BR1100705A - Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazina - Google Patents

Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazina

Info

Publication number: BR1100705A
Authority: BR; Brazil
Prior art keywords: dimethoxy; amino; quinazolinyl; piperazine; hydrochloride
Prior art date: 1994-10-18

Application number

BR1100705-2A

Other languages

English (en)

Inventor

Anthony Mannino

Rodger F Henry

Wayne R Heitmann

Bruce W Horrom

Original Assignee

Anthony Mannino

Rodger F. Henry

Wayne R. Heitmann

Bruce W. Horrom

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-18

Filing date

1997-05-08

Publication date

1999-10-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23264439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR1100705(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-05-08 Application filed by Anthony Mannino, Rodger F. Henry, Wayne R. Heitmann, Bruce W. Horrom filed Critical Anthony Mannino

1999-10-13 Publication of BR1100705A publication Critical patent/BR1100705A/pt

Links

238000000034 method Methods 0.000 title abstract 2
-1 4-amino-6,7-dimethoxy-quinazolinyl Chemical group 0.000 title 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
MSQACBWWAIBWIC-UHFFFAOYSA-N hydron;piperazine;chloride Chemical compound Cl.C1CNCCN1 MSQACBWWAIBWIC-UHFFFAOYSA-N 0.000 title 1
230000004048 modification Effects 0.000 title 1
238000012986 modification Methods 0.000 title 1
IWSWDOUXSCRCKW-UHFFFAOYSA-N [6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-yl]azanium;chloride Chemical compound Cl.N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 IWSWDOUXSCRCKW-UHFFFAOYSA-N 0.000 abstract 2
UKESBLFBQANJHH-UHFFFAOYSA-N 1-(Tetrahydro-2-furoyl)piperazine Chemical compound C1CNCCN1C(=O)C1CCCO1 UKESBLFBQANJHH-UHFFFAOYSA-N 0.000 abstract 1
HWIIAAVGRHKSOJ-UHFFFAOYSA-N 2-chloro-6,7-dimethoxyquinazolin-4-amine Chemical compound ClC1=NC(N)=C2C=C(OC)C(OC)=CC2=N1 HWIIAAVGRHKSOJ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003495 polar organic solvent Substances 0.000 abstract 1
239000002516 radical scavenger Substances 0.000 abstract 1
NZMOFYDMGFQZLS-UHFFFAOYSA-N terazosin hydrochloride dihydrate Chemical compound [H+].O.O.[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 NZMOFYDMGFQZLS-UHFFFAOYSA-N 0.000 abstract 1
KKCIOUWDFWQUBT-UHFFFAOYSA-N thyronine Chemical compound C1=CC(CC(N)C(O)=O)=CC=C1OC1=CC=C(O)C=C1 KKCIOUWDFWQUBT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BR1100705-2A 1994-10-18 1997-05-08 Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazina BR1100705A (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/324,635 US5504207A (en)	1994-10-18	1994-10-18	Process and intermediate for the preparation of terazosin hydrochloride dihydrate

Publications (1)

Publication Number	Publication Date
BR1100705A true BR1100705A (pt)	1999-10-13

Family

ID=23264439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR1100705-2A BR1100705A (pt)	1994-10-18	1997-05-08	Processo para a preparação de diidrato de cloridrato de 1-(4-amino-6,7-dimetóxi-quinazolinil)-4-(2-tetra-idrofu roil) piperazina e modificação cristalina anidra de forma iv de cloridrato de 1-(4-amino-6,7-dimetóxi-2-quinazolinil)-4-(2-tetraidrof uroil) piperazina

Country Status (11)

