ATE472530T1 - Pyrrolidonderivate als mao-b hemmer - Google Patents

Pyrrolidonderivate als mao-b hemmer

Info

Publication number: ATE472530T1
Authority: AT; Austria
Prior art keywords: hemmer; mao; pyrrolidone derivatives; pyrrolidone; derivatives
Prior art date: 2002-09-20

Application number

AT03750564T

Other languages

English (en)

Inventor

Hans Iding

Synese Jolidon

Daniela Krummenacher

Rosa Rodriguez-Sarmiento

Andrew Thomas

Beat Wirz

Wolfgang Wostl

Rene Wyler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-20

Filing date

2003-09-18

Publication date

2010-07-15

2003-09-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-07-15 Application granted granted Critical

2010-07-15 Publication of ATE472530T1 publication Critical patent/ATE472530T1/de

Links

102000010909 Monoamine Oxidase Human genes 0.000 title 1
108010062431 Monoamine oxidase Proteins 0.000 title 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical class O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT03750564T 2002-09-20 2003-09-18 Pyrrolidonderivate als mao-b hemmer ATE472530T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02021319		2002-09-20
PCT/EP2003/010356 WO2004026825A1 (en)	2002-09-20	2003-09-18	Pyrrolidone derivatives as maob inhibitors

Publications (1)

Publication Number	Publication Date
ATE472530T1 true ATE472530T1 (de)	2010-07-15

Family

ID=32010924

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT03748052T ATE459601T1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer
AT03750564T ATE472530T1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT03748052T ATE459601T1 (de)	2002-09-20	2003-09-18	Pyrrolidonderivate als mao-b hemmer

Country Status (31)

Country	Link
US (4)	US7151111B2 (de)
EP (3)	EP1542969B1 (de)
JP (3)	JP4335142B2 (de)
KR (3)	KR100676014B1 (de)
CN (3)	CN100383118C (de)
AR (3)	AR041299A1 (de)
AT (2)	ATE459601T1 (de)
AU (3)	AU2003267381B2 (de)
BR (4)	BR0314314A (de)
CA (3)	CA2498785C (de)
CY (1)	CY1110745T1 (de)
DE (2)	DE60333202D1 (de)
DK (1)	DK1542970T3 (de)
ES (2)	ES2338646T3 (de)
GT (3)	GT200300204A (de)
HR (3)	HRP20050263B1 (de)
JO (2)	JO2605B1 (de)
MX (3)	MXPA05002878A (de)
MY (3)	MY134480A (de)
NO (3)	NO329754B1 (de)
NZ (3)	NZ538048A (de)
PA (3)	PA8583001A1 (de)
PE (3)	PE20050077A1 (de)
PL (3)	PL376019A1 (de)
PT (1)	PT1542970E (de)
RU (3)	RU2323209C2 (de)
SI (1)	SI1542970T1 (de)
TW (3)	TWI286132B (de)
UY (3)	UY27991A1 (de)
WO (3)	WO2004026825A1 (de)
ZA (3)	ZA200501137B (de)

