BR112012000209A2 - processo para a produção de heterodímeros de ácido glutâmico - Google Patents
processo para a produção de heterodímeros de ácido glutâmicoInfo
- Publication number
- BR112012000209A2 BR112012000209A2 BR112012000209A BR112012000209A BR112012000209A2 BR 112012000209 A2 BR112012000209 A2 BR 112012000209A2 BR 112012000209 A BR112012000209 A BR 112012000209A BR 112012000209 A BR112012000209 A BR 112012000209A BR 112012000209 A2 BR112012000209 A2 BR 112012000209A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterodimers
- production
- glutamic acid
- glutamic
- acid
- Prior art date
Links
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 title 1
- 235000013922 glutamic acid Nutrition 0.000 title 1
- 239000004220 glutamic acid Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18712009P | 2009-06-15 | 2009-06-15 | |
| US61/187,120 | 2009-06-15 | ||
| PCT/US2010/038645 WO2010147965A2 (en) | 2009-06-15 | 2010-06-15 | Process for production of heterodimers of glutamic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012000209A2 true BR112012000209A2 (pt) | 2017-07-11 |
| BR112012000209B1 BR112012000209B1 (pt) | 2020-10-13 |
| BR112012000209B8 BR112012000209B8 (pt) | 2021-07-27 |
Family
ID=43067201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012000209A BR112012000209B8 (pt) | 2009-06-15 | 2010-06-15 | heterodímeros de ácido glutâmico e seus processos de preparação |
| BR112012000210A BR112012000210A2 (pt) | 2009-06-15 | 2010-06-15 | processo para a produção de heterodímeoros de ácido glutâmico. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012000210A BR112012000210A2 (pt) | 2009-06-15 | 2010-06-15 | processo para a produção de heterodímeoros de ácido glutâmico. |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US8465725B2 (pt) |
| AU (1) | AU2010260195B2 (pt) |
| BR (2) | BR112012000209B8 (pt) |
| WO (1) | WO2010147965A2 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6528499B1 (en) * | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
| CA2669127C (en) | 2006-11-08 | 2016-09-13 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
| US9193763B2 (en) | 2007-08-17 | 2015-11-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| AU2013344778C1 (en) | 2012-11-15 | 2024-06-27 | Endocyte, Inc. | Conjugates for treating diseases caused by PSMA expressing cells |
| JP6908964B2 (ja) | 2013-10-18 | 2021-07-28 | ピーエスエムエー ディベロップメント カンパニー，エルエルシー | Ｐｓｍａリガンドコンジュゲートによる併用療法 |
| EP3456700A1 (en) | 2013-10-18 | 2019-03-20 | Deutsches Krebsforschungszentrum | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| WO2015057250A1 (en) | 2013-10-18 | 2015-04-23 | Psma Development Company, Llc | Combination therapies with psma ligand conjugates |
| CN105849568B (zh) | 2013-11-14 | 2018-05-04 | 恩多塞特公司 | 用于正电子发射断层术的化合物 |
| US20150147339A1 (en) | 2013-11-15 | 2015-05-28 | Psma Development Company, Llc | Biomarkers for psma targeted therapy for prostate cancer |
| US9956305B2 (en) | 2014-09-08 | 2018-05-01 | Molecular Insight Pharmaceuticals, Inc. | Organ protection in PSMA-targeted radionuclide therapy of prostate cancer |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| KR20210003135A (ko) | 2018-04-17 | 2021-01-11 | 엔도사이트, 인코포레이티드 | 암의 치료 방법 |
| JP7604397B2 (ja) | 2019-05-20 | 2024-12-23 | エンドサイト・インコーポレイテッド | Ｐｓｍａコンジュゲートの調製方法 |
| CN111072653A (zh) * | 2019-12-26 | 2020-04-28 | 浙江工业大学 | 一种由取代2-芳基吲哚嗪直接合成1,3-双硫代吲哚嗪类化合物的方法 |
| WO2021202376A1 (en) | 2020-03-30 | 2021-10-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for blocking uptake of prostate-specific membrane antigen (psma)-targeted radionuclides by exocrine organs |
| WO2025250655A1 (en) * | 2024-05-29 | 2025-12-04 | Cornell University | Preparation of radiohalogenated compounds for nuclear medicine by reductive elimination from bismuth(v) halides |
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| CA2669127C (en) | 2006-11-08 | 2016-09-13 | Molecular Insight Pharmaceuticals, Inc. | Heterodimers of glutamic acid |
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| WO2009076434A1 (en) | 2007-12-12 | 2009-06-18 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of integrin vla-4 |
| AU2009204133B2 (en) | 2008-01-09 | 2014-04-10 | Molecular Insight Pharmaceuticals, Inc. | Inhibitors of carbonic anhydrase IX |
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| BRPI0922839A2 (pt) | 2008-12-05 | 2019-09-03 | Molecular Insight Pharmaceuticals, Inc. | radiofarmacêuticos específicos de ca-ix para tratamento e imageamento de câncer. |
| WO2010065906A2 (en) | 2008-12-05 | 2010-06-10 | Molecular Insight Pharmaceuticals, Inc. | Ca-ix specific radiopharmaceuticals for the treatment and imaging of cancer |
-
2010
- 2010-06-15 BR BR112012000209A patent/BR112012000209B8/pt active IP Right Grant
- 2010-06-15 WO PCT/US2010/038645 patent/WO2010147965A2/en not_active Ceased
- 2010-06-15 BR BR112012000210A patent/BR112012000210A2/pt not_active IP Right Cessation
- 2010-06-15 US US12/815,637 patent/US8465725B2/en active Active
- 2010-06-15 AU AU2010260195A patent/AU2010260195B2/en active Active
-
2013
- 2013-05-09 US US13/890,912 patent/US9149547B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110008253A1 (en) | 2011-01-13 |
| WO2010147965A3 (en) | 2011-07-28 |
| WO2010147965A2 (en) | 2010-12-23 |
| BR112012000209B8 (pt) | 2021-07-27 |
| US9149547B2 (en) | 2015-10-06 |
| BR112012000209B1 (pt) | 2020-10-13 |
| AU2010260195A1 (en) | 2012-01-19 |
| US8465725B2 (en) | 2013-06-18 |
| US20140030188A1 (en) | 2014-01-30 |
| BR112012000210A2 (pt) | 2019-09-24 |
| AU2010260195B2 (en) | 2014-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15G | Petition not considered as such [chapter 15.7 patent gazette] | ||
| B151 | Others concerning applications: resolution cancelled [chapter 15.31 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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