GR3021319T3 - Process and intermediate for the preparation of terazosin hydrochloride dihydrate - Google Patents

Process and intermediate for the preparation of terazosin hydrochloride dihydrate

Info

Publication number: GR3021319T3
Authority: GR; Greece
Prior art keywords: tetrahydrofuroyl; dimethoxy; amino; preparation; hydrochloride dihydrate
Prior art date: 1994-10-18

Application number

GR960402604T

Other languages

English (en)

Inventor

Anthony Mannino

Wayne R Heitmann

Rodger F Henry

Bruce W Horrom

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-18

Filing date

1996-10-10

Publication date

1997-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23264439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3021319(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-10-10 Application filed by Abbott Lab filed Critical Abbott Lab

1997-01-31 Publication of GR3021319T3 publication Critical patent/GR3021319T3/el

Links

KKCIOUWDFWQUBT-UHFFFAOYSA-N thyronine Chemical compound C1=CC(CC(N)C(O)=O)=CC=C1OC1=CC=C(O)C=C1 KKCIOUWDFWQUBT-UHFFFAOYSA-N 0.000 title abstract 2
IWSWDOUXSCRCKW-UHFFFAOYSA-N [6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-yl]azanium;chloride Chemical compound Cl.N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 IWSWDOUXSCRCKW-UHFFFAOYSA-N 0.000 abstract 2
UKESBLFBQANJHH-UHFFFAOYSA-N 1-(Tetrahydro-2-furoyl)piperazine Chemical compound C1CNCCN1C(=O)C1CCCO1 UKESBLFBQANJHH-UHFFFAOYSA-N 0.000 abstract 1
HWIIAAVGRHKSOJ-UHFFFAOYSA-N 2-chloro-6,7-dimethoxyquinazolin-4-amine Chemical compound ClC1=NC(N)=C2C=C(OC)C(OC)=CC2=N1 HWIIAAVGRHKSOJ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003495 polar organic solvent Substances 0.000 abstract 1
239000002516 radical scavenger Substances 0.000 abstract 1
NZMOFYDMGFQZLS-UHFFFAOYSA-N terazosin hydrochloride dihydrate Chemical compound [H+].O.O.[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 NZMOFYDMGFQZLS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GR960402604T 1994-10-18 1996-10-10 Process and intermediate for the preparation of terazosin hydrochloride dihydrate GR3021319T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/324,635 US5504207A (en)	1994-10-18	1994-10-18	Process and intermediate for the preparation of terazosin hydrochloride dihydrate

Publications (1)

Publication Number	Publication Date
GR3021319T3 true GR3021319T3 (en)	1997-01-31

Family

ID=23264439

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GR960300047T GR960300047T1 (en)	1994-10-18	1996-08-31	Process and intermediate for the preparation of terazosin hydrochloride dihydrate
GR960402604T GR3021319T3 (en)	1994-10-18	1996-10-10	Process and intermediate for the preparation of terazosin hydrochloride dihydrate

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GR960300047T GR960300047T1 (en)	1994-10-18	1996-08-31	Process and intermediate for the preparation of terazosin hydrochloride dihydrate

Country Status (11)

Country	Link
US (1)	US5504207A (el)
EP (1)	EP0708104B1 (el)
JP (1)	JP2711230B2 (el)
AT (1)	ATE143959T1 (el)
BR (1)	BR1100705A (el)
CA (1)	CA2143971C (el)
DE (1)	DE69500064T2 (el)
DK (1)	DK0708104T3 (el)
ES (1)	ES2089993T3 (el)
GR (2)	GR960300047T1 (el)
HK (1)	HK130297A (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5587377A (en) *	1995-10-24	1996-12-24	Invamed, Inc.	Terazosin crystalline polymorph and pharmaceutical compositions thereof
DE19546573A1 (de) *	1995-12-13	1997-06-19	Uetikon Chemie Gmbh	Kristallines Polymorph von Terazosin-Hydrochlorid, sowie Verfahren zu seiner Herstellung
US5952003A (en) *	1996-08-01	1999-09-14	Novartis Corporation	Terazosin capsules
EP0849265A1 (de) *	1996-12-20	1998-06-24	HEUMANN PHARMA GmbH	Neue polymorphe Form von Doxazosin-Mesylat (Form II)
EP0849264A1 (de) *	1996-12-20	1998-06-24	HEUMANN PHARMA GmbH	Neue polymorphe Form von doxazosinmesylat (Form I)
PT849266E (pt) *	1996-12-20	2007-03-30	Heumann Pcs Gmbh	Nova forma polimorfa de mesilato de doxazosina (forma iii)
US6248888B1 (en)	1997-11-14	2001-06-19	Teva Pharmaceutical Industries Ltd.	Process for the preparation of terazosin hydrochloride dihydrate
US6200573B1 (en)	1999-12-03	2001-03-13	Starcor Pharmaceuticals, Inc.	Method of medical management for lower urinary tract symptoms and benign prostatic hyperplasia
US20070161791A1 (en) *	2006-01-09	2007-07-12	Narsimha Reddy Penthala	Process for the preparation of terazosin hydrocloride dihydrate
AU2007286186A1 (en) *	2006-08-08	2008-02-21	Auspex Pharmaceuticals, Inc.	Preparation and utility of substituted quinazoline compounds with alpha-adrenergic blocking effects

