BR0316401A - composto ou um sal farmaceuticamente aceitável ou um derivado de pró-droga de éster do mesmo, derivados de pró-droga e de sal de um composto, formulações farmacêutica, para tratar a osteoporose, e para tratar psorìase, métodos para tratar um mamìfero para prevenir ou aliviar os efeitos patológicos, para tratar ou previnir estados de doenças mediados pelo receptor de vitamimna d, e para tratar um mamìfero para prevenir ou aliviar o efeito de mostarda, processo para preparar um composto, e, uso de um composto - Google Patents

composto ou um sal farmaceuticamente aceitável ou um derivado de pró-droga de éster do mesmo, derivados de pró-droga e de sal de um composto, formulações farmacêutica, para tratar a osteoporose, e para tratar psorìase, métodos para tratar um mamìfero para prevenir ou aliviar os efeitos patológicos, para tratar ou previnir estados de doenças mediados pelo receptor de vitamimna d, e para tratar um mamìfero para prevenir ou aliviar o efeito de mostarda, processo para preparar um composto, e, uso de um composto

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Publication number
BR0316401A
BR0316401A BRPI0316401-2A BR0316401A BR0316401A BR 0316401 A BR0316401 A BR 0316401A BR 0316401 A BR0316401 A BR 0316401A BR 0316401 A BR0316401 A BR 0316401A
Authority
BR
Brazil
Prior art keywords
treating
compound
mammal
prevent
prodrug
Prior art date
Application number
BRPI0316401-2A
Other languages
English (en)
Inventor
Emilio Enrique Bunel
Robert Peter Gajewski
Charles David Jones
Jianliang Lu
Tianwei Ma
Sunil Nagpal
Ying Kwong Yee
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR0316401A publication Critical patent/BR0316401A/pt

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
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    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

"COMPOSTO OU UM SAL FARMACEUTICAMENTE ACEITáVEL OU UM DERIVADO DE PRó-DROGA DE éSTER DO MESMO, DERIVADOS DE PRó-DROGA E DE SAL DE UM COMPOSTO, FORMULAçõES FARMACêUTICA, PARA TRATAR A OSTEOPOROSE, E PARA TRATAR PSORìASE, MéTODOS PARA TRATAR UM MAMìFERO PARA PREVENIR OU ALIVIAR OS EFEITOS PATOLóGICOS, PARA TRATAR OU PREVENIR ESTADOS DE DOENçA MEDIADOS PELO RECEPTOR DE VITAMINA D, E PARA TRATAR UM MAMìFERO PARA PREVENIR OU ALIVIAR O EFEITO DE MOSTARDA, PROCESSO PARA PREPARAR UM COMPOSTO, E, USO DE UM COMPOSTO". A presente invenção diz respeito a novos compostos de diarila ligado a carbono, não secosteroidais com atividade moduladora do receptor de vitamina D (VDR) que são menos hipercalcêmicas do que l<244>c,25 diidróxi vitamina D3. Estes compostos são úteis para tratar doenças ósseas e psoríase.
BRPI0316401-2A 2002-11-22 2003-11-20 composto ou um sal farmaceuticamente aceitável ou um derivado de pró-droga de éster do mesmo, derivados de pró-droga e de sal de um composto, formulações farmacêutica, para tratar a osteoporose, e para tratar psorìase, métodos para tratar um mamìfero para prevenir ou aliviar os efeitos patológicos, para tratar ou previnir estados de doenças mediados pelo receptor de vitamimna d, e para tratar um mamìfero para prevenir ou aliviar o efeito de mostarda, processo para preparar um composto, e, uso de um composto BR0316401A (pt)

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PCT/US2003/035055 WO2004048309A1 (en) 2002-11-22 2003-11-20 Vitamin d receptor modulators

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CA2589667A1 (en) * 2004-12-21 2006-06-29 Eli Lilly And Company Vitamin d receptor modulators
DK1836151T3 (da) 2004-12-21 2009-06-02 Lilly Co Eli D-vitamin-receptormodulatorer
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JP2010208997A (ja) * 2009-03-11 2010-09-24 Okayama Univ 置換ジフェニルメタン酸誘導体を含有する医薬組成物
CN101906443B (zh) * 2010-06-25 2012-07-25 绍兴文理学院 (2S)-[2-(t-叔丁基)二甲基硅氧基]-2-环丙基-1-乙基-三苯基膦的合成方法
CN103193695B (zh) * 2013-04-22 2015-08-05 中国药科大学 3-苯基-3-吡咯基戊烷类衍生物及其医药用途
CN104030913A (zh) * 2014-06-26 2014-09-10 江南大学 一种四溴双酚a类似物四溴双酚a己酸的合成方法

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DK1836151T3 (da) 2004-12-21 2009-06-02 Lilly Co Eli D-vitamin-receptormodulatorer

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US7772425B2 (en) 2010-08-10
CY1108988T1 (el) 2014-07-02
DE60326082D1 (de) 2009-03-19
US20090018058A1 (en) 2009-01-15
JP2006507344A (ja) 2006-03-02
EP1565422A1 (en) 2005-08-24
CN1714070A (zh) 2005-12-28
JP4594099B2 (ja) 2010-12-08
US7566803B2 (en) 2009-07-28
AU2003287500A1 (en) 2004-06-18
EP1565422B1 (en) 2009-02-04
MXPA05005439A (es) 2005-08-03
ATE422197T1 (de) 2009-02-15
SI1565422T1 (sl) 2009-08-31
CA2506891A1 (en) 2004-06-10
PT1565422E (pt) 2009-04-24
CA2506891C (en) 2012-04-24
ES2319984T3 (es) 2009-05-18
WO2004048309A1 (en) 2004-06-10

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