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TWI286132B (en) *	2002-09-20	2007-09-01	Hoffmann La Roche	4-pyrrolidino-phenyl-benzyl ether derivatives
GB0314373D0 (en) *	2003-06-19	2003-07-23	Glaxo Group Ltd	Chemical compounds
RU2378270C2 (ru) *	2004-08-02	2010-01-10	Ф. Хоффманн-Ля Рош Аг	Бензилокси-производные в качестве ингибиторов моноаминоксидазы b
KR100845366B1 (ko) *	2004-08-02	2008-07-09	에프. 호프만-라 로슈 아게	모노아민 산화효소 ｂ 억제제로서 벤질옥시 유도체
AU2006218193A1 (en)	2005-02-25	2006-08-31	F. Hoffmann-La Roche Ag	Tablets with improved drug substance dispersibility
US7501528B2 (en) *	2005-03-15	2009-03-10	Hoffmann-La Roche Inc.	Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
EP1861362B1 (de) *	2005-03-15	2008-11-26	F.Hoffmann-La Roche Ag	Verfahren zur herstellung von enantiomerenreinen 4-pyrrolidinophenyl- benzyletherderivaten
TW200728258A (en) *	2005-10-10	2007-08-01	Glaxo Group Ltd	Novel compounds
TW200730494A (en)	2005-10-10	2007-08-16	Glaxo Group Ltd	Novel compounds
EP1943216B1 (de) *	2005-10-10	2010-06-30	Glaxo Group Limited	Prolinamidderivate als natriumkanalmodulatoren
US8372380B2 (en) *	2007-03-30	2013-02-12	The Regents Of The University Of California	In vivo imaging of sulfotransferases
KR101220182B1 (ko)	2009-02-25	2013-01-11	에스케이바이오팜 주식회사	치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CZ304053B6 (cs) *	2011-08-22	2013-09-04	Farmak, A. S.	Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
KR102018284B1 (ko) *	2013-02-28	2019-09-05	삼성디스플레이 주식회사	박막 트랜지스터 어레이 기판 및 이를 포함하는 유기 발광 표시 장치
MX2015011144A (es)	2013-03-14	2016-02-09	Dart Neuroscience Cayman Ltd	Compuestos de quinolina y naftiridina, substituidos, como inhibidores de monoanina-oxidasas (mao).
CZ305213B6 (cs) *	2013-04-29	2015-06-10	Farmak, A. S.	Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
CN105705487A (zh) *	2013-10-29	2016-06-22	豪夫迈·罗氏有限公司	可用于治疗阿尔茨海默病的吡咯烷酮衍生物的晶形及其制备
EP3237379B1 (de)	2014-12-23	2022-04-06	Convergence Pharmaceuticals Limited	Verfahren zur herstellung von alpha-carboxamid-pyrrolidinderivaten
JP2018509400A (ja) *	2015-03-27	2018-04-05	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	セムブラギリンを含む医薬製剤
WO2019065794A1 (ja)	2017-09-27	2019-04-04	国立大学法人鹿児島大学	Ｐａｃ１受容体拮抗薬を用いた鎮痛薬
WO2019071162A2 (en)	2017-10-05	2019-04-11	Biogen Inc.	PROCESS FOR THE PREPARATION OF PYRROLIDINE ALPHA-CARBOXAMIDE DERIVATIVES
CN108299272B (zh) *	2018-01-31	2019-10-18	福州大学	一种合成1-氯-2,2,2-三氟亚乙基取代咯酮化合物的方法
CA3092747A1 (en) *	2018-03-08	2019-09-12	Sunshine Lake Pharma Co., Ltd.	Pyrrolidineamide derivatives and uses thereof
US20220184081A1 (en)	2019-02-27	2022-06-16	Kagoshima University	Antipruritic agent using pac1 receptor antagonist
EP4147701A4 (de)	2020-05-08	2024-06-12	Kagoshima University	Antidepressivum/anxiolytisches arzneimittel mit pac1-rezeptorantagonist
CN112851561A (zh) *	2021-01-29	2021-05-28	南京艾美斐生物医药科技有限公司	一种nr6a1蛋白受体抑制剂及其制备和应用
WO2022268520A1 (de)	2021-06-21	2022-12-29	Bayer Aktiengesellschaft	Verwendung von substituierten pyrrolidinonen oder deren salzen zur steigerung der stresstoleranz in pflanzen.

