PA PA20038583601A patent/PA8583601A1/es unknown
- 2003-09-18 PL PL03376018A patent/PL376018A1/xx not_active Application Discontinuation
- 2003-09-18 PL PL376021A patent/PL216030B1/pl unknown
- 2003-09-18 AT AT03748052T patent/ATE459601T1/de active
- 2003-09-18 UY UY27991A patent/UY27991A1/es not_active Application Discontinuation
- 2003-09-18 CN CNB038219522A patent/CN100383118C/zh not_active Expired - Fee Related
- 2003-09-18 RU RU2005111969/04A patent/RU2323209C2/ru not_active IP Right Cessation
- 2003-09-18 KR KR1020057004699A patent/KR100681586B1/ko not_active Expired - Fee Related
- 2003-09-18 DK DK03750564.1T patent/DK1542970T3/da active
- 2003-09-18 BR BRPI0314631-6A patent/BRPI0314631B1/pt unknown
- 2003-09-18 JO JO2003116A patent/JO2605B1/en active
- 2003-09-18 EP EP03748052A patent/EP1542969B1/de not_active Expired - Lifetime
- 2003-09-18 AT AT03750564T patent/ATE472530T1/de active
- 2003-09-18 PE PE2003000956A patent/PE20050078A1/es not_active Application Discontinuation
- 2003-09-18 WO PCT/EP2003/010384 patent/WO2004026827A1/en not_active Ceased
- 2003-09-18 CA CA2498785A patent/CA2498785C/en not_active Expired - Fee Related
- 2003-09-18 EP EP03750564A patent/EP1542970B1/de not_active Expired - Lifetime
- 2003-09-18 BR BR0314631-6A patent/BR0314631A/pt not_active IP Right Cessation
- 2003-09-18 DE DE60333202T patent/DE60333202D1/de not_active Expired - Lifetime
- 2003-09-18 US US10/666,594 patent/US7235581B2/en not_active Expired - Fee Related
- 2003-09-18 WO PCT/EP2003/010356 patent/WO2004026825A1/en not_active Ceased
- 2003-09-18 AU AU2003267381A patent/AU2003267381B2/en not_active Ceased
- 2003-09-18 AR ARP030103385A patent/AR041299A1/es not_active Application Discontinuation
- 2003-09-18 BR BR0314299-0A patent/BR0314299A/pt active Search and Examination
- 2003-09-18 NZ NZ538049A patent/NZ538049A/en unknown
- 2003-09-18 JO JO2003115A patent/JO2604B1/en active
- 2003-09-18 BR BR0314314-7A patent/BR0314314A/pt not_active IP Right Cessation
- 2003-09-18 HR HRP20050263AA patent/HRP20050263B1/hr not_active IP Right Cessation
- 2003-09-18 NZ NZ538048A patent/NZ538048A/en not_active IP Right Cessation
- 2003-09-18 MY MYPI20033559A patent/MY135696A/en unknown
- 2003-09-18 GT GT200300204A patent/GT200300204A/es unknown
- 2003-09-18 HR HR20050261A patent/HRP20050261A2/hr not_active Application Discontinuation
- 2003-09-18 TW TW092125746A patent/TWI331994B/zh not_active IP Right Cessation
- 2003-09-18 JP JP2004537119A patent/JP4335140B2/ja not_active Expired - Fee Related
- 2003-09-18 MY MYPI20033558A patent/MY133332A/en unknown
- 2003-09-18 MX MXPA05002878A patent/MXPA05002878A/es active IP Right Grant
- 2003-09-18 PE PE2003000958A patent/PE20050079A1/es active IP Right Grant
- 2003-09-18 ES ES03750564T patent/ES2344557T3/es not_active Expired - Lifetime
- 2003-09-19 UY UY27993A patent/UY27993A1/es not_active Application Discontinuation
2005
- 2005-02-08 ZA ZA200501137A patent/ZA200501137B/xx unknown
- 2005-02-08 NO NO20050665A patent/NO330012B1/no not_active IP Right Cessation
- 2005-02-08 NO NO20050652A patent/NO329754B1/no not_active IP Right Cessation
- 2005-02-09 NO NO20050701A patent/NO20050701L/no not_active Application Discontinuation
- 2005-02-14 ZA ZA200501311A patent/ZA200501311B/en unknown
- 2005-02-22 ZA ZA200501557A patent/ZA200501557B/xx unknown
2006
- 2006-01-05 US US11/325,747 patent/US7122562B2/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