Country	Link
US (1)	US5504207A (pt)
EP (1)	EP0708104B1 (pt)
JP (1)	JP2711230B2 (pt)
AT (1)	ATE143959T1 (pt)
BR (1)	BR1100705A (pt)
CA (1)	CA2143971C (pt)
DE (1)	DE69500064T2 (pt)
DK (1)	DK0708104T3 (pt)
ES (1)	ES2089993T3 (pt)
GR (2)	GR960300047T1 (pt)
HK (1)	HK130297A (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5587377A (en) *	1995-10-24	1996-12-24	Invamed, Inc.	Terazosin crystalline polymorph and pharmaceutical compositions thereof
DE19546573A1 (de) *	1995-12-13	1997-06-19	Uetikon Chemie Gmbh	Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung
US5952003A (en) *	1996-08-01	1999-09-14	Novartis Corporation	Terazosin capsules
EP0849265A1 (de) *	1996-12-20	1998-06-24	HEUMANN PHARMA GmbH	Neue polymorphe Form von Doxazosin-Mesylat (Form II)
EP0849264A1 (de) *	1996-12-20	1998-06-24	HEUMANN PHARMA GmbH	Neue polymorphe Form von doxazosinmesylat (Form I)
PT849266E (pt) *	1996-12-20	2007-03-30	Heumann Pcs Gmbh	Nova forma polimorfa de mesilato de doxazosina (forma iii)
US6248888B1 (en)	1997-11-14	2001-06-19	Teva Pharmaceutical Industries Ltd.	Process for the preparation of terazosin hydrochloride dihydrate
US6200573B1 (en)	1999-12-03	2001-03-13	Starcor Pharmaceuticals, Inc.	Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia
US20070161791A1 (en) *	2006-01-09	2007-07-12	Narsimha Reddy Penthala	Process for the preparation of terazosin hydrocloride dihydrate
AU2007286186A1 (en) *	2006-08-08	2008-02-21	Auspex Pharmaceuticals, Inc.	Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4026894A (en) *	1975-10-14	1977-05-31	Abbott Laboratories	Antihypertensive agents
GB1591490A (en) *	1977-08-04	1981-06-24	Abbott Lab	1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
EP0237608B1 (de) *	1986-03-21	1992-01-29	HEUMANN PHARMA GMBH & CO	Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung
US5212176A (en) *	1990-06-29	1993-05-18	Abbott Laboratories	R(+)-terazosin
WO1992003453A1 (en) *	1990-08-23	1992-03-05	Dainippon Ink & Chemicals, Inc.	Antiviral agent
JP2652272B2 (ja) *	1990-12-31	1997-09-10	住化ファインケム株式会社	１−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
US5294615A (en) *	1993-04-29	1994-03-15	Abbott Laboratories	Terazosin polymorph and pharmaceutical composition

1994
- 1994-10-18 US US08/324,635 patent/US5504207A/en not_active Expired - Fee Related
1995
- 1995-03-06 DK DK95103188.9T patent/DK0708104T3/da active
- 1995-03-06 AT AT95103188T patent/ATE143959T1/de not_active IP Right Cessation
- 1995-03-06 DE DE69500064T patent/DE69500064T2/de not_active Revoked
- 1995-03-06 EP EP95103188A patent/EP0708104B1/en not_active Revoked
- 1995-03-06 CA CA002143971A patent/CA2143971C/en not_active Expired - Fee Related
- 1995-03-06 ES ES95103188T patent/ES2089993T3/es not_active Expired - Lifetime
- 1995-03-16 JP JP7057435A patent/JP2711230B2/ja not_active Expired - Fee Related
1996
- 1996-08-31 GR GR960300047T patent/GR960300047T1/el unknown
- 1996-10-10 GR GR960402604T patent/GR3021319T3/el unknown
1997
- 1997-05-08 BR BR1100705-2A patent/BR1100705A/pt active Search and Examination
- 1997-06-26 HK HK130297A patent/HK130297A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2711230B2 (ja)	1998-02-10
CA2143971C (en)	1997-06-03
EP0708104A1 (en)	1996-04-24
DE69500064D1 (de)	1996-11-14
JPH08134066A (ja)	1996-05-28
ES2089993T1 (es)	1996-10-16
ATE143959T1 (de)	1996-10-15
HK130297A (en)	1997-09-19
EP0708104B1 (en)	1996-10-09
GR960300047T1 (en)	1996-08-31
US5504207A (en)	1996-04-02
DE69500064T2 (de)	1997-04-10
GR3021319T3 (en)	1997-01-31
ES2089993T3 (es)	1997-02-16
DK0708104T3 (da)	1997-03-10
CA2143971A1 (en)	1996-04-19

Legal Events

Date	Code	Title	Description
1997-09-09	AN	Processing applications according to articles 230 and 231 of law 9279/96: notification of filing an application
1998-05-05	HHFK	Processing applications according to articles 230 and 231 of law 9.279/96: republication
1998-12-15	MT	Patent procedure suspended until requirement met - articles 230 and 231 of law 9279/96
1999-07-13	FGAN	Processing applications according to articles 230 and 231 of law 9.279/96: granting
1999-10-13	NB	Patent issued - articles 230 and 231 of law 9279/96
2006-08-29	B23L	Information on processing applications according to articles 230 and 231 of law 9.279/96 modified	Free format text: REFERENTE A RPI 1501 DE 13/10/1999 COD. 23.9, QUANTO AO PRAZO DE VALIDADE.

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