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FR2500831A1 (fr)	1981-02-27	1982-09-03	Delalande Sa	Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
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EP1255513B1 (de) *	2000-02-14	2005-05-25	Potencia Medical AG	Penisprothese
TWI286132B (en) *	2002-09-20	2007-09-01	Hoffmann La Roche	4-pyrrolidino-phenyl-benzyl ether derivatives
US20040267292A1 (en) *	2003-06-27	2004-12-30	Byrum Randal T.	Implantable band with transverse attachment mechanism
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2003
- 2003-09-17 TW TW092125618A patent/TWI286132B/zh not_active IP Right Cessation
- 2003-09-17 PE PE2003000952A patent/PE20050077A1/es not_active Application Discontinuation
- 2003-09-17 PA PA20038583001A patent/PA8583001A1/es unknown
- 2003-09-17 MY MYPI20033545A patent/MY134480A/en unknown
- 2003-09-18 TW TW092125746A patent/TWI331994B/zh not_active IP Right Cessation
- 2003-09-18 AU AU2003267381A patent/AU2003267381B2/en not_active Ceased
- 2003-09-18 KR KR1020057004718A patent/KR100676014B1/ko not_active Expired - Fee Related
- 2003-09-18 KR KR1020057004683A patent/KR100676015B1/ko not_active Expired - Fee Related
- 2003-09-18 JO JO2003116A patent/JO2605B1/en active
- 2003-09-18 GT GT200300204A patent/GT200300204A/es unknown
- 2003-09-18 PL PL03376019A patent/PL376019A1/xx not_active Application Discontinuation
- 2003-09-18 WO PCT/EP2003/010356 patent/WO2004026825A1/en not_active Ceased
- 2003-09-18 UY UY27991A patent/UY27991A1/es not_active Application Discontinuation
- 2003-09-18 ES ES03748052T patent/ES2338646T3/es not_active Expired - Lifetime
- 2003-09-18 US US10/667,087 patent/US7151111B2/en not_active Expired - Lifetime
- 2003-09-18 DE DE60333202T patent/DE60333202D1/de not_active Expired - Lifetime
- 2003-09-18 JP JP2004537121A patent/JP4335142B2/ja not_active Expired - Fee Related
- 2003-09-18 PE PE2003000956A patent/PE20050078A1/es not_active Application Discontinuation
- 2003-09-18 MX MXPA05002878A patent/MXPA05002878A/es active IP Right Grant
- 2003-09-18 CA CA2498785A patent/CA2498785C/en not_active Expired - Fee Related
- 2003-09-18 AR ARP030103385A patent/AR041299A1/es not_active Application Discontinuation
- 2003-09-18 RU RU2005111969/04A patent/RU2323209C2/ru not_active IP Right Cessation
- 2003-09-18 DE DE60331559T patent/DE60331559D1/de not_active Expired - Lifetime
- 2003-09-18 CN CNB038219522A patent/CN100383118C/zh not_active Expired - Fee Related
- 2003-09-18 KR KR1020057004699A patent/KR100681586B1/ko not_active Expired - Fee Related
- 2003-09-18 GT GT200300205A patent/GT200300205A/es unknown
- 2003-09-18 RU RU2005111974/04A patent/RU2336267C2/ru not_active IP Right Cessation
- 2003-09-18 TW TW092125735A patent/TWI337604B/zh not_active IP Right Cessation
- 2003-09-18 NZ NZ538048A patent/NZ538048A/en not_active IP Right Cessation
- 2003-09-18 AR ARP030103384A patent/AR041298A1/es unknown
- 2003-09-18 EP EP03748052A patent/EP1542969B1/de not_active Expired - Lifetime
- 2003-09-18 AT AT03748052T patent/ATE459601T1/de active
- 2003-09-18 AT AT03750564T patent/ATE472530T1/de active
- 2003-09-18 BR BR0314314-7A patent/BR0314314A/pt not_active IP Right Cessation
- 2003-09-18 NZ NZ538049A patent/NZ538049A/en unknown
- 2003-09-18 JO JO2003115A patent/JO2604B1/en active
- 2003-09-18 BR BR0314299-0A patent/BR0314299A/pt active Search and Examination