KR100681586B1 (ko)	2007-02-09
DK1542970T3 (da)	2010-08-02
PL376019A1 (en)	2005-12-12
AR041297A1 (es)	2005-05-11
EP1542969A1 (de)	2005-06-22
CN1681779A (zh)	2005-10-12
GT200300204A (es)	2004-04-29
HK1083498A1 (zh)	2006-07-07
PE20050077A1 (es)	2005-03-01
NZ538046A (en)	2007-08-31
TWI286132B (en)	2007-09-01
KR20050057456A (ko)	2005-06-16
JO2604B1 (en)	2011-11-01
CA2498785C (en)	2011-07-26
RU2005111968A (ru)	2006-11-10
MY133332A (en)	2007-11-30
JO2605B1 (en)	2011-11-01
EP1542969B1 (de)	2010-03-03
EP1542970A1 (de)	2005-06-22
CN100383118C (zh)	2008-04-23
CA2496756A1 (en)	2004-04-01
BR0314299A (pt)	2005-12-13
HRP20050263A2 (en)	2006-12-31
GT200300206A (es)	2004-04-29
CA2496756C (en)	2012-01-10
AU2003267381A1 (en)	2004-04-08
UY27993A1 (es)	2004-03-31
US7151111B2 (en)	2006-12-19
JP2006503834A (ja)	2006-02-02
MY135696A (en)	2008-06-30
AU2003270213A1 (en)	2004-04-08
US20040106650A1 (en)	2004-06-03
PA8583501A1 (es)	2004-04-23
HK1084383A1 (en)	2006-07-28
ES2338646T3 (es)	2010-05-11
ATE459601T1 (de)	2010-03-15
AU2003273901A1 (en)	2004-04-08
EP1542971A1 (de)	2005-06-22
HK1083499A1 (zh)	2006-07-07
US20040116707A1 (en)	2004-06-17
BR0314314A (pt)	2005-07-26
HRP20050263B1 (hr)	2013-09-30
SI1542970T1 (sl)	2010-08-31
PE20050079A1 (es)	2005-03-01
NO330012B1 (no)	2011-02-07
BR0314631A (pt)	2005-08-02
EP1542970B1 (de)	2010-06-30
TW200413350A (en)	2004-08-01
CN100400509C (zh)	2008-07-09
JP2006503833A (ja)	2006-02-02
CY1110745T1 (el)	2015-06-10
NO329754B1 (no)	2010-12-13
ZA200501557B (en)	2005-09-08
HRP20050262A2 (en)	2006-06-30
AU2003273901B2 (en)	2008-07-10
PA8583601A1 (es)	2004-09-16
US20040097578A1 (en)	2004-05-20
DE60333202D1 (de)	2010-08-12
AR041298A1 (es)	2005-05-11
US7122562B2 (en)	2006-10-17
BRPI0314631B1 (pt)	2018-04-17
US7235581B2 (en)	2007-06-26
KR20050057466A (ko)	2005-06-16
JP4335142B2 (ja)	2009-09-30
RU2005111969A (ru)	2006-01-20
KR100676014B1 (ko)	2007-01-30
DE60331559D1 (de)	2010-04-15
MY134480A (en)	2007-12-31
PE20050078A1 (es)	2005-02-28
US20060122235A1 (en)	2006-06-08
WO2004026826A1 (en)	2004-04-01
ZA200501137B (en)	2006-12-27
GT200300205A (es)	2004-04-29
NZ538048A (en)	2007-05-31
TW200408624A (en)	2004-06-01
RU2323209C2 (ru)	2008-04-27
WO2004026825A1 (en)	2004-04-01
MXPA05002881A (es)	2005-05-27
PL216030B1 (pl)	2014-02-28
JP4335140B2 (ja)	2009-09-30
PL376021A1 (en)	2005-12-12
RU2336267C2 (ru)	2008-10-20
ZA200501311B (en)	2006-10-25
HRP20050261A2 (en)	2006-05-31
PL376018A1 (en)	2005-12-12
CA2498785A1 (en)	2004-04-01
RU2336268C2 (ru)	2008-10-20
CA2498335A1 (en)	2004-04-01
AU2003270213B8 (en)	2009-03-05
WO2004026827A1 (en)	2004-04-01
NO20050665L (no)	2005-04-18
PA8583001A1 (es)	2004-04-23
MXPA05002880A (es)	2005-05-27
MXPA05002878A (es)	2005-05-27
JP4335141B2 (ja)	2009-09-30
NZ538049A (en)	2007-05-31
CN100503562C (zh)	2009-06-24
RU2005111974A (ru)	2006-01-20
TWI331994B (en)	2010-10-21
US7037935B2 (en)	2006-05-02
JP2006510596A (ja)	2006-03-30
AU2003270213B2 (en)	2009-02-12
TWI337604B (en)	2011-02-21
UY27991A1 (es)	2004-03-31
CN1681777A (zh)	2005-10-12
NO20050652L (no)	2005-03-08
UY27990A1 (es)	2004-03-31
CN1681778A (zh)	2005-10-12
AR041299A1 (es)	2005-05-11
AU2003267381B2 (en)	2009-08-27
ES2344557T3 (es)	2010-08-31
PT1542970E (pt)	2010-07-19
KR100676015B1 (ko)	2007-01-30
TW200410935A (en)	2004-07-01
NO20050701L (no)	2005-03-02
KR20050057450A (ko)	2005-06-16

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