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4026894A (en) *	1975-10-14	1977-05-31	Abbott Laboratories	Antihypertensive agents
GB1591490A (en) *	1977-08-04	1981-06-24	Abbott Lab	1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
EP0237608B1 (de) *	1986-03-21	1992-01-29	HEUMANN PHARMA GMBH & CO	Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung
US5212176A (en) *	1990-06-29	1993-05-18	Abbott Laboratories	R(+)-terazosin
WO1992003453A1 (en) *	1990-08-23	1992-03-05	Dainippon Ink & Chemicals, Inc.	Antiviral agent
JP2652272B2 (ja) *	1990-12-31	1997-09-10	住化ファインケム株式会社	１−（４−アミノ−６，７−ジメトキシ−２−キナゾリニル）−４−（２−テトラヒドロフロイル）ピペラジン塩酸塩の新規な結晶体および該結晶体の製造方法
US5294615A (en) *	1993-04-29	1994-03-15	Abbott Laboratories	Terazosin polymorph and pharmaceutical composition

1994
- 1994-10-18 US US08/324,635 patent/US5504207A/en not_active Expired - Fee Related
1995
- 1995-03-06 DK DK95103188.9T patent/DK0708104T3/da active
- 1995-03-06 AT AT95103188T patent/ATE143959T1/de not_active IP Right Cessation
- 1995-03-06 DE DE69500064T patent/DE69500064T2/de not_active Revoked
- 1995-03-06 EP EP95103188A patent/EP0708104B1/en not_active Revoked
- 1995-03-06 CA CA002143971A patent/CA2143971C/en not_active Expired - Fee Related
- 1995-03-06 ES ES95103188T patent/ES2089993T3/es not_active Expired - Lifetime
- 1995-03-16 JP JP7057435A patent/JP2711230B2/ja not_active Expired - Fee Related
1996
- 1996-08-31 GR GR960300047T patent/GR960300047T1/el unknown
- 1996-10-10 GR GR960402604T patent/GR3021319T3/el unknown
1997
- 1997-05-08 BR BR1100705-2A patent/BR1100705A/pt active Search and Examination
- 1997-06-26 HK HK130297A patent/HK130297A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2711230B2 (ja)	1998-02-10
BR1100705A (pt)	1999-10-13
CA2143971C (en)	1997-06-03
EP0708104A1 (en)	1996-04-24
DE69500064D1 (de)	1996-11-14
JPH08134066A (ja)	1996-05-28
ES2089993T1 (es)	1996-10-16
ATE143959T1 (de)	1996-10-15
HK130297A (en)	1997-09-19
EP0708104B1 (en)	1996-10-09
GR960300047T1 (en)	1996-08-31
US5504207A (en)	1996-04-02
DE69500064T2 (de)	1997-04-10
ES2089993T3 (es)	1997-02-16
DK0708104T3 (da)	1997-03-10
CA2143971A1 (en)	1996-04-19

Publication	Publication Date	Title
GR960300047T1 (en)	1996-08-31	Process and intermediate for the preparation of terazosin hydrochloride dihydrate
EA199900953A1 (ru)	2000-10-30	ЗАМЕЩЕННЫЕ ПИРАЗОЛЫ, КАК ИНГИБИТОРЫ p38 КИНАЗЫ
MY128639A (en)	2007-02-28	1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor antagonists
NZ311403A (en)	1999-11-29	Imidazole compounds and pharmaceuticals
EE200000656A (et)	2002-04-15	Raadiosidesüsteemis kasutatav meetod ja seadmestik
YU91002A (sh)	2006-05-25	Derivati acilfenil-karbamida, postupak za njihovu proizvodnju i njihova primena kao leka
ATE251195T1 (de)	2003-10-15	In-situ herstellung von polyasparaginestermischungen
ATE440078T1 (de)	2009-09-15	Verfahren zur herstellung von alkylaminen
DE50202504D1 (de)	2005-04-21	Neue 4-aminofuropyrimidine und ihre verwendung
MXPA03008811A (es)	2004-02-18	Procedimiento para la preparacion de 4,6-diaminopirimido (5,4-d) pirimidinas.
DE50304758D1 (de)	2006-10-05	Chipkondensator und verfahren zu dessen herstellung
MY143958A (en)	2011-07-29	Quinazolinone derivatives and their use as cb agonists
GB0221245D0 (en)	2002-10-23	Chemical process
ATE253550T1 (de)	2003-11-15	In-situ herstellung einer polyasparaginsäureestermischung
YU12000A (sh)	2002-11-15	Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
ATE392725T1 (de)	2008-05-15	Eine schaltung, die ein differenzsignal abgreift
ATE376328T1 (de)	2007-11-15	Verbesserungen bezüglich der inhaltsauswahl
MXPA02001406A (es)	2002-08-12	Heterociclilos-2h-cromenos substituidos.
ATE446952T1 (de)	2009-11-15	Herstellungsverfahren von 2-cyanopyridinen
TW200505911A (en)	2005-02-16	Crystal of benzimidazole derivative and process for producing the same
WO2004052831A3 (de)	2004-09-30	Verfahren zur herstellung optisch aktiver dihydropyrone
DE50102050D1 (de)	2004-05-27	Verfahren zur herstellung von heterocyclischen verbindungen
WO2002081442A3 (de)	2002-12-27	Verfahren zum herstellen von δ1-pyrrolinen
ATE354376T1 (de)	2007-03-15	Zusammensetzungen für die elektroporation
IL158530A0 (en)	2004-05-12	Method for producing 1,3-disubstituted 2-nitroguanidines