- 2003-09-18 RU RU2005111968/04A patent/RU2336268C2/ru not_active IP Right Cessation
- 2003-09-18 EP EP03750564A patent/EP1542970B1/de not_active Expired - Lifetime
- 2003-09-18 HR HRP20050263AA patent/HRP20050263B1/hr not_active IP Right Cessation
- 2003-09-18 BR BRPI0314631-6A patent/BRPI0314631B1/pt unknown
- 2003-09-18 AU AU2003273901A patent/AU2003273901B2/en not_active Ceased
- 2003-09-18 PE PE2003000958A patent/PE20050079A1/es active IP Right Grant
- 2003-09-18 JP JP2004537119A patent/JP4335140B2/ja not_active Expired - Fee Related
- 2003-09-18 MX MXPA05002881A patent/MXPA05002881A/es active IP Right Grant
- 2003-09-18 PA PA20038583501A patent/PA8583501A1/es unknown
- 2003-09-18 WO PCT/EP2003/010383 patent/WO2004026826A1/en not_active Ceased
- 2003-09-18 AU AU2003270213A patent/AU2003270213B8/en not_active Ceased
- 2003-09-18 GT GT200300206A patent/GT200300206A/es unknown
- 2003-09-18 PT PT03750564T patent/PT1542970E/pt unknown
- 2003-09-18 UY UY27990A patent/UY27990A1/es not_active Application Discontinuation
- 2003-09-18 CN CNB038217678A patent/CN100400509C/zh not_active Expired - Fee Related
- 2003-09-18 WO PCT/EP2003/010384 patent/WO2004026827A1/en not_active Ceased
- 2003-09-18 HR HR20050261A patent/HRP20050261A2/hr not_active Application Discontinuation
- 2003-09-18 NZ NZ538046A patent/NZ538046A/en not_active IP Right Cessation
- 2003-09-18 MY MYPI20033559A patent/MY135696A/en unknown
- 2003-09-18 AR ARP030103383A patent/AR041297A1/es unknown
- 2003-09-18 SI SI200331830T patent/SI1542970T1/sl unknown
- 2003-09-18 PL PL03376018A patent/PL376018A1/xx not_active Application Discontinuation
- 2003-09-18 CN CNB038212560A patent/CN100503562C/zh not_active Expired - Fee Related
- 2003-09-18 PA PA20038583601A patent/PA8583601A1/es unknown
- 2003-09-18 CA CA002498335A patent/CA2498335A1/en not_active Abandoned
- 2003-09-18 CA CA2496756A patent/CA2496756C/en not_active Expired - Fee Related
- 2003-09-18 US US10/666,594 patent/US7235581B2/en not_active Expired - Fee Related
- 2003-09-18 US US10/667,088 patent/US7037935B2/en not_active Expired - Fee Related
- 2003-09-18 BR BR0314631-6A patent/BR0314631A/pt not_active IP Right Cessation
- 2003-09-18 MY MYPI20033558A patent/MY133332A/en unknown
- 2003-09-18 MX MXPA05002880A patent/MXPA05002880A/es active IP Right Grant
- 2003-09-18 HR HR20050262A patent/HRP20050262A2/xx not_active Application Discontinuation
- 2003-09-18 DK DK03750564.1T patent/DK1542970T3/da active
- 2003-09-18 ES ES03750564T patent/ES2344557T3/es not_active Expired - Lifetime
- 2003-09-18 JP JP2004537120A patent/JP4335141B2/ja not_active Expired - Fee Related
- 2003-09-18 EP EP03757866A patent/EP1542971A1/de not_active Withdrawn
- 2003-09-18 PL PL376021A patent/PL216030B1/pl unknown
- 2003-09-19 UY UY27993A patent/UY27993A1/es not_active Application Discontinuation
2005
- 2005-02-08 ZA ZA200501137A patent/ZA200501137B/xx unknown
- 2005-02-08 NO NO20050652A patent/NO329754B1/no not_active IP Right Cessation
- 2005-02-08 NO NO20050665A patent/NO330012B1/no not_active IP Right Cessation
- 2005-02-09 NO NO20050701A patent/NO20050701L/no not_active Application Discontinuation
- 2005-02-14 ZA ZA200501311A patent/ZA200501311B/en unknown
- 2005-02-22 ZA ZA200501557A patent/ZA200501557B/xx unknown
2006
- 2006-01-05 US US11/325,747 patent/US7122562B2/en not_active Expired - Fee Related
2010
- 2010-08-20 CY CY20101100770T patent/CY1110745T1/el unknown

Also Published As

Publication number	Publication date
ZA200501311B (en)	2006-10-25
GT200300205A (es)	2004-04-29
KR20050057466A (ko)	2005-06-16
PA8583001A1 (es)	2004-04-23
KR100676014B1 (ko)	2007-01-30
AU2003270213B8 (en)	2009-03-05
CA2498335A1 (en)	2004-04-01
HK1084383A1 (en)	2006-07-28
PL376019A1 (en)	2005-12-12
NZ538046A (en)	2007-08-31
NO20050665L (no)	2005-04-18
MXPA05002878A (es)	2005-05-27
PA8583601A1 (es)	2004-09-16
NZ538048A (en)	2007-05-31
CN100383118C (zh)	2008-04-23
ATE459601T1 (de)	2010-03-15
JP2006503833A (ja)	2006-02-02
TW200408624A (en)	2004-06-01
KR100676015B1 (ko)	2007-01-30
UY27990A1 (es)	2004-03-31
UY27991A1 (es)	2004-03-31
TW200410935A (en)	2004-07-01
US7235581B2 (en)	2007-06-26
PL376021A1 (en)	2005-12-12
JP4335141B2 (ja)	2009-09-30
BR0314631A (pt)	2005-08-02
US7122562B2 (en)	2006-10-17
NO20050652L (no)	2005-03-08
US20060122235A1 (en)	2006-06-08
ES2338646T3 (es)	2010-05-11
WO2004026827A1 (en)	2004-04-01
HRP20050263A2 (en)	2006-12-31
US20040106650A1 (en)	2004-06-03
AR041298A1 (es)	2005-05-11
GT200300204A (es)	2004-04-29
CN100400509C (zh)	2008-07-09
PT1542970E (pt)	2010-07-19
RU2005111974A (ru)	2006-01-20
AU2003267381A1 (en)	2004-04-08
PE20050077A1 (es)	2005-03-01
TWI331994B (en)	2010-10-21
PE20050078A1 (es)	2005-02-28
TWI286132B (en)	2007-09-01
MY134480A (en)	2007-12-31
PL376018A1 (en)	2005-12-12
NO329754B1 (no)	2010-12-13
EP1542970B1 (de)	2010-06-30
JP2006503834A (ja)	2006-02-02
HK1083498A1 (zh)	2006-07-07
CN1681777A (zh)	2005-10-12
US7151111B2 (en)	2006-12-19
UY27993A1 (es)	2004-03-31
WO2004026825A1 (en)	2004-04-01
MY135696A (en)	2008-06-30
RU2323209C2 (ru)	2008-04-27
DE60331559D1 (de)	2010-04-15
TWI337604B (en)	2011-02-21
RU2005111969A (ru)	2006-01-20
NZ538049A (en)	2007-05-31
MXPA05002881A (es)	2005-05-27
PL216030B1 (pl)	2014-02-28
EP1542971A1 (de)	2005-06-22
AU2003273901B2 (en)	2008-07-10
RU2005111968A (ru)	2006-11-10
KR100681586B1 (ko)	2007-02-09
JO2604B1 (en)	2011-11-01
AU2003270213B2 (en)	2009-02-12
AR041297A1 (es)	2005-05-11
KR20050057456A (ko)	2005-06-16
JO2605B1 (en)	2011-11-01
HRP20050262A2 (en)	2006-06-30
CA2498785C (en)	2011-07-26
CA2498785A1 (en)	2004-04-01
BR0314299A (pt)	2005-12-13
BRPI0314631B1 (pt)	2018-04-17
DE60333202D1 (de)	2010-08-12
HRP20050263B1 (hr)	2013-09-30
HRP20050261A2 (en)	2006-05-31
CN100503562C (zh)	2009-06-24
WO2004026826A1 (en)	2004-04-01
PA8583501A1 (es)	2004-04-23
ES2344557T3 (es)	2010-08-31
US20040097578A1 (en)	2004-05-20
NO330012B1 (no)	2011-02-07
DK1542970T3 (da)	2010-08-02
AU2003270213A1 (en)	2004-04-08
AR041299A1 (es)	2005-05-11
ZA200501557B (en)	2005-09-08
RU2336268C2 (ru)	2008-10-20
RU2336267C2 (ru)	2008-10-20
NO20050701L (no)	2005-03-02
EP1542969B1 (de)	2010-03-03
EP1542970A1 (de)	2005-06-22
MXPA05002880A (es)	2005-05-27
PE20050079A1 (es)	2005-03-01
CN1681779A (zh)	2005-10-12
CN1681778A (zh)	2005-10-12
AU2003267381B2 (en)	2009-08-27
MY133332A (en)	2007-11-30
SI1542970T1 (sl)	2010-08-31
CA2496756C (en)	2012-01-10
KR20050057450A (ko)	2005-06-16
BR0314314A (pt)	2005-07-26
EP1542969A1 (de)	2005-06-22
CA2496756A1 (en)	2004-04-01
JP2006510596A (ja)	2006-03-30
US7037935B2 (en)	2006-05-02
TW200413350A (en)	2004-08-01
US20040116707A1 (en)	2004-06-17
CY1110745T1 (el)	2015-06-10
GT200300206A (es)	2004-04-29
ZA200501137B (en)	2006-12-27
JP4335142B2 (ja)	2009-09-30
HK1083499A1 (zh)	2006-07-07
AU2003273901A1 (en)	2004-04-08
JP4335140B2 (ja)	2009-09